Gene Symbol | Plin3 |
Entrez Gene ID | 66905 |
Full Name | perilipin 3 |
Synonyms | 1300012C15Rik,M6prbp1,Tip47 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Plin3 cDNA ORF clone
gRNAs
Gene Symbol | Plin3 |
Entrez Gene ID | 66905 |
Full Name | perilipin 3 |
Synonyms | 1300012C15Rik,M6prbp1,Tip47 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_025836.3 | NP_080112.1 | perilipin-3 |
Homo sapiens (human) | PLIN3 | NP_001157666.1 |
Canis lupus familiaris (dog) | PLIN3 | XP_542149.3 |
Gallus gallus (chicken) | LOC100857433 | XP_003642906.1 |
Rattus norvegicus (Norway rat) | Plin3 | XP_236783.4 |
Pan troglodytes (chimpanzee) | PLIN3 | XP_512292.3 |
Bos taurus (cattle) | PLIN3 | NP_001070514.1 |
Mus musculus (house mouse) | Plin3 | NP_080112.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100487248 | XP_004911098.1 |
Danio rerio (zebrafish) | si:rp71-61h23.4 | XP_005166988.1 |
The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis.
Ferguson D, Zhang J, Davis MA, Helsley RN, Vedin LL, Lee RG, Crooke RM, Graham MJ, Allende DS, Parini P, Brown JM
Journal of lipid research58(2)420-432(2017 Feb)
Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis.
Kaushik S, Cuervo AM
Nature cell biology17(6)759-70(2015 Jun)
Postprandial triglyceride-rich lipoproteins regulate perilipin-2 and perilipin-3 lipid-droplet-associated proteins in macrophages.
Varela LM, L?pez S, Ortega-G?mez A, Berm?dez B, Buers I, Robenek H, Muriana FJ, Abia R
The Journal of nutritional biochemistry26(4)327-36(2015 Apr)
Perilipins 2 and 3 lack a carboxy-terminal domain present in perilipin 1 involved in sequestering ABHD5 and suppressing basal lipolysis.
Patel S, Yang W, Kozusko K, Saudek V, Savage DB
Proceedings of the National Academy of Sciences of the United States of America111(25)9163-8(2014 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
our studies demonstrate that the lipid droplets (LDs) scaffold protein, PLIN3, is essential for HCV core-induced hepatic steatosis and provide new insights into the pathogenesis of HCV.
Title: The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis.
Postprandial triglyceride rich lipoproteins may be involved in atherosclerotic plaque formation through the regulation of perilipin-2 and perilipin-3 proteins in macrophages.
Title: Postprandial triglyceride-rich lipoproteins regulate perilipin-2 and perilipin-3 lipid-droplet-associated proteins in macrophages.
Collectively these data suggest that whereas perilipin 1 potently suppresses basal lipolysis in adipocytes, perilipins 2 and 3 facilitate higher rates of basal lipolysis
Title: Perilipins 2 and 3 lack a carboxy-terminal domain present in perilipin 1 involved in sequestering ABHD5 and suppressing basal lipolysis.
These findings show that TIP47 affects hepatic lipid and glucose metabolism and may be a target for the treatment of nonalcoholic fatty liver and related metabolic disorders.
Title: Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice.
Data indicate that PLIN2 and PLIN3 may participate in acute lipid droplet formation in mammalian testes.
Title: Transient scrotal hyperthermia induces lipid droplet accumulation and reveals a different ADFP expression pattern between the testes and liver in mice.
The following Plin3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Plin3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu18769 | |
Clone ID Related Accession (Same CDS sequence) | NM_025836.3 | |
Accession Version | NM_025836.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1314bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Mus musculus(house mouse) | |
Product | perilipin-3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK004970.1 and AK167214.1. On May 4, 2007 this sequence version replaced NM_025836.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK004970.1, AK132313.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164143 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTCTAGCA ATGGTACAGA TGCGCCTGCC GAAGCTCAAG CTGCTATGGA GGAACCTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_080112.1 |
CDS | 76..1389 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGTCTAGCA ATGGTACAGA TGCGCCTGCC GAAGCTCAAG CTGCTATGGA GGAACCTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis. |
Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis. |
Postprandial triglyceride-rich lipoproteins regulate perilipin-2 and perilipin-3 lipid-droplet-associated proteins in macrophages. |
Perilipins 2 and 3 lack a carboxy-terminal domain present in perilipin 1 involved in sequestering ABHD5 and suppressing basal lipolysis. |