Gene Symbol | Prok1 |
Entrez Gene ID | 246691 |
Full Name | prokineticin 1 |
Synonyms | EG-VEGF |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Prok1 cDNA ORF clone
Gene Symbol | Prok1 |
Entrez Gene ID | 246691 |
Full Name | prokineticin 1 |
Synonyms | EG-VEGF |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001044382.1 | NP_001037847.1 | prokineticin-1 precursor |
NM_001044382.2 | NP_001037847.1 | prokineticin-1 isoform 1 precursor |
NM_001357885.1 | NP_001344814.1 | prokineticin-1 isoform 2 |
XM_017319584.1 | XP_017175073.1 | prokineticin-1 isoform X2 |
XM_017319583.1 | XP_017175072.1 | prokineticin-1 isoform X1 |
Danio rerio (zebrafish) | prok1 | NP_001099168.1 |
Bos taurus (cattle) | PROK1 | NP_001029190.1 |
Homo sapiens (human) | PROK1 | NP_115790.1 |
Gallus gallus (chicken) | PROK1 | XP_425816.1 |
PROK1 | XP_001101188.1 | |
Mus musculus (house mouse) | Prok1 | NP_001037847.1 |
Rattus norvegicus (Norway rat) | Prok1 | NP_620206.1 |
Pan troglodytes (chimpanzee) | PROK1 | XP_001162989.1 |
Canis lupus familiaris (dog) | PROK1 | XP_003639164.1 |
Xenopus tropicalis (tropical clawed frog) | prok1 | XP_002933044.1 |
EG-VEGF Maintenance Over Early Gestation to Develop a Pregnancy-Induced Hypertensive Animal Model.
Reynaud D, Sergent F, Nahed RA, Brouillet S, Benharouga M, Alfaidy N
Methods in molecular biology (Clifton, N.J.)1710317-324(2018)
Prokineticin1 and pregnancy.
Alfaidy N
Annales d'endocrinologie77(2)101-4(2016 Jun)
PPAR? controls pregnancy outcome through activation of EG-VEGF: new insights into the mechanism of placental development.
Garnier V, Traboulsi W, Salomon A, Brouillet S, Fournier T, Winkler C, Desvergne B, Hoffmann P, Zhou QY, Congiu C, Onnis V, Benharouga M, Feige JJ, Alfaidy N
American journal of physiology. Endocrinology and metabolism309(4)E357-69(2015 Aug)
The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation.
Labialle S, Marty V, Bortolin-Cavaill? ML, Hoareau-Osman M, Prad?re JP, Valet P, Martin PG, Cavaill? J
The EMBO journal33(19)2216-30(2014 Oct)
Epicardial-myocardial signaling directing coronary vasculogenesis.
Olivey HE, Svensson EC
Circulation research106(5)818-32(2010 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
EG-VEGF is a new mediator of PPARgamma effects during pregnancy and bring new insights into the fine mechanism of trophoblast invasion.
Title: PPAR? controls pregnancy outcome through activation of EG-VEGF: new insights into the mechanism of placental development.
Prokineticin-1 (Prok-1) works coordinately with glial cell line-derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cells.
Title: Prokineticin-1 (Prok-1) works coordinately with glial cell line-derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cells.
EG-VEGF was mainly localised in the labyrinth in mouse placenta. It may have direct effect on both endothelial & trophoblastic cells & is likely to play an important role in mouse placentation.
Title: Placental expression of EG-VEGF and its receptors PKR1 (prokineticin receptor-1) and PKR2 throughout mouse gestation.
This is the first report demonstrating that Prok-1 acts as a gut mucosa/mesenchyme-derived factor and maintains proliferation and differentiation of enteric neural crest cells.
Title: Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells.
plays a role in regulating the phenotype and growth properties of endothelial cells within distinct capillary beds
Title: Mouse endocrine gland-derived vascular endothelial growth factor: a distinct expression pattern from its human ortholog suggests different roles as a regulator of organ-specific angiogenesis.
