Ppp4c cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Ppp4c
Entrez Gene ID	56420
Full Name	protein phosphatase 4, catalytic subunit
Synonyms	1110002D08Rik,AU016079,Ppx
General protein information	Preferred Names protein phosphatase 4, catalytic subunit Names serine/threonine-protein phosphatase 4 catalytic subunit PP-X PP4C pp4 protein phosphatase X
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 F3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001360464.1	NP_001347393.1	serine/threonine-protein phosphatase 4 catalytic subunit
NM_019674.3	NP_062648.1	serine/threonine-protein phosphatase 4 catalytic subunit
XM_006508049.1	XP_006508112.1	serine/threonine-protein phosphatase 4 catalytic subunit isoform X1
XM_006508049.2	XP_006508112.1	serine/threonine-protein phosphatase 4 catalytic subunit isoform X1
NM_019674.4	NP_062648.1	serine/threonine-protein phosphatase 4 catalytic subunit

Pathways from BioSystems

Homologies

	PPP4C	XP_001108500.1
Canis lupus familiaris (dog)	PPP4C	XP_547067.1
Rattus norvegicus (Norway rat)	Ppp4c	NP_599186.1
Danio rerio (zebrafish)	ppp4cb	NP_001104638.1
Kluyveromyces lactis	KLLA0E10055g	XP_454403.1
Drosophila melanogaster (fruit fly)	Pp4-19C	NP_524803.1
Neurospora crassa	NCU08301	XP_962514.2
Arabidopsis thaliana (thale cress)	PPX1	NP_194402.1
Oryza sativa (rice)	Os09g0284200	NP_001062774.1
Pan troglodytes (chimpanzee)	PPP4C	XP_001148577.1
Eremothecium gossypii	AGOS_AGR136W	NP_986802.2
Schizosaccharomyces pombe (fission yeast)	SPBC26H8.05c	NP_596646.1
Xenopus tropicalis (tropical clawed frog)	ppp4c	NP_988943.1
Bos taurus (cattle)	PPP4C	NP_001092578.1
Mus musculus (house mouse)	Ppp4c	NP_062648.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003779	XP_310323.5
Caenorhabditis elegans (roundworm)	pph-4.1	NP_499603.1
Homo sapiens (human)	PPP4C	NP_002711.1
Saccharomyces cerevisiae (baker's yeast)	PPH3	NP_010360.1
Magnaporthe oryzae (rice blast fungus)	MGG_01528	XP_003714501.1
Arabidopsis thaliana (thale cress)	PPX2	NP_200337.1

Gene Ontology
Bibliography

Related articles in PubMed

Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes.
Hwang J, Lee JA, Pallas DC
The Journal of biological chemistry291(40)21008-21019(2016 Sep)

T cell proliferation and adaptive immune responses are critically regulated by protein phosphatase 4.
Liao FH, Hsiao WY, Lin YC, Chan YC, Huang CY
Cell cycle (Georgetown, Tex.)15(8)1073-83(2016)

Protein phosphatase 4 (PP4) functions as a critical regulator in tumor necrosis factor (TNF)-?-induced hepatic insulin resistance.
Zhao H, Huang X, Jiao J, Zhang H, Liu J, Qin W, Meng X, Shen T, Lin Y, Chu J, Li J
Scientific reports518093(2015 Dec)

Phosphatase PP4 Negatively Regulates Type I IFN Production and Antiviral Innate Immunity by Dephosphorylating and Deactivating TBK1.
Zhan Z, Cao H, Xie X, Yang L, Zhang P, Chen Y, Fan H, Liu Z, Liu X
Journal of immunology (Baltimore, Md. : 1950)195(8)3849-57(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LCMT-1 homozygous knock-out MEFs exhibited hyperphosphorylation of HDAC3, a reported target of the methylation-dependent PP4R1-PP4c complex. Collectively, our data suggest that LCMT-1 coordinately regulates the carboxyl methylation of PP2A-related phosphatases and, consequently, their holoenzyme assembly and function.
Title: Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes.

T cell-specific ablation of PP4 resulted in defective adaptive immunity, impaired T cell homeostatic expansion, and inefficient T cell proliferation.
Title: T cell proliferation and adaptive immune responses are critically regulated by protein phosphatase 4.

