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GSK3B cDNA ORF clone, Mus musculus(House mouse)

Gene Symbol GSK3B
Entrez Gene ID 56637
Full Name glycogen synthase kinase 3 beta
Synonyms 7330414F15Rik,8430431H08Rik,C86142,GSK-3,GSK-3beta,GSK3
General protein information
Preferred Names

glycogen synthase kinase 3 beta

Names

glycogen synthase kinase-3 beta
GSK-3 beta
serine/threonine-protein kinase GSK3B

Gene Type protein-coding
Organism Mus musculus(House mouse)
Genome

16

16|16 B3


mRNA and Protein(s)

mRNA Protein Name
NM_019827.6 NP_062801.1 glycogen synthase kinase-3 beta isoform 1
XM_006522426.3 XP_006522489.1 glycogen synthase kinase-3 beta isoform X2
NM_001347232.1 NP_001334161.1 glycogen synthase kinase-3 beta isoform 2



Bos taurus (cattle) GSK3B NP_001094780.1
Mus musculus (house mouse) Gsk3b NP_062801.1
Rattus norvegicus (Norway rat) Gsk3b NP_114469.1
Caenorhabditis elegans (roundworm) gsk-3 NP_493243.1
Xenopus tropicalis (tropical clawed frog) gsk3b XP_002941025.2
Pan troglodytes (chimpanzee) GSK3B XP_003339094.1
Canis lupus familiaris (dog) GSK3B XP_535751.2
Danio rerio (zebrafish) gsk3b NP_571456.1
Homo sapiens (human) GSK3B NP_002084.2
Arabidopsis thaliana (thale cress) SK13 NP_196968.2
Gallus gallus (chicken) GSK3B XP_416557.4
Oryza sativa (rice) Os05g0134000 NP_001054564.1


Related articles in PubMed

Glycogen synthase kinase 3 regulates photic signaling in the suprachiasmatic nucleus.
Paul JR, McKeown AS, Davis JA, Totsch SK, Mintz EM, Kraft TW, Cowell RM, Gamble KL
The European journal of neuroscience45(8)1102-1110(2017 Apr)

Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model.
Zhang ZH, Wu QY, Zheng R, Chen C, Chen Y, Liu Q, Hoffmann PR, Ni JZ, Song GL
The Journal of neuroscience : the official journal of the Society for Neuroscience37(9)2449-2462(2017 Mar)

Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway.
Shen C, Zhou J, Wang X, Yu XY, Liang C, Liu B, Pan X, Zhao Q, Song JL, Wang J, Bao M, Wu C, Li Y, Song YH
EBioMedicine16238-250(2017 Feb)

Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.
Liu TY, Chen YC, Jong YJ, Tsai HJ, Lee CC, Chang YS, Chang JG, Chang YF
Open biology7(1)(2017 Jan)

Valproic Acid Protects Primary Dopamine Neurons from MPP
Zhang C, Yuan X, Hu Z, Liu S, Li H, Wu M, Yuan J, Zhao Z, Su J, Wang X, Liao Y, Liu Q
BioMed research international20178124501(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

changes in GSK-3beta activity and/or levels regulate the production and subsequent secretion of fractalkine, a chemokine involved in the immune response that has been linked to AD and to other different neurological disorders.
Title: Glycogen synthase kinase-3β regulates fractalkine production by altering its trafficking from Golgi to plasma membrane: implications for Alzheimer's disease.

Data show that glycogen synthase kinase 3 beta (GSK3beta) inhibitor thiadiazolidinone-8 blocks angiotensin II (ang II) induced muscle atrophy, which paves the way for targeted therapy to treat muscle wasting.
Title: Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway.

These findings indicated that VPA's neuroprotective effect in the MPP(+)-model of Parkinson's disease is associated with GSK3beta phosphorylation via Akt and ERK activation in the mitochondrial intrinsic apoptotic pathway.
Title: Valproic Acid Protects Primary Dopamine Neurons from MPP

Hepatocyte growth factor prevents high glucose-induced podocyte injury via an autophagy-promoting mechanism, which involves GSK3beta inhibition.
Title: HGF alleviates high glucose-induced injury in podocytes by GSK3β inhibition and autophagy restoration.

GSK3b may up-regulate BK channels, an effect disrupted by lithium or additional expression of AKT and possibly participating in the regulation of cell volume and excitability.
Title: Up-Regulation of the Large-Conductance Ca2+-Activated K+ Channel by Glycogen Synthase Kinase GSK3β.