The following Prok1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prok1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu01020 | |
Clone ID Related Accession (Same CDS sequence) | NM_001044382.1 , NM_001044382.2 | |
Accession Version | NM_001044382.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-04-27 | |
Organism | Mus musculus(House mouse) | |
Product | prokineticin-1 precursor | |
Comment | PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC117006.1. On or before Nov 11, 2006 this sequence version replaced XM_900104.2, XM_913240.2, XM_922694.2, XM_987168.1, XM_987197.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC117006.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849383, SAMN01164135 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGAGAGGCG CTGTGCATAT CTTCATCATG CTCCTTCTAG CAACGGCGTC CGACTGTGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001037847.1 |
CDS | 59..376 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001044382.1 |
1 | ATGAGAGGCG CTGTGCATAT CTTCATCATG CTCCTTCTAG CAACGGCGTC CGACTGTGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu01020 | |
Clone ID Related Accession (Same CDS sequence) | NM_001044382.1 , NM_001044382.2 | |
Accession Version | NM_001044382.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-09-29 | |
Organism | Mus musculus(house mouse) | |
Product | prokineticin-1 isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC117006.1, AK044344.1, AC132405.3 and AW123932.1. On Nov 10, 2017 this sequence version replaced NM_001044382.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC117006.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849383, SAMN01164135 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAGAGGCG CTGTGCATAT CTTCATCATG CTCCTTCTAG CAACGGCGTC CGACTGTGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001037847.1 |
CDS | 59..376 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001044382.2 |
1 | ATGAGAGGCG CTGTGCATAT CTTCATCATG CTCCTTCTAG CAACGGCGTC CGACTGTGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu80620 | |
Clone ID Related Accession (Same CDS sequence) | NM_001357885.1 , XM_017319584.1 | |
Accession Version | NM_001357885.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-24 | |
Organism | Mus musculus(house mouse) | |
Product | prokineticin-1 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC132405.3 and AW123932.1. On Nov 10, 2017 this sequence version replaced XM_017319584.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC042707.1, BG973041.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAAAGCCG TCGTGAAGAC CAAGGCCTGT GAACGAGATA TCCAGTGTGG GGCCGGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001344814.1 |
CDS | 22..291 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001357885.1 |
1 | ATGAAAGCCG TCGTGAAGAC CAAGGCCTGT GAACGAGATA TCCAGTGTGG GGCCGGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu80619 | |
Clone ID Related Accession (Same CDS sequence) | XM_017319583.1 | |
Accession Version | XM_017319583.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | prokineticin-1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGGGTAC ATGGAGGACC CAATGAGCTG CACAGTCACA GTGCCACCAA GCCAGCGCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017175072.1 |
CDS | 39..368 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017319583.1 |
1 | ATGGGGGTAC ATGGAGGACC CAATGAGCTG CACAGTCACA GTGCCACCAA GCCAGCGCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu80620 | |
Clone ID Related Accession (Same CDS sequence) | NM_001357885.1 , XM_017319584.1 | |
Accession Version | XM_017319584.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(House mouse) | |
Product | prokineticin-1 isoform X2 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAAGCCG TCGTGAAGAC CAAGGCCTGT GAACGAGATA TCCAGTGTGG GGCCGGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017175073.1 |
CDS | 918..1187 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017319584.1 |
1 | ATGAAAGCCG TCGTGAAGAC CAAGGCCTGT GAACGAGATA TCCAGTGTGG GGCCGGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
EG-VEGF Maintenance Over Early Gestation to Develop a Pregnancy-Induced Hypertensive Animal Model. |
Prokineticin1 and pregnancy. |
PPAR? controls pregnancy outcome through activation of EG-VEGF: new insights into the mechanism of placental development. |
The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. |
Epicardial-myocardial signaling directing coronary vasculogenesis. |