Gene Symbol | Pdk4 |
Entrez Gene ID | 27273 |
Full Name | pyruvate dehydrogenase kinase, isoenzyme 4 |
Synonyms | AV005916 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Pdk4 cDNA ORF clone
gRNAs
Gene Symbol | Pdk4 |
Entrez Gene ID | 27273 |
Full Name | pyruvate dehydrogenase kinase, isoenzyme 4 |
Synonyms | AV005916 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_013743.2 | NP_038771.1 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial |
Pan troglodytes (chimpanzee) | PDK4 | NP_001233460.1 |
Mus musculus (house mouse) | Pdk4 | NP_038771.1 |
Bos taurus (cattle) | PDK4 | NP_001095353.1 |
Rattus norvegicus (Norway rat) | Pdk4 | NP_446003.1 |
Gallus gallus (chicken) | PDK4 | NP_001186838.1 |
PDK4 | XP_001093471.1 | |
Danio rerio (zebrafish) | pdk4 | NP_001122176.1 |
Homo sapiens (human) | PDK4 | NP_002603.1 |
Canis lupus familiaris (dog) | PDK4 | XP_005628582.1 |
SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart.
Khan D, Sarikhani M, Dasgupta S, Maniyadath B, Pandit AS, Mishra S, Ahamed F, Dubey A, Fathma N, Atreya HS, Kolthur-Seetharam U, Sundaresan NR
Journal of cellular physiology(2018 Jan)
Pyruvate dehydrogenase kinase 4 mediates lipogenesis and contributes to the pathogenesis of nonalcoholic steatohepatitis.
Zhang M, Zhao Y, Li Z, Wang C
Biochemical and biophysical research communications495(1)582-586(2018 01)
Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells.
Trinidad AG, Whalley N, Rowlinson R, Delpuech O, Dudley P, Rooney C, Critchlow SE
Oncogene36(44)6164-6176(2017 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
In conclusion, our data indicated that PDK4 potentially contributes to the hepatic steatosis in NASH via regulating several signaling pathway and PDK4 may be a new therapeutic strategy against NAFLD.
Title: Pyruvate dehydrogenase kinase 4 mediates lipogenesis and contributes to the pathogenesis of nonalcoholic steatohepatitis.
Taken together these data support a model where PDHK4 regulates KRAS signalling and its tumorigenic properties and suggest that inhibition of PDHK4 could represent a novel therapeutic strategy to target KRAS mutant colorectal and lung cancers
Title: Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells.
Pyruvate dehydrogenase kinase 4 is a direct transcriptional target of FoxO1 in the heart. FoxO1 directly regulates Pdk4 transcription in the heart, thereby controlling PDH activity and subsequent glucose oxidation rates.
Title: FoxO1 regulates myocardial glucose oxidation rates via transcriptional control of pyruvate dehydrogenase kinase 4 expression.
PDK4 mediates cisplatin-induced acute kidney injury.
Title: Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury.
inhibition of PDK4 activity in Hepatocellular carcinoma cells increased cyclin E1, cyclin A2, and E2F1 proteins.
Title: Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of Cyclins.
The following Pdk4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pdk4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu18196 | |
Clone ID Related Accession (Same CDS sequence) | NM_013743.2 | |
Accession Version | NM_013743.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1239bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-31 | |
Organism | Mus musculus(house mouse) | |
Product | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC023174.4. On Nov 17, 2006 this sequence version replaced NM_013743.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ001418.1, AK004543.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## |
1 | ATGAAGGCAG CCCGCTTCGT GATGCGCAGC GCCAGCTCGC TGAGCAGCGC CAGCCTGGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_038771.1 |
CDS | 117..1355 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGAAGGCAG CCCGCTTCGT GATGCGCAGC GCCAGCTCGC TGAGCAGCGC CAGCCTGGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart. |
Pyruvate dehydrogenase kinase 4 mediates lipogenesis and contributes to the pathogenesis of nonalcoholic steatohepatitis. |
Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells. |