Ccbe1 cDNA ORF clone, Mus musculus(house mouse)
Gene Symbol | Ccbe1 |
Entrez Gene ID | 320924 |
Full Name | collagen and calcium binding EGF domains 1 |
Synonyms | 4933426F18Rik,9430093N24Rik,mKIAA1983 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
XM_006526021.3 | XP_006526084.1 | collagen and calcium-binding EGF domain-containing protein 1 isoform X1 |
NM_178793.4 | NP_848908.1 | collagen and calcium-binding EGF domain-containing protein 1 precursor |
XM_006526021.4 | XP_006526084.1 | collagen and calcium-binding EGF domain-containing protein 1 isoform X1 |

Homo sapiens (human) | CCBE1 | NP_597716.1 |
Mus musculus (house mouse) | Ccbe1 | NP_848908.1 |
CCBE1 | XP_001090495.2 | |
Xenopus tropicalis (tropical clawed frog) | ccbe1 | XP_002936721.2 |
Pan troglodytes (chimpanzee) | CCBE1 | XP_512156.3 |
Canis lupus familiaris (dog) | CCBE1 | XP_852585.2 |
Bos taurus (cattle) | CCBE1 | XP_002697885.2 |
Rattus norvegicus (Norway rat) | Ccbe1 | XP_341625.5 |
Gallus gallus (chicken) | CCBE1 | XP_001233358.1 |
Danio rerio (zebrafish) | ccbe1 | NP_001157395.1 |

Related articles in PubMed
Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts.
Sharma B, Ho L, Ford GH, Chen HI, Goldstone AB, Woo YJ, Quertermous T, Reversade B, Red-Horse K
Developmental cell42(6)655-666.e3(2017 09)
Repression by PRDM13 is critical for generating precision in neuronal identity.
Mona B, Uruena A, Kollipara RK, Ma Z, Borromeo MD, Chang JC, Johnson JE
eLife6(2017 Aug)
Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1.
Jha SK, Rauniyar K, Karpanen T, Lepp?nen VM, Brouillard P, Vikkula M, Alitalo K, Jeltsch M
Scientific reports7(1)4916(2017 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Collagen domains of CCBE1 are crucial for the activation of VEGFC in vitro and in vivo. The EGF domains of CCBE1 are dispensable for regulation of VEGFC processing in vitro, however, they are necessary for full lymphangiogenic activity of CCBE1 in vivo.
Title: Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain.
CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation.
Title: CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation.
Ccbe1 has an essential role in lymphangiogenesis [review]
Title: A fisheye view on lymphangiogenesis.
The secreted lymphangiogenic protein CCBE1 is essential for fetal but not postnatal erythropoiesis.
Title: The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis.
Ccbe1 expression marks the cardiac and lymphatic progenitor lineages during early stages of mouse development
Title: Ccbe1 expression marks the cardiac and lymphatic progenitor lineages during early stages of mouse development.
The following Ccbe1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccbe1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu17984 | |
Clone ID Related Accession (Same CDS sequence) | NM_178793.4 | |
Accession Version | NM_178793.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1227bp) Protein sequence SNP |
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Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-14 | |
Organism | Mus musculus(house mouse) | |
Product | collagen and calcium-binding EGF domain-containing protein 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ179960.1, AK035153.1, AC102243.14 and AV264768.2. On Feb 2, 2007 this sequence version replaced NM_178793.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK039742.1, AK028377.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGTGCCGC CGCCTCTTCC GAGCCGGGGA GGAGCAGCCA AGAGGCAGCT GGGCAAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_848908.1 |
CDS | 85..1311 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGGTGCCGC CGCCTCTTCC GAGCCGGGGA GGAGCAGCCA AGAGGCAGCT GGGCAAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu54655 | |
Clone ID Related Accession (Same CDS sequence) | XM_006526021.3 , XM_006526021.4 | |
Accession Version | XM_006526021.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1017bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | collagen and calcium-binding EGF domain-containing protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000084.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006526021.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACGATAA TACGCTGCCT CCCACTGTCC AGAACGGTGA GCTACAGTAT ACCTACAGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006526084.1 |
CDS | 547..1563 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGACGATAA TACGCTGCCT CCCACTGTCC AGAACGGTGA GCTACAGTAT ACCTACAGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu54655 | |
Clone ID Related Accession (Same CDS sequence) | XM_006526021.3 , XM_006526021.4 | |
Accession Version | XM_006526021.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1017bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | collagen and calcium-binding EGF domain-containing protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000084.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006526021.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACGATAA TACGCTGCCT CCCACTGTCC AGAACGGTGA GCTACAGTAT ACCTACAGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006526084.1 |
CDS | 543..1559 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGACGATAA TACGCTGCCT CCCACTGTCC AGAACGGTGA GCTACAGTAT ACCTACAGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts. |
![]() |
Repression by PRDM13 is critical for generating precision in neuronal identity. |
![]() |
Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1. |