The following GSK3B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GSK3B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OMu23112 NM_019827.6
Latest version!
Mus musculus glycogen synthase kinase 3 beta (Gsk3b), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
OMu52312 NM_001347232.1
Latest version!
Mus musculus glycogen synthase kinase 3 beta (Gsk3b), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
OMu52313 XM_006522426.3
Latest version!
Mus musculus glycogen synthase kinase 3 beta (Gsk3b), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
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All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OMu23112
Clone ID Related Accession (Same CDS sequence) NM_019827.6
Accession Version NM_019827.6 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1263bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Mus musculus(House mouse)
Product glycogen synthase kinase-3 beta isoform 1
Comment PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC120020.9 and AC154284.1. On Oct 19, 2007 this sequence version replaced NM_019827.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB066114.1, AK154293.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGTCGGGGC GACCGAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT 
TCAGCTTTTG GTAGCATGAA AGTTAGCAGA GATAAAGATG GCAGCAAGGT AACCACAGTA
GTGGCAACTC CTGGCCAGGG TCCTGACAGG CCACAGGAAG TCAGTTATAC AGACACGAAA
GTGATTGGAA ATGGATCATT TGGTGTGGTA TATCAAGCCA AACTTTGTGA TTCTGGAGAA
CTGGTTGCCA TCAAGAAAGT TCTACAGGAC AAGCGATTTA AGAACCGAGA GCTCCAGATC
ATGAGAAAGC TAGACCACTG TAACATAGTC CGACTGCGGT ATTTCTTCTA CTCGAGTGGT
GAGAAGAAAG ATGAGGTCTA CCTTAACCTG GTGCTGGACT ATGTTCCGGA GACAGTGTAC
AGAGTCGCCA GACACTATAG TCGAGCCAAG CAGACACTCC CTGTGATCTA TGTCAAGTTG
TATATGTATC AGCTGTTCAG AAGTCTAGCC TATATCCATT CCTTTGGAAT CTGCCATCGA
GACATTAAAC CACAGAACCT CTTGTTGGAT CCTGATACAG CTGTATTAAA ACTCTGTGAC
TTTGGAAGTG CAAAGCAGCT GGTCCGAGGA GAGCCCAATG TTTCATATAT CTGTTCTCGG
TACTACAGGG CACCAGAGTT GATCTTTGGA GCCACTGATT ACACGTCCAG TATAGATGTA
TGGTCTGCAG GCTGTGTGTT GGCTGAATTG TTGCTAGGAC AACCAATATT TCCTGGGGAC
AGTGGTGTGG ATCAGTTGGT GGAAATAATA AAGGTCCTAG GAACACCAAC AAGGGAGCAA
ATTAGAGAAA TGAACCCAAA TTATACAGAA TTCAAATTCC CTCAAATCAA GGCACATCCT
TGGACAAAGG TCTTCCGGCC CCGAACTCCA CCAGAGGCAA TTGCACTGTG CAGCCGTCTG
CTGGAGTACA CACCTACCGC CCGGCTAACA CCACTGGAAG CTTGTGCACA TTCATTTTTC
GATGAATTGC GGGACCCAAA TGTCAAACTA CCAAATGGGC GAGACACACC TGCACTCTTC
AACTTTACCA CTCAAGAACT GTCAAGTAAC CCCCCTCTGG CCACCATCCT TATCCCTCCA
CATGCTCGGA TTCAGGCCGC TGCTTCACCG CCTGCCAACG CCACAGCAGC CTCAGATACT
AATGCTGGAG ACCGTGGACA GACCAATAAC GCCGCTTCTG CATCAGCTTC CAACTCCACC
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_062801.1
CDS1526..2788
Misc Feature(1)1469..1471
Misc Feature(2)1550..1552
Misc Feature(3)1676..2554
Misc Feature(4)1691..2545
Misc Feature(5)order(1709..1723,1733..1735,1772..1774,1778..1780,1811..1813,1853..1855,1919..1930,1937..1939,1943..1948,2066..2068,2072..2074,2078..2083,2087..2089,2123..2125,2132..2134,2165..2167,2171..2182,2186..2188,2300..2302)
Misc Feature(6)order(1709..1720,1733..1735,1772..1774,1778..1780,1853..1855,1919..1930,1937..1939,2072..2074,2078..2083,2087..2089,2123..2125)
Misc Feature(7)order(1721..1726,2159..2185,2207..2212,2303..2317,2321..2326,2336..2338,2396..2407)
Misc Feature(8)order(1811..1813,1943..1945,2066..2068,2072..2074,2132..2134,2165..2167,2171..2182,2186..2188,2300..2302)
Misc Feature(9)order(2120..2152,2156..2188)
Misc Feature(10)2171..2173
Misc Feature(11)order(2207..2209,2312..2317,2321..2326,2333..2338,2396..2413)
Misc Feature(12)2690..2692
Exon (1)1..1613
Exon (2)1614..1807
Exon (3)1808..1891
Exon (4)1892..2002
Exon (5)2003..2133
Exon (6)2134..2240
Exon (7)2241..2338
Exon (8)2339..2434
Exon (9)2435..2621
Exon (10)2622..2720
Exon (11)2721..8298
Translation

