Rab5a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rab5a
Entrez Gene ID	271457
Full Name	RAB5A, member RAS oncogene family
Synonyms	2410015H04Rik,AI663973,AU021172,nnyRab5a
General protein information	Preferred Names RAB5A, member RAS oncogene family Names ras-related protein Rab-5A
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 C\|17 27.82 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_025887.4	NP_080163.1	ras-related protein Rab-5A

Pathways from BioSystems

Homologies

	RAB5A	XP_001088608.1
Bos taurus (cattle)	RAB5A	NP_001069654.1
Danio rerio (zebrafish)	rab5aa	NP_958893.1
Homo sapiens (human)	RAB5A	NP_004153.2
Mus musculus (house mouse)	Rab5a	NP_080163.1
Gallus gallus (chicken)	RAB5A	NP_001006363.1
Danio rerio (zebrafish)	rab5ab	NP_957264.1
Arabidopsis thaliana (thale cress)	ARA7	NP_193699.1
Xenopus tropicalis (tropical clawed frog)	rab5a	NP_001008068.1
Canis lupus familiaris (dog)	RAB5A	NP_001003317.1
Pan troglodytes (chimpanzee)	RAB5A	XP_516319.2
Caenorhabditis elegans (roundworm)	rab-5	NP_492481.1
Oryza sativa (rice)	Os03g0666500	NP_001050846.1
Rattus norvegicus (Norway rat)	Rab5a	NP_073183.1
Arabidopsis thaliana (thale cress)	RHA1	NP_199326.1
Oryza sativa (rice)	Os12g0631100	NP_001067340.1

Gene Ontology
Bibliography

Related articles in PubMed

ELMOD1 stimulates ARF6-GTP hydrolysis to stabilize apical structures in developing vestibular hair cells.
Krey JF, Dumont RA, Wilmarth PA, David LL, Johnson KR, Barr-Gillespie PG
The Journal of neuroscience : the official journal of the Society for Neuroscience(2017 Dec)

Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice.
Shin SW, John Vogt E, Jimenez-Movilla M, Baibakov B, Dean J
Nature communications8(1)1643(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SH3GLB1 controls nicotinic acetylcholine receptors endocytic trafficking in a phosphorylation- and RAB5-dependent manner at steps upstream of autophagosome formation.
Title: Progress of endocytic CHRN to autophagic degradation is regulated by RAB5-GTPase and T145 phosphorylation of SH3GLB1 at mouse neuromuscular junctions in vivo.

E. chaffeensis secretes Etf-1 to induce autophagy to repurpose the host cytoplasm and capture nutrients for its growth through RAB5 and class III PtdIns3K, while avoiding autolysosomal killing.
Title: Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase.

These data highlight a requirement of Rab5 and the endosomal system for the regulation of gluconeogenic gene expression that has important implications for metabolic diseases.
Title: Regulation of liver metabolism by the endosomal GTPase Rab5.

Inpp5e, through functional interactions with Rab20 on the phagosome, activates Rab5, which, in turn, increases PtdIns3P and delays phagosome acidification.
Title: Inpp5e increases the Rab5 association and phosphatidylinositol 3-phosphate accumulation at the phagosome through an interaction with Rab20.

FGF21 has a role in promoting endothelial cell angiogenesis through a dynamin-2 and Rab5 dependent pathway
Title: FGF21 promotes endothelial cell angiogenesis through a dynamin-2 and Rab5 dependent pathway.

The following Rab5a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rab5a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18328	NM_025887.4 Latest version!	Mus musculus RAB5A, member RAS oncogene family (Rab5a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rab5a ( NM_025887.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080163.1 Mus musculus RAB5A, member RAS oncogene family (Rab5a), mRNA.

