Rnf10 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Rnf10 |
| Entrez Gene ID | 50849 |
| Full Name | ring finger protein 10 |
| Synonyms | AA675014,RIE2,mKIAA0262 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome | |
| Summary | The protein encoding this gene is a member of the really interesting new gene finger protein family. Members of this family contain protein motifs similar to zinc finger domains and are involved in many processes that include transcriptional regulation, DNA repair and signal transduction. Expression of this gene is upregulated during neuronal differentiation of cultured cells, and inhibition of its expression impairs differentiation and cell cycle exit, providing evidence for a function in neuronal differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| XM_017320970.1 | XP_017176459.1 | RING finger protein 10 isoform X1 |
| NM_001302449.1 | NP_001289378.1 | RING finger protein 10 isoform 3 |
| XM_006530404.1 | XP_006530467.1 | RING finger protein 10 isoform X2 |
| XM_017320970.2 | XP_017176459.1 | RING finger protein 10 isoform X1 |
| NM_016698.2 | NP_057907.2 | RING finger protein 10 isoform 2 |
| NM_001302448.1 | NP_001289377.1 | RING finger protein 10 isoform 1 |
| XM_030254658.1 | XP_030110518.1 | RING finger protein 10 isoform X3 |
| Drosophila melanogaster (fruit fly) | CG12099 | NP_647623.1 |
| Bos taurus (cattle) | RNF10 | NP_001070337.1 |
| Rattus norvegicus (Norway rat) | Rnf10 | NP_001011904.1 |
| Homo sapiens (human) | RNF10 | NP_055683.3 |
| Canis lupus familiaris (dog) | RNF10 | XP_851332.2 |
| Danio rerio (zebrafish) | rnf10 | NP_001116727.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP007954 | XP_317518.4 |
| RNF10 | XP_002798843.1 | |
| Mus musculus (house mouse) | Rnf10 | NP_057907.2 |
| Gallus gallus (chicken) | RNF10 | XP_415267.2 |
| Xenopus tropicalis (tropical clawed frog) | rnf10 | NP_989388.1 |
| Pan troglodytes (chimpanzee) | RNF10 | XP_001161754.2 |
Related articles in PubMed
Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Sundberg JP, Dadras SS, Silva KA, Kennedy VE, Garland G, Murray SA, Sundberg BA, Schofield PN, Pratt CH
PloS one12(7)e0180682(2017)
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)
RING finger protein 10 regulates retinoic acid-induced neuronal differentiation and the cell cycle exit of P19 embryonic carcinoma cells.
Malik YS, Sheikh MA, Lai M, Cao R, Zhu X
Journal of cellular biochemistry114(9)2007-15(2013 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Results showed that increase in Rnf10 expression upon RA induction is necessary for the positive regulation of cyclin kinase inhibitor p21 expression, which leads to cell cycle arrest and is critical for neuronal differentiation.
Title: RING finger protein 10 regulates retinoic acid-induced neuronal differentiation and the cell cycle exit of P19 embryonic carcinoma cells.
The following Rnf10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rnf10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu10449 | |
| Clone ID Related Accession (Same CDS sequence) | NM_016698.2 | |
| Accession Version | NM_016698.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2415bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-07-09 | |
| Organism | Mus musculus(house mouse) | |
| Product | RING finger protein 10 isoform 2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK146728.1, AK129106.1 and AV451382.1. On Nov 20, 2009 this sequence version replaced NM_016698.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK146728.1, AB026621.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCCGCAGA GCTCCCCCAG CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_057907.2 |
| CDS | 483..2897 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_016698.2 |
ORF Insert Sequence:
1 | ATGCCGCAGA GCTCCCCCAG CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu69393 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001302448.1 | |
| Accession Version | NM_001302448.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2418bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-07-09 | |
| Organism | Mus musculus(house mouse) | |
| Product | RING finger protein 10 isoform 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK146728.1, AK004579.1, AC145070.10 and AA792805.1. On Oct 22, 2014 this sequence version replaced XM_006530402.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: AK156502.1, AK004579.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCCGCAGA GCTCCCCCAG CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001289377.1 |
| CDS | 483..2900 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001302448.1 |
ORF Insert Sequence:
1 | ATGCCGCAGA GCTCCCCCAG CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu69394 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001302449.1 | |
| Accession Version | NM_001302449.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2412bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-07-09 | |
| Organism | Mus musculus(house mouse) | |
| Product | RING finger protein 10 isoform 3 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK146728.1, AK034953.1, AC145070.10 and AA792805.1. On Oct 22, 2014 this sequence version replaced XM_006530403.1. Transcript Variant: This variant (3) uses alternate in-frame splice sites in the coding region compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK034953.1, SRR1660815.107520.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCCGCAGA GCTCCCCCAG CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001289378.1 |
| CDS | 483..2894 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001302449.1 |
ORF Insert Sequence:
1 | ATGCCGCAGA GCTCCCCCAG CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu35954 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006530404.1 | |
| Accession Version | XM_006530404.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2067bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-07 | |
| Organism | Mus musculus(house mouse) | |
| Product | RING finger protein 10 isoform X2 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGTAGCAG AGGCTCAGCG GGCAGAGTTT AGCCCTGCCC AGTTCTCTGG CCCTAAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006530467.1 |
| CDS | 159..2225 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006530404.1 |
ORF Insert Sequence:
1 | ATGGTAGCAG AGGCTCAGCG GGCAGAGTTT AGCCCTGCCC AGTTCTCTGG CCCTAAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu81416 | |
| Clone ID Related Accession (Same CDS sequence) | XM_017320970.1 , XM_017320970.2 | |
| Accession Version | XM_017320970.1 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2415bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-06-21 | |
| Organism | Mus musculus(house mouse) | |
| Product | RING finger protein 10 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGCCGCAGA GCTCCCCCAG CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_017176459.1 |
| CDS | 153..2567 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_017320970.1 |
ORF Insert Sequence:
1 | ATGCCGCAGA GCTCCCCCAG CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu81416 | |
| Clone ID Related Accession (Same CDS sequence) | XM_017320970.1 , XM_017320970.2 | |
| Accession Version | XM_017320970.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2415bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-07 | |
| Organism | Mus musculus(house mouse) | |
| Product | RING finger protein 10 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017320970.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGCCGCAGA GCTCCCCCAG CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_017176459.1 |
| CDS | 509..2923 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_017320970.2 |
ORF Insert Sequence:
1 | ATGCCGCAGA GCTCCCCCAG CGCCGCCGCC ACCGCCTCCG ACATGGACAA GAACAGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu88966 | |
| Clone ID Related Accession (Same CDS sequence) | XM_030254658.1 | |
| Accession Version | XM_030254658.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2064bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-07 | |
| Organism | Mus musculus(house mouse) | |
| Product | RING finger protein 10 isoform X3 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGTAGCAG AGGCTCAGCG GGCAGAGTTT AGCCCTGCCC AGTTCTCTGG CCCTAAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_030110518.1 |
| CDS | 202..2265 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_030254658.1 |
ORF Insert Sequence:
1 | ATGGTAGCAG AGGCTCAGCG GGCAGAGTTT AGCCCTGCCC AGTTCTCTGG CCCTAAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. |
|
High-throughput discovery of novel developmental phenotypes. |
|
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
|
RING finger protein 10 regulates retinoic acid-induced neuronal differentiation and the cell cycle exit of P19 embryonic carcinoma cells. |