Target ORF information:

RefSeq Version NM_019827.6
Organism Mus musculus(House mouse)
Definition Mus musculus glycogen synthase kinase 3 beta (Gsk3b), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_019827.6

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGTCGGGGC GACCGAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT 
TCAGCTTTTG GTAGCATGAA AGTTAGCAGA GATAAAGATG GCAGCAAGGT AACCACAGTA
GTGGCAACTC CTGGCCAGGG TCCTGACAGG CCACAGGAAG TCAGTTATAC AGACACGAAA
GTGATTGGAA ATGGATCATT TGGTGTGGTA TATCAAGCCA AACTTTGTGA TTCTGGAGAA
CTGGTTGCCA TCAAGAAAGT TCTACAGGAC AAGCGATTTA AGAACCGAGA GCTCCAGATC
ATGAGAAAGC TAGACCACTG TAACATAGTC CGACTGCGGT ATTTCTTCTA CTCGAGTGGT
GAGAAGAAAG ATGAGGTCTA CCTTAACCTG GTGCTGGACT ATGTTCCGGA GACAGTGTAC
AGAGTCGCCA GACACTATAG TCGAGCCAAG CAGACACTCC CTGTGATCTA TGTCAAGTTG
TATATGTATC AGCTGTTCAG AAGTCTAGCC TATATCCATT CCTTTGGAAT CTGCCATCGA
GACATTAAAC CACAGAACCT CTTGTTGGAT CCTGATACAG CTGTATTAAA ACTCTGTGAC
TTTGGAAGTG CAAAGCAGCT GGTCCGAGGA GAGCCCAATG TTTCATATAT CTGTTCTCGG
TACTACAGGG CACCAGAGTT GATCTTTGGA GCCACTGATT ACACGTCCAG TATAGATGTA
TGGTCTGCAG GCTGTGTGTT GGCTGAATTG TTGCTAGGAC AACCAATATT TCCTGGGGAC
AGTGGTGTGG ATCAGTTGGT GGAAATAATA AAGGTCCTAG GAACACCAAC AAGGGAGCAA
ATTAGAGAAA TGAACCCAAA TTATACAGAA TTCAAATTCC CTCAAATCAA GGCACATCCT
TGGACAAAGG TCTTCCGGCC CCGAACTCCA CCAGAGGCAA TTGCACTGTG CAGCCGTCTG
CTGGAGTACA CACCTACCGC CCGGCTAACA CCACTGGAAG CTTGTGCACA TTCATTTTTC
GATGAATTGC GGGACCCAAA TGTCAAACTA CCAAATGGGC GAGACACACC TGCACTCTTC
AACTTTACCA CTCAAGAACT GTCAAGTAAC CCCCCTCTGG CCACCATCCT TATCCCTCCA
CATGCTCGGA TTCAGGCCGC TGCTTCACCG CCTGCCAACG CCACAGCAGC CTCAGATACT
AATGCTGGAG ACCGTGGACA GACCAATAAC GCCGCTTCTG CATCAGCTTC CAACTCCACC
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu52312
Clone ID Related Accession (Same CDS sequence) NM_001347232.1
Accession Version NM_001347232.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1302bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Mus musculus(House mouse)
Product glycogen synthase kinase-3 beta isoform 2
