Gene Symbol | Dkk2 |
Entrez Gene ID | 56811 |
Full Name | dickkopf WNT signaling pathway inhibitor 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Dkk2 cDNA ORF clone
gRNAs
Gene Symbol | Dkk2 |
Entrez Gene ID | 56811 |
Full Name | dickkopf WNT signaling pathway inhibitor 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_020265.4 | NP_064661.2 | dickkopf-related protein 2 precursor |
XM_006501818.4 | XP_006501881.1 | dickkopf-related protein 2 isoform X1 |
XM_006501818.3 | XP_006501881.1 | dickkopf-related protein 2 isoform X1 |
Homo sapiens (human) | DKK2 | NP_055236.1 |
Pan troglodytes (chimpanzee) | DKK2 | XP_001170814.1 |
Canis lupus familiaris (dog) | DKK2 | XP_535681.3 |
Danio rerio (zebrafish) | dkk2 | NP_001104679.1 |
Rattus norvegicus (Norway rat) | Dkk2 | NP_001099942.1 |
DKK2 | XP_001085254.1 | |
Bos taurus (cattle) | DKK2 | NP_001076084.1 |
Mus musculus (house mouse) | Dkk2 | NP_064661.2 |
Gallus gallus (chicken) | DKK2 | XP_420494.1 |
Xenopus tropicalis (tropical clawed frog) | dkk2 | XP_002940336.1 |
Dickkopf2 rescues erectile function by enhancing penile neurovascular regeneration in a mouse model of cavernous nerve injury.
Ghatak K, Yin GN, Choi MJ, Limanjaya A, Minh NN, Ock J, Song KM, Kang DH, Kwon YG, Kim HM, Ryu JK, Suh JK
Scientific reports7(1)17819(2017 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
these data reveal a novel mechanism that the Bmp4-Msx1 pathway and Osr2 control tooth organogenesis through antagonistic regulation of expression of secreted Wnt antagonists.
Title: Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists.
Spermatogenesis-associated protein 3 (Spata3) and dickkopf-related protein 2 (Dkk2) were confirmed to interact with MIC3. The tandem repeat EGF domains of MIC3 were critical in mediating the interactions with the identified host proteins. The results show that MIC3 interacts with host proteins that are involved in reproduction, growth, and development.
Title: Identification of host proteins, Spata3 and Dkk2, interacting with Toxoplasma gondii micronemal protein MIC3.
Dkk2 deletion results in alterations of liver morphology leading to an increased frequency of liver cancer
Title: Increased liver carcinogenesis and enrichment of stem cell properties in livers of Dickkopf 2 (Dkk2) deleted mice.
These findings demonstrate that DKK1 and DKK2 have differential roles in normalization and functionality of tumor blood vessels, in addition to angiogenesis.
Title: Distinct roles of DKK1 and DKK2 in tumor angiogenesis.
Bmp4 signaling suppresses tooth developmental inhibitors in the tooth mesenchyme, including Dkk2 and Osr2, and synergizes with Msx1 to activate mesenchymal odontogenic potential for tooth morphogenesis and sequential tooth formation
Title: Roles of Bmp4 during tooth morphogenesis and sequential tooth formation.
The following Dkk2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dkk2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu32140 | |
Clone ID Related Accession (Same CDS sequence) | XM_006501818.4 , XM_006501818.3 | |
Accession Version | XM_006501818.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 819bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | dickkopf-related protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006501818.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCCGCGC TGATGCGGGT CAAGGATTCA TCCCGCTGCC TTCTCCTACT GGCCGCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006501881.1 |
CDS | 791..1609 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCCGCGC TGATGCGGGT CAAGGATTCA TCCCGCTGCC TTCTCCTACT GGCCGCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu11947 | |
Clone ID Related Accession (Same CDS sequence) | NM_020265.4 | |
Accession Version | NM_020265.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 780bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-07 | |
Organism | Mus musculus(house mouse) | |
Product | dickkopf-related protein 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC127260.3. On Jun 18, 2009 this sequence version replaced NM_020265.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC096448.1, SRR1660813.128489.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCCGCGC TGATGCGGGT CAAGGATTCA TCCCGCTGCC TTCTCCTACT GGCCGCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_064661.2 |
CDS | 742..1521 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCCGCGC TGATGCGGGT CAAGGATTCA TCCCGCTGCC TTCTCCTACT GGCCGCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu32140 | |
Clone ID Related Accession (Same CDS sequence) | XM_006501818.4 , XM_006501818.3 | |
Accession Version | XM_006501818.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 819bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | dickkopf-related protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006501818.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCCGCGC TGATGCGGGT CAAGGATTCA TCCCGCTGCC TTCTCCTACT GGCCGCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006501881.1 |
CDS | 768..1586 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCCGCGC TGATGCGGGT CAAGGATTCA TCCCGCTGCC TTCTCCTACT GGCCGCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Dickkopf2 rescues erectile function by enhancing penile neurovascular regeneration in a mouse model of cavernous nerve injury. |