Gene Symbol | Homer2 |
Entrez Gene ID | 26557 |
Full Name | homer scaffolding protein 2 |
Synonyms | 9330120H11Rik,AW539445,CPD,Vesl-2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Homer2 cDNA ORF clone
gRNAs
Gene Symbol | Homer2 |
Entrez Gene ID | 26557 |
Full Name | homer scaffolding protein 2 |
Synonyms | 9330120H11Rik,AW539445,CPD,Vesl-2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_030242610.1 | XP_030098470.1 | homer protein homolog 2 isoform X1 |
XM_006540909.1 | XP_006540972.1 | homer protein homolog 2 isoform X1 |
XM_030242611.1 | XP_030098471.1 | homer protein homolog 2 isoform X2 |
NM_011983.2 | NP_036113.1 | homer protein homolog 2 isoform 1 |
NM_001164086.1 | NP_001157558.1 | homer protein homolog 2 isoform 2 |
NM_001164087.1 | NP_001157559.1 | homer protein homolog 2 isoform 3 |
Pan troglodytes (chimpanzee) | HOMER2 | XP_510553.3 |
Mus musculus (house mouse) | Homer2 | NP_036113.1 |
Danio rerio (zebrafish) | homer2 | NP_001018470.1 |
Homo sapiens (human) | HOMER2 | NP_955362.1 |
Bos taurus (cattle) | HOMER2 | NP_001068935.1 |
Rattus norvegicus (Norway rat) | Homer2 | NP_445761.1 |
Drosophila melanogaster (fruit fly) | homer | NP_477396.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010076 | XP_319234.3 |
HOMER2 | XP_001082200.2 | |
Canis lupus familiaris (dog) | HOMER2 | XP_005618788.1 |
Gallus gallus (chicken) | HOMER2 | XP_413836.4 |
Xenopus tropicalis (tropical clawed frog) | homer2 | NP_001016054.1 |
Homer2 within the central nucleus of the amygdala modulates withdrawal-induced anxiety in a mouse model of binge-drinking.
Lee KM, Coelho MA, Sern KR, Szumlinski KK
Neuropharmacology128448-459(2018 Jan)
A mass spectrometry-based proteomic analysis of Homer2-interacting proteins in the mouse brain.
Goulding SP, Szumlinski KK, Contet C, MacCoss MJ, Wu CC
Journal of proteomics166127-137(2017 Aug)
Homer2 regulates alcohol and stress cross-sensitization.
Quadir SG, Santos JR, Campbell RR, Wroten MG, Singh N, Holloway JJ, Bal SK, Camarini R, Szumlinski KK
Addiction biology21(3)613-33(2016 May)
Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse.
Fujiwara K, Fujita Y, Kasai A, Onaka Y, Hashimoto H, Okada H, Yamashita T
Translational psychiatry6e766(2016 Mar)
Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene.
Smothers CT, Szumlinski KK, Worley PF, Woodward JJ
Synapse (New York, N.Y.)70(1)33-9(2016 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
stress-alcohol locomotor cross-sensitization was regulated by Homer2.
Title: Homer2 regulates alcohol and stress cross-sensitization.
NMDA receptor function, but not ethanol sensitivity, is reduced in hippocampal neurons lacking the Homer2 gene
Title: Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene.
mouse mutants homozygous for the targeted deletion of Homer2 present with early-onset rapidly progressive hearing loss.
Title: HOMER2, a stereociliary scaffolding protein, is essential for normal hearing in humans and mice.
Findings indicate an important regulation of plasma membrane Ca(2+)-ATPase (PMCA) by Homer2 protein that has a central role on PMCA-mediated Ca(2+) signaling in parotid acinar cells.
Title: Homer2 protein regulates plasma membrane Ca??-ATPase-mediated Ca?? signaling in mouse parotid gland acinar cells.
This study deministrated that PFC Homer2 overexpression enhances cocaine-conditioned reward in mice.
Title: Imbalances in prefrontal cortex CC-Homer1 versus CC-Homer2 expression promote cocaine preference.
The following Homer2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Homer2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu13588 | |
Clone ID Related Accession (Same CDS sequence) | NM_011983.2 | |
Accession Version | NM_011983.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | homer protein homolog 2 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK163423.1, AF093260.2 and AC140366.2. On Aug 12, 2009 this sequence version replaced NM_011983.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF093260.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGAGAAC AGCCCATCTT CACCACGCGA GCGCACGTCT TCCAGATTGA CCCCAGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_036113.1 |
CDS | 163..1227 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGGAGAAC AGCCCATCTT CACCACGCGA GCGCACGTCT TCCAGATTGA CCCCAGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu13609 | |
Clone ID Related Accession (Same CDS sequence) | NM_001164086.1 | |
Accession Version | NM_001164086.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-15 | |
Organism | Mus musculus(house mouse) | |
Product | homer protein homolog 2 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK163423.1, AF093259.2 and AC140366.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB017136.1, AF093259.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGAGAAC AGCCCATCTT CACCACGCGA GCGCACGTCT TCCAGATTGA CCCCAGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001157558.1 |
CDS | 163..1194 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGGAGAAC AGCCCATCTT CACCACGCGA GCGCACGTCT TCCAGATTGA CCCCAGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu13662 | |
Clone ID Related Accession (Same CDS sequence) | XM_030242610.1 , XM_006540909.1 , NM_001164087.1 | |
Accession Version | NM_001164087.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | homer protein homolog 2 isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ083069.1, DV657327.1, AF093260.2 and AC140366.2. Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGACTTTCA CCAAAACGTC ACAGAAGTTC GGGCAGTGGG CTGACAGCAG AGCCAACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001157559.1 |
CDS | 338..1210 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGACTTTCA CCAAAACGTC ACAGAAGTTC GGGCAGTGGG CTGACAGCAG AGCCAACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu13662 | |
Clone ID Related Accession (Same CDS sequence) | XM_030242610.1 , XM_006540909.1 , NM_001164087.1 | |
Accession Version | XM_006540909.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | homer protein homolog 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACTTTCA CCAAAACGTC ACAGAAGTTC GGGCAGTGGG CTGACAGCAG AGCCAACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006540972.1 |
CDS | 605..1477 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGACTTTCA CCAAAACGTC ACAGAAGTTC GGGCAGTGGG CTGACAGCAG AGCCAACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu13662 | |
Clone ID Related Accession (Same CDS sequence) | XM_030242610.1 , XM_006540909.1 , NM_001164087.1 | |
Accession Version | XM_030242610.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | homer protein homolog 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACTTTCA CCAAAACGTC ACAGAAGTTC GGGCAGTGGG CTGACAGCAG AGCCAACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030098470.1 |
CDS | 502..1374 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGACTTTCA CCAAAACGTC ACAGAAGTTC GGGCAGTGGG CTGACAGCAG AGCCAACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu89501 | |
Clone ID Related Accession (Same CDS sequence) | XM_030242611.1 | |
Accession Version | XM_030242611.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | homer protein homolog 2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACTTTCA CCAAAACGTC ACAGAAGTTC GGGCAGTGGG CTGACAGCAG AGCCAACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030098471.1 |
CDS | 498..1337 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGACTTTCA CCAAAACGTC ACAGAAGTTC GGGCAGTGGG CTGACAGCAG AGCCAACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Homer2 within the central nucleus of the amygdala modulates withdrawal-induced anxiety in a mouse model of binge-drinking. |
A mass spectrometry-based proteomic analysis of Homer2-interacting proteins in the mouse brain. |
Homer2 regulates alcohol and stress cross-sensitization. |
Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse. |
Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene. |