Gene Symbol | Htra2 |
Entrez Gene ID | 64704 |
Full Name | HtrA serine peptidase 2 |
Synonyms | AI481710,Omi,Prss25,mnd2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Htra2 cDNA ORF clone
gRNAs
Gene Symbol | Htra2 |
Entrez Gene ID | 64704 |
Full Name | HtrA serine peptidase 2 |
Synonyms | AI481710,Omi,Prss25,mnd2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_019752.3 | NP_062726.3 | serine protease HTRA2, mitochondrial |
Homo sapiens (human) | HTRA2 | NP_037379.1 |
Pan troglodytes (chimpanzee) | HTRA2 | XP_003309140.2 |
Canis lupus familiaris (dog) | HTRA2 | XP_532992.3 |
Danio rerio (zebrafish) | LOC560917 | XP_002663637.2 |
Danio rerio (zebrafish) | zgc:173425 | NP_001098612.1 |
Danio rerio (zebrafish) | si:busm1-sl7.7 | XP_003199743.1 |
Danio rerio (zebrafish) | LOC100003308 | NP_001103205.1 |
Danio rerio (zebrafish) | LOC799006 | XP_001339411.5 |
Danio rerio (zebrafish) | si:dkey-84o3.3 | XP_002665896.3 |
Bos taurus (cattle) | HTRA2 | NP_001071424.1 |
Gallus gallus (chicken) | HTRA2 | XP_423666.3 |
Danio rerio (zebrafish) | LOC100536969 | XP_003199752.2 |
Danio rerio (zebrafish) | si:dkey-84o3.7 | XP_001335201.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000240 | XP_310886.5 |
Danio rerio (zebrafish) | zgc:174193 | NP_001108178.1 |
Danio rerio (zebrafish) | si:dkey-33c12.10 | XP_003199749.2 |
Danio rerio (zebrafish) | si:dkey-33c12.2 | XP_005172803.1 |
Danio rerio (zebrafish) | LOC100329860 | XP_002664149.3 |
Danio rerio (zebrafish) | LOC797876 | XP_001923767.4 |
Danio rerio (zebrafish) | LOC100331049 | XP_002665901.2 |
Danio rerio (zebrafish) | LOC799537 | NP_001103640.1 |
Rattus norvegicus (Norway rat) | Htra2 | NP_001100069.1 |
Danio rerio (zebrafish) | LOC100149563 | NP_001122292.1 |
Danio rerio (zebrafish) | LOC797799 | NP_001103998.1 |
Drosophila melanogaster (fruit fly) | HtrA2 | NP_001262565.1 |
HTRA2 | XP_001110803.1 | |
Mus musculus (house mouse) | Htra2 | NP_062726.3 |
Danio rerio (zebrafish) | LOC793110 | XP_001332804.5 |
Danio rerio (zebrafish) | LOC793521 | XP_001333305.1 |
Danio rerio (zebrafish) | LOC100330919 | XP_005161042.1 |
Mitochondrial Omi/HtrA2 Promotes Caspase Activation Through Cleavage of HAX-1 in Aging Heart.
Liu X, Lei J, Wang K, Ma L, Liu D, Du Y, Wu Y, Zhang S, Wang W, Ma X, Liu H
Rejuvenation research20(3)183-192(2017 Jun)
Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction.
Wang K, Yuan Y, Liu X, Lau WB, Zuo L, Wang X, Ma L, Jiao K, Shang J, Wang W, Ma X, Liu H
Scientific reports637927(2016 Dec)
HtrA2 suppresses autoimmune arthritis and regulates activation of STAT3.
Lee SH, Moon YM, Seo HB, Kim SY, Kim EK, Yi J, Nam MK, Min JK, Park SH, Rhim H, Cho ML
Scientific reports639393(2016 Dec)
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Mice overexpressing wild-type or G399S mutant HtrA2 have mitochondrial defects resulting in neurodegeneration.
Title: Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2.
Protease Omi impairs mitochondrial function by cleaving Hax-1, which induces apoptosis in oxygen-glucose deprivation and reoxygenation -treated N2a cells and causes reperfusion injury in middle cerebral artery occlusion mice.
Title: Protease Omi cleaving Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cells and cerebral injury in MCAO mice.
Protease Omi facilitates neurite outgrowth by cleaving the transcription factor E2F1 in differentiated neuroblastoma cells; E2F1 is a substrate of Omi.
Title: Protease Omi facilitates neurite outgrowth in mouse neuroblastoma N2a cells by cleaving transcription factor E2F1.
The NG2 proteoglycan protects oligodendrocyte precursor cells against oxidative stress via interaction with OMI/HtrA2.
Title: The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2.
Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.
Title: Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.
The following Htra2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Htra2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu22610 | |
Clone ID Related Accession (Same CDS sequence) | NM_019752.3 | |
Accession Version | NM_019752.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1377bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-21 | |
Organism | Mus musculus(house mouse) | |
Product | serine protease HTRA2, mitochondrial | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC104324.21, AF175324.1 and BM899329.1. On Jul 18, 2009 this sequence version replaced NM_019752.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC049880.1, AK146338.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## |
1 | ATGGCTGCGC TGAAAGCGGG GCGGGGTGCA AACTGGAGCC TTCGGGCATG GCGGGCTTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_062726.3 |
CDS | 146..1522 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGGCTGCGC TGAAAGCGGG GCGGGGTGCA AACTGGAGCC TTCGGGCATG GCGGGCTTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Mitochondrial Omi/HtrA2 Promotes Caspase Activation Through Cleavage of HAX-1 in Aging Heart. |
Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction. |
HtrA2 suppresses autoimmune arthritis and regulates activation of STAT3. |
High-throughput discovery of novel developmental phenotypes. |