Gene Symbol | Ncoa4 |
Entrez Gene ID | 27057 |
Full Name | nuclear receptor coactivator 4 |
Synonyms | ARA70,Rfg |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Ncoa4 cDNA ORF clone
gRNAs
Gene Symbol | Ncoa4 |
Entrez Gene ID | 27057 |
Full Name | nuclear receptor coactivator 4 |
Synonyms | ARA70,Rfg |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006519068.3 | XP_006519131.1 | nuclear receptor coactivator 4 isoform X2 |
NM_001284319.1 | NP_001271248.1 | nuclear receptor coactivator 4 isoform b |
NM_001033988.2 | NP_001029160.1 | nuclear receptor coactivator 4 isoform a |
XM_017316028.2 | XP_017171517.1 | nuclear receptor coactivator 4 isoform X3 |
NM_019744.4 | NP_062718.2 | nuclear receptor coactivator 4 isoform a |
XM_017316028.1 | XP_017171517.1 | nuclear receptor coactivator 4 isoform X3 |
XM_006519067.3 | XP_006519130.1 | nuclear receptor coactivator 4 isoform X1 |
XM_006519068.4 | XP_006519131.1 | nuclear receptor coactivator 4 isoform X2 |
Homo sapiens (human) | NCOA4 | NP_001138732.1 |
Pan troglodytes (chimpanzee) | NCOA4 | XP_003312606.1 |
Bos taurus (cattle) | NCOA4 | NP_001069336.1 |
Mus musculus (house mouse) | Ncoa4 | NP_001029160.1 |
Canis lupus familiaris (dog) | NCOA4 | XP_005637547.1 |
Danio rerio (zebrafish) | ncoa4 | NP_957423.1 |
Xenopus tropicalis (tropical clawed frog) | ncoa4 | XP_004919877.1 |
NCOA4 | XP_001106334.2 | |
Rattus norvegicus (Norway rat) | Ncoa4 | NP_001029179.1 |
Gallus gallus (chicken) | NCOA4 | NP_001006495.1 |
Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.
Gao X, Lee HY, Li W, Platt RJ, Barrasa MI, Ma Q, Elmes RR, Rosenfeld MG, Lodish HF
Proceedings of the National Academy of Sciences of the United States of America114(38)10107-10112(2017 Sep)
PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis.
Ryu MS, Zhang D, Protchenko O, Shakoury-Elizeh M, Philpott CC
The Journal of clinical investigation127(5)1786-1797(2017 May)
NCOA4 Deficiency Impairs Systemic Iron Homeostasis.
Bellelli R, Federico G, Matte' A, Colecchia D, Iolascon A, Chiariello M, Santoro M, De Franceschi L, Carlomagno F
Cell reports14(3)411-421(2016 Jan)
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, Menon S, Wang Z, Honda A, Pardee G, Cantwell J, Luu C, Cornella-Taracido I, Harrington E, Fekkes P, Lei H, Fang Q, Digan ME, Burdick D, Powers AF, Helliwell SB, D'Aquin S, Bastien J, Wang H, Wiederschain D, Kuerth J, Bergman P, Schwalb D, Thomas J, Ugwonali S, Harbinski F, Tallarico J, Wilson CJ, Myer VE, Porter JA, Bussiere DE, Finan PM, Labow MA, Mao X, Hamann LG, Manning BD, Valdez RA, Nicholson T, Schirle M, Knapp MS, Keaney EP, Murphy LO
Nature cell biology16(11)1069-79(2014 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These studies demonstrate the importance of ferritin for the vectorial transfer of imported iron to mitochondria in developing red cells and of PCBP1 and NCOA4 in mediating iron flux through ferritin.
Title: PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis.
NCOA4 prevents iron accumulation and ensures efficient erythropoiesis, playing a central role in balancing iron levels in vivo.
Title: NCOA4 Deficiency Impairs Systemic Iron Homeostasis.
provide a new mechanism for selective autophagy of ferritin and reveal a previously unappreciated role for autophagy and NCOA4 in the control of iron homeostasis in vivo
Title: Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
NCOA4 acts as a regulator of DNA replication origins that helps prevent inappropriate DNA synthesis and replication stress.
Title: NCOA4 transcriptional coactivator inhibits activation of DNA replication origins.
High ARA70alpha inhibited cell proliferation, and that ARA70beta promotes proliferation in breast cancer.
Title: Distinct function of androgen receptor coactivator ARA70? and ARA70? in mammary gland development, and in breast cancer.
