Vsig4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Vsig4
Entrez Gene ID	278180
Full Name	V-set and immunoglobulin domain containing 4
Synonyms	A530061A11,BC025105,CRIg,Z39IG
General protein information	Preferred Names V-set and immunoglobulin domain containing 4 Names V-set and immunoglobulin domain-containing protein 4 complement receptor of the immunoglobulin superfamily
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X\|X C3

mRNA and Protein(s)

mRNA	Protein	Name
NM_177789.5	NP_808457.1	V-set and immunoglobulin domain-containing protein 4 precursor
NM_177789.4	NP_808457.1	V-set and immunoglobulin domain-containing protein 4 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	VSIG4	NP_009199.1
	VSIG4	XP_001099264.2
Canis lupus familiaris (dog)	VSIG4	XP_005641479.1
Mus musculus (house mouse)	Vsig4	NP_808457.1
Rattus norvegicus (Norway rat)	Vsig4	NP_001020175.1
Pan troglodytes (chimpanzee)	VSIG4	XP_001151444.1

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of Macrophage Complement Receptor CRIg by TRIM72 Polarizes Innate Immunity of the Lung.
Nagre N, Cong X, Terrazas C, Pepper I, Schreiber JM, Fu H, Sill JM, Christman JW, Satoskar AR, Zhao X
American journal of respiratory cell and molecular biology(2017 Dec)

V-set and Ig domain-containing 4 (VSIG4)-expressing hepatic F4/80
Shin W, Jeon Y, Choi I, Kim YJ
European journal of immunology(2017 Dec)

CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells.
Yuan X, Yang BH, Dong Y, Yamamura A, Fu W
eLife6(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

VSIG4 signaling provides an anti-immune evasion mechanism that prevents the outgrowth of intracellular bacteria in macrophages
Title: Extracellular stimulation of VSIG4/complement receptor Ig suppresses intracellular bacterial infection by inducing autophagy.

These findings reveal a pattern recognition role for CRIg in the direct capture of circulating Gram-positive bacteria from the bloodstream via binding to bacterial teichoic acid.
Title: CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria.

plays a negative role in helper T cell-dependent antibody isotype switching
Title: Endogenous VSIG4 negatively regulates the helper T cell-mediated antibody response.

complement receptor of the immunoglobulin superfamily-L-factor H protects glomerular mesangial cells from complement-mediated injury and proliferative lesions
Title: A novel CRIg-targeted complement inhibitor protects cells from complement damage.

The macrophage-expressed VSIG4 may act to alleviate renal tubulointerstitial injury via inhibition of T cell infiltration and secretion of inflammation related factors.
Title: Costimulatory molecule VSIG4 exclusively expressed on macrophages alleviates renal tubulointerstitial injury in VSIG4 KO mice.

The following Vsig4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vsig4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu06856	NM_177789.5 Latest version!	Mus musculus V-set and immunoglobulin domain containing 4 (Vsig4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
View Old Accession Versions >>
OMu06856	NM_177789.4	Mus musculus V-set and immunoglobulin domain containing 4 (Vsig4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Vsig4 ( NM_177789.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_808457.1 Mus musculus V-set and immunoglobulin domain containing 4 (Vsig4), mRNA.

Price & Availability↑

CloneID	OMu06856
Clone ID Related Accession (Same CDS sequence)	NM_177789.5 , NM_177789.4
Accession Version	NM_177789.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 843bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Mus musculus(house mouse)
Product	V-set and immunoglobulin domain-containing protein 4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL831708.9. On Jul 27, 2018 this sequence version replaced NM_177789.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC025105.1, AK041014.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGATCT CATCAGGCTT GCTGTTCCTG GGCCACCTAA TAGTGCTCAC CTATGGCCAC 
CCCACCCTAA AAACACCTGA GAGTGTGACA GGGACCTGGA AAGGAGATGT GAAGATTCAG 
TGCATCTATG ATCCCCTGAG AGGCTACAGG CAAGTTTTGG TGAAATGGCT GGTAAGACAC 
GGCTCTGACT CCGTCACCAT CTTCCTACGT GACTCCACTG GAGACCATAT CCAGCAGGCA 
AAGTACAGAG GCCGCCTGAA AGTGAGCCAC AAAGTTCCAG GAGATGTGTC CCTCCAAATA 
AATACCCTGC AGATGGATGA CAGGAATCAC TATACATGTG AGGTCACCTG GCAGACTCCT 
GATGGAAACC AAGTAATAAG AGATAAGATC ATTGAGCTCC GTGTTCGGAA ATATAATCCA 
CCTAGAATCA ATACTGAAGC ACCTACAACC CTGCACTCCT CTTTGGAAGC AACAACTATA 
ATGAGTTCAA CCTCTGACTT GACCACTAAT GGGACTGGAA AACTTGAGGA GACCATTGCT 
GGTTCAGGGA GGAACCTGCC AATCTTTGCC ATAATCTTCA TCATCTCCCT TTGCTGCATA 
GTAGCTGTCA CCATACCTTA TATCTTGTTC CGCTGCAGGA CATTCCAACA AGAGTATGTC 
TATGGAGTGA GCAGGGTGTT TGCCAGGAAG ACAAGCAACT CTGAAGAAAC CACAAGGGTG 
ACTACCATCG CAACTGATGA ACCAGATTCC CAGGCTCTGA TTAGTGACTA CTCTGATGAT 
CCTTGCCTCA GCCAGGAGTA CCAAATAACC ATCAGATCAA CAATGTCTAT TCCTGCCTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_808457.1
CDS	71..913
Translation	MEISSGLLFLGHLIVLTYGHPTLKTPESVTGTWKGDVKIQCIYDPLRGYRQVLVKWLVRHGSDSVTIFLRDSTGDHIQQAKYRGRLKVSHKVPGDVSLQINTLQMDDRNHYTCEVTWQTPDGNQVIRDKIIELRVRKYNPPRINTEAPTTLHSSLEATTIMSSTSDLTTNGTGKLEETIAGSGRNLPIFAIIFIISLCCIVAVTIPYILFRCRTFQQEYVYGVSRVFARKTSNSEETTRVTTIATDEPDSQALISDYSDDPCLSQEYQITIRSTMSIPAC

