Gene Symbol | Gmfg |
Entrez Gene ID | 63986 |
Full Name | glia maturation factor, gamma |
Synonyms | 0610039G16Rik,2310057N07Rik,AI324845 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Gmfg cDNA ORF clone
gRNAs
Gene Symbol | Gmfg |
Entrez Gene ID | 63986 |
Full Name | glia maturation factor, gamma |
Synonyms | 0610039G16Rik,2310057N07Rik,AI324845 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_022024.2 | NP_071307.1 | glia maturation factor gamma isoform a |
XM_006540272.3 | XP_006540335.1 | glia maturation factor gamma isoform X1 |
NM_001039192.1 | NP_001034281.1 | glia maturation factor gamma isoform a |
XM_006540273.3 | XP_006540336.1 | glia maturation factor gamma isoform X2 |
NM_001377092.1 | NP_001364021.1 | glia maturation factor gamma isoform c |
NM_001290550.2 | NP_001277479.1 | glia maturation factor gamma isoform b |
NM_001039192.2 | NP_001034281.1 | glia maturation factor gamma isoform a |
NM_022024.3 | NP_071307.1 | glia maturation factor gamma isoform a |
NM_001290550.1 | NP_001277479.1 | glia maturation factor gamma isoform b |
Mus musculus (house mouse) | Gmfg | NP_071307.1 |
Canis lupus familiaris (dog) | GMFG | XP_853348.2 |
Homo sapiens (human) | GMFG | NP_004868.1 |
Bos taurus (cattle) | GMFG | NP_001019708.1 |
Caenorhabditis elegans (roundworm) | Y50D7A.10 | NP_871652.2 |
Xenopus tropicalis (tropical clawed frog) | gmfg | NP_001025651.1 |
Pan troglodytes (chimpanzee) | GMFG | XP_512648.2 |
Rattus norvegicus (Norway rat) | Gmfg | NP_851605.1 |
Mus musculus (house mouse) | Gm9835 | XP_006505279.1 |
Danio rerio (zebrafish) | gmfg | NP_001035136.1 |
Analysis of the interactions between GMF and Arp2/3 complex in two binding sites by molecular dynamics simulation.
Popinako A, Antonov M, Dibrova D, Chemeris A, Sokolova OS
Biochemical and biophysical research communications(2018 Jan)
Structural basis for regulation of Arp2/3 complex by GMF.
Luan Q, Nolen BJ
Nature structural & molecular biology20(9)1062-8(2013 Sep)
GMF severs actin-Arp2/3 complex branch junctions by a cofilin-like mechanism.
Ydenberg CA, Padrick SB, Sweeney MO, Gandhi M, Sokolova O, Goode BL
Current biology : CB23(12)1037-45(2013 Jun)
Coronary veins determine the pattern of sympathetic innervation in the developing heart.
Nam J, Onitsuka I, Hatch J, Uchida Y, Ray S, Huang S, Li W, Zang H, Ruiz-Lozano P, Mukouyama YS
Development (Cambridge, England)140(7)1475-85(2013 Apr)
Glia maturation factor-gamma is preferentially expressed in microvascular endothelial and inflammatory cells and modulates actin cytoskeleton reorganization.
Ikeda K, Kundu RK, Ikeda S, Kobara M, Matsubara H, Quertermous T
Circulation research99(4)424-33(2006 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin.
Title: Structural basis for regulation of Arp2/3 complex by GMF.
GMF debranches filaments by a mechanism related to cofilin-mediated severing, but in which GMF has evolved to target molecular junctions between actin-related proteins in the Arp2/3 complex and actin subunits in the daughter filament of the branch.
Title: GMF severs actin-Arp2/3 complex branch junctions by a cofilin-like mechanism.
GMFG is a novel factor in actin cytoskeleton reorganization and is expressed preferentially in microvascular endothelial and inflammatory cells in embryonic development.
Title: Glia maturation factor-gamma is preferentially expressed in microvascular endothelial and inflammatory cells and modulates actin cytoskeleton reorganization.
