Gene Symbol | Tob2 |
Entrez Gene ID | 57259 |
Full Name | transducer of ERBB2, 2 |
Synonyms | 2900090N22Rik,4930545K18Rik,AV071822,mKIAA1663 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Tob2 cDNA ORF clone
gRNAs
Gene Symbol | Tob2 |
Entrez Gene ID | 57259 |
Full Name | transducer of ERBB2, 2 |
Synonyms | 2900090N22Rik,4930545K18Rik,AV071822,mKIAA1663 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_020507.3 | NP_065253.1 | protein Tob2 |
Rattus norvegicus (Norway rat) | Tob2 | NP_001007147.1 |
Xenopus tropicalis (tropical clawed frog) | tob2 | NP_001016213.1 |
Gallus gallus (chicken) | TOB2 | NP_001012552.1 |
Pan troglodytes (chimpanzee) | TOB2 | XP_515158.4 |
TOB2 | XP_001104336.1 | |
Bos taurus (cattle) | TOB2 | NP_001076856.1 |
Mus musculus (house mouse) | Tob2 | NP_065253.1 |
Canis lupus familiaris (dog) | TOB2 | XP_005625885.1 |
Homo sapiens (human) | TOB2 | NP_057356.1 |
MiR-5100 promotes osteogenic differentiation by targeting Tob2.
Wang H, Cui Y, Luan J, Zhou X, Li C, Li H, Shi L, Han J
Journal of bone and mineral metabolism35(6)608-615(2017 Nov)
BTG/Tob family members Tob1 and Tob2 inhibit proliferation of mouse embryonic stem cells via Id3 mRNA degradation.
Chen Y, Wang C, Wu J, Li L
Biochemical and biophysical research communications462(3)208-14(2015 Jul)
MicroRNA-322 (miR-322) and its target protein Tob2 modulate Osterix (Osx) mRNA stability.
G?mez B, Rodr?guez-Carballo E, Bartrons R, Rosa JL, Ventura F
The Journal of biological chemistry288(20)14264-75(2013 May)
Tob2 inhibits peroxisome proliferator-activated receptor ?2 expression by sequestering Smads and C/EBP? during adipocyte differentiation.
Takahashi A, Morita M, Yokoyama K, Suzuki T, Yamamoto T
Molecular and cellular biology32(24)5067-77(2012 Dec)
Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation.
Ajima R, Akiyama T, Usui M, Yoneda M, Yoshida Y, Nakamura T, Minowa O, Noda M, Tanaka S, Noda T, Yamamoto T
FEBS letters582(9)1313-8(2008 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Tob1(-/-), Tob2(-/-), and Tob1/2 double knockout (DKO, Tob1(-/-) & Tob2(-/-)) embryonic stem cells (ESCs) grew faster than wild type (WT) ESCs without losing pluripotency.
Title: BTG/Tob family members Tob1 and Tob2 inhibit proliferation of mouse embryonic stem cells via Id3 mRNA degradation.
miR-322 and its target protein Tob2 modulate Osx mRNA stability
Title: MicroRNA-322 (miR-322) and its target protein Tob2 modulate Osterix (Osx) mRNA stability.
Tob2 protein suppresses PPARgamma2 transcription by inhibiting BMP2-induced Smad1/5 phosphorylation through its interaction with Smad6 and by sequestering C/EBPalpha from the PPARgamma2 promoter.
Title: Tob2 inhibits peroxisome proliferator-activated receptor ?2 expression by sequestering Smads and C/EBP? during adipocyte differentiation.
Tob2 negatively regulates formation of osteoclasts by suppressing RANKL expression through its interaction with vitamin D receptor
Title: Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation.
The following Tob2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tob2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu12011 | |
Clone ID Related Accession (Same CDS sequence) | NM_020507.3 | |
Accession Version | NM_020507.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-23 | |
Organism | Mus musculus(house mouse) | |
Product | protein Tob2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK618657.1, AK143542.1, AK049766.1, DV644744.1 and AV220845.1. On Jun 12, 2006 this sequence version replaced NM_020507.2. ##Evidence-Data-START## Transcript exon combination :: AK143542.1, BC094031.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCAGCTGG AGATCAAAGT GGCCCTCAAC TTCATCATCT CCTACTTATA CAACAAGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_065253.1 |
CDS | 498..1535 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGCAGCTGG AGATCAAAGT GGCCCTCAAC TTCATCATCT CCTACTTATA CAACAAGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
MiR-5100 promotes osteogenic differentiation by targeting Tob2. |
BTG/Tob family members Tob1 and Tob2 inhibit proliferation of mouse embryonic stem cells via Id3 mRNA degradation. |
MicroRNA-322 (miR-322) and its target protein Tob2 modulate Osterix (Osx) mRNA stability. |
Tob2 inhibits peroxisome proliferator-activated receptor ?2 expression by sequestering Smads and C/EBP? during adipocyte differentiation. |
Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation. |