Siva1 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Siva1 |
| Entrez Gene ID | 30954 |
| Full Name | SIVA1, apoptosis-inducing factor |
| Synonyms | CD27bp,Siva |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_013929.2 | NP_038957.2 | apoptosis regulatory protein Siva isoform 1 |
| NM_001161737.1 | NP_001155209.1 | apoptosis regulatory protein Siva isoform 2 |
| Mus musculus (house mouse) | Siva1 | NP_038957.2 |
| Gallus gallus (chicken) | SIVA1 | NP_001264464.1 |
| Bos taurus (cattle) | SIVA1 | NP_001180107.1 |
| Rattus norvegicus (Norway rat) | Siva1 | NP_001094452.1 |
| Danio rerio (zebrafish) | siva1 | XP_700568.6 |
| Canis lupus familiaris (dog) | SIVA1 | XP_855513.1 |
| Homo sapiens (human) | SIVA1 | NP_006418.2 |
| Pan troglodytes (chimpanzee) | SIVA1 | XP_510197.3 |
| SIVA1 | XP_001095069.2 | |
| Xenopus tropicalis (tropical clawed frog) | siva1 | NP_001039138.1 |
Related articles in PubMed
E3 ubiquitin ligase Cbl-b activates the p53 pathway by targeting Siva1, a negative regulator of ARF, in FLT3 inhibitor-resistant acute myeloid leukemia.
Park IK, Blum W, Baker SD, Caligiuri MA
Leukemia31(2)502-505(2017 02)
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)
The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development.
Van Nostrand JL, Brisac A, Mello SS, Jacobs SB, Luong R, Attardi LD
Cancer discovery5(6)622-35(2015 Jun)
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules.
Li N, Jiang P, Du W, Wu Z, Li C, Qiao M, Yang X, Wu M
Proceedings of the National Academy of Sciences of the United States of America108(31)12851-6(2011 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These findings collectively reveal a novel role for the p53 target gene SIVA both in regulating metabolism and in enabling tumorigenesis, independently of p53.
Title: The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development.
Data indicate that p53 target Siva is pivotal in regulating apoptosis in the pathology of renal ischemia reperfusion injury.
Title: p53 target Siva regulates apoptosis in ischemic kidneys.
Data show that SLIMMER delayed Siva-1-dependent apoptosis in C2C12 myoblasts.
Title: SLIMMER (FHL1B/KyoT3) interacts with the proapoptotic protein Siva-1 (CD27BP) and delays skeletal myoblast apoptosis.
lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival
Title: The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival.
Siva's expression pattern suggests that it plays an instructive role in apoptosis, and accordingly, we demonstrate that Siva is essential for p53-dependent apoptosis in cerebellar granule neurons.
Title: Siva is an apoptosis-selective p53 target gene important for neuronal cell death.
The following Siva1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Siva1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu08216 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001161737.1 | |
| Accession Version | NM_001161737.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 333bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-23 | |
| Organism | Mus musculus(house mouse) | |
| Product | apoptosis regulatory protein Siva isoform 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB524656.1, AF033112.1, AW060433.1 and AC124373.4. Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AV576296.1, BY367725.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCCCAAGC GGAGCTGCCC GTTCGCAGAC GCAGCCCCGC TCCAACTCAA AGTCCACGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001155209.1 |
| CDS | 140..472 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001161737.1 |
ORF Insert Sequence:
1 | ATGCCCAAGC GGAGCTGCCC GTTCGCAGAC GCAGCCCCGC TCCAACTCAA AGTCCACGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu10178 | |
| Clone ID Related Accession (Same CDS sequence) | NM_013929.2 | |
| Accession Version | NM_013929.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-23 | |
| Organism | Mus musculus(house mouse) | |
| Product | apoptosis regulatory protein Siva isoform 1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB524656.1, AK017570.1, AW060433.1 and AC124373.4. On Jun 18, 2009 this sequence version replaced NM_013929.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012279.1, CB204343.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCCCAAGC GGAGCTGCCC GTTCGCAGAC GCAGCCCCGC TCCAACTCAA AGTCCACGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_038957.2 |
| CDS | 140..667 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_013929.2 |
ORF Insert Sequence:
1 | ATGCCCAAGC GGAGCTGCCC GTTCGCAGAC GCAGCCCCGC TCCAACTCAA AGTCCACGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
E3 ubiquitin ligase Cbl-b activates the p53 pathway by targeting Siva1, a negative regulator of ARF, in FLT3 inhibitor-resistant acute myeloid leukemia. |
|
High-throughput discovery of novel developmental phenotypes. |
|
The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development. |
|
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
|
Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules. |