Gene Symbol | Phf6 |
Entrez Gene ID | 70998 |
Full Name | PHD finger protein 6 |
Synonyms | 2700007B13Rik,4931428F02Rik,mKIAA1823 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Phf6 cDNA ORF clone
gRNAs
Gene Symbol | Phf6 |
Entrez Gene ID | 70998 |
Full Name | PHD finger protein 6 |
Synonyms | 2700007B13Rik,4931428F02Rik,mKIAA1823 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001290546.1 | NP_001277475.1 | PHD finger protein 6 isoform 2 |
NM_027642.2 | NP_081918.1 | PHD finger protein 6 isoform 1 |
Homo sapiens (human) | PHF6 | NP_001015877.1 |
Gallus gallus (chicken) | PHF6 | XP_004940719.1 |
PHF6 | XP_001098349.2 | |
Canis lupus familiaris (dog) | PHF6 | XP_005641890.1 |
Mus musculus (house mouse) | Phf6 | NP_081918.1 |
Pan troglodytes (chimpanzee) | PHF6 | XP_003317748.1 |
Danio rerio (zebrafish) | phf6 | NP_956059.1 |
Bos taurus (cattle) | PHF6 | NP_001069237.1 |
Rattus norvegicus (Norway rat) | Phf6 | XP_006257715.1 |
Xenopus tropicalis (tropical clawed frog) | phf6 | NP_001107695.1 |
PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes.
Soto-Feliciano YM, Bartlebaugh JME, Liu Y, S?nchez-Rivera FJ, Bhutkar A, Weintraub AS, Buenrostro JD, Cheng CS, Regev A, Jacks TE, Young RA, Hemann MT
Genes & development31(10)973-989(2017 May)
Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos.
Cui W, Dai X, Marcho C, Han Z, Zhang K, Tremblay KD, Mager J
Scientific reports637396(2016 Nov)
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
active maintenance of a precise chromatin landscape is essential for sustaining proper leukemia cell identity and that loss of a single factor (PHF6) can cause focal changes in chromatin accessibility and nucleosome positioning that render cells susceptible to lineage transition
Title: PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes.
These results place miR-128 upstream of PHF6 in a pathway vital for cortical lamination as well as for the development of neuronal morphology and intrinsic excitability.
Title: miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6.
As part of a cell-intrinsic transcriptional pathway, PHF6 regulates neuronal migration in the brain.
Title: The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain.
Strongest Phf6 gene expression and nuclear localisation of Phf6 protein were observed in the developing central nervous system, the anterior pituitary gland, the primordia of facial structures and the limb buds.
Title: Protein and gene expression analysis of Phf6, the gene mutated in the B?rjeson-Forssman-Lehmann Syndrome of intellectual disability and obesity.
The following Phf6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Phf6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu13933 | |
Clone ID Related Accession (Same CDS sequence) | NM_027642.2 | |
Accession Version | NM_027642.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1095bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2020-01-01 | |
Organism | Mus musculus(house mouse) | |
Product | PHD finger protein 6 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK016480.1, BC055330.1 and CJ287261.1. On Mar 14, 2014 this sequence version replaced NM_027642.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC043127.1, AK141804.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTCAAGCT CAATTGAACA GAAAAAAGGG TCTACGAGAC AGCGTAAATG TGGCTTTTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_081918.1 |
CDS | 270..1364 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGTCAAGCT CAATTGAACA GAAAAAAGGG TCTACGAGAC AGCGTAAATG TGGCTTTTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu17094 | |
Clone ID Related Accession (Same CDS sequence) | NM_001290546.1 | |
Accession Version | NM_001290546.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2020-01-01 | |
Organism | Mus musculus(house mouse) | |
Product | PHD finger protein 6 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK016