Gene Symbol | Clec14a |
Entrez Gene ID | 66864 |
Full Name | C-type lectin domain family 14, member a |
Synonyms | 1200003C23Rik,AI642649 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Clec14a cDNA ORF clone
Gene Symbol | Clec14a |
Entrez Gene ID | 66864 |
Full Name | C-type lectin domain family 14, member a |
Synonyms | 1200003C23Rik,AI642649 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_025809.5 | NP_080085.3 | C-type lectin domain family 14 member A precursor |
Canis lupus familiaris (dog) | CLEC14A | XP_005623407.1 |
Pan troglodytes (chimpanzee) | CLEC14A | XP_522832.1 |
CLEC14A | XP_001091540.1 | |
Mus musculus (house mouse) | Clec14a | NP_080085.3 |
Homo sapiens (human) | CLEC14A | NP_778230.1 |
Bos taurus (cattle) | CLEC14A | NP_001071358.1 |
Rattus norvegicus (Norway rat) | Clec14a | NP_001014099.1 |
Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis.
Lee S, Rho SS, Park H, Park JA, Kim J, Lee IK, Koh GY, Mochizuki N, Kim YM, Kwon YG
The Journal of clinical investigation127(2)457-471(2017 Feb)
Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth.
Noy PJ, Lodhia P, Khan K, Zhuang X, Ward DG, Verissimo AR, Bacon A, Bicknell R
Oncogene34(47)5821-31(2015 Nov)
Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro.
Ki MK, Jeoung MH, Choi JR, Rho SS, Kwon YG, Shim H, Chung J, Hong HJ, Song BD, Lee S
Oncogene32(48)5449-57(2013 Nov)
Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification.
Zhou P, Zhang Y, Ma Q, Gu F, Day DS, He A, Zhou B, Li J, Stevens SM, Romo D, Pu WT
Proceedings of the National Academy of Sciences of the United States of America110(38)15395-400(2013 Sep)
The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.
Naba A, Clauser KR, Hoersch S, Liu H, Carr SA, Hynes RO
Molecular & cellular proteomics : MCP11(4)M111.014647(2012 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
CLEC14A acts in vascular homeostasis by fine-tuning VEGFR-2 and VEGFR-3 signaling in endothelial cells
Title: Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis.
clec14a-CTLD may be a key domain in angiogenesis
Title: Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro.
These findings demonstrate that Clec14a is a novel endothelial cells specific protein that appears to play a role in cell-cell adhesion and angiogenesis.
Title: Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion.
The following Clec14a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Clec14a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu15364 | |
Clone ID Related Accession (Same CDS sequence) | NM_025809.5 | |
Accession Version | NM_025809.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1380bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-18 | |
Organism | Mus musculus(house mouse) | |
Product | C-type lectin domain family 14 member A precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY233495.1, AK014681.1, CK331838.1, AK033733.1, AK080201.1 and BB307353.2. On May 14, 2009 this sequence version replaced NM_025809.4. COMPLETENESS: complete on the 3' end. |
1 | ATGAGGCCAG CGCTTGCCCT GTGCCTCCTC TGTCCTGCGT TCTGGCCTCG GCCAGGGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_080085.3 |
CDS | 425..1804 |
Translation |
Target ORF information:
Target ORF information:
|
NM_025809.5 |
1 | ATGAGGCCAG CGCTTGCCCT GTGCCTCCTC TGTCCTGCGT TCTGGCCTCG GCCAGGGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis. |
Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth. |
Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro. |
Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. |
The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. |