Sh2d1b1 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Sh2d1b1 |
| Entrez Gene ID | 26904 |
| Full Name | SH2 domain containing 1B1 |
| Synonyms | EAT-2,EAT-2A,Eat2,Eat2a,Sh2d1b |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_012009.5 | NP_036139.3 | SH2 domain-containing protein 1B |
| NM_012009.4 | NP_036139.3 | SH2 domain-containing protein 1B |
| Homo sapiens (human) | SH2D1B | NP_444512.2 |
| Pan troglodytes (chimpanzee) | SH2D1B | XP_003949678.1 |
| Rattus norvegicus (Norway rat) | Sh2d1b | XP_577285.1 |
| Canis lupus familiaris (dog) | SH2D1B | XP_005640915.1 |
| Bos taurus (cattle) | SH2D1B | NP_001180091.1 |
| Mus musculus (house mouse) | Sh2d1b1 | NP_036139.3 |
| Danio rerio (zebrafish) | si:dkey-11p10.10 | NP_001189421.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100486929 | XP_002932331.1 |
| SH2D1B | XP_001118174.1 | |
| Gallus gallus (chicken) | SH2D1B | NP_001265002.1 |
Related articles in PubMed
A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education.
Wu N, Zhong MC, Roncagalli R, P?rez-Quintero LA, Guo H, Zhang Z, Lenoir C, Dong Z, Latour S, Veillette A
Nature immunology17(4)387-96(2016 Apr)
Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling.
Talaei N, Yu T, Manion K, Bremner R, Wither JE
Journal of immunology (Baltimore, Md. : 1950)195(10)4623-31(2015 Nov)
Immune cell inhibition by SLAMF7 is mediated by a mechanism requiring src kinases, CD45, and SHIP-1 that is defective in multiple myeloma cells.
Guo H, Cruz-Munoz ME, Wu N, Robbins M, Veillette A
Molecular and cellular biology35(1)41-51(2015 Jan)
EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase C?, Ca++, and Erk, leading to granule polarization.
P?rez-Quintero LA, Roncagalli R, Guo H, Latour S, Davidson D, Veillette A
The Journal of experimental medicine211(4)727-42(2014 Apr)
Signaling lymphocyte activation molecule regulates development of colitis in mice.
van Driel B, Liao G, Romero X, O'Keeffe MS, Wang G, Faubion WA, Berger SB, Magelky EM, Manocha M, Azcutia V, Grisham M, Luscinskas FW, Mizoguchi E, de Waal Malefyt R, Reinecker HC, Bhan AK, Wang N, Terhorst C
Gastroenterology143(6)1544-1554.e7(2012 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
EAT-2 negatively regulates cytokine production in dendritic cells downstream of SLAM engagement and a genetic polymorphism that disturbs this process promotes the development of lupus.
Title: Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling.
EAT-2 mediates its effects in natural killer cells by linking SLAM family receptors to phospholipase Cgamma, calcium fluxes, and Erk kinase.
Title: EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase C?, Ca++, and Erk, leading to granule polarization.
EAT-2A and EAT-2B act as positive regulators of signaling lymphocyte activation molecule family receptor-specific NK cell functions in C57BL/6 mice.
Title: Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse.
EAT-2 mediates CRACC function. In the absence of EAT-2, CRACC inhibited natural killer cell function.
Title: Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function.
Taken together, the data suggest that both EAT-2A and EAT-2B are adapters that recruit Src kinases to SLAM family receptors using a mechanism that is distinct from that of SAP.
Title: Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters.
The following Sh2d1b1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sh2d1b1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu09327 | |
| Clone ID Related Accession (Same CDS sequence) | NM_012009.5 , NM_012009.4 | |
| Accession Version | NM_012009.5 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-25 | |
| Organism | Mus musculus(house mouse) | |
| Product | SH2 domain-containing protein 1B | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC123650.7 and BC116698.1. On Feb 16, 2018 this sequence version replaced NM_012009.4. Transcript Variant: This variant (1) represents the longer, protein-coding transcript. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK089191.1, BC116698.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGATCTGC CTTACTACCA TGGCTGCCTG ACCAAGCGAG AGTGTGAAGC CCTGCTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_036139.3 |
| CDS | 59..457 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_012009.5 |
ORF Insert Sequence:
1 | ATGGATCTGC CTTACTACCA TGGCTGCCTG ACCAAGCGAG AGTGTGAAGC CCTGCTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu09327 | |
| Clone ID Related Accession (Same CDS sequence) | NM_012009.5 , NM_012009.4 | |
| Accession Version | NM_012009.4 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-10-01 | |
| Organism | Mus musculus(house mouse) | |
| Product | SH2 domain-containing protein 1B | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC117508.1. On Jun 10, 2007 this sequence version replaced NM_012009.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC116698.1, AK089191.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGATCTGC CTTACTACCA TGGCTGCCTG ACCAAGCGAG AGTGTGAAGC CCTGCTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_036139.3 |
| CDS | 53..451 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_012009.4 |
ORF Insert Sequence:
1 | ATGGATCTGC CTTACTACCA TGGCTGCCTG ACCAAGCGAG AGTGTGAAGC CCTGCTCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education. |
|
Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling. |
|
Immune cell inhibition by SLAMF7 is mediated by a mechanism requiring src kinases, CD45, and SHIP-1 that is defective in multiple myeloma cells. |
|
EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase C?, Ca++, and Erk, leading to granule polarization. |
|
Signaling lymphocyte activation molecule regulates development of colitis in mice. |