Gene Symbol | Evc2 |
Entrez Gene ID | 68525 |
Full Name | EvC ciliary complex subunit 2 |
Synonyms | 1110017L09Rik,Lbn,limbin |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Evc2 cDNA ORF clone
gRNAs
Gene Symbol | Evc2 |
Entrez Gene ID | 68525 |
Full Name | EvC ciliary complex subunit 2 |
Synonyms | 1110017L09Rik,Lbn,limbin |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006504082.3 | XP_006504145.1 | limbin isoform X1 |
NM_145920.3 | NP_666032.1 | limbin precursor |
XM_006504082.2 | XP_006504145.1 | limbin isoform X1 |
Homo sapiens (human) | EVC2 | NP_667338.3 |
Pan troglodytes (chimpanzee) | EVC2 | XP_001155684.1 |
Canis lupus familiaris (dog) | EVC2 | XP_005618640.1 |
Bos taurus (cattle) | EVC2 | NP_776352.1 |
Xenopus tropicalis (tropical clawed frog) | evc2 | XP_002939100.2 |
Mus musculus (house mouse) | Evc2 | NP_666032.1 |
Rattus norvegicus (Norway rat) | Evc2 | NP_001099482.1 |
Gallus gallus (chicken) | EVC2 | NP_001073217.1 |
EVC2 | XP_001118862.2 |
The Role of Ellis-Van Creveld 2(EVC2) in Mice During Cranial Bone Development.
Kwon EK, Louie K, Kulkarni A, Yatabe M, Ruellas ACO, Snider TN, Mochida Y, Cevidanes LHS, Mishina Y, Zhang H
Anatomical record (Hoboken, N.J. : 2007)301(1)46-55(2018 Jan)
Loss of Function of Evc2 in Dental Mesenchyme Leads to Hypomorphic Enamel.
Zhang H, Takeda H, Tsuji T, Kamiya N, Kunieda T, Mochida Y, Mishina Y
Journal of dental research96(4)421-429(2017 Apr)
Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice.
Zhang H, Kamiya N, Tsuji T, Takeda H, Scott G, Rajderkar S, Ray MK, Mochida Y, Allen B, Lefebvre V, Hung IH, Ornitz DM, Kunieda T, Mishina Y
PLoS genetics12(12)e1006510(2016 Dec)
Expression of Evc2 in craniofacial tissues and craniofacial bone defects in Evc2 knockout mouse.
Badri MK, Zhang H, Ohyama Y, Venkitapathi S, Alamoudi A, Kamiya N, Takeda H, Ray M, Scott G, Tsuji T, Kunieda T, Mishina Y, Mochida Y
Archives of oral biology68142-52(2016 Aug)
Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.
Burnicka-Turek O, Steimle JD, Huang W, Felker L, Kamp A, Kweon J, Peterson M, Reeves RH, Maslen CL, Gruber PJ, Yang XH, Shendure J, Moskowitz IP
Human molecular genetics25(14)3011-3028(2016 07)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Mutations in Evc2 affect dental mesenchymal stem cell homeostasis, which further leads to hypomorphic enamel formation in mice.
Title: Loss of Function of Evc2 in Dental Mesenchyme Leads to Hypomorphic Enamel.
Elevation of FGF signaling, mainly due to increased Fgf18 expression upon inactivation of Evc2 in the perichondrium, critically contributes to the pathogenesis of limb dwarfism. The limb dwarfism phenotype is partially rescued by inactivation of one allele of Fgf18 in the Evc2 mutant mice
Title: Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice.
Loss of EVC2 is associated with facial bone growth defect.
Title: Ellis Van Creveld2 is Required for Postnatal Craniofacial Bone Development.
This study identifies the types of Evc2-expressing cells in craniofacial tissues. Consistent with the expression pattern, abnormal craniofacial bone morphology was found in the Evc2 KO mice, suggesting that EVC2 may be important during craniofacial growth and development.
Title: Expression of Evc2 in craniofacial tissues and craniofacial bone defects in Evc2 knockout mouse.
data reveal that the Hh pathway involves Evc/Evc2-dependent modulations that are necessary for normal endochondral bone formation
Title: The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia.
The following Evc2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Evc2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu12012 | |
Clone ID Related Accession (Same CDS sequence) | NM_145920.3 | |
Accession Version | NM_145920.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3663bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-21 | |
Organism | Mus musculus(house mouse) | |
Product | limbin precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY270131.1, AB083066.1 and AW548747.2. On Aug 15, 2009 this sequence version replaced NM_145920.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC064473.1, SRR1660817.180071.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGGGCGA CGGGCCCCAC GGGCGCTGGG GGACGAGCCA CGTGGGTGCT GGCTGGGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_666032.1 |
CDS | 71..3733 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGGGGGCGA CGGGCCCCAC GGGCGCTGGG GGACGAGCCA CGTGGGTGCT GGCTGGGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu35177 | |
Clone ID Related Accession (Same CDS sequence) | XM_006504082.3 , XM_006504082.2 | |
Accession Version | XM_006504082.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3258bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | limbin isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006504082.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAATCCA GACTTTCAGA AAGAGCTTTC TGCAAGTGGG AGAATGCTAC TCTGTCAGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006504145.1 |
CDS | 470..3727 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAATCCA GACTTTCAGA AAGAGCTTTC TGCAAGTGGG AGAATGCTAC TCTGTCAGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu35177 | |
Clone ID Related Accession (Same CDS sequence) | XM_006504082.3 , XM_006504082.2 | |
Accession Version | XM_006504082.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3258bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | limbin isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006504082.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAATCCA GACTTTCAGA AAGAGCTTTC TGCAAGTGGG AGAATGCTAC TCTGTCAGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006504145.1 |
CDS | 448..3705 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAATCCA GACTTTCAGA AAGAGCTTTC TGCAAGTGGG AGAATGCTAC TCTGTCAGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The Role of Ellis-Van Creveld 2(EVC2) in Mice During Cranial Bone Development. |
Loss of Function of Evc2 in Dental Mesenchyme Leads to Hypomorphic Enamel. |
Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice. |
Expression of Evc2 in craniofacial tissues and craniofacial bone defects in Evc2 knockout mouse. |
Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms. |