Data show that protein phosphatase 4 (PP4) is an important regulator in inflammatory related insulin resistance.
Title: Protein phosphatase 4 (PP4) functions as a critical regulator in tumor necrosis factor (TNF)-?-induced hepatic insulin resistance.

Thus, serine/threonine phosphatase PP4 functions as a novel feedback negative regulator of RNA virus-triggered innate immunity.
Title: Phosphatase PP4 Negatively Regulates Type I IFN Production and Antiviral Innate Immunity by Dephosphorylating and Deactivating TBK1.

Taken together, our results establish a novel role for PP4 in CSR, and reveal crucial functions for PP4 in the maintenance of genomic stability, GC formation, and B cell-mediated immune responses.
Title: PP4 is essential for germinal center formation and class switch recombination in mice.

The following Ppp4c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppp4c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu13508	NM_019674.4 Latest version!	Mus musculus protein phosphatase 4, catalytic subunit (Ppp4c), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu13508	NM_001360464.1 Latest version!	Mus musculus protein phosphatase 4, catalytic subunit (Ppp4c), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu39787	XM_006508049.2 Latest version!	Mus musculus protein phosphatase 4, catalytic subunit (Ppp4c), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu39787	XM_006508049.1	Mus musculus protein phosphatase 4, catalytic subunit (Ppp4c), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu13508	NM_019674.3	Mus musculus protein phosphatase 4, catalytic subunit (Ppp4c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ppp4c ( NM_001360464.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001347393.1 Mus musculus protein phosphatase 4, catalytic subunit (Ppp4c), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu13508
Clone ID Related Accession (Same CDS sequence)	NM_001360464.1 , NM_019674.3 , NM_019674.4
Accession Version	NM_001360464.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Mus musculus(house mouse)
Product	serine/threonine-protein phosphatase 4 catalytic subunit
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC124505.4. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK144244.1, BI411046.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAGA TCAGCGACCT GGACCGGCAG ATCGAGCAGC TACGGCGCTG CGAGCTGATC 
AAAGAGAGCG AAGTCAAGGC CCTGTGCGCC AAGGCCAGAG AAATCTTGGT AGAAGAGAGC 
AACGTGCAGA GGGTGGACTC GCCAGTCACA GTATGCGGTG ACATCCATGG ACAATTCTAT 
GACCTCAAGG AGCTGTTCAG AGTAGGTGGC GATGTCCCTG AGACCAACTA CCTCTTCATG 
GGAGACTTTG TGGACCGTGG TTTCTACAGT GTTGAAACCT TCCTCCTCCT GCTGGCTCTT 
AAGGTTCGCT ATCCTGACAG AATCACTTTG ATCCGGGGCA ATCATGAGAG TCGCCAGATT 
ACCCAGGTCT ATGGGTTCTA TGATGAGTGC TTACGGAAAT ATGGTTCAGT GACTGTATGG 
CGCTACTGTA CTGAGATCTT TGACTACCTC AGCCTGTCTG CCATCATTGA TGGCAAGATC 
TTCTGTGTGC ATGGAGGTCT TTCCCCTTCC ATCCAGACCT TGGACCAGAT CCGGACAATT 
GACCGAAAGC AAGAGGTACC CCATGATGGA CCCATGTGCG ACCTCCTGTG GTCTGACCCT 
GAAGACACAA CAGGCTGGGG AGTGAGCCCC CGCGGGGCAG GTTACCTGTT TGGCAGTGAC 
GTGGTCGCCC AGTTCAATGC AGCCAACGAC ATTGATATGA TCTGCCGTGC CCACCAATTA 
GTGATGGAAG GCTACAAGTG GCACTTCAAT GAGACCGTGC TTACTGTGTG GTCAGCGCCT 
AATTACTGCT ACCGCTGTGG CAATGTGGCA GCCATCTTAG AACTGGATGA GCACCTCCAG 
AAAGATTTCA TCATCTTCGA GGCTGCACCC CAAGAGACAC GTGGCATCCC CTCCAAAAAG 
CCAGTGGCCG ACTATTTCCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001347393.1
CDS	207..1130
Translation	MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKKPVADYFL

Target ORF information:

RefSeq Version	NM_001360464.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus protein phosphatase 4, catalytic subunit (Ppp4c), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001360464.1

ORF Insert Sequence:

