Nmu cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Nmu
Entrez Gene ID	56183
Full Name	neuromedin U
General protein information	Preferred Names neuromedin U Names neuromedin-U neuromedin U precursor-related peptide/neuromedin U preproprotein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 C3.3

mRNA and Protein(s)

mRNA Protein Name

NM_019515.1 NP_062388.1 neuromedin-U precursor
Pathways from BioSystems

mRNA	Protein	Name
NM_019515.1	NP_062388.1	neuromedin-U precursor

Homologies

Mus musculus (house mouse)	Nmu	NP_062388.1
Danio rerio (zebrafish)	nmu	XP_005160570.1
Homo sapiens (human)	NMU	NP_006672.1
Canis lupus familiaris (dog)	NMU	XP_005628261.1
Bos taurus (cattle)	NMU	NP_001178082.1
Gallus gallus (chicken)	NMU	NP_001264850.1
Xenopus tropicalis (tropical clawed frog)	nmu	XP_004911525.1
Rattus norvegicus (Norway rat)	Nmu	NP_071575.1
Pan troglodytes (chimpanzee)	NMU	XP_001142975.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of neuromedin U in accelerating of non-alcoholic steatohepatitis in mice.
Teranishi H, Hayashi M, Higa R, Mori K, Miyazawa T, Hino J, Amano Y, Tozawa R, Ida T, Hanada T, Miyazato M, Hanada R, Kangawa K, Nakao K
Peptides99134-141(2018 01)

Identification of neuromedin U precursor-related peptide and its possible role in the regulation of prolactin release.
Mori K, Ida T, Fudetani M, Mori M, Kaiya H, Hino J, Nakahara K, Murakami N, Miyazato M, Kangawa K
Scientific reports7(1)10468(2017 Sep)

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation.
Klose CSN, Mahlak?iv T, Moeller JB, Rankin LC, Flamar AL, Kabata H, Monticelli LA, Moriyama S, Putzel GG, Rakhilin N, Shen X, Kostenis E, K?nig GM, Senda T, Carpenter D, Farber DL, Artis D
Nature549(7671)282-286(2017 09)

Neuronal regulation of type 2 innate lymphoid cells via neuromedin U.
Cardoso V, Chesn? J, Ribeiro H, Garc?a-Cassani B, Carvalho T, Bouchery T, Shah K, Barbosa-Morais NL, Harris N, Veiga-Fernandes H
Nature549(7671)277-281(2017 09)

Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway.
Hanada R, Teranishi H, Pearson JT, Kurokawa M, Hosoda H, Fukushima N, Fukue Y, Serino R, Fujihara H, Ueta Y, Ikawa M, Okabe M, Murakami N, Shirai M, Yoshimatsu H, Kangawa K, Kojima M
Nature medicine10(10)1067-73(2004 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggested that NMU can act directly on beta cells through NMUR1 in an autocrine or paracrine fashion to suppress insulin secretion. Collectively, our results highlight the crucial role of NMU in suppressing pancreatic insulin secretion, and may improve our understanding of glucose homeostasis.
Title: Neuromedin U suppresses glucose-stimulated insulin secretion in pancreatic ? cells.

These results suggest that NMU and NMS are involved in thermoregulation via the prostaglandin E2 and beta3 adrenergic receptors, but that endogenous NMS might play a more predominant role than NMU.
Title: Involvement of endogenous neuromedin U and neuromedin S in thermoregulation.

the anorectic effect of the lipidated NMU is partly mediated by a decrease in gastric emptying which is subject to tachyphylaxis after continuous dosing.
Title: Neuromedin U inhibits food intake partly by inhibiting gastric emptying.

Beta-adrenergic and cholinergic mechanisms are involved in the anxiolytic action of neuromedin-U.
Title: Anxiolytic action of neuromedin-U and neurotransmitters involved in mice.

Data show that neuromedin U (NMU)-deficient mice developed less severe arthritis than control mice.
Title: The neuropeptide neuromedin U promotes autoantibody-mediated arthritis.

The following Nmu gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nmu cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11183	NM_019515.1 Latest version!	Mus musculus neuromedin U (Nmu), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nmu ( NM_019515.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062388.1 Mus musculus neuromedin U (Nmu), mRNA.