Price & Availability↑

CloneID	OMu18328
Clone ID Related Accession (Same CDS sequence)	NM_025887.4
Accession Version	NM_025887.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	ras-related protein Rab-5A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC165960.4. On Apr 29, 2007 this sequence version replaced NM_025887.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK081999.1, SRR1660821.168658.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCTAATC GAGGAGCAAC AAGACCCAAC GGGCCAAATA CTGGAAATAA AATATGCCAG 
TTCAAACTGG TCCTTCTAGG AGAGTCTGCT GTTGGCAAAT CAAGCCTGGT TCTTCGCTTT 
GTGAAAGGCC AATTTCATGA ATTTCAAGAG AGTACCATTG GGGCTGCCTT TCTAACCCAA 
ACTGTGTGTC TTGATGACAC AACAGTAAAA TTTGAAATAT GGGATACAGC TGGTCAAGAA 
CGGTATCATA GCTTAGCACC AATGTACTAC CGAGGAGCAC AAGCAGCCAT AGTTGTGTAT 
GATATCACAA ATGAGGAATC CTTTGCGAGA GCAAAAAACT GGGTTAAAGA ACTTCAAAGG 
CAAGCAAGTC CTAATATTGT GATAGCTTTG TCAGGAAACA AAGCTGACTT AGCAAATAAA 
AGAGCTGTTG ACTTCCAGGA AGCACAGTCC TATGCAGATG ACAACAGCTT ATTATTTATG 
GAGACATCAG CTAAGACATC AATGAATGTA AATGAAATAT TTATGGCAAT AGCTAAAAAG 
CTGCCAAAGA ATGAACCACA GAATCCTGGT GCAAACTCAG CCAGAGGACG AGGAGTAGAC 
CTTACTGAGC CTGCACAGCC AGCCAGAAGC CAGTGTTGTA GTAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080163.1
CDS	468..1115
Translation	MANRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVDLTEPAQPARSQCCSN

Target ORF information:

RefSeq Version	NM_025887.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus RAB5A, member RAS oncogene family (Rab5a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025887.4

ORF Insert Sequence:

ATGGCTAATC GAGGAGCAAC AAGACCCAAC GGGCCAAATA CTGGAAATAA AATATGCCAG 
TTCAAACTGG TCCTTCTAGG AGAGTCTGCT GTTGGCAAAT CAAGCCTGGT TCTTCGCTTT 
GTGAAAGGCC AATTTCATGA ATTTCAAGAG AGTACCATTG GGGCTGCCTT TCTAACCCAA 
ACTGTGTGTC TTGATGACAC AACAGTAAAA TTTGAAATAT GGGATACAGC TGGTCAAGAA 
CGGTATCATA GCTTAGCACC AATGTACTAC CGAGGAGCAC AAGCAGCCAT AGTTGTGTAT 
GATATCACAA ATGAGGAATC CTTTGCGAGA GCAAAAAACT GGGTTAAAGA ACTTCAAAGG 
CAAGCAAGTC CTAATATTGT GATAGCTTTG TCAGGAAACA AAGCTGACTT AGCAAATAAA 
AGAGCTGTTG ACTTCCAGGA AGCACAGTCC TATGCAGATG ACAACAGCTT ATTATTTATG 
GAGACATCAG CTAAGACATC AATGAATGTA AATGAAATAT TTATGGCAAT AGCTAAAAAG 
CTGCCAAAGA ATGAACCACA GAATCCTGGT GCAAACTCAG CCAGAGGACG AGGAGTAGAC 
CTTACTGAGC CTGCACAGCC AGCCAGAAGC CAGTGTTGTA GTAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ELMOD1 stimulates ARF6-GTP hydrolysis to stabilize apical structures in developing vestibular hair cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience(2017 Dec)
Krey JF,Dumont RA,Wilmarth PA,David LL,Johnson KR,Barr-Gillespie PG

Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice.
Nature communications8(1)1643(2017 Nov)
Shin SW,John Vogt E,Jimenez-Movilla M,Baibakov B,Dean J

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Rab5a cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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