ATGGCGGAGA TCAGCGACCT GGACCGGCAG ATCGAGCAGC TACGGCGCTG CGAGCTGATC 
AAAGAGAGCG AAGTCAAGGC CCTGTGCGCC AAGGCCAGAG AAATCTTGGT AGAAGAGAGC 
AACGTGCAGA GGGTGGACTC GCCAGTCACA GTATGCGGTG ACATCCATGG ACAATTCTAT 
GACCTCAAGG AGCTGTTCAG AGTAGGTGGC GATGTCCCTG AGACCAACTA CCTCTTCATG 
GGAGACTTTG TGGACCGTGG TTTCTACAGT GTTGAAACCT TCCTCCTCCT GCTGGCTCTT 
AAGGTTCGCT ATCCTGACAG AATCACTTTG ATCCGGGGCA ATCATGAGAG TCGCCAGATT 
ACCCAGGTCT ATGGGTTCTA TGATGAGTGC TTACGGAAAT ATGGTTCAGT GACTGTATGG 
CGCTACTGTA CTGAGATCTT TGACTACCTC AGCCTGTCTG CCATCATTGA TGGCAAGATC 
TTCTGTGTGC ATGGAGGTCT TTCCCCTTCC ATCCAGACCT TGGACCAGAT CCGGACAATT 
GACCGAAAGC AAGAGGTACC CCATGATGGA CCCATGTGCG ACCTCCTGTG GTCTGACCCT 
GAAGACACAA CAGGCTGGGG AGTGAGCCCC CGCGGGGCAG GTTACCTGTT TGGCAGTGAC 
GTGGTCGCCC AGTTCAATGC AGCCAACGAC ATTGATATGA TCTGCCGTGC CCACCAATTA 
GTGATGGAAG GCTACAAGTG GCACTTCAAT GAGACCGTGC TTACTGTGTG GTCAGCGCCT 
AATTACTGCT ACCGCTGTGG CAATGTGGCA GCCATCTTAG AACTGGATGA GCACCTCCAG 
AAAGATTTCA TCATCTTCGA GGCTGCACCC CAAGAGACAC GTGGCATCCC CTCCAAAAAG 
CCAGTGGCCG ACTATTTCCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ppp4c ( NM_019674.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062648.1 Mus musculus protein phosphatase 4, catalytic subunit (Ppp4c), mRNA.

Price & Availability↑

CloneID	OMu13508
Clone ID Related Accession (Same CDS sequence)	NM_001360464.1 , NM_019674.3 , NM_019674.4
Accession Version	NM_019674.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Mus musculus(house mouse)
Product	serine/threonine-protein phosphatase 4 catalytic subunit
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC124505.4. On Nov 17, 2006 this sequence version replaced NM_019674.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001993.1, AF088911.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGAGA TCAGCGACCT GGACCGGCAG ATCGAGCAGC TACGGCGCTG CGAGCTGATC 
AAAGAGAGCG AAGTCAAGGC CCTGTGCGCC AAGGCCAGAG AAATCTTGGT AGAAGAGAGC 
AACGTGCAGA GGGTGGACTC GCCAGTCACA GTATGCGGTG ACATCCATGG ACAATTCTAT 
GACCTCAAGG AGCTGTTCAG AGTAGGTGGC GATGTCCCTG AGACCAACTA CCTCTTCATG 
GGAGACTTTG TGGACCGTGG TTTCTACAGT GTTGAAACCT TCCTCCTCCT GCTGGCTCTT 
AAGGTTCGCT ATCCTGACAG AATCACTTTG ATCCGGGGCA ATCATGAGAG TCGCCAGATT 
ACCCAGGTCT ATGGGTTCTA TGATGAGTGC TTACGGAAAT ATGGTTCAGT GACTGTATGG 
CGCTACTGTA CTGAGATCTT TGACTACCTC AGCCTGTCTG CCATCATTGA TGGCAAGATC 
TTCTGTGTGC ATGGAGGTCT TTCCCCTTCC ATCCAGACCT TGGACCAGAT CCGGACAATT 
GACCGAAAGC AAGAGGTACC CCATGATGGA CCCATGTGCG ACCTCCTGTG GTCTGACCCT 
GAAGACACAA CAGGCTGGGG AGTGAGCCCC CGCGGGGCAG GTTACCTGTT TGGCAGTGAC 
GTGGTCGCCC AGTTCAATGC AGCCAACGAC ATTGATATGA TCTGCCGTGC CCACCAATTA 
GTGATGGAAG GCTACAAGTG GCACTTCAAT GAGACCGTGC TTACTGTGTG GTCAGCGCCT 
AATTACTGCT ACCGCTGTGG CAATGTGGCA GCCATCTTAG AACTGGATGA GCACCTCCAG 
AAAGATTTCA TCATCTTCGA GGCTGCACCC CAAGAGACAC GTGGCATCCC CTCCAAAAAG 
CCAGTGGCCG ACTATTTCCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062648.1
CDS	115..1038
Translation	MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKKPVADYFL

