Gene Symbol | Cables1 |
Entrez Gene ID | 63955 |
Full Name | CDK5 and Abl enzyme substrate 1 |
Synonyms | Cables,ik3-1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Cables1 cDNA ORF clone
gRNAs
Gene Symbol | Cables1 |
Entrez Gene ID | 63955 |
Full Name | CDK5 and Abl enzyme substrate 1 |
Synonyms | Cables,ik3-1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001146287.1 | NP_001139759.1 | CDK5 and ABL1 enzyme substrate 1 isoform 1 |
NM_022021.2 | NP_071304.2 | CDK5 and ABL1 enzyme substrate 1 isoform 2 |
Pan troglodytes (chimpanzee) | CABLES1 | XP_003315866.1 |
Rattus norvegicus (Norway rat) | Cables1 | NP_001100874.1 |
Canis lupus familiaris (dog) | CABLES1 | XP_003435064.2 |
Bos taurus (cattle) | CABLES1 | XP_002697772.3 |
Mus musculus (house mouse) | Cables1 | NP_001139759.1 |
Xenopus tropicalis (tropical clawed frog) | cables1 | XP_004915270.1 |
Danio rerio (zebrafish) | cables1 | NP_001099135.1 |
Homo sapiens (human) | CABLES1 | NP_001094089.1 |
Gallus gallus (chicken) | CABLES1 | XP_001232075.3 |
Truncated Cables1 causes agenesis of the corpus callosum in mice.
Mizuno S, Tra DT, Mizobuchi A, Iseki H, Mizuno-Iijima S, Kim JD, Ishida J, Matsuda Y, Kunita S, Fukamizu A, Sugiyama F, Yagami K
Laboratory investigation; a journal of technical methods and pathology94(3)321-30(2014 Mar)
Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in Apc(Min) mice.
Arnason T, Pino MS, Yilmaz O, Kirley SD, Rueda BR, Chung DC, Zukerberg LR
Cancer biology & therapy14(7)672-8(2013 Jul)
A novel locus on proximal chromosome 18 associated with agenesis of the corpus callosum in mice.
Mizuno S, Mizobuchi A, Iseki H, Iijima S, Matsuda Y, Kunita S, Sugiyama F, Yagami K
Mammalian genome : official journal of the International Mammalian Genome Society21(11-12)525-33(2010 Dec)
Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress.
Wang N, Guo L, Rueda BR, Tilly JL
EMBO reports11(8)633-9(2010 Aug)
Loss of CABLES1, a cyclin-dependent kinase-interacting protein that inhibits cell cycle progression, results in germline expansion at the expense of oocyte quality in adult female mice.
Lee HJ, Sakamoto H, Luo H, Skaznik-Wikiel ME, Friel AM, Niikura T, Tilly JC, Niikura Y, Klein R, Styer AK, Zukerberg LR, Tilly JL, Rueda BR
Cell cycle (Georgetown, Tex.)6(21)2678-84(2007 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Agenesis of the corpus callosum frequency in Cables1(+/TAS) mice was significantly lower than that in Cables1(-/TAS) mice, indicating that wild-type Cables1 interfered with the dominant negative effect of Cables1(TAS).
Title: Truncated Cables1 causes agenesis of the corpus callosum in mice.
Loss of Cables1 enhances tumor progression in the Apc(Min/+) mouse model and activates the Wnt/beta-catenin signaling pathway. Cables1 is a tumor suppressor gene on chromosome 18q in this in vivo mouse model.
Title: Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in Apc(Min) mice.
Data show that oocytes lacking Cables1 exhibit lower basal levels of TAp63alpha and reduced accumulation of phosphorylated TAp63alpha in response to genotoxic stress.
Title: Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress.
Cables1 null mice exhibit a significant expansion of oocyte numbers at the expense of oocyte quality throughout adulthood.
Title: Loss of CABLES1, a cyclin-dependent kinase-interacting protein that inhibits cell cycle progression, results in germline expansion at the expense of oocyte quality in adult female mice.
Cables is a relevant target of the chromosome 18q deletions frequently seen in human colorectal cancer.
Title: The Cables gene on chromosome 18Q regulates colon cancer progression in vivo.
The following Cables1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cables1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu19263 | |
Clone ID Related Accession (Same CDS sequence) | NM_001146287.1 | |
Accession Version | NM_001146287.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1785bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-21 | |
Organism | Mus musculus(house mouse) | |
Product | CDK5 and ABL1 enzyme substrate 1 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC100751.6, AK158396.1, BQ917292.1, CX202925.1, CB205636.1 and CA751142.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK156273.1, AK158396.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCGGCGG CGACCGCCAC CGCGGGCACG GCCGCCTGCA GCAGCAGCAG CAGCAGTCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001139759.1 |
CDS | 533..2317 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCGGCGG CGACCGCCAC CGCGGGCACG GCCGCCTGCA GCAGCAGCAG CAGCAGTCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu19595 | |
Clone ID Related Accession (Same CDS sequence) | NM_022021.2 | |
Accession Version | NM_022021.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | CDK5 and ABL1 enzyme substrate 1 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC100751.6, CX213994.1, BQ917292.1, CX202925.1, CB205636.1 and CA751142.1. On Apr 4, 2009 this sequence version replaced NM_022021.1. Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. This difference results in a shorter protein (isoform 2), compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF133208.1, AF328140.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCGGCGG CGACCGCCAC CGCGGGCACG GCCGCCTGCA GCAGCAGCAG CAGCAGTCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_071304.2 |
CDS | 533..2239 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGGCGG CGACCGCCAC CGCGGGCACG GCCGCCTGCA GCAGCAGCAG CAGCAGTCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Truncated Cables1 causes agenesis of the corpus callosum in mice. |
Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in Apc(Min) mice. |
A novel locus on proximal chromosome 18 associated with agenesis of the corpus callosum in mice. |
Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress. |
Loss of CABLES1, a cyclin-dependent kinase-interacting protein that inhibits cell cycle progression, results in germline expansion at the expense of oocyte quality in adult female mice. |