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC120020.9 and AC154284.1. On Nov 18, 2016 this sequence version replaced XM_006522425.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.92831.1, SRR1660823.55222.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGTCGGGGC GACCGAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT 
TCAGCTTTTG GTAGCATGAA AGTTAGCAGA GATAAAGATG GCAGCAAGGT AACCACAGTA
GTGGCAACTC CTGGCCAGGG TCCTGACAGG CCACAGGAAG TCAGTTATAC AGACACGAAA
GTGATTGGAA ATGGATCATT TGGTGTGGTA TATCAAGCCA AACTTTGTGA TTCTGGAGAA
CTGGTTGCCA TCAAGAAAGT TCTACAGGAC AAGCGATTTA AGAACCGAGA GCTCCAGATC
ATGAGAAAGC TAGACCACTG TAACATAGTC CGACTGCGGT ATTTCTTCTA CTCGAGTGGT
GAGAAGAAAG ATGAGGTCTA CCTTAACCTG GTGCTGGACT ATGTTCCGGA GACAGTGTAC
AGAGTCGCCA GACACTATAG TCGAGCCAAG CAGACACTCC CTGTGATCTA TGTCAAGTTG
TATATGTATC AGCTGTTCAG AAGTCTAGCC TATATCCATT CCTTTGGAAT CTGCCATCGA
GACATTAAAC CACAGAACCT CTTGTTGGAT CCTGATACAG CTGTATTAAA ACTCTGTGAC
TTTGGAAGTG CAAAGCAGCT GGTCCGAGGA GAGCCCAATG TTTCATATAT CTGTTCTCGG
TACTACAGGG CACCAGAGTT GATCTTTGGA GCCACTGATT ACACGTCCAG TATAGATGTA
TGGTCTGCAG GCTGTGTGTT GGCTGAATTG TTGCTAGGAC AACCAATATT TCCTGGGGAC
AGTGGTGTGG ATCAGTTGGT GGAAATAATA AAGGTCCTAG GAACACCAAC AAGGGAGCAA
ATTAGAGAAA TGAACCCAAA TTATACAGAA TTCAAATTCC CTCAAATCAA GGCACATCCT
TGGACAAAGG ACTCACCAGG AGCAGGACAT TTCACCCCAG GAGTGCGGGT CTTCCGGCCC
CGAACTCCAC CAGAGGCAAT TGCACTGTGC AGCCGTCTGC TGGAGTACAC ACCTACCGCC
CGGCTAACAC CACTGGAAGC TTGTGCACAT TCATTTTTCG ATGAATTGCG GGACCCAAAT
GTCAAACTAC CAAATGGGCG AGACACACCT GCACTCTTCA ACTTTACCAC TCAAGAACTG
TCAAGTAACC CCCCTCTGGC CACCATCCTT ATCCCTCCAC ATGCTCGGAT TCAGGCCGCT
GCTTCACCGC CTGCCAACGC CACAGCAGCC TCAGATACTA ATGCTGGAGA CCGTGGACAG
ACCAATAACG CCGCTTCTGC ATCAGCTTCC AACTCCACCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001334161.1
CDS1526..2827
Misc Feature(1)1469..1471
Exon (1)1..1613
Exon (2)1614..1807
Exon (3)1808..1891
Exon (4)1892..2002
Exon (5)2003..2133
Exon (6)2134..2240
Exon (7)2241..2338
Exon (8)2339..2434
Exon (9)2435..2473
Exon (10)2474..2660
Exon (11)2661..2759
Exon (12)2760..8342
Translation

