Gene Symbol | Vps53 |
Entrez Gene ID | 68299 |
Full Name | VPS53 GARP complex subunit |
Synonyms | 2010002A08Rik,2310040I21Rik,3100002B05Rik,Hccs1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Vps53 cDNA ORF clone
gRNAs
Gene Symbol | Vps53 |
Entrez Gene ID | 68299 |
Full Name | VPS53 GARP complex subunit |
Synonyms | 2010002A08Rik,2310040I21Rik,3100002B05Rik,Hccs1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006534053.3 | XP_006534116.1 | vacuolar protein sorting-associated protein 53 homolog isoform X2 |
NM_026664.4 | NP_080940.2 | vacuolar protein sorting-associated protein 53 homolog isoform 1 |
XM_006534052.3 | XP_006534115.1 | vacuolar protein sorting-associated protein 53 homolog isoform X1 |
NM_001364738.1 | NP_001351667.1 | vacuolar protein sorting-associated protein 53 homolog isoform 2 |
NM_026664.3 | NP_080940.2 | vacuolar protein sorting-associated protein 53 homolog |
Bos taurus (cattle) | VPS53 | NP_001180097.1 |
Danio rerio (zebrafish) | vps53 | NP_001007459.2 |
Arabidopsis thaliana (thale cress) | AT1G50970 | NP_175510.2 |
Gallus gallus (chicken) | VPS53 | NP_001012824.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP006623 | XP_316653.4 |
Caenorhabditis elegans (roundworm) | vps-53 | NP_001255027.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_01331 | XP_003714256.1 |
Canis lupus familiaris (dog) | VPS53 | XP_548308.2 |
Mus musculus (house mouse) | Vps53 | NP_080940.2 |
Rattus norvegicus (Norway rat) | Vps53 | NP_001099283.1 |
Neurospora crassa | NCU03024 | XP_965410.1 |
Arabidopsis thaliana (thale cress) | HIT1 | NP_564573.3 |
Xenopus tropicalis (tropical clawed frog) | LOC100496110 | XP_002934389.2 |
Pan troglodytes (chimpanzee) | VPS53 | XP_001151796.1 |
Schizosaccharomyces pombe (fission yeast) | vps53 | NP_593341.1 |
Oryza sativa (rice) | Os01g0906200 | NP_001045132.2 |
Homo sapiens (human) | VPS53 | NP_001121631.1 |
Drosophila melanogaster (fruit fly) | CG3338 | NP_608825.2 |
EARP is a multisubunit tethering complex involved in endocytic recycling.
Schindler C, Chen Y, Pu J, Guo X, Bonifacino JS
Nature cell biology17(5)639-50(2015 May)
Loss of vps54 function leads to vesicle traffic impairment, protein mis-sorting and embryonic lethality.
Karlsson P, Droce A, Moser JM, Cuhlmann S, Padilla CO, Heimann P, Bartsch JW, F?chtbauer A, F?chtbauer EM, Schmitt-John T
International journal of molecular sciences14(6)10908-25(2013 May)
HCCS1 overexpression induces apoptosis via cathepsin D and intracellular calcium, and HCCS1 disruption in mice causes placental abnormality.
Gan Y, Zhao X, Hu J, Wang ZG, Zhao XT
Cell death and differentiation15(9)1481-90(2008 Sep)
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic acids research31(1)278-81(2003 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Disruption of HCCS1 in mice leads to embryonic lethality, accompanied by abnormal labyrinth architecture resulting from the excessive proliferation of trophoblast cells in the placenta.
Title: HCCS1 overexpression induces apoptosis via cathepsin D and intracellular calcium, and HCCS1 disruption in mice causes placental abnormality.
The following Vps53 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vps53 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu84049 | |
Clone ID Related Accession (Same CDS sequence) | NM_001364738.1 | |
Accession Version | NM_001364738.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 216bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-07-11 | |
Organism | Mus musculus(house mouse) | |
Product | vacuolar protein sorting-associated protein 53 homolog isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK009586.1, AK008026.1 and AL591129.24. ##Evidence-Data-START## Transcript exon combination :: AK008026.1, BY708014.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGATGGAGG AGGAGGAACT GGAGTTTGTG GAGGAGCTGG AGGCTGTGCT GCAGCTCACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001351667.1 |
CDS | 140..355 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGATGGAGG AGGAGGAACT GGAGTTTGTG GAGGAGCTGG AGGCTGTGCT GCAGCTCACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu02771 | |
Clone ID Related Accession (Same CDS sequence) | NM_026664.4 , NM_026664.3 | |
Accession Version | NM_026664.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2499bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-07-13 | |
Organism | Mus musculus(house mouse) | |
Product | vacuolar protein sorting-associated protein 53 homolog isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK009586.1 and AK033495.1. On Jul 3, 2018 this sequence version replaced NM_026664.3. ##Evidence-Data-START## Transcript exon combination :: AK033495.1, AK019408.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGATGGAGG AGGAGGAACT GGAGTTTGTG GAGGAGCTGG AGGCTGTGCT GCAGCTCACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_080940.2 |
CDS | 140..2638 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGATGGAGG AGGAGGAACT GGAGTTTGTG GAGGAGCTGG AGGCTGTGCT GCAGCTCACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu02771 | |
Clone ID Related Accession (Same CDS sequence) | NM_026664.4 , NM_026664.3 | |
Accession Version | NM_026664.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2499bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-05-12 | |
Organism | Mus musculus(house mouse) | |
Product | vacuolar protein sorting-associated protein 53 homolog | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK033495.1. On Apr 6, 2007 this sequence version replaced NM_026664.2. ##Evidence-Data-START## Transcript exon combination :: AK033495.1, AK019408.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGATGGAGG AGGAGGAACT GGAGTTTGTG GAGGAGCTGG AGGCTGTGCT GCAGCTCACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_080940.2 |
CDS | 132..2630 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGATGGAGG AGGAGGAACT GGAGTTTGTG GAGGAGCTGG AGGCTGTGCT GCAGCTCACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu46824 | |
Clone ID Related Accession (Same CDS sequence) | XM_006534052.3 | |
Accession Version | XM_006534052.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2424bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | vacuolar protein sorting-associated protein 53 homolog isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006534052.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGTGGTAA AGGTATTCCC AAGCCAGGAT CCTCTTGATC AAGCTGACTT CAATGCCGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006534115.1 |
CDS | 93..2516 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGTGGTAA AGGTATTCCC AAGCCAGGAT CCTCTTGATC AAGCTGACTT CAATGCCGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu46825 | |
Clone ID Related Accession (Same CDS sequence) | XM_006534053.3 | |
Accession Version | XM_006534053.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2130bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | vacuolar protein sorting-associated protein 53 homolog isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006534053.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGTGAAAG AGATCACCCG AGATATTAAG CAGTTAGATC ACGCCAAGCG CCACCTGACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006534116.1 |
CDS | 1509..3638 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGTGAAAG AGATCACCCG AGATATTAAG CAGTTAGATC ACGCCAAGCG CCACCTGACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
EARP is a multisubunit tethering complex involved in endocytic recycling. |
Loss of vps54 function leads to vesicle traffic impairment, protein mis-sorting and embryonic lethality. |
HCCS1 overexpression induces apoptosis via cathepsin D and intracellular calcium, and HCCS1 disruption in mice causes placental abnormality. |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |