Gene Symbol | Proz |
Entrez Gene ID | 66901 |
Full Name | protein Z, vitamin K-dependent plasma glycoprotein |
Synonyms | 1300015B06Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Proz cDNA ORF clone
gRNAs
Gene Symbol | Proz |
Entrez Gene ID | 66901 |
Full Name | protein Z, vitamin K-dependent plasma glycoprotein |
Synonyms | 1300015B06Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006508859.4 | XP_006508922.1 | vitamin K-dependent protein Z isoform X2 |
XM_006508859.3 | XP_006508922.1 | vitamin K-dependent protein Z isoform X3 |
XM_006508858.4 | XP_006508921.1 | vitamin K-dependent protein Z isoform X1 |
NM_001357219.1 | NP_001344148.1 | vitamin K-dependent protein Z isoform 2 precursor |
NM_025834.4 | NP_080110.1 | vitamin K-dependent protein Z isoform 1 precursor |
XM_006508858.3 | XP_006508921.1 | vitamin K-dependent protein Z isoform X2 |
XM_006508856.1 | XP_006508919.1 | vitamin K-dependent protein Z isoform X1 |
NM_025834.3 | NP_080110.1 | vitamin K-dependent protein Z precursor |
NM_001357220.1 | NP_001344149.1 | vitamin K-dependent protein Z isoform 3 |
Mus musculus (house mouse) | Proz | NP_080110.1 |
Gallus gallus (chicken) | PROZ | XP_416945.3 |
Rattus norvegicus (Norway rat) | Proz | XP_006253535.1 |
Homo sapiens (human) | PROZ | NP_003882.1 |
Pan troglodytes (chimpanzee) | PROZ | XP_522739.3 |
PROZ | XP_001087442.1 | |
Xenopus tropicalis (tropical clawed frog) | proz | NP_001116189.1 |
Bos taurus (cattle) | PROZ | XP_002692060.3 |
Protein z exerts pro-angiogenic effects and upregulates CXCR4.
Butschkau A, Wagner NM, Genz B, Vollmar B
PloS one9(12)e113554(2014)
Protein Z-deficiency is associated with enhanced neointima formation and inflammatory response after vascular injury in mice.
Butschkau A, Wagner NM, Bierhansl L, Genz B, Vollmar B
International journal of clinical and experimental pathology7(9)6064-71(2014)
Protein Z, protein Z-dependent protease inhibitor (serpinA10), and the acute-phase response.
Girard TJ, Lasky NM, Tuley EA, Broze GJ Jr
Journal of thrombosis and haemostasis : JTH11(2)375-8(2013 Feb)
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature474(7351)337-42(2011 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
PZ contributes to a reduced neointima formation after vascular injury, underlining the modulatory role of the coagulation cascade in vascular homeostasis.
Title: Protein Z-deficiency is associated with enhanced neointima formation and inflammatory response after vascular injury in mice.
Letter: protein Z is not a typical acute phase reactant.
Title: Protein Z, protein Z-dependent protease inhibitor (serpinA10), and the acute-phase response.
PZ and ZPI deficiency would be associated with a modest thrombotic risk with ZPI deficiency producing a more severe phenotype.
Title: Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency.