Target ORF information:

RefSeq Version	NM_019674.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus protein phosphatase 4, catalytic subunit (Ppp4c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019674.3

ORF Insert Sequence:

ATGGCGGAGA TCAGCGACCT GGACCGGCAG ATCGAGCAGC TACGGCGCTG CGAGCTGATC 
AAAGAGAGCG AAGTCAAGGC CCTGTGCGCC AAGGCCAGAG AAATCTTGGT AGAAGAGAGC 
AACGTGCAGA GGGTGGACTC GCCAGTCACA GTATGCGGTG ACATCCATGG ACAATTCTAT 
GACCTCAAGG AGCTGTTCAG AGTAGGTGGC GATGTCCCTG AGACCAACTA CCTCTTCATG 
GGAGACTTTG TGGACCGTGG TTTCTACAGT GTTGAAACCT TCCTCCTCCT GCTGGCTCTT 
AAGGTTCGCT ATCCTGACAG AATCACTTTG ATCCGGGGCA ATCATGAGAG TCGCCAGATT 
ACCCAGGTCT ATGGGTTCTA TGATGAGTGC TTACGGAAAT ATGGTTCAGT GACTGTATGG 
CGCTACTGTA CTGAGATCTT TGACTACCTC AGCCTGTCTG CCATCATTGA TGGCAAGATC 
TTCTGTGTGC ATGGAGGTCT TTCCCCTTCC ATCCAGACCT TGGACCAGAT CCGGACAATT 
GACCGAAAGC AAGAGGTACC CCATGATGGA CCCATGTGCG ACCTCCTGTG GTCTGACCCT 
GAAGACACAA CAGGCTGGGG AGTGAGCCCC CGCGGGGCAG GTTACCTGTT TGGCAGTGAC 
GTGGTCGCCC AGTTCAATGC AGCCAACGAC ATTGATATGA TCTGCCGTGC CCACCAATTA 
GTGATGGAAG GCTACAAGTG GCACTTCAAT GAGACCGTGC TTACTGTGTG GTCAGCGCCT 
AATTACTGCT ACCGCTGTGG CAATGTGGCA GCCATCTTAG AACTGGATGA GCACCTCCAG 
AAAGATTTCA TCATCTTCGA GGCTGCACCC CAAGAGACAC GTGGCATCCC CTCCAAAAAG 
CCAGTGGCCG ACTATTTCCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ppp4c ( NM_019674.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062648.1 Mus musculus protein phosphatase 4, catalytic subunit (Ppp4c), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu13508
Clone ID Related Accession (Same CDS sequence)	NM_001360464.1 , NM_019674.3 , NM_019674.4
Accession Version	NM_019674.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Mus musculus(house mouse)
Product	serine/threonine-protein phosphatase 4 catalytic subunit
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC124505.4. On Feb 3, 2018 this sequence version replaced NM_019674.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001993.1, AF088911.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAGA TCAGCGACCT GGACCGGCAG ATCGAGCAGC TACGGCGCTG CGAGCTGATC 
AAAGAGAGCG AAGTCAAGGC CCTGTGCGCC AAGGCCAGAG AAATCTTGGT AGAAGAGAGC 
AACGTGCAGA GGGTGGACTC GCCAGTCACA GTATGCGGTG ACATCCATGG ACAATTCTAT 
GACCTCAAGG AGCTGTTCAG AGTAGGTGGC GATGTCCCTG AGACCAACTA CCTCTTCATG 
GGAGACTTTG TGGACCGTGG TTTCTACAGT GTTGAAACCT TCCTCCTCCT GCTGGCTCTT 
AAGGTTCGCT ATCCTGACAG AATCACTTTG ATCCGGGGCA ATCATGAGAG TCGCCAGATT 
ACCCAGGTCT ATGGGTTCTA TGATGAGTGC TTACGGAAAT ATGGTTCAGT GACTGTATGG 
CGCTACTGTA CTGAGATCTT TGACTACCTC AGCCTGTCTG CCATCATTGA TGGCAAGATC 
TTCTGTGTGC ATGGAGGTCT TTCCCCTTCC ATCCAGACCT TGGACCAGAT CCGGACAATT 
GACCGAAAGC AAGAGGTACC CCATGATGGA CCCATGTGCG ACCTCCTGTG GTCTGACCCT 
GAAGACACAA CAGGCTGGGG AGTGAGCCCC CGCGGGGCAG GTTACCTGTT TGGCAGTGAC 
GTGGTCGCCC AGTTCAATGC AGCCAACGAC ATTGATATGA TCTGCCGTGC CCACCAATTA 
GTGATGGAAG GCTACAAGTG GCACTTCAAT GAGACCGTGC TTACTGTGTG GTCAGCGCCT 
AATTACTGCT ACCGCTGTGG CAATGTGGCA GCCATCTTAG AACTGGATGA GCACCTCCAG 
AAAGATTTCA TCATCTTCGA GGCTGCACCC CAAGAGACAC GTGGCATCCC CTCCAAAAAG 
CCAGTGGCCG ACTATTTCCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062648.1
CDS	191..1114
Translation	MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKKPVADYFL

