Gene Symbol | Apoa5 |
Entrez Gene ID | 66113 |
Full Name | apolipoprotein A-V |
Synonyms | 1300007O05Rik,Apoav,RAP3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Apoa5 cDNA ORF clone
gRNAs
Gene Symbol | Apoa5 |
Entrez Gene ID | 66113 |
Full Name | apolipoprotein A-V |
Synonyms | 1300007O05Rik,Apoav,RAP3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_080434.4 | NP_536682.2 | apolipoprotein A-V precursor |
XM_006510538.3 | XP_006510601.1 | apolipoprotein A-V isoform X1 |
NM_001348095.1 | NP_001335024.1 | apolipoprotein A-V precursor |
Homo sapiens (human) | APOA5 | NP_443200.2 |
Canis lupus familiaris (dog) | APOA5 | XP_546511.1 |
Mus musculus (house mouse) | Apoa5 | NP_536682.2 |
APOA5 | XP_002799851.1 | |
Gallus gallus (chicken) | APOA5 | XP_004948132.1 |
Pan troglodytes (chimpanzee) | APOA5 | XP_003313361.1 |
Bos taurus (cattle) | APOA5 | NP_001076961.1 |
Rattus norvegicus (Norway rat) | Apoa5 | NP_542143.1 |
Xenopus tropicalis (tropical clawed frog) | apoa5 | NP_001116904.1 |
Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport.
Bartelt A, John C, Schaltenberg N, Berb?e JFP, Worthmann A, Cherradi ML, Schlein C, Piepenburg J, Boon MR, Rinninger F, Heine M, Toedter K, Niemeier A, Nilsson SK, Fischer M, Wijers SL, van Marken Lichtenbelt W, Scheja L, Rensen PCN, Heeren J
Nature communications815010(2017 Apr)
Metformin ameliorates obesity-associated hypertriglyceridemia in mice partly through the apolipoprotein A5 pathway.
Li R, Chen LZ, Zhao W, Zhao SP, Huang XS
Biochemical and biophysical research communications478(3)1173-8(2016 09)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The data suggest that apoA-V suppresses the production of chylomicrons, playing a previously unknown role in lipid metabolism that may contribute to the postprandial hypertriglyceridemia associated with apoA-V deficiency.
Title: Apolipoprotein A-V deficiency enhances chylomicron production in lymph fistula mice.
novel role for ApoA5 as a modulator of susceptibility to diet-induced liver and muscle insulin resistance through regulation of ectopic lipid accumulation in liver and skeletal muscle.
Title: ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content.
Data indicate that apolipoprotein A5 (APOA5) plays a role in the central regulation of food intake.
Title: Apolipoprotein A5 deficiency aggravates high-fat diet-induced obesity due to impaired central regulation of food intake.
Clearance of triglyceride-rich lipoproteins by hepatic SDC1 is atheroprotective and mediated by multivalent binding to ApoE and ApoAV.
Title: Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans.
Gene transfer of human apoA-V improves the severe hypertriglyceridemia phenotype of apoa5 null mice.
Title: Gene transfer of apolipoprotein A-V improves the hypertriglyceridemic phenotype of apoa5 (-/-) mice.
The following Apoa5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Apoa5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu09631 | |
Clone ID Related Accession (Same CDS sequence) | NM_080434.4 , XM_006510538.3 , NM_001348095.1 | |
Accession Version | NM_080434.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1107bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-09 | |
Organism | Mus musculus(house mouse) | |
Product | apolipoprotein A-V precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK050280.1 and AC164105.4. On Feb 8, 2017 this sequence version replaced NM_080434.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCTGCAG TCATCACTTG GGCCCTCGCC CTCCTCGCAG TGTTCGCAAG CACTCAGGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_536682.2 |
CDS | 30..1136 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCTGCAG TCATCACTTG GGCCCTCGCC CTCCTCGCAG TGTTCGCAAG CACTCAGGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu09631 | |
Clone ID Related Accession (Same CDS sequence) | NM_080434.4 , XM_006510538.3 , NM_001348095.1 | |
Accession Version | NM_001348095.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1107bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-22 | |
Organism | Mus musculus(house mouse) | |
Product | apolipoprotein A-V precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC164105.4 and AK050280.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCTGCAG TCATCACTTG GGCCCTCGCC CTCCTCGCAG TGTTCGCAAG CACTCAGGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001335024.1 |
CDS | 224..1330 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCTGCAG TCATCACTTG GGCCCTCGCC CTCCTCGCAG TGTTCGCAAG CACTCAGGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu09631 | |
Clone ID Related Accession (Same CDS sequence) | NM_080434.4 , XM_006510538.3 , NM_001348095.1 | |
Accession Version | XM_006510538.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1107bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | apolipoprotein A-V isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006510538.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGCAG TCATCACTTG GGCCCTCGCC CTCCTCGCAG TGTTCGCAAG CACTCAGGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006510601.1 |
CDS | 192..1298 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCTGCAG TCATCACTTG GGCCCTCGCC CTCCTCGCAG TGTTCGCAAG CACTCAGGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport. |
Metformin ameliorates obesity-associated hypertriglyceridemia in mice partly through the apolipoprotein A5 pathway. |