Gene Symbol | Slc5a2 |
Entrez Gene ID | 246787 |
Full Name | solute carrier family 5 (sodium/glucose cotransporter), member 2 |
Synonyms | Sglt2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Slc5a2 cDNA ORF clone
Gene Symbol | Slc5a2 |
Entrez Gene ID | 246787 |
Full Name | solute carrier family 5 (sodium/glucose cotransporter), member 2 |
Synonyms | Sglt2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_133254.3 | NP_573517.1 | sodium/glucose cotransporter 2 |
NM_133254.4 | NP_573517.1 | sodium/glucose cotransporter 2 |
NM_133254.5 | NP_573517.1 | sodium/glucose cotransporter 2 |
Mus musculus (house mouse) | Slc5a2 | NP_573517.1 |
Bos taurus (cattle) | SLC5A2 | NP_976236.1 |
Rattus norvegicus (Norway rat) | Slc5a2 | NP_072112.2 |
Pan troglodytes (chimpanzee) | SLC5A2 | XP_003315117.1 |
SLC5A2 | XP_001113206.1 | |
Danio rerio (zebrafish) | slc5a2 | NP_998091.1 |
Xenopus tropicalis (tropical clawed frog) | slc5a2 | XP_002940641.2 |
Homo sapiens (human) | SLC5A2 | NP_003032.1 |
Canis lupus familiaris (dog) | SLC5A2 | XP_005621284.1 |
Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry.
Sawada Y, Izumida Y, Takeuchi Y, Aita Y, Wada N, Li E, Murayama Y, Piao X, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Kadowaki T, Shimano H, Yahagi N
Biochemical and biophysical research communications493(1)40-45(2017 11)
Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development.
Gerl K, Steppan D, Fuchs M, Wagner C, Willam C, Kurtz A, Kurt B
The American journal of pathology187(7)1496-1511(2017 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Taken together, it was concluded that the effect of SGLT2 inhibition on weight loss is in part mediated via the liver-brain-adipose neurocircuitry.
Title: Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry.
SGLT-2 inhibition with dapagliflozin reduces the activation of the Nlrp3/ASC inflammasome and attenuates the development of diabetic cardiomyopathy in mice with type 2 diabetes. Effects are augmentated of the by DPP4 inhibitor Saxagliptin.
Title: SGLT-2 Inhibition with Dapagliflozin Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Cardiomyopathy in Mice with Type 2 Diabetes. Further Augmentation of the Effects with Saxagliptin, a DPP4 Inhibitor.
Tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2, suppress albuminuria and tubulointerstitial injury in obese and type 2 diabetic mice. Inhibition of glucose entry into tubular cells by tofogliflozin may exert renoprotective properties in diabetes.
Title: Tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2, suppresses renal damage in KKAy/Ta mice, obese and type 2 diabetic animals.
these results suggest that SGLT2i treatment acutely suppresses energy expenditure in BAT via regulation of an inter-organ neural network consisting of the common hepatic vagal branch and sympathetic nerves.
Title: Dapagliflozin, a Sodium-Glucose Co-Transporter 2 Inhibitor, Acutely Reduces Energy Expenditure in BAT via Neural Signals in Mice.
SGLT2 inhibition induced gluconeogenesis mainly in the kidney, whereas for low carbohydrate diet, it was predominantly in the liver.
Title: Sodium-Glucose Cotransporter 2 Inhibitor and a Low Carbohydrate Diet Affect Gluconeogenesis and Glycogen Content Differently in the Kidney and the Liver of Non-Diabetic Mice.
The following Slc5a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc5a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu13413 | |
Clone ID Related Accession (Same CDS sequence) | NM_133254.3 , NM_133254.4 , NM_133254.5 | |
Accession Version | NM_133254.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2013bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | sodium/glucose cotransporter 2 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC124566.5. On Mar 21, 2007 this sequence version replaced NM_133254.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC022226.1, AK128900.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGAGCAAC ACGTAGAGGC AGGCTCTGAA CTTGGGGAGC AGAAGGTCCT GATTGATAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_573517.1 |
CDS | 1..2013 |
Translation |
Target ORF information:
Target ORF information:
|
NM_133254.3 |
1 | ATGGAGCAAC ACGTAGAGGC AGGCTCTGAA CTTGGGGAGC AGAAGGTCCT GATTGATAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu13413 | |
Clone ID Related Accession (Same CDS sequence) | NM_133254.3 , NM_133254.4 , NM_133254.5 | |
Accession Version | NM_133254.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2013bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-26 | |
Organism | Mus musculus(house mouse) | |
Product | sodium/glucose cotransporter 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC124566.5. On Jun 9, 2018 this sequence version replaced NM_133254.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK128900.1, AY033886.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGCAAC ACGTAGAGGC AGGCTCTGAA CTTGGGGAGC AGAAGGTCCT GATTGATAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_573517.1 |
CDS | 15..2027 |
Translation |
Target ORF information:
Target ORF information:
|
NM_133254.4 |
1 | ATGGAGCAAC ACGTAGAGGC AGGCTCTGAA CTTGGGGAGC AGAAGGTCCT GATTGATAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu13413 | |
Clone ID Related Accession (Same CDS sequence) | NM_133254.3 , NM_133254.4 , NM_133254.5 | |
Accession Version | NM_133254.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2013bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-13 | |
Organism | Mus musculus(house mouse) | |
Product | sodium/glucose cotransporter 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC124566.5. On Jun 17, 2019 this sequence version replaced NM_133254.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK128900.1, BC022226.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGAGCAAC ACGTAGAGGC AGGCTCTGAA CTTGGGGAGC AGAAGGTCCT GATTGATAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_573517.1 |
CDS | 15..2027 |
Translation |
Target ORF information:
Target ORF information:
|
NM_133254.5 |
1 | ATGGAGCAAC ACGTAGAGGC AGGCTCTGAA CTTGGGGAGC AGAAGGTCCT GATTGATAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry. |
Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development. |