Target ORF information:

RefSeq Version	NM_019674.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus protein phosphatase 4, catalytic subunit (Ppp4c), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019674.4

ORF Insert Sequence:

ATGGCGGAGA TCAGCGACCT GGACCGGCAG ATCGAGCAGC TACGGCGCTG CGAGCTGATC 
AAAGAGAGCG AAGTCAAGGC CCTGTGCGCC AAGGCCAGAG AAATCTTGGT AGAAGAGAGC 
AACGTGCAGA GGGTGGACTC GCCAGTCACA GTATGCGGTG ACATCCATGG ACAATTCTAT 
GACCTCAAGG AGCTGTTCAG AGTAGGTGGC GATGTCCCTG AGACCAACTA CCTCTTCATG 
GGAGACTTTG TGGACCGTGG TTTCTACAGT GTTGAAACCT TCCTCCTCCT GCTGGCTCTT 
AAGGTTCGCT ATCCTGACAG AATCACTTTG ATCCGGGGCA ATCATGAGAG TCGCCAGATT 
ACCCAGGTCT ATGGGTTCTA TGATGAGTGC TTACGGAAAT ATGGTTCAGT GACTGTATGG 
CGCTACTGTA CTGAGATCTT TGACTACCTC AGCCTGTCTG CCATCATTGA TGGCAAGATC 
TTCTGTGTGC ATGGAGGTCT TTCCCCTTCC ATCCAGACCT TGGACCAGAT CCGGACAATT 
GACCGAAAGC AAGAGGTACC CCATGATGGA CCCATGTGCG ACCTCCTGTG GTCTGACCCT 
GAAGACACAA CAGGCTGGGG AGTGAGCCCC CGCGGGGCAG GTTACCTGTT TGGCAGTGAC 
GTGGTCGCCC AGTTCAATGC AGCCAACGAC ATTGATATGA TCTGCCGTGC CCACCAATTA 
GTGATGGAAG GCTACAAGTG GCACTTCAAT GAGACCGTGC TTACTGTGTG GTCAGCGCCT 
AATTACTGCT ACCGCTGTGG CAATGTGGCA GCCATCTTAG AACTGGATGA GCACCTCCAG 
AAAGATTTCA TCATCTTCGA GGCTGCACCC CAAGAGACAC GTGGCATCCC CTCCAAAAAG 
CCAGTGGCCG ACTATTTCCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ppp4c ( XM_006508049.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006508112.1 Mus musculus protein phosphatase 4, catalytic subunit (Ppp4c), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu39787
Clone ID Related Accession (Same CDS sequence)	XM_006508049.1 , XM_006508049.2
Accession Version	XM_006508049.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	serine/threonine-protein phosphatase 4 catalytic subunit isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAGACT TTGTGGACCG TGGTTTCTAC AGTGTTGAAA CCTTCCTCCT CCTGCTGGCT 
CTTAAGGTTC GCTATCCTGA CAGAATCACT TTGATCCGGG GCAATCATGA GAGTCGCCAG 
ATTACCCAGG TCTATGGGTT CTATGATGAG TGCTTACGGA AATATGGTTC AGTGACTGTA 
TGGCGCTACT GTACTGAGAT CTTTGACTAC CTCAGCCTGT CTGCCATCAT TGATGGCAAG 
ATCTTCTGTG TGCATGGAGG TCTTTCCCCT TCCATCCAGA CCTTGGACCA GATCCGGACA 
ATTGACCGAA AGCAAGAGGT ACCCCATGAT GGACCCATGT GCGACCTCCT GTGGTCTGAC 
CCTGAAGACA CAACAGGCTG GGGAGTGAGC CCCCGCGGGG CAGGTTACCT GTTTGGCAGT 
GACGTGGTCG CCCAGTTCAA TGCAGCCAAC GACATTGATA TGATCTGCCG TGCCCACCAA 
TTAGTGATGG AAGGCTACAA GTGGCACTTC AATGAGACCG TGCTTACTGT GTGGTCAGCG 
CCTAATTACT GCTACCGCTG TGGCAATGTG GCAGCCATCT TAGAACTGGA TGAGCACCTC 
CAGAAAGATT TCATCATCTT CGAGGCTGCA CCCCAAGAGA CACGTGGCAT CCCCTCCAAA 
AAGCCAGTGG CCGACTATTT CCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006508112.1
CDS	286..972
Translation	MGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKKPVADYFL

