Gene Symbol | Tctn1 |
Entrez Gene ID | 654470 |
Full Name | tectonic family member 1 |
Synonyms | G730031O11Rik,Tect1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Tctn1 cDNA ORF clone
gRNAs
Gene Symbol | Tctn1 |
Entrez Gene ID | 654470 |
Full Name | tectonic family member 1 |
Synonyms | G730031O11Rik,Tect1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001039153.3 | NP_001034242.2 | tectonic-1 precursor |
Mus musculus (house mouse) | Tctn1 | NP_001034242.2 |
Rattus norvegicus (Norway rat) | Tctn1 | NP_001171084.1 |
Danio rerio (zebrafish) | tctn1 | XP_001920842.4 |
Homo sapiens (human) | TCTN1 | NP_001076007.1 |
Gallus gallus (chicken) | TCTN1 | XP_415162.3 |
TCTN1 | XP_001099978.2 | |
Xenopus tropicalis (tropical clawed frog) | tctn1 | NP_001120638.1 |
Pan troglodytes (chimpanzee) | TCTN1 | XP_003313991.1 |
Canis lupus familiaris (dog) | TCTN1 | XP_005636285.1 |
Bos taurus (cattle) | TCTN1 | NP_001039521.2 |
Three Tctn proteins are functionally conserved in the regulation of neural tube patterning and Gli3 processing but not ciliogenesis and Hedgehog signaling in the mouse.
Wang C, Li J, Meng Q, Wang B
Developmental biology430(1)156-165(2017 10)
Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models.
Kurogi S, Sekimoto T, Funamoto T, Ota T, Nakamura S, Nagai T, Nakahara M, Yoshinobu K, Araki K, Araki M, Chosa E
Scientific reports740692(2017 Jan)
MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone.
Li C, Jensen VL, Park K, Kennedy J, Garcia-Gonzalo FR, Romani M, De Mori R, Bruel AL, Gaillard D, Doray B, Lopez E, Rivi?re JB, Faivre L, Thauvin-Robinet C, Reiter JF, Blacque OE, Valente EM, Leroux MR
PLoS biology14(3)e1002416(2016 Mar)
Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling.
Yee LE, Garcia-Gonzalo FR, Bowie RV, Li C, Kennedy JK, Ashrafi K, Blacque OE, Leroux MR, Reiter JF
PLoS genetics11(11)e1005627(2015 Nov)
Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling.
Garcia-Gonzalo FR, Phua SC, Roberson EC, Garcia G 3rd, Abedin M, Schurmans S, Inoue T, Reiter JF
Developmental cell34(4)400-409(2015 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results suggest that Tctn1, Tctn2, and Tctn3 are functionally divergent with respect to their role in ciliogenesis and Hedgehog signaling but conserved in neural tube patterning and Gli3 processing.
Title: Three Tctn proteins are functionally conserved in the regulation of neural tube patterning and Gli3 processing but not ciliogenesis and Hedgehog signaling in the mouse.
Loss of Tctn1 is associated with ciliopathies.
Title: A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.
During neural tube development, mouse Tectonic is required for formation of the most ventral cell types and for full Hedgehog (Hh) pathway activation. Tectonic plays an additional role in repressing Hh pathway activity.
Title: Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition.
The following Tctn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tctn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu18362 | |
Clone ID Related Accession (Same CDS sequence) | NM_001039153.3 | |
Accession Version | NM_001039153.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1782bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-21 | |
Organism | Mus musculus(house mouse) | |
Product | tectonic-1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DQ278867.1, AK138661.1, AK036568.1, DV657549.1, AC127266.4, CX202489.1 and AW121310.1. On Apr 18, 2014 this sequence version replaced NM_001039153.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ278867.1, AK036568.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGGTCGC GGGGTCTCCC GCCGCTCCTG CTGGTGCTCC TAAACTGCTA CACCTCTTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001034242.2 |
CDS | 92..1873 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGGGGTCGC GGGGTCTCCC GCCGCTCCTG CTGGTGCTCC TAAACTGCTA CACCTCTTCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Three Tctn proteins are functionally conserved in the regulation of neural tube patterning and Gli3 processing but not ciliogenesis and Hedgehog signaling in the mouse. |
Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models. |
MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone. |
Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling. |
Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling. |