Gene Symbol | Btd |
Entrez Gene ID | 26363 |
Full Name | biotinidase |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Btd cDNA ORF clone
Gene Symbol | Btd |
Entrez Gene ID | 26363 |
Full Name | biotinidase |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_025295.4 | NP_079571.1 | biotinidase isoform 1 precursor |
XM_006519029.3 | XP_006519092.1 | biotinidase isoform X1 |
NM_001374217.1 | NP_001361146.1 | biotinidase isoform 2 |
Bos taurus (cattle) | BTD | NP_001095676.1 |
Mus musculus (house mouse) | Btd | NP_079571.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010733 | XP_311447.4 |
Rattus norvegicus (Norway rat) | Btd | NP_001012047.1 |
Danio rerio (zebrafish) | btd | NP_001039309.1 |
Pan troglodytes (chimpanzee) | BTD | XP_003309694.1 |
Canis lupus familiaris (dog) | BTD | XP_005634447.1 |
Xenopus tropicalis (tropical clawed frog) | btd | XP_002932835.1 |
Gallus gallus (chicken) | BTD | NP_001186553.1 |
Drosophila melanogaster (fruit fly) | vanin-like | NP_572297.1 |
Drosophila melanogaster (fruit fly) | CG32751 | NP_727068.1 |
Homo sapiens (human) | BTD | NP_001268653.1 |
Characterization and functional analysis of cellular immunity in mice with biotinidase deficiency.
Pindolia K, Li H, Cardwell C, Wolf B
Molecular genetics and metabolism112(1)49-56(2014 May)
Biotinidase knockout mice show cellular energy deficit and altered carbon metabolism gene expression similar to that of nutritional biotin deprivation: clues for the pathogenesis in the human inherited disorder.
Hern?ndez-V?zquez A, Wolf B, Pindolia K, Ortega-Cuellar D, Hern?ndez-Gonz?lez R, Heredia-Ant?nez A, Ibarra-Gonz?lez I, Vel?zquez-Arellano A
Molecular genetics and metabolism110(3)248-54(2013 Nov)
Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M
Circulation research113(10)1138-47(2013 Oct)
Neurological deficits in mice with profound biotinidase deficiency are associated with demylination and axonal degeneration.
Pindolia K, Chen J, Cardwell C, Cui X, Chopp M, Wolf B
Neurobiology of disease47(3)428-35(2012 Sep)
Development and characterization of a mouse with profound biotinidase deficiency: a biotin-responsive neurocutaneous disorder.
Pindolia K, Jordan M, Guo C, Matthews N, Mock DM, Strovel E, Blitzer M, Wolf B
Molecular genetics and metabolism102(2)161-9(2011 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Biotinidase knockout mice show cellular energy deficit and altered carbon metabolism gene expression similar to that of nutritional biotin deprivation.
Title: Biotinidase knockout mice show cellular energy deficit and altered carbon metabolism gene expression similar to that of nutritional biotin deprivation: clues for the pathogenesis in the human inherited disorder.
This study demonistrated that biotinidase deficiency mice showed demylination and axonal degeneration.
Title: Neurological deficits in mice with profound biotinidase deficiency are associated with demylination and axonal degeneration.
results indicate low expression of biotinidase throughout the brain, but increased concentrations within the dorsal cochlear nucleus, ventral cochlear nucleus, and superior olivary complex as well as in the hair cells and spiral ganglion of the cochlea
Title: Localization of biotinidase in the brain: implications for its role in hearing loss in biotinidase deficiency.
The following Btd gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Btd cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu49999 | |
Clone ID Related Accession (Same CDS sequence) | XM_006519029.3 , NM_001374217.1 | |
Accession Version | XM_006519029.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1239bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | biotinidase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006519029.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCGTCTC CCAAGCTGGT CAGGTGGAAC CCGTGTCTGG AGCCCTTTCG GTTCAATGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006519092.1 |
CDS | 193..1431 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006519029.3 |
1 | ATGCCGTCTC CCAAGCTGGT CAGGTGGAAC CCGTGTCTGG AGCCCTTTCG GTTCAATGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu49999 | |
Clone ID Related Accession (Same CDS sequence) | XM_006519029.3 , NM_001374217.1 | |
Accession Version | NM_001374217.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1239bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-12 | |
Organism | Mus musculus(house mouse) | |
Product | biotinidase isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC109509.20. On Sep 13, 2019 this sequence version replaced XM_006519029.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR7345562.5049249.1, SRR7345562.2723298.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCCGTCTC CCAAGCTGGT CAGGTGGAAC CCGTGTCTGG AGCCCTTTCG GTTCAATGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001361146.1 |
CDS | 157..1395 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001374217.1 |
1 | ATGCCGTCTC CCAAGCTGGT CAGGTGGAAC CCGTGTCTGG AGCCCTTTCG GTTCAATGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu20613 | |
Clone ID Related Accession (Same CDS sequence) | NM_025295.4 | |
Accession Version | NM_025295.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1590bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-12 | |
Organism | Mus musculus(house mouse) | |
Product | biotinidase isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ181966.1, AK135375.1, AK005506.1 and BU700769.1. On Dec 9, 2009 this sequence version replaced NM_025295.3. ##Evidence-Data-START## Transcript exon combination :: AU067281.1, AK135375.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCGAAGCA GATTTATGGT CTGCATTATG TCTGGAGCCC GCACTGCGCC TGCTCTCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_079571.1 |
CDS | 69..1658 |
Translation |
Target ORF information:
Target ORF information:
|
NM_025295.4 |
1 | ATGCGAAGCA GATTTATGGT CTGCATTATG TCTGGAGCCC GCACTGCGCC TGCTCTCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Characterization and functional analysis of cellular immunity in mice with biotinidase deficiency. |
Biotinidase knockout mice show cellular energy deficit and altered carbon metabolism gene expression similar to that of nutritional biotin deprivation: clues for the pathogenesis in the human inherited disorder. |
Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. |
Neurological deficits in mice with profound biotinidase deficiency are associated with demylination and axonal degeneration. |
Development and characterization of a mouse with profound biotinidase deficiency: a biotin-responsive neurocutaneous disorder. |