Target ORF information:

RefSeq Version NM_001347232.1
Organism Mus musculus(House mouse)
Definition Mus musculus glycogen synthase kinase 3 beta (Gsk3b), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001347232.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGTCGGGGC GACCGAGAAC CACCTCCTTT GCGGAGAGCT GCAAGCCAGT GCAGCAGCCT 
TCAGCTTTTG GTAGCATGAA AGTTAGCAGA GATAAAGATG GCAGCAAGGT AACCACAGTA
GTGGCAACTC CTGGCCAGGG TCCTGACAGG CCACAGGAAG TCAGTTATAC AGACACGAAA
GTGATTGGAA ATGGATCATT TGGTGTGGTA TATCAAGCCA AACTTTGTGA TTCTGGAGAA
CTGGTTGCCA TCAAGAAAGT TCTACAGGAC AAGCGATTTA AGAACCGAGA GCTCCAGATC
ATGAGAAAGC TAGACCACTG TAACATAGTC CGACTGCGGT ATTTCTTCTA CTCGAGTGGT
GAGAAGAAAG ATGAGGTCTA CCTTAACCTG GTGCTGGACT ATGTTCCGGA GACAGTGTAC
AGAGTCGCCA GACACTATAG TCGAGCCAAG CAGACACTCC CTGTGATCTA TGTCAAGTTG
TATATGTATC AGCTGTTCAG AAGTCTAGCC TATATCCATT CCTTTGGAAT CTGCCATCGA
GACATTAAAC CACAGAACCT CTTGTTGGAT CCTGATACAG CTGTATTAAA ACTCTGTGAC
TTTGGAAGTG CAAAGCAGCT GGTCCGAGGA GAGCCCAATG TTTCATATAT CTGTTCTCGG
TACTACAGGG CACCAGAGTT GATCTTTGGA GCCACTGATT ACACGTCCAG TATAGATGTA
TGGTCTGCAG GCTGTGTGTT GGCTGAATTG TTGCTAGGAC AACCAATATT TCCTGGGGAC
AGTGGTGTGG ATCAGTTGGT GGAAATAATA AAGGTCCTAG GAACACCAAC AAGGGAGCAA
ATTAGAGAAA TGAACCCAAA TTATACAGAA TTCAAATTCC CTCAAATCAA GGCACATCCT
TGGACAAAGG ACTCACCAGG AGCAGGACAT TTCACCCCAG GAGTGCGGGT CTTCCGGCCC
CGAACTCCAC CAGAGGCAAT TGCACTGTGC AGCCGTCTGC TGGAGTACAC ACCTACCGCC
CGGCTAACAC CACTGGAAGC TTGTGCACAT TCATTTTTCG ATGAATTGCG GGACCCAAAT
GTCAAACTAC CAAATGGGCG AGACACACCT GCACTCTTCA ACTTTACCAC TCAAGAACTG
TCAAGTAACC CCCCTCTGGC CACCATCCTT ATCCCTCCAC ATGCTCGGAT TCAGGCCGCT
GCTTCACCGC CTGCCAACGC CACAGCAGCC TCAGATACTA ATGCTGGAGA CCGTGGACAG
ACCAATAACG CCGCTTCTGC ATCAGCTTCC AACTCCACCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu52313
Clone ID Related Accession (Same CDS sequence) XM_006522426.3
Accession Version XM_006522426.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1002bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-22
Organism Mus musculus(House mouse)
Product glycogen synthase kinase-3 beta isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006522426.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGAGAAAGC TAGACCACTG TAACATAGTC CGACTGCGGT ATTTCTTCTA CTCGAGTGGT 
GAGAAGAAAG ATGAGGTCTA CCTTAACCTG GTGCTGGACT ATGTTCCGGA GACAGTGTAC
AGAGTCGCCA GACACTATAG TCGAGCCAAG CAGACACTCC CTGTGATCTA TGTCAAGTTG
TATATGTATC AGCTGTTCAG AAGTCTAGCC TATATCCATT CCTTTGGAAT CTGCCATCGA
GACATTAAAC CACAGAACCT CTTGTTGGAT CCTGATACAG CTGTATTAAA ACTCTGTGAC
TTTGGAAGTG CAAAGCAGCT GGTCCGAGGA GAGCCCAATG TTTCATATAT CTGTTCTCGG
TACTACAGGG CACCAGAGTT GATCTTTGGA GCCACTGATT ACACGTCCAG TATAGATGTA
TGGTCTGCAG GCTGTGTGTT GGCTGAATTG TTGCTAGGAC AACCAATATT TCCTGGGGAC
AGTGGTGTGG ATCAGTTGGT GGAAATAATA AAGGTCCTAG GAACACCAAC AAGGGAGCAA
ATTAGAGAAA TGAACCCAAA TTATACAGAA TTCAAATTCC CTCAAATCAA GGCACATCCT
TGGACAAAGG ACTCACCAGG AGCAGGACAT TTCACCCCAG GAGTGCGGGT CTTCCGGCCC
CGAACTCCAC CAGAGGCAAT TGCACTGTGC AGCCGTCTGC TGGAGTACAC ACCTACCGCC
CGGCTAACAC CACTGGAAGC TTGTGCACAT TCATTTTTCG ATGAATTGCG GGACCCAAAT
GTCAAACTAC CAAATGGGCG AGACACACCT GCACTCTTCA ACTTTACCAC TCAAGAACTG
TCAAGTAACC CCCCTCTGGC CACCATCCTT ATCCCTCCAC ATGCTCGGAT TCAGGCCGCT
GCTTCACCGC CTGCCAACGC CACAGCAGCC TCAGATACTA ATGCTGGAGA CCGTGGACAG
ACCAATAACG CCGCTTCTGC ATCAGCTTCC AACTCCACCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006522489.1
CDS398..1399
Misc Feature(1)398..1165
Misc Feature(2)order(515..517,638..640,644..646,704..706,737..739,743..754,758..760,872..874)
Misc Feature(3)order(692..724,728..760)
Misc Feature(4)order(731..757,779..784,875..889,893..898,908..910,968..979)
Misc Feature(5)order(779..781,884..889,893..898,905..910,968..985)
Translation

