Gene Symbol | Vkorc1l1 |
Entrez Gene ID | 69568 |
Full Name | vitamin K epoxide reductase complex, subunit 1-like 1 |
Synonyms | 2310024K08Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Vkorc1l1 cDNA ORF clone
gRNAs
Gene Symbol | Vkorc1l1 |
Entrez Gene ID | 69568 |
Full Name | vitamin K epoxide reductase complex, subunit 1-like 1 |
Synonyms | 2310024K08Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_027121.4 | NP_081397.1 | vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 1 |
NM_001001327.2 | NP_001001327.1 | vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 2 |
NM_001286382.1 | NP_001273311.1 | vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 3 |
Mus musculus (house mouse) | Vkorc1l1 | NP_081397.1 |
Homo sapiens (human) | VKORC1L1 | NP_775788.2 |
Pan troglodytes (chimpanzee) | VKORC1L1 | XP_527770.2 |
VKORC1L1 | XP_001088069.1 | |
Bos taurus (cattle) | VKORC1L1 | XP_002698121.1 |
Rattus norvegicus (Norway rat) | Vkorc1l1 | NP_976083.1 |
Xenopus tropicalis (tropical clawed frog) | vkorc1l1 | NP_001016769.2 |
Canis lupus familiaris (dog) | VKORC1L1 | XP_848485.1 |
Gallus gallus (chicken) | VKORC1L1 | NP_001001328.1 |
Danio rerio (zebrafish) | vkorc1l1 | NP_001018524.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000543 | XP_310541.3 |
VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo.
Lacombe J, Rishavy MA, Berkner KL, Ferron M
JCI insight3(1)(2018 Jan)
Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse: VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain.
Caspers M, Czogalla KJ, Liphardt K, M?ller J, Westhofen P, Watzka M, Oldenburg J
Thrombosis research135(5)977-83(2015 May)
GGCX and VKORC1 inhibit osteocalcin endocrine functions.
Ferron M, Lacombe J, Germain A, Oury F, Karsenty G
The Journal of cell biology208(6)761-76(2015 Mar)
VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.
Hammed A, Matagrin B, Spohn G, Prouillac C, Benoit E, Lattard V
The Journal of biological chemistry288(40)28733-42(2013 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
quantified mRNA levels for VKORC1, VKORC1L1, GGCX, and NQO1 and measured VKOR enzymatic activities in 29 different tissues
Title: Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse: VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain.
The involvement of VKORC1L1 in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists.
Title: VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.
molecular cloning
Title: Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
The following Vkorc1l1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vkorc1l1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu22145 | |
Clone ID Related Accession (Same CDS sequence) | NM_001001327.2 | |
Accession Version | NM_001001327.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-26 | |
Organism | Mus musculus(house mouse) | |
Product | vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC085133.1, CK639505.1, AK078942.1, CF533903.1, AK033702.1, CN457470.1 and BE954096.1. On Nov 2, 2013 this sequence version replaced NM_001001327.1. Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: BC085133.1, SRR1660825.76371.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGCGC CCGTCCTGCT GAGAGTGTCG GTGCCGCGTT GGGAACGGGT GGCCCGGTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001001327.1 |
CDS | 64..447 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCGGCGC CCGTCCTGCT GAGAGTGTCG GTGCCGCGTT GGGAACGGGT GGCCCGGTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22150 | |
Clone ID Related Accession (Same CDS sequence) | NM_001286382.1 | |
Accession Version | NM_001286382.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-26 | |
Organism | Mus musculus(house mouse) | |
Product | vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC085133.1, CN701203.1, CK639505.1, AK078942.1, CF533903.1, AK033702.1, CN457470.1 and BE954096.1. Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: CN701203.1, CN697837.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCGGCGC CCGTCCTGCT GAGAGTGTCG GTGCCGCGTT GGGAACGGGT GGCCCGATGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001273311.1 |
CDS | 64..456 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCGGCGC CCGTCCTGCT GAGAGTGTCG GTGCCGCGTT GGGAACGGGT GGCCCGATGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22149 | |
Clone ID Related Accession (Same CDS sequence) | NM_027121.4 | |
Accession Version | NM_027121.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-26 | |
Organism | Mus musculus(house mouse) | |
Product | vitamin K epoxide reductase complex subunit 1-like protein 1 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC085133.1, CN701203.1, CK639505.1, AK078942.1, CF533903.1, AK033702.1, CN457470.1 and BE954096.1. On Nov 2, 2013 this sequence version replaced NM_027121.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1660813.122071.1, SRR1660817.33191.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGCGC CCGTCCTGCT GAGAGTGTCG GTGCCGCGTT GGGAACGGGT GGCCCGGTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_081397.1 |
CDS | 64..594 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGGCGC CCGTCCTGCT GAGAGTGTCG GTGCCGCGTT GGGAACGGGT GGCCCGGTAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo. |
Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse: VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain. |
GGCX and VKORC1 inhibit osteocalcin endocrine functions. |
VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy. |