Gene Symbol | Chaf1a |
Entrez Gene ID | 27221 |
Full Name | chromatin assembly factor 1, subunit A (p150) |
Synonyms | AL023013,AL024058,CAF-1,Cac1p |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Chaf1a cDNA ORF clone
gRNAs
Gene Symbol | Chaf1a |
Entrez Gene ID | 27221 |
Full Name | chromatin assembly factor 1, subunit A (p150) |
Synonyms | AL023013,AL024058,CAF-1,Cac1p |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_013733.3 | NP_038761.1 | chromatin assembly factor 1 subunit A |
Pan troglodytes (chimpanzee) | CHAF1A | XP_512286.3 |
CHAF1A | XP_002801077.1 | |
Bos taurus (cattle) | CHAF1A | NP_001095312.1 |
Rattus norvegicus (Norway rat) | Chaf1a | XP_343672.2 |
Gallus gallus (chicken) | CHAF1A | NP_001073220.2 |
Canis lupus familiaris (dog) | CHAF1A | XP_542156.4 |
Mus musculus (house mouse) | Chaf1a | NP_038761.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100485264 | XP_002934050.1 |
Homo sapiens (human) | CHAF1A | NP_005474.2 |
The histone chaperone CAF-1 safeguards somatic cell identity.
Cheloufi S, Elling U, Hopfgartner B, Jung YL, Murn J, Ninova M, Hubmann M, Badeaux AI, Euong Ang C, Tenen D, Wesche DJ, Abazova N, Hogue M, Tasdemir N, Brumbaugh J, Rathert P, Jude J, Ferrari F, Blanco A, Fellner M, Wenzel D, Zinner M, Vidal SE, Bell O, Stadtfeld M, Chang HY, Almouzni G, Lowe SW, Rinn J, Wernig M, Aravin A, Shi Y, Park PJ, Penninger JM, Zuber J, Hochedlinger K
Nature528(7581)218-24(2015 Dec)
Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons.
Hatanaka Y, Inoue K, Oikawa M, Kamimura S, Ogonuki N, Kodama EN, Ohkawa Y, Tsukada Y, Ogura A
Proceedings of the National Academy of Sciences of the United States of America112(47)14641-6(2015 Nov)
The p150 subunit of the histone chaperone Caf-1 interacts with the transcriptional repressor Gfi1.
Heyd F, Chen R, Afshar K, Saba I, Lazure C, Fiolka K, M?r?y T
Biochimica et biophysica acta1809(4-6)255-61(2011 Apr-Jun)
HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair.
Baldeyron C, Soria G, Roche D, Cook AJ, Almouzni G
The Journal of cell biology193(1)81-95(2011 Apr)
Two fundamentally distinct PCNA interaction peptides contribute to chromatin assembly factor 1 function.
Rolef Ben-Shahar T, Castillo AG, Osborne MJ, Borden KL, Kornblatt J, Verreault A
Molecular and cellular biology29(24)6353-65(2009 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
the histone chaperone CAF-1 to be a novel regulator of somatic cell identity during transcription-factor-induced cell-fate transitions and provide a potential strategy to modulate cellular plasticity in a regenerative setting
Title: The histone chaperone CAF-1 safeguards somatic cell identity.
CAF-1 is an essential guardian of the genome in preimplantation mouse embryos.
Title: Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons.
Findings suggest that p150 may link the DNA-bound Gfi1 repressor complex to histones enabling modifications required for transcriptional silencing.
Title: The p150 subunit of the histone chaperone Caf-1 interacts with the transcriptional repressor Gfi1.
This recruitment is strictly dependent on p150CAF-1, the largest subunit of chromatin assembly factor 1 (CAF-1), and its ability to interact with HP1alpha.
Title: HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair.
Data show that human CAF-1 (p150) contains two PCNA interaction peptides, and suggest that these peptides are part of the mechanism that enables CAF-1 to function behind replication forks without interfering with other PCNA-mediated processes.
Title: Two fundamentally distinct PCNA interaction peptides contribute to chromatin assembly factor 1 function.
The following Chaf1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Chaf1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu09855 | |
Clone ID Related Accession (Same CDS sequence) | NM_013733.3 | |
Accession Version | NM_013733.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2736bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-26 | |
Organism | Mus musculus(house mouse) | |
Product | chromatin assembly factor 1 subunit A | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK034839.1. On Apr 6, 2007 this sequence version replaced NM_013733.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK034839.1, BC053740.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTTGGAGG AGCCGGAGGC CGCGACGCGG ACAGCCGCGG CCGTGGATTG CAAAGACAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_038761.1 |
CDS | 97..2832 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGTTGGAGG AGCCGGAGGC CGCGACGCGG ACAGCCGCGG CCGTGGATTG CAAAGACAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The histone chaperone CAF-1 safeguards somatic cell identity. |
Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons. |
The p150 subunit of the histone chaperone Caf-1 interacts with the transcriptional repressor Gfi1. |
HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair. |
Two fundamentally distinct PCNA interaction peptides contribute to chromatin assembly factor 1 function. |