Target ORF information:

RefSeq Version XM_006522426.3
Organism Mus musculus(House mouse)
Definition Mus musculus glycogen synthase kinase 3 beta (Gsk3b), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006522426.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGAGAAAGC TAGACCACTG TAACATAGTC CGACTGCGGT ATTTCTTCTA CTCGAGTGGT 
GAGAAGAAAG ATGAGGTCTA CCTTAACCTG GTGCTGGACT ATGTTCCGGA GACAGTGTAC
AGAGTCGCCA GACACTATAG TCGAGCCAAG CAGACACTCC CTGTGATCTA TGTCAAGTTG
TATATGTATC AGCTGTTCAG AAGTCTAGCC TATATCCATT CCTTTGGAAT CTGCCATCGA
GACATTAAAC CACAGAACCT CTTGTTGGAT CCTGATACAG CTGTATTAAA ACTCTGTGAC
TTTGGAAGTG CAAAGCAGCT GGTCCGAGGA GAGCCCAATG TTTCATATAT CTGTTCTCGG
TACTACAGGG CACCAGAGTT GATCTTTGGA GCCACTGATT ACACGTCCAG TATAGATGTA
TGGTCTGCAG GCTGTGTGTT GGCTGAATTG TTGCTAGGAC AACCAATATT TCCTGGGGAC
AGTGGTGTGG ATCAGTTGGT GGAAATAATA AAGGTCCTAG GAACACCAAC AAGGGAGCAA
ATTAGAGAAA TGAACCCAAA TTATACAGAA TTCAAATTCC CTCAAATCAA GGCACATCCT
TGGACAAAGG ACTCACCAGG AGCAGGACAT TTCACCCCAG GAGTGCGGGT CTTCCGGCCC
CGAACTCCAC CAGAGGCAAT TGCACTGTGC AGCCGTCTGC TGGAGTACAC ACCTACCGCC
CGGCTAACAC CACTGGAAGC TTGTGCACAT TCATTTTTCG ATGAATTGCG GGACCCAAAT
GTCAAACTAC CAAATGGGCG AGACACACCT GCACTCTTCA ACTTTACCAC TCAAGAACTG
TCAAGTAACC CCCCTCTGGC CACCATCCTT ATCCCTCCAC ATGCTCGGAT TCAGGCCGCT
GCTTCACCGC CTGCCAACGC CACAGCAGCC TCAGATACTA ATGCTGGAGA CCGTGGACAG
ACCAATAACG CCGCTTCTGC ATCAGCTTCC AACTCCACCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Glycogen synthase kinase 3 regulates photic signaling in the suprachiasmatic nucleus.
The European journal of neuroscience45(8)1102-1110(2017 Apr)
Paul JR,McKeown AS,Davis JA,Totsch SK,Mintz EM,Kraft TW,Cowell RM,Gamble KL


book

Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model.
The Journal of neuroscience : the official journal of the Society for Neuroscience37(9)2449-2462(2017 Mar)
Zhang ZH,Wu QY,Zheng R,Chen C,Chen Y,Liu Q,Hoffmann PR,Ni JZ,Song GL


book

Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway.
EBioMedicine16238-250(2017 Feb)
Shen C,Zhou J,Wang X,Yu XY,Liang C,Liu B,Pan X,Zhao Q,Song JL,Wang J,Bao M,Wu C,Li Y,Song YH


book

Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.
Open biology7(1)(2017 Jan)
Liu TY,Chen YC,Jong YJ,Tsai HJ,Lee CC,Chang YS,Chang JG,Chang YF


book

Valproic Acid Protects Primary Dopamine Neurons from MPP
BioMed research international20178124501(2017)
Zhang C,Yuan X,Hu Z,Liu S,Li H,Wu M,Yuan J,Zhao Z,Su J,Wang X,Liao Y,Liu Q


 
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