Target ORF information:

RefSeq Version	NM_177789.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus V-set and immunoglobulin domain containing 4 (Vsig4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177789.5

ORF Insert Sequence:

ATGGAGATCT CATCAGGCTT GCTGTTCCTG GGCCACCTAA TAGTGCTCAC CTATGGCCAC 
CCCACCCTAA AAACACCTGA GAGTGTGACA GGGACCTGGA AAGGAGATGT GAAGATTCAG 
TGCATCTATG ATCCCCTGAG AGGCTACAGG CAAGTTTTGG TGAAATGGCT GGTAAGACAC 
GGCTCTGACT CCGTCACCAT CTTCCTACGT GACTCCACTG GAGACCATAT CCAGCAGGCA 
AAGTACAGAG GCCGCCTGAA AGTGAGCCAC AAAGTTCCAG GAGATGTGTC CCTCCAAATA 
AATACCCTGC AGATGGATGA CAGGAATCAC TATACATGTG AGGTCACCTG GCAGACTCCT 
GATGGAAACC AAGTAATAAG AGATAAGATC ATTGAGCTCC GTGTTCGGAA ATATAATCCA 
CCTAGAATCA ATACTGAAGC ACCTACAACC CTGCACTCCT CTTTGGAAGC AACAACTATA 
ATGAGTTCAA CCTCTGACTT GACCACTAAT GGGACTGGAA AACTTGAGGA GACCATTGCT 
GGTTCAGGGA GGAACCTGCC AATCTTTGCC ATAATCTTCA TCATCTCCCT TTGCTGCATA 
GTAGCTGTCA CCATACCTTA TATCTTGTTC CGCTGCAGGA CATTCCAACA AGAGTATGTC 
TATGGAGTGA GCAGGGTGTT TGCCAGGAAG ACAAGCAACT CTGAAGAAAC CACAAGGGTG 
ACTACCATCG CAACTGATGA ACCAGATTCC CAGGCTCTGA TTAGTGACTA CTCTGATGAT 
CCTTGCCTCA GCCAGGAGTA CCAAATAACC ATCAGATCAA CAATGTCTAT TCCTGCCTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Vsig4 ( NM_177789.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_808457.1 Mus musculus V-set and immunoglobulin domain containing 4 (Vsig4), mRNA.

Price & Availability↑

CloneID	OMu06856
Clone ID Related Accession (Same CDS sequence)	NM_177789.5 , NM_177789.4
Accession Version	NM_177789.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 843bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-31
Organism	Mus musculus(house mouse)
Product	V-set and immunoglobulin domain-containing protein 4 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL831708.9. On May 2, 2007 this sequence version replaced NM_177789.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK041014.1, BC025105.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END##

