Gene Symbol | Chmp2b |
Entrez Gene ID | 68942 |
Full Name | charged multivesicular body protein 2B |
Synonyms | 1190006E07Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Chmp2b cDNA ORF clone
Gene Symbol | Chmp2b |
Entrez Gene ID | 68942 |
Full Name | charged multivesicular body protein 2B |
Synonyms | 1190006E07Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_026879.3 | NP_081155.1 | charged multivesicular body protein 2b |
NM_026879.2 | NP_081155.1 | charged multivesicular body protein 2b |
Pan troglodytes (chimpanzee) | CHMP2B | XP_003950194.1 |
Bos taurus (cattle) | CHMP2B | NP_001030549.1 |
Rattus norvegicus (Norway rat) | Chmp2b | XP_343996.5 |
Gallus gallus (chicken) | CHMP2B | NP_001025963.1 |
Danio rerio (zebrafish) | chmp2bb | NP_998069.1 |
Drosophila melanogaster (fruit fly) | CHMP2B | NP_647947.1 |
Arabidopsis thaliana (thale cress) | VPS2.3 | NP_563696.1 |
Oryza sativa (rice) | Os10g0476400 | NP_001064848.1 |
Xenopus tropicalis (tropical clawed frog) | chmp2b | NP_998866.1 |
Homo sapiens (human) | CHMP2B | NP_054762.2 |
Canis lupus familiaris (dog) | CHMP2B | XP_544799.3 |
Caenorhabditis elegans (roundworm) | C01A2.4 | NP_493357.2 |
CHMP2B | XP_001104518.1 | |
Mus musculus (house mouse) | Chmp2b | NP_081155.1 |
Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation.
Clayton EL, Mancuso R, Nielsen TT, Mizielinska S, Holmes H, Powell N, Norona F, Larsen JO, Milioto C, Wilson KM, Lythgoe MF, Ourselin S, Nielsen JE, Johannsen P, Holm I, Collinge J, , Oliver PL, Gomez-Nicola D, Isaacs AM
Human molecular genetics26(5)873-887(2017 03)
A transgenic mouse expressing CHMP2Bintron5 mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia.
Vernay A, Therreau L, Blot B, Risson V, Dirrig-Grosch S, Waegaert R, Lequeu T, Sellal F, Schaeffer L, Sadoul R, Loeffler JP, Ren? F
Human molecular genetics25(15)3341-3360(2016 Aug)
Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology.
Clayton EL, Mizielinska S, Edgar JR, Nielsen TT, Marshall S, Norona FE, Robbins M, Damirji H, Holm IE, Johannsen P, Nielsen JE, Asante EA, Collinge J, , Isaacs AM
Acta neuropathologica130(4)511-23(2015 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The presence of early microglial changes in our CHMP2B mutant mice indicates neuroinflammation may be a contributing factor to the neurodegeneration observed in FTD.
Title: Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation.
Study showed that mutant CHMP2B causes the pathological accumulation of endolysosomal components early in the frontotemporal dementia disease course
Title: Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology.
This study showing that CHMP2B resides at synapses and is involved in synaptic plasticity.
Title: Regulation of postsynaptic function by the dementia-related ESCRT-III subunit CHMP2B.
Forebrain-specific expression of frontotemporal dementia-associated mutant CHMP2B in mice causes several age-dependent neurodegenerative phenotypes, including social behavioral impairments.
Title: Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia.
Chmp2b is one of the most highly regulated cell-autonomous targets of Lbx1 in the embryonic mouse neural tube
Title: Population-specific regulation of Chmp2b by Lbx1 during onset of synaptogenesis in lateral association interneurons.
The following Chmp2b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Chmp2b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu03206 | |
Clone ID Related Accession (Same CDS sequence) | NM_026879.3 , NM_026879.2 | |
Accession Version | NM_026879.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-22 | |
Organism | Mus musculus(house mouse) | |
Product | charged multivesicular body protein 2b | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CT009578.7, AK084111.1 and BC055809.1. On Apr 20, 2018 this sequence version replaced NM_026879.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC055809.1, AK084111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164137 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCCTCCC TCTTCAAGAA GAAGACTGTG GACGATGTCA TAAAGGAACA GAATCGAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_081155.1 |
CDS | 255..896 |
Translation |
Target ORF information:
Target ORF information:
|
NM_026879.3 |
1 | ATGGCCTCCC TCTTCAAGAA GAAGACTGTG GACGATGTCA TAAAGGAACA GAATCGAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu03206 | |
Clone ID Related Accession (Same CDS sequence) | NM_026879.3 , NM_026879.2 | |
Accession Version | NM_026879.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-11-19 | |
Organism | Mus musculus(house mouse) | |
Product | charged multivesicular body protein 2b | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK084111.1. On Apr 6, 2007 this sequence version replaced NM_026879.1. ##Evidence-Data-START## Transcript exon combination :: AK084111.1, BC055809.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164137 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCCTCCC TCTTCAAGAA GAAGACTGTG GACGATGTCA TAAAGGAACA GAATCGAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_081155.1 |
CDS | 190..831 |
Translation |
Target ORF information:
Target ORF information:
|
NM_026879.2 |
1 | ATGGCCTCCC TCTTCAAGAA GAAGACTGTG GACGATGTCA TAAAGGAACA GAATCGAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation. |
A transgenic mouse expressing CHMP2Bintron5 mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia. |
Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology. |