Target ORF information:

RefSeq Version	XM_006508049.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus protein phosphatase 4, catalytic subunit (Ppp4c), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006508049.1

ORF Insert Sequence:

ATGGGAGACT TTGTGGACCG TGGTTTCTAC AGTGTTGAAA CCTTCCTCCT CCTGCTGGCT 
CTTAAGGTTC GCTATCCTGA CAGAATCACT TTGATCCGGG GCAATCATGA GAGTCGCCAG 
ATTACCCAGG TCTATGGGTT CTATGATGAG TGCTTACGGA AATATGGTTC AGTGACTGTA 
TGGCGCTACT GTACTGAGAT CTTTGACTAC CTCAGCCTGT CTGCCATCAT TGATGGCAAG 
ATCTTCTGTG TGCATGGAGG TCTTTCCCCT TCCATCCAGA CCTTGGACCA GATCCGGACA 
ATTGACCGAA AGCAAGAGGT ACCCCATGAT GGACCCATGT GCGACCTCCT GTGGTCTGAC 
CCTGAAGACA CAACAGGCTG GGGAGTGAGC CCCCGCGGGG CAGGTTACCT GTTTGGCAGT 
GACGTGGTCG CCCAGTTCAA TGCAGCCAAC GACATTGATA TGATCTGCCG TGCCCACCAA 
TTAGTGATGG AAGGCTACAA GTGGCACTTC AATGAGACCG TGCTTACTGT GTGGTCAGCG 
CCTAATTACT GCTACCGCTG TGGCAATGTG GCAGCCATCT TAGAACTGGA TGAGCACCTC 
CAGAAAGATT TCATCATCTT CGAGGCTGCA CCCCAAGAGA CACGTGGCAT CCCCTCCAAA 
AAGCCAGTGG CCGACTATTT CCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ppp4c ( XM_006508049.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006508112.1 Mus musculus protein phosphatase 4, catalytic subunit (Ppp4c), transcript variant X1, mRNA.

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CloneID	OMu39787
Clone ID Related Accession (Same CDS sequence)	XM_006508049.1 , XM_006508049.2
Accession Version	XM_006508049.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 687bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	serine/threonine-protein phosphatase 4 catalytic subunit isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006508049.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAGACT TTGTGGACCG TGGTTTCTAC AGTGTTGAAA CCTTCCTCCT CCTGCTGGCT 
CTTAAGGTTC GCTATCCTGA CAGAATCACT TTGATCCGGG GCAATCATGA GAGTCGCCAG 
ATTACCCAGG TCTATGGGTT CTATGATGAG TGCTTACGGA AATATGGTTC AGTGACTGTA 
TGGCGCTACT GTACTGAGAT CTTTGACTAC CTCAGCCTGT CTGCCATCAT TGATGGCAAG 
ATCTTCTGTG TGCATGGAGG TCTTTCCCCT TCCATCCAGA CCTTGGACCA GATCCGGACA 
ATTGACCGAA AGCAAGAGGT ACCCCATGAT GGACCCATGT GCGACCTCCT GTGGTCTGAC 
CCTGAAGACA CAACAGGCTG GGGAGTGAGC CCCCGCGGGG CAGGTTACCT GTTTGGCAGT 
GACGTGGTCG CCCAGTTCAA TGCAGCCAAC GACATTGATA TGATCTGCCG TGCCCACCAA 
TTAGTGATGG AAGGCTACAA GTGGCACTTC AATGAGACCG TGCTTACTGT GTGGTCAGCG 
CCTAATTACT GCTACCGCTG TGGCAATGTG GCAGCCATCT TAGAACTGGA TGAGCACCTC 
CAGAAAGATT TCATCATCTT CGAGGCTGCA CCCCAAGAGA CACGTGGCAT CCCCTCCAAA 
AAGCCAGTGG CCGACTATTT CCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006508112.1
CDS	497..1183
Translation	MGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKKPVADYFL

Target ORF information:

RefSeq Version	XM_006508049.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus protein phosphatase 4, catalytic subunit (Ppp4c), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006508049.2

ORF Insert Sequence:

ATGGGAGACT TTGTGGACCG TGGTTTCTAC AGTGTTGAAA CCTTCCTCCT CCTGCTGGCT 
CTTAAGGTTC GCTATCCTGA CAGAATCACT TTGATCCGGG GCAATCATGA GAGTCGCCAG 
ATTACCCAGG TCTATGGGTT CTATGATGAG TGCTTACGGA AATATGGTTC AGTGACTGTA 
TGGCGCTACT GTACTGAGAT CTTTGACTAC CTCAGCCTGT CTGCCATCAT TGATGGCAAG 
ATCTTCTGTG TGCATGGAGG TCTTTCCCCT TCCATCCAGA CCTTGGACCA GATCCGGACA 
ATTGACCGAA AGCAAGAGGT ACCCCATGAT GGACCCATGT GCGACCTCCT GTGGTCTGAC 
CCTGAAGACA CAACAGGCTG GGGAGTGAGC CCCCGCGGGG CAGGTTACCT GTTTGGCAGT 
GACGTGGTCG CCCAGTTCAA TGCAGCCAAC GACATTGATA TGATCTGCCG TGCCCACCAA 
TTAGTGATGG AAGGCTACAA GTGGCACTTC AATGAGACCG TGCTTACTGT GTGGTCAGCG 
CCTAATTACT GCTACCGCTG TGGCAATGTG GCAGCCATCT TAGAACTGGA TGAGCACCTC 
CAGAAAGATT TCATCATCTT CGAGGCTGCA CCCCAAGAGA CACGTGGCAT CCCCTCCAAA 
AAGCCAGTGG CCGACTATTT CCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes.
The Journal of biological chemistry291(40)21008-21019(2016 Sep)
Hwang J,Lee JA,Pallas DC

T cell proliferation and adaptive immune responses are critically regulated by protein phosphatase 4.
Cell cycle (Georgetown, Tex.)15(8)1073-83(2016)
Liao FH,Hsiao WY,Lin YC,Chan YC,Huang CY

Protein phosphatase 4 (PP4) functions as a critical regulator in tumor necrosis factor (TNF)-?-induced hepatic insulin resistance.
Scientific reports518093(2015 Dec)
Zhao H,Huang X,Jiao J,Zhang H,Liu J,Qin W,Meng X,Shen T,Lin Y,Chu J,Li J

Phosphatase PP4 Negatively Regulates Type I IFN Production and Antiviral Innate Immunity by Dephosphorylating and Deactivating TBK1.
Journal of immunology (Baltimore, Md. : 1950)195(8)3849-57(2015 Oct)
Zhan Z,Cao H,Xie X,Yang L,Zhang P,Chen Y,Fan H,Liu Z,Liu X

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Ppp4c cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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