The following Proz gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Proz cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu40445 | |
Clone ID Related Accession (Same CDS sequence) | NM_001357219.1 , XM_006508856.1 | |
Accession Version | NM_001357219.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-29 | |
Organism | Mus musculus(house mouse) | |
Product | vitamin K-dependent protein Z isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC127308.3. On Oct 24, 2017 this sequence version replaced XM_006508856.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC038045.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCTGGCT GCATCTTGCT GCTCCGGGGC TTCATCCTTA CCCTCATCCT GCACCAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001344148.1 |
CDS | 123..848 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCTGGCT GCATCTTGCT GCTCCGGGGC TTCATCCTTA CCCTCATCCT GCACCAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu40445 | |
Clone ID Related Accession (Same CDS sequence) | NM_001357219.1 , XM_006508856.1 | |
Accession Version | XM_006508856.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(House mouse) | |
Product | vitamin K-dependent protein Z isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGGCT GCATCTTGCT GCTCCGGGGC TTCATCCTTA CCCTCATCCT GCACCAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006508919.1 |
CDS | 446..1171 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCTGGCT GCATCTTGCT GCTCCGGGGC TTCATCCTTA CCCTCATCCT GCACCAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu40447 | |
Clone ID Related Accession (Same CDS sequence) | XM_006508858.4 , XM_006508858.3 | |
Accession Version | XM_006508858.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | vitamin K-dependent protein Z isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006508858.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGGCT GCATCTTGCT GCTCCGGGGC TTCATCCTTA CCCTCATCCT GCACCAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006508921.1 |
CDS | 445..1074 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCTGGCT GCATCTTGCT GCTCCGGGGC TTCATCCTTA CCCTCATCCT GCACCAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu40448 | |
Clone ID Related Accession (Same CDS sequence) | XM_006508859.4 , XM_006508859.3 | |
Accession Version | XM_006508859.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | vitamin K-dependent protein Z isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006508859.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGGCT GCATCTTGCT GCTCCGGGGC TTCATCCTTA CCCTCATCCT GCACCAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006508922.1 |
CDS | 450..1076 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCTGGCT GCATCTTGCT GCTCCGGGGC TTCATCCTTA CCCTCATCCT GCACCAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu01124 | |
Clone ID Related Accession (Same CDS sequence) | NM_025834.4 , NM_025834.3 | |
Accession Version | NM_025834.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-28 | |
Organism | Mus musculus(house mouse) | |
Product | vitamin K-dependent protein Z isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC127308.3, AK008819.1 and AK005011.2. On Oct 24, 2017 this sequence version replaced NM_025834.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK008819.1, AK005011.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCTGGCT GCATCTTGCT GCTCCGGGGC TTCATCCTTA CCCTCATCCT GCACCAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_080110.1 |
CDS | 123..1322 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCTGGCT GCATCTTGCT GCTCCGGGGC TTCATCCTTA CCCTCATCCT GCACCAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu01124 | |
Clone ID Related Accession (Same CDS sequence) | NM_025834.4 , NM_025834.3 | |
Accession Version | NM_025834.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-02-14 | |
Organism | Mus musculus(House mouse) | |
Product | vitamin K-dependent protein Z precursor | |
Comment | PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC127308.3. On Nov 17, 2006 this sequence version replaced NM_025834.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK008819.1, AK005011.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCTGGCT GCATCTTGCT GCTCCGGGGC TTCATCCTTA CCCTCATCCT GCACCAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_080110.1 |
CDS | 123..1322 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCTGGCT GCATCTTGCT GCTCCGGGGC TTCATCCTTA CCCTCATCCT GCACCAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu83801 | |
Clone ID Related Accession (Same CDS sequence) | NM_001357220.1 | |
Accession Version | NM_001357220.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-22 | |
Organism | Mus musculus(house mouse) | |
Product | vitamin K-dependent protein Z isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC127308.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC024104.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCAGCAAG AGCCTCAGCA GCAGGATGAG TTCTGGAGAC AGTATGGGGG TGGCTCTCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001344149.1 |
CDS | 487..1476 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCAGCAAG AGCCTCAGCA GCAGGATGAG TTCTGGAGAC AGTATGGGGG TGGCTCTCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu40447 | |
Clone ID Related Accession (Same CDS sequence) | XM_006508858.4 , XM_006508858.3 | |
Accession Version | XM_006508858.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 630bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | vitamin K-dependent protein Z isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006508858.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGGCT GCATCTTGCT GCTCCGGGGC TTCATCCTTA CCCTCATCCT GCACCAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006508921.1 |
CDS | 443..1072 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCTGGCT GCATCTTGCT GCTCCGGGGC TTCATCCTTA CCCTCATCCT GCACCAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu40448 | |
Clone ID Related Accession (Same CDS sequence) | XM_006508859.4 , XM_006508859.3 | |
Accession Version | XM_006508859.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | vitamin K-dependent protein Z isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006508859.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGGCT GCATCTTGCT GCTCCGGGGC TTCATCCTTA CCCTCATCCT GCACCAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006508922.1 |
CDS | 447..1073 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCTGGCT GCATCTTGCT GCTCCGGGGC TTCATCCTTA CCCTCATCCT GCACCAGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Protein z exerts pro-angiogenic effects and upregulates CXCR4. |
Protein Z-deficiency is associated with enhanced neointima formation and inflammatory response after vascular injury in mice. |
Protein Z, protein Z-dependent protease inhibitor (serpinA10), and the acute-phase response. |
A conditional knockout resource for the genome-wide study of mouse gene function. |