Gene Symbol | Macc1 |
Entrez Gene ID | 238455 |
Full Name | metastasis associated in colon cancer 1 |
Synonyms | 4732474O15Rik,Gm267 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Macc1 cDNA ORF clone
Gene Symbol | Macc1 |
Entrez Gene ID | 238455 |
Full Name | metastasis associated in colon cancer 1 |
Synonyms | 4732474O15Rik,Gm267 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006515861.2 | XP_006515924.1 | metastasis-associated in colon cancer protein 1 isoform X1 |
XM_006515861.3 | XP_006515924.1 | metastasis-associated in colon cancer protein 1 isoform X1 |
XM_006515863.3 | XP_006515926.1 | metastasis-associated in colon cancer protein 1 isoform X2 |
NM_001163136.1 | NP_001156608.1 | metastasis-associated in colon cancer protein 1 |
XM_006515862.2 | XP_006515925.1 | metastasis-associated in colon cancer protein 1 isoform X2 |
Gallus gallus (chicken) | MACC1 | XP_418705.4 |
Canis lupus familiaris (dog) | MACC1 | XP_005628662.1 |
Bos taurus (cattle) | MACC1 | XP_002686732.1 |
Mus musculus (house mouse) | Macc1 | NP_001156608.1 |
Danio rerio (zebrafish) | macc1 | NP_001186695.1 |
Rattus norvegicus (Norway rat) | Macc1 | NP_001178704.1 |
Xenopus tropicalis (tropical clawed frog) | macc1 | XP_002933345.1 |
Homo sapiens (human) | MACC1 | NP_877439.3 |
Pan troglodytes (chimpanzee) | MACC1 | XP_003318388.1 |
Metastasis-associated in colon cancer-1 upregulates vascular endothelial growth factor-C/D to promote lymphangiogenesis in human gastric cancer.
Sun L, Duan J, Jiang Y, Wang L, Huang N, Lin L, Liao Y, Liao W
Cancer letters357(1)242-53(2015 Feb)
Analysis of HGF, MACC1, C-met and apoptosis-related genes in cervical carcinoma mice.
Chen XP, Ren XP, Lan JY, Chen YG, Shen ZJ
Molecular biology reports41(3)1247-56(2014 Mar)
In vivo imaging of colorectal cancer growth and metastasis by targeting MACC1 with shRNA in xenografted mice.
Pichorner A, Sack U, Kobelt D, Kelch I, Arlt F, Smith J, Walther W, Schlag PM, Stein U
Clinical & experimental metastasis29(6)573-83(2012 Aug)
MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.
Stein U, Walther W, Arlt F, Schwabe H, Smith J, Fichtner I, Birchmeier W, Schlag PM
Nature medicine15(1)59-67(2009 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data suggest a critical role for MACC1 in lymphatic dissemination of GC, providing evidence that MACC1 upregulated VEGF-C/VEGF-D secretion to promote lymphangiogenesis via c-Met signaling.
Title: Metastasis-associated in colon cancer-1 upregulates vascular endothelial growth factor-C/D to promote lymphangiogenesis in human gastric cancer.
HGF, MACC1 and C-met genes involve into malignant cervical tumors occurrence, development and prognosis, and might become potential molecular target therapy site of cervical cancer
Title: Analysis of HGF, MACC1, C-met and apoptosis-related genes in cervical carcinoma mice.
MACC1 has a role in colorectal cancer and can be used for imaging in xenografts
Title: In vivo imaging of colorectal cancer growth and metastasis by targeting MACC1 with shRNA in xenografted mice.
MACC1 will be useful for the identification of poor prognosis subjects with colorectal cancer and is a promising new target for intervention in metastasis formation.
Title: MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.
The following Macc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Macc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu08749 | |
Clone ID Related Accession (Same CDS sequence) | XM_006515863.3 , NM_001163136.1 , XM_006515862.2 | |
Accession Version | NM_001163136.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2556bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-27 | |
Organism | Mus musculus(house mouse) | |
Product | metastasis-associated in colon cancer protein 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC138307.2 and AC132596.5. On or before Jul 10, 2009 this sequence version replaced XM_906766.2, XM_138397.6. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. CCDS Note: The exon combination of this CCDS representation is inferred based on orthologous transcript alignments, e.g., human AJ313524.1, BC137090.1 or BC144470.1. Partial mouse transcript data also support this representation, e.g., mRNA accession AK028965.1, and RNA-Seq data from the ENCODE project. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849382, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## |
1 | ATGCTAATCA GTGAAAGAGC CTATTGTTGG CCACGAGAAA TTGGTCGAAG TAGATCTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001156608.1 |
CDS | 1..2556 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001163136.1 |
1 | ATGCTAATCA GTGAAAGAGC CTATTGTTGG CCACGAGAAA TTGGTCGAAG TAGATCTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu08749 | |
Clone ID Related Accession (Same CDS sequence) | XM_006515863.3 , NM_001163136.1 , XM_006515862.2 | |
Accession Version | XM_006515863.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2556bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | metastasis-associated in colon cancer protein 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006515863.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTAATCA GTGAAAGAGC CTATTGTTGG CCACGAGAAA TTGGTCGAAG TAGATCTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006515926.1 |
CDS | 409..2964 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006515863.3 |
1 | ATGCTAATCA GTGAAAGAGC CTATTGTTGG CCACGAGAAA TTGGTCGAAG TAGATCTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu08749 | |
Clone ID Related Accession (Same CDS sequence) | XM_006515863.3 , NM_001163136.1 , XM_006515862.2 | |
Accession Version | XM_006515862.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2556bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | metastasis-associated in colon cancer protein 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006515862.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTAATCA GTGAAAGAGC CTATTGTTGG CCACGAGAAA TTGGTCGAAG TAGATCTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006515925.1 |
CDS | 351..2906 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006515862.2 |
1 | ATGCTAATCA GTGAAAGAGC CTATTGTTGG CCACGAGAAA TTGGTCGAAG TAGATCTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu47837 | |
Clone ID Related Accession (Same CDS sequence) | XM_006515861.2 , XM_006515861.3 | |
Accession Version | XM_006515861.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2586bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | metastasis-associated in colon cancer protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006515861.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATCTCTC CAGAGAAAGA TGGTAGCAAA ATGCTAATCA GTGAAAGAGC CTATTGTTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006515924.1 |
CDS | 396..2981 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006515861.2 |
1 | ATGATCTCTC CAGAGAAAGA TGGTAGCAAA ATGCTAATCA GTGAAAGAGC CTATTGTTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu47837 | |
Clone ID Related Accession (Same CDS sequence) | XM_006515861.2 , XM_006515861.3 | |
Accession Version | XM_006515861.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2586bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | metastasis-associated in colon cancer protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006515861.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATCTCTC CAGAGAAAGA TGGTAGCAAA ATGCTAATCA GTGAAAGAGC CTATTGTTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006515924.1 |
CDS | 397..2982 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006515861.3 |
1 | ATGATCTCTC CAGAGAAAGA TGGTAGCAAA ATGCTAATCA GTGAAAGAGC CTATTGTTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Metastasis-associated in colon cancer-1 upregulates vascular endothelial growth factor-C/D to promote lymphangiogenesis in human gastric cancer. |
Analysis of HGF, MACC1, C-met and apoptosis-related genes in cervical carcinoma mice. |
In vivo imaging of colorectal cancer growth and metastasis by targeting MACC1 with shRNA in xenografted mice. |
MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. |