The following Gmfg gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gmfg cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu20484 | |
Clone ID Related Accession (Same CDS sequence) | XM_006540273.3 , NM_001290550.2 , NM_001290550.1 | |
Accession Version | NM_001290550.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-23 | |
Organism | Mus musculus(house mouse) | |
Product | glia maturation factor gamma isoform b | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC149606.6 and BE629139.1. Transcript Variant: This variant (3) lacks an alternate exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BE629139.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGTGGTGC TGGAGGATGA ACTCCAGAAC ATCTCCCCAG AAGAACTTAA GTTGGAATTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001277479.1 |
CDS | 152..457 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGTGGTGC TGGAGGATGA ACTCCAGAAC ATCTCCCCAG AAGAACTTAA GTTGGAATTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu20484 | |
Clone ID Related Accession (Same CDS sequence) | XM_006540273.3 , NM_001290550.2 , NM_001290550.1 | |
Accession Version | XM_006540273.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | glia maturation factor gamma isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006540273.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGTGGTGC TGGAGGATGA ACTCCAGAAC ATCTCCCCAG AAGAACTTAA GTTGGAATTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006540336.1 |
CDS | 127..432 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGTGGTGC TGGAGGATGA ACTCCAGAAC ATCTCCCCAG AAGAACTTAA GTTGGAATTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu38451 | |
Clone ID Related Accession (Same CDS sequence) | XM_006540272.3 , NM_001377092.1 | |
Accession Version | XM_006540272.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | glia maturation factor gamma isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006540272.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAAGTGG ACAAAGACCG GCAGATGGTG GTGCTGGAGG ATGAACTCCA GAACATCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006540335.1 |
CDS | 221..550 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAAAGTGG ACAAAGACCG GCAGATGGTG GTGCTGGAGG ATGAACTCCA GAACATCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu17907 | |
Clone ID Related Accession (Same CDS sequence) | NM_022024.2 , NM_001039192.1 , NM_001039192.2 , NM_022024.3 | |
Accession Version | NM_022024.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-16 | |
Organism | Mus musculus(house mouse) | |
Product | glia maturation factor gamma isoform a | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK002834.1 and AC149606.6. On Jan 28, 2006 this sequence version replaced NM_022024.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a). ##Evidence-Data-START## Transcript exon combination :: AK002834.1, AK014214.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTCGGACT CCCTGGTGGT GTGTGAAGTG GACCCGGAGC TAAAGGAAAC ATTGAGGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_071307.1 |
CDS | 126..554 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGTCGGACT CCCTGGTGGT GTGTGAAGTG GACCCGGAGC TAAAGGAAAC ATTGAGGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu17907 | |
Clone ID Related Accession (Same CDS sequence) | NM_022024.2 , NM_001039192.1 , NM_001039192.2 , NM_022024.3 | |
Accession Version | NM_001039192.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-16 | |
Organism | Mus musculus(house mouse) | |
Product | glia maturation factor gamma isoform a | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK009967.1 and AC149606.6. Transcript Variant: This variant (2) contains an alternate first exon compared to variant 1. Variants 1 and 2 both encode the same isoform (a). ##Evidence-Data-START## Transcript exon combination :: AK009967.1, CB201551.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTCGGACT CCCTGGTGGT GTGTGAAGTG GACCCGGAGC TAAAGGAAAC ATTGAGGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001034281.1 |
CDS | 103..531 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCGGACT CCCTGGTGGT GTGTGAAGTG GACCCGGAGC TAAAGGAAAC ATTGAGGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu17907 | |
Clone ID Related Accession (Same CDS sequence) | NM_022024.2 , NM_001039192.1 , NM_001039192.2 , NM_022024.3 | |
Accession Version | NM_001039192.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2020-01-04 | |
Organism | Mus musculus(house mouse) | |
Product | glia maturation factor gamma isoform a | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK009967.1 and AC149606.6. On Dec 13, 2019 this sequence version replaced NM_001039192.1. Transcript Variant: This variant (2) contains an alternate first exon compared to variant 1. Variants 1 and 2 encode the same isoform (a). ##Evidence-Data-START## Transcript exon combination :: BY709542.1, AK009967.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTCGGACT CCCTGGTGGT GTGTGAAGTG GACCCGGAGC TAAAGGAAAC ATTGAGGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001034281.1 |
CDS | 103..531 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCGGACT CCCTGGTGGT GTGTGAAGTG GACCCGGAGC TAAAGGAAAC ATTGAGGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu17907 | |
Clone ID Related Accession (Same CDS sequence) | NM_022024.2 , NM_001039192.1 , NM_001039192.2 , NM_022024.3 | |
Accession Version | NM_022024.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2020-01-04 | |
Organism | Mus musculus(house mouse) | |
Product | glia maturation factor gamma isoform a | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK002834.1 and AC149606.6. On Dec 13, 2019 this sequence version replaced NM_022024.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 encode the same isoform (a). ##Evidence-Data-START## Transcript exon combination :: AK014214.1, AK002834.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTCGGACT CCCTGGTGGT GTGTGAAGTG GACCCGGAGC TAAAGGAAAC ATTGAGGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_071307.1 |
CDS | 104..532 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCGGACT CCCTGGTGGT GTGTGAAGTG GACCCGGAGC TAAAGGAAAC ATTGAGGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu20484 | |
Clone ID Related Accession (Same CDS sequence) | XM_006540273.3 , NM_001290550.2 , NM_001290550.1 | |
Accession Version | NM_001290550.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-12 | |
Organism | Mus musculus(house mouse) | |
Product | glia maturation factor gamma isoform b | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC149606.6 and BE629139.1. On Dec 13, 2019 this sequence version replaced NM_001290550.1. Transcript Variant: This variant (3) lacks an alternate exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. ##Evidence-Data-START## Transcript exon combination :: BE629139.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGTGGTGC TGGAGGATGA ACTCCAGAAC ATCTCCCCAG AAGAACTTAA GTTGGAATTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001277479.1 |
CDS | 130..435 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGTGGTGC TGGAGGATGA ACTCCAGAAC ATCTCCCCAG AAGAACTTAA GTTGGAATTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu38451 | |
Clone ID Related Accession (Same CDS sequence) | XM_006540272.3 , NM_001377092.1 | |
Accession Version | NM_001377092.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 330bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-12 | |
Organism | Mus musculus(house mouse) | |
Product | glia maturation factor gamma isoform c | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC149606.6. On Dec 13, 2019 this sequence version replaced XM_006540272.4. ##Evidence-Data-START## CDS exon combination :: AA475512.1, AA289126.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAAAGTGG ACAAAGACCG GCAGATGGTG GTGCTGGAGG ATGAACTCCA GAACATCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001364021.1 |
CDS | 175..504 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAAAGTGG ACAAAGACCG GCAGATGGTG GTGCTGGAGG ATGAACTCCA GAACATCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Analysis of the interactions between GMF and Arp2/3 complex in two binding sites by molecular dynamics simulation. |
Structural basis for regulation of Arp2/3 complex by GMF. |
GMF severs actin-Arp2/3 complex branch junctions by a cofilin-like mechanism. |
Coronary veins determine the pattern of sympathetic innervation in the developing heart. |
Glia maturation factor-gamma is preferentially expressed in microvascular endothelial and inflammatory cells and modulates actin cytoskeleton reorganization. |