ATGGAGATCT CATCAGGCTT GCTGTTCCTG GGCCACCTAA TAGTGCTCAC CTATGGCCAC 
CCCACCCTAA AAACACCTGA GAGTGTGACA GGGACCTGGA AAGGAGATGT GAAGATTCAG 
TGCATCTATG ATCCCCTGAG AGGCTACAGG CAAGTTTTGG TGAAATGGCT GGTAAGACAC 
GGCTCTGACT CCGTCACCAT CTTCCTACGT GACTCCACTG GAGACCATAT CCAGCAGGCA 
AAGTACAGAG GCCGCCTGAA AGTGAGCCAC AAAGTTCCAG GAGATGTGTC CCTCCAAATA 
AATACCCTGC AGATGGATGA CAGGAATCAC TATACATGTG AGGTCACCTG GCAGACTCCT 
GATGGAAACC AAGTAATAAG AGATAAGATC ATTGAGCTCC GTGTTCGGAA ATATAATCCA 
CCTAGAATCA ATACTGAAGC ACCTACAACC CTGCACTCCT CTTTGGAAGC AACAACTATA 
ATGAGTTCAA CCTCTGACTT GACCACTAAT GGGACTGGAA AACTTGAGGA GACCATTGCT 
GGTTCAGGGA GGAACCTGCC AATCTTTGCC ATAATCTTCA TCATCTCCCT TTGCTGCATA 
GTAGCTGTCA CCATACCTTA TATCTTGTTC CGCTGCAGGA CATTCCAACA AGAGTATGTC 
TATGGAGTGA GCAGGGTGTT TGCCAGGAAG ACAAGCAACT CTGAAGAAAC CACAAGGGTG 
ACTACCATCG CAACTGATGA ACCAGATTCC CAGGCTCTGA TTAGTGACTA CTCTGATGAT 
CCTTGCCTCA GCCAGGAGTA CCAAATAACC ATCAGATCAA CAATGTCTAT TCCTGCCTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_808457.1
CDS	71..913
Translation	MEISSGLLFLGHLIVLTYGHPTLKTPESVTGTWKGDVKIQCIYDPLRGYRQVLVKWLVRHGSDSVTIFLRDSTGDHIQQAKYRGRLKVSHKVPGDVSLQINTLQMDDRNHYTCEVTWQTPDGNQVIRDKIIELRVRKYNPPRINTEAPTTLHSSLEATTIMSSTSDLTTNGTGKLEETIAGSGRNLPIFAIIFIISLCCIVAVTIPYILFRCRTFQQEYVYGVSRVFARKTSNSEETTRVTTIATDEPDSQALISDYSDDPCLSQEYQITIRSTMSIPAC

Target ORF information:

RefSeq Version	NM_177789.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus V-set and immunoglobulin domain containing 4 (Vsig4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177789.4

ORF Insert Sequence:

ATGGAGATCT CATCAGGCTT GCTGTTCCTG GGCCACCTAA TAGTGCTCAC CTATGGCCAC 
CCCACCCTAA AAACACCTGA GAGTGTGACA GGGACCTGGA AAGGAGATGT GAAGATTCAG 
TGCATCTATG ATCCCCTGAG AGGCTACAGG CAAGTTTTGG TGAAATGGCT GGTAAGACAC 
GGCTCTGACT CCGTCACCAT CTTCCTACGT GACTCCACTG GAGACCATAT CCAGCAGGCA 
AAGTACAGAG GCCGCCTGAA AGTGAGCCAC AAAGTTCCAG GAGATGTGTC CCTCCAAATA 
AATACCCTGC AGATGGATGA CAGGAATCAC TATACATGTG AGGTCACCTG GCAGACTCCT 
GATGGAAACC AAGTAATAAG AGATAAGATC ATTGAGCTCC GTGTTCGGAA ATATAATCCA 
CCTAGAATCA ATACTGAAGC ACCTACAACC CTGCACTCCT CTTTGGAAGC AACAACTATA 
ATGAGTTCAA CCTCTGACTT GACCACTAAT GGGACTGGAA AACTTGAGGA GACCATTGCT 
GGTTCAGGGA GGAACCTGCC AATCTTTGCC ATAATCTTCA TCATCTCCCT TTGCTGCATA 
GTAGCTGTCA CCATACCTTA TATCTTGTTC CGCTGCAGGA CATTCCAACA AGAGTATGTC 
TATGGAGTGA GCAGGGTGTT TGCCAGGAAG ACAAGCAACT CTGAAGAAAC CACAAGGGTG 
ACTACCATCG CAACTGATGA ACCAGATTCC CAGGCTCTGA TTAGTGACTA CTCTGATGAT 
CCTTGCCTCA GCCAGGAGTA CCAAATAACC ATCAGATCAA CAATGTCTAT TCCTGCCTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of Macrophage Complement Receptor CRIg by TRIM72 Polarizes Innate Immunity of the Lung.
American journal of respiratory cell and molecular biology(2017 Dec)
Nagre N,Cong X,Terrazas C,Pepper I,Schreiber JM,Fu H,Sill JM,Christman JW,Satoskar AR,Zhao X

V-set and Ig domain-containing 4 (VSIG4)-expressing hepatic F4/80
European journal of immunology(2017 Dec)
Shin W,Jeon Y,Choi I,Kim YJ

CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells.
eLife6(2017 Nov)
Yuan X,Yang BH,Dong Y,Yamamura A,Fu W

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Vsig4 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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