Price & Availability↑

CloneID	OMu11183
Clone ID Related Accession (Same CDS sequence)	NM_019515.1
Accession Version	NM_019515.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 525bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	neuromedin-U precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF203444.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF203444.1, AK077478.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END##

ATGTCGCGAG CAGCGGGTCA CCGTCCAGGG CTGTCCGCAG GACAATTGGC TGCTGCAACC 
GCATCTCCTC TCCTGTCACT GCTGCTGCTG CTCGCCTGCT GTGCAGACGC TTGCAAAGGT 
GTGCCAATAT CACCTCAAAG ATTGCAGCCA GAACAAGAAC TACAATTGTG GAATGAGATT 
CATGAAGCTT GTGCGTCCTT TCTGTCCATT GATTCCAGGC CTCAGGCATC TGTTGCACTG 
AGGGAGCTTT GCCGTATAGT GATGGAGATT TCCCAGAAGC CTCAGGAACA AAGTGAGAAA 
GATAATACTA AGAGGTTCTT ATTTCACTAT TCAAAGACAC AGAAGTTGGG AAATTCAAAT 
GTTGTGTCCT CTGTTGTGCA TCCGTTGCTG CAGCTCGTCC CTCAACTGCA TGAGAGAAGA 
ATGAAGAGAT TCAAAGCAGA ATACCAGAGT CCTTCCGTGG GTCAAAGTAA GGGATACTTT 
TTATTCAGGC CACGCAACGG GAAGAGGTCA ACAAGTTTCA TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062388.1
CDS	106..630
Translation	MSRAAGHRPGLSAGQLAAATASPLLSLLLLLACCADACKGVPISPQRLQPEQELQLWNEIHEACASFLSIDSRPQASVALRELCRIVMEISQKPQEQSEKDNTKRFLFHYSKTQKLGNSNVVSSVVHPLLQLVPQLHERRMKRFKAEYQSPSVGQSKGYFLFRPRNGKRSTSFI

Target ORF information:

RefSeq Version	NM_019515.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus neuromedin U (Nmu), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019515.1

ORF Insert Sequence:

ATGTCGCGAG CAGCGGGTCA CCGTCCAGGG CTGTCCGCAG GACAATTGGC TGCTGCAACC 
GCATCTCCTC TCCTGTCACT GCTGCTGCTG CTCGCCTGCT GTGCAGACGC TTGCAAAGGT 
GTGCCAATAT CACCTCAAAG ATTGCAGCCA GAACAAGAAC TACAATTGTG GAATGAGATT 
CATGAAGCTT GTGCGTCCTT TCTGTCCATT GATTCCAGGC CTCAGGCATC TGTTGCACTG 
AGGGAGCTTT GCCGTATAGT GATGGAGATT TCCCAGAAGC CTCAGGAACA AAGTGAGAAA 
GATAATACTA AGAGGTTCTT ATTTCACTAT TCAAAGACAC AGAAGTTGGG AAATTCAAAT 
GTTGTGTCCT CTGTTGTGCA TCCGTTGCTG CAGCTCGTCC CTCAACTGCA TGAGAGAAGA 
ATGAAGAGAT TCAAAGCAGA ATACCAGAGT CCTTCCGTGG GTCAAAGTAA GGGATACTTT 
TTATTCAGGC CACGCAACGG GAAGAGGTCA ACAAGTTTCA TTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of neuromedin U in accelerating of non-alcoholic steatohepatitis in mice.
Peptides99134-141(2018 01)
Teranishi H,Hayashi M,Higa R,Mori K,Miyazawa T,Hino J,Amano Y,Tozawa R,Ida T,Hanada T,Miyazato M,Hanada R,Kangawa K,Nakao K

Identification of neuromedin U precursor-related peptide and its possible role in the regulation of prolactin release.
Scientific reports7(1)10468(2017 Sep)
Mori K,Ida T,Fudetani M,Mori M,Kaiya H,Hino J,Nakahara K,Murakami N,Miyazato M,Kangawa K

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation.
Nature549(7671)282-286(2017 09)
Klose CSN,Mahlak?iv T,Moeller JB,Rankin LC,Flamar AL,Kabata H,Monticelli LA,Moriyama S,Putzel GG,Rakhilin N,Shen X,Kostenis E,K?nig GM,Senda T,Carpenter D,Farber DL,Artis D

Neuronal regulation of type 2 innate lymphoid cells via neuromedin U.
Nature549(7671)277-281(2017 09)
Cardoso V,Chesn? J,Ribeiro H,Garc?a-Cassani B,Carvalho T,Bouchery T,Shah K,Barbosa-Morais NL,Harris N,Veiga-Fernandes H

Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway.
Nature medicine10(10)1067-73(2004 Oct)
Hanada R,Teranishi H,Pearson JT,Kurokawa M,Hosoda H,Fukushima N,Fukue Y,Serino R,Fujihara H,Ueta Y,Ikawa M,Okabe M,Murakami N,Shirai M,Yoshimatsu H,Kangawa K,Kojima M

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Nmu cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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