The following Ncoa4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ncoa4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu08544 | |
Clone ID Related Accession (Same CDS sequence) | NM_001284319.1 | |
Accession Version | NM_001284319.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1593bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-06-10 | |
Organism | Mus musculus(house mouse) | |
Product | nuclear receptor coactivator 4 isoform b | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154532.3, AK014479.1, AK032951.1, AK143965.1 and BB750616.1. Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 2. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK156999.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164140 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGCCAAT TCAATTGTCT TATTCATCAA CTGGAGTATA CTCAGAACAA AGATCTTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001271248.1 |
CDS | 416..2008 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGGCCAAT TCAATTGTCT TATTCATCAA CTGGAGTATA CTCAGAACAA AGATCTTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu11491 | |
Clone ID Related Accession (Same CDS sequence) | NM_001033988.2 , NM_019744.4 | |
Accession Version | NM_001033988.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1878bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-06-10 | |
Organism | Mus musculus(house mouse) | |
Product | nuclear receptor coactivator 4 isoform a | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154532.3, CJ088075.1, AK146498.1, AK143965.1 and BB750616.1. On Sep 28, 2013 this sequence version replaced NM_001033988.1. Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK143965.1, SRR1660823.126647.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAACACAT CCCTGGAACA GAGTGGCTGC TACAGTAATA GAGAAACTCT TCTGAGGTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001029160.1 |
CDS | 139..2016 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAACACAT CCCTGGAACA GAGTGGCTGC TACAGTAATA GAGAAACTCT TCTGAGGTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu11491 | |
Clone ID Related Accession (Same CDS sequence) | NM_001033988.2 , NM_019744.4 | |
Accession Version | NM_019744.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1878bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-06-10 | |
Organism | Mus musculus(house mouse) | |
Product | nuclear receptor coactivator 4 isoform a | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154532.3, AK014479.1, AK032951.1, AK143965.1 and BB750616.1. On Sep 28, 2013 this sequence version replaced NM_019744.3. Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147036.1, AK146384.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAACACAT CCCTGGAACA GAGTGGCTGC TACAGTAATA GAGAAACTCT TCTGAGGTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_062718.2 |
CDS | 49..1926 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAACACAT CCCTGGAACA GAGTGGCTGC TACAGTAATA GAGAAACTCT TCTGAGGTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu50030 | |
Clone ID Related Accession (Same CDS sequence) | XM_006519067.3 | |
Accession Version | XM_006519067.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1902bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | nuclear receptor coactivator 4 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006519067.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTCAAG GAACAGTGAG CAGAATGAAC ACATCCCTGG AACAGAGTGG CTGCTACAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006519130.1 |
CDS | 96..1997 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCTCAAG GAACAGTGAG CAGAATGAAC ACATCCCTGG AACAGAGTGG CTGCTACAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu50031 | |
Clone ID Related Accession (Same CDS sequence) | XM_006519068.3 , XM_006519068.4 | |
Accession Version | XM_006519068.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1899bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | nuclear receptor coactivator 4 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006519068.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTCAAG GAACAGTGAG CAGAATGAAC ACATCCCTGG AACAGAGTGG CTGCTACAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006519131.1 |
CDS | 99..1997 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCTCAAG GAACAGTGAG CAGAATGAAC ACATCCCTGG AACAGAGTGG CTGCTACAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu50031 | |
Clone ID Related Accession (Same CDS sequence) | XM_006519068.3 , XM_006519068.4 | |
Accession Version | XM_006519068.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1899bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | nuclear receptor coactivator 4 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006519068.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTCAAG GAACAGTGAG CAGAATGAAC ACATCCCTGG AACAGAGTGG CTGCTACAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006519131.1 |
CDS | 99..1997 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCTCAAG GAACAGTGAG CAGAATGAAC ACATCCCTGG AACAGAGTGG CTGCTACAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu78772 | |
Clone ID Related Accession (Same CDS sequence) | XM_017316028.2 , XM_017316028.1 | |
Accession Version | XM_017316028.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1875bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | nuclear receptor coactivator 4 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017316028.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAACACAT CCCTGGAACA GAGTGGCTGC TACAGTAATA GAGAAACTCT TCTGAGGTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017171517.1 |
CDS | 147..2021 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAACACAT CCCTGGAACA GAGTGGCTGC TACAGTAATA GAGAAACTCT TCTGAGGTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu78772 | |
Clone ID Related Accession (Same CDS sequence) | XM_017316028.2 , XM_017316028.1 | |
Accession Version | XM_017316028.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1875bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | nuclear receptor coactivator 4 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000080.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAACACAT CCCTGGAACA GAGTGGCTGC TACAGTAATA GAGAAACTCT TCTGAGGTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017171517.1 |
CDS | 134..2008 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAACACAT CCCTGGAACA GAGTGGCTGC TACAGTAATA GAGAAACTCT TCTGAGGTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation. |
PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis. |
NCOA4 Deficiency Impairs Systemic Iron Homeostasis. |
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. |