Gene Symbol | Impa1 |
Entrez Gene ID | 55980 |
Full Name | inositol (myo)-1(or 4)-monophosphatase 1 |
Synonyms | 2610002K09Rik,2900059K10Rik,AI325909 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Impa1 cDNA ORF clone
Gene Symbol | Impa1 |
Entrez Gene ID | 55980 |
Full Name | inositol (myo)-1(or 4)-monophosphatase 1 |
Synonyms | 2610002K09Rik,2900059K10Rik,AI325909 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_018864.6 | NP_061352.2 | inositol monophosphatase 1 isoform 1 |
XM_006530078.3 | XP_006530141.1 | inositol monophosphatase 1 isoform X2 |
NM_001310433.1 | NP_001297362.1 | inositol monophosphatase 1 isoform 2 |
XM_006530077.3 | XP_006530140.1 | inositol monophosphatase 1 isoform X1 |
XM_006530077.4 | XP_006530140.1 | inositol monophosphatase 1 isoform X1 |
XM_006530078.4 | XP_006530141.1 | inositol monophosphatase 1 isoform X2 |
Rattus norvegicus (Norway rat) | Impa1 | NP_114446.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP006570 | XP_316595.4 |
Caenorhabditis elegans (roundworm) | ttx-7 | NP_001122453.1 |
Saccharomyces cerevisiae (baker's yeast) | INM2 | NP_010573.3 |
Magnaporthe oryzae (rice blast fungus) | MGG_06165 | XP_003712046.1 |
Homo sapiens (human) | IMPA1 | NP_001138350.1 |
Neurospora crassa | NCU06348 | XP_962382.1 |
Xenopus tropicalis (tropical clawed frog) | impa1 | NP_001017057.1 |
Drosophila melanogaster (fruit fly) | CG9391 | NP_649294.1 |
Saccharomyces cerevisiae (baker's yeast) | INM1 | NP_011912.1 |
Oryza sativa (rice) | Os03g0587000 | NP_001050574.1 |
Pan troglodytes (chimpanzee) | LOC100613673 | XP_003311833.1 |
IMPA1 | XP_001092596.2 | |
Mus musculus (house mouse) | Impa1 | NP_061352.2 |
Arabidopsis thaliana (thale cress) | VTC4 | NP_186936.1 |
Canis lupus familiaris (dog) | IMPA1 | XP_535114.1 |
Bos taurus (cattle) | IMPA1 | NP_776786.1 |
Gallus gallus (chicken) | IMPA1 | XP_418310.3 |
Danio rerio (zebrafish) | impa1 | NP_001002745.1 |
IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes.
Sade Y, Toker L, Kara NZ, Einat H, Rapoport S, Moechars D, Berry GT, Bersudsky Y, Agam G
Translational psychiatry6(12)e968(2016 12)
Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis.
Ohnishi T, Murata T, Watanabe A, Hida A, Ohba H, Iwayama Y, Mishima K, Gondo Y, Yoshikawa T
The Journal of biological chemistry289(15)10785-96(2014 Apr)
Human myo-inositol monophosphatase 2 rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes.
Ohnishi T, Tanizawa Y, Watanabe A, Nakamura T, Ohba H, Hirata H, Kaneda C, Iwayama Y, Arimoto T, Watanabe K, Mori I, Yoshikawa T
Journal of neurochemistry124(5)685-94(2013 Mar)
Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens.
Singh N, Halliday AC, Knight M, Lack NA, Lowe E, Churchill GC
Acta crystallographica. Section F, Structural biology and crystallization communications68(Pt 10)1149-52(2012 Oct)
An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons.
Andreassi C, Zimmermann C, Mitter R, Fusco S, De Vita S, Devita S, Saiardi A, Riccio A
Nature neuroscience13(3)291-301(2010 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Lithium affects the phosphatidylinositol signaling system in two ways: depleting inositol, consequently decreasing phosphoinositides; elevating inositol monophosphate levels followed by phosphoinositols accumulation. Each or both may mediate lithium-induced behavior
Title: IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes.
IMPase has a role in intracellular myo-inositol synthesis in craniofacial development and the maintenance of proper brain function
Title: Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis.
