Gene Symbol | Prrt2 |
Entrez Gene ID | 69017 |
Full Name | proline-rich transmembrane protein 2 |
Synonyms | 1500031I19Rik,AI195361,DSPB3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Prrt2 cDNA ORF clone
Gene Symbol | Prrt2 |
Entrez Gene ID | 69017 |
Full Name | proline-rich transmembrane protein 2 |
Synonyms | 1500031I19Rik,AI195361,DSPB3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_017312280.1 | XP_017167769.1 | proline-rich transmembrane protein 2 isoform X1 |
XM_017312280.2 | XP_017167769.1 | proline-rich transmembrane protein 2 isoform X1 |
XM_030242963.1 | XP_030098823.1 | proline-rich transmembrane protein 2 isoform X1 |
XM_030242964.1 | XP_030098824.1 | proline-rich transmembrane protein 2 isoform X2 |
NM_001102563.1 | NP_001096033.1 | proline-rich transmembrane protein 2 |
PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum.
Tan GH, Liu YY, Wang L, Li K, Zhang ZQ, Li HF, Yang ZF, Li Y, Li D, Wu MY, Yu CL, Long JJ, Chen RC, Li LX, Yin LP, Liu JW, Cheng XW, Shen Q, Shu YS, Sakimura K, Liao LJ, Wu ZY, Xiong ZQ
Cell research28(1)90-110(2018 Jan)
The PRRT2 knockout mouse recapitulates the neurological diseases associated with PRRT2 mutations.
Michetti C, Castroflorio E, Marchionni I, Forte N, Sterlini B, Binda F, Fruscione F, Baldelli P, Valtorta F, Zara F, Corradi A, Benfenati F
Neurobiology of disease9966-83(2017 Mar)
PRRT2 mutations lead to neuronal dysfunction and neurodevelopmental defects.
Liu YT, Nian FS, Chou WJ, Tai CY, Kwan SY, Chen C, Kuo PW, Lin PH, Chen CY, Huang CW, Lee YC, Soong BW, Tsai JW
Oncotarget7(26)39184-39196(2016 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
PRRT2 interacts with the Src homology 3 domain-bearing protein Intersectin 1, an intracellular protein involved in synaptic vesicle cycling.
Title: A Novel Topology of Proline-rich Transmembrane Protein 2 (PRRT2): HINTS FOR AN INTRACELLULAR FUNCTION AT THE SYNAPSE.
Mutants associated with paroxysmal kinesigenic dyskinesia with infantile convulsions C lead to dramatically reduced PRRT2 levels.
Title: Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions.
The following Prrt2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prrt2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu03745 | |
Clone ID Related Accession (Same CDS sequence) | NM_001102563.1 | |
Accession Version | NM_001102563.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Mus musculus(house mouse) | |
Product | proline-rich transmembrane protein 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB873187.1, BB872849.1, BC053419.1, CB246480.1 and BF323287.1. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCAGCCA GCAGCTCTCA GGTCTCTGAG ATGAAGGGGG TGGAAGACAG TTCCAAAACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001096033.1 |
CDS | 272..1312 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001102563.1 |
1 | ATGGCAGCCA GCAGCTCTCA GGTCTCTGAG ATGAAGGGGG TGGAAGACAG TTCCAAAACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu39866 | |
Clone ID Related Accession (Same CDS sequence) | XM_030242964.1 | |
Accession Version | XM_030242964.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | proline-rich transmembrane protein 2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGCCA GCAGCTCTCA GGTCTCTGAG ATGAAGGGGG TGGAAGACAG TTCCAAAACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030098824.1 |
CDS | 365..1417 |
Translation |
Target ORF information:
Target ORF information:
|
XM_030242964.1 |
1 | ATGGCAGCCA GCAGCTCTCA GGTCTCTGAG ATGAAGGGGG TGGAAGACAG TTCCAAAACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu82209 | |
Clone ID Related Accession (Same CDS sequence) | XM_017312280.1 , XM_017312280.2 , XM_030242963.1 | |
Accession Version | XM_017312280.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | proline-rich transmembrane protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGCCA GCAGCTCTCA GGTCTCTGAG ATGAAGGGGG TGGAAGACAG TTCCAAAACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017167769.1 |
CDS | 167..1264 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017312280.1 |
1 | ATGGCAGCCA GCAGCTCTCA GGTCTCTGAG ATGAAGGGGG TGGAAGACAG TTCCAAAACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu82209 | |
Clone ID Related Accession (Same CDS sequence) | XM_017312280.1 , XM_017312280.2 , XM_030242963.1 | |
Accession Version | XM_017312280.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | proline-rich transmembrane protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017312280.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGCCA GCAGCTCTCA GGTCTCTGAG ATGAAGGGGG TGGAAGACAG TTCCAAAACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017167769.1 |
CDS | 269..1366 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017312280.2 |
1 | ATGGCAGCCA GCAGCTCTCA GGTCTCTGAG ATGAAGGGGG TGGAAGACAG TTCCAAAACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu82209 | |
Clone ID Related Accession (Same CDS sequence) | XM_017312280.1 , XM_017312280.2 , XM_030242963.1 | |
Accession Version | XM_030242963.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | proline-rich transmembrane protein 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000073.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGCCA GCAGCTCTCA GGTCTCTGAG ATGAAGGGGG TGGAAGACAG TTCCAAAACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030098823.1 |
CDS | 223..1320 |
Translation |
Target ORF information:
Target ORF information:
|
XM_030242963.1 |
1 | ATGGCAGCCA GCAGCTCTCA GGTCTCTGAG ATGAAGGGGG TGGAAGACAG TTCCAAAACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum. |
The PRRT2 knockout mouse recapitulates the neurological diseases associated with PRRT2 mutations. |
PRRT2 mutations lead to neuronal dysfunction and neurodevelopmental defects. |