Comparison of MmIMPase 1 and HsIMPase 1 revealed a core r.m.s. deviation of 0.516 A
Title: Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens.
local synthesis of IMPA1 is required for neurotrophin-dependent axon growth; selective regulation of IMPA1 levels in axons may provide a target for the development of new therapeutic strategies for specific neurological and psychiatric diseases
Title: An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons.
IMPA1-/- mouse represents a novel model to study inositol homeostasis, and indicates that genetic inactivation of IMPA1 can mimic some actions of lithium
Title: IMPA1 is essential for embryonic development and lithium-like pilocarpine sensitivity.
The following Impa1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Impa1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu11078 | |
Clone ID Related Accession (Same CDS sequence) | NM_018864.6 | |
Accession Version | NM_018864.6 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-24 | |
Organism | Mus musculus(house mouse) | |
Product | inositol monophosphatase 1 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY283562.1, AK152774.1 and AK145472.1. On Jul 14, 2015 this sequence version replaced NM_018864.5. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK145472.1, AK083238.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCAGACC CTTGGCAGGA GTGCATGGAC TATGCAGTAA TCCTCGCGAG GCAAGCTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_061352.2 |
CDS | 122..955 |
Translation |
Target ORF information:
Target ORF information:
|
NM_018864.6 |
1 | ATGGCAGACC CTTGGCAGGA GTGCATGGAC TATGCAGTAA TCCTCGCGAG GCAAGCTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu69577 | |
Clone ID Related Accession (Same CDS sequence) | NM_001310433.1 | |
Accession Version | NM_001310433.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-24 | |
Organism | Mus musculus(house mouse) | |
Product | inositol monophosphatase 1 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY283562.1, AK152774.1 and AK145472.1. On Jul 14, 2015 this sequence version replaced XM_006530079.2. Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG917301.1, BG863136.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCAGACC CTTGGCAGGA GTGCATGGAC TATGCAGTAA TCCTCGCGAG GCAAGCTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001297362.1 |
CDS | 122..748 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001310433.1 |
1 | ATGGCAGACC CTTGGCAGGA GTGCATGGAC TATGCAGTAA TCCTCGCGAG GCAAGCTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu31283 | |
Clone ID Related Accession (Same CDS sequence) | XM_006530077.3 , XM_006530077.4 | |
Accession Version | XM_006530077.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | inositol monophosphatase 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006530077.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGGGCC GGGGCGCCTG CCGGGCCCTC CTCCCGGCGG TGCTCTCCGT AGCGCTCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006530140.1 |
CDS | 23..1015 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006530077.3 |
1 | ATGCTGGGCC GGGGCGCCTG CCGGGCCCTC CTCCCGGCGG TGCTCTCCGT AGCGCTCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu31284 | |
Clone ID Related Accession (Same CDS sequence) | XM_006530078.3 , XM_006530078.4 | |
Accession Version | XM_006530078.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | inositol monophosphatase 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006530078.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGGGCC GGGGCGCCTG CCGGGCCCTC CTCCCGGCGG TGCTCTCCGT AGCGCTCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006530141.1 |
CDS | 33..818 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006530078.3 |
1 | ATGCTGGGCC GGGGCGCCTG CCGGGCCCTC CTCCCGGCGG TGCTCTCCGT AGCGCTCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu31283 | |
Clone ID Related Accession (Same CDS sequence) | XM_006530077.3 , XM_006530077.4 | |
Accession Version | XM_006530077.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | inositol monophosphatase 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006530077.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGGGCC GGGGCGCCTG CCGGGCCCTC CTCCCGGCGG TGCTCTCCGT AGCGCTCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006530140.1 |
CDS | 84..1076 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006530077.4 |
1 | ATGCTGGGCC GGGGCGCCTG CCGGGCCCTC CTCCCGGCGG TGCTCTCCGT AGCGCTCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu31284 | |
Clone ID Related Accession (Same CDS sequence) | XM_006530078.3 , XM_006530078.4 | |
Accession Version | XM_006530078.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | inositol monophosphatase 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006530078.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGGGCC GGGGCGCCTG CCGGGCCCTC CTCCCGGCGG TGCTCTCCGT AGCGCTCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006530141.1 |
CDS | 48..833 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006530078.4 |
1 | ATGCTGGGCC GGGGCGCCTG CCGGGCCCTC CTCCCGGCGG TGCTCTCCGT AGCGCTCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes. |
Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis. |
Human myo-inositol monophosphatase 2 rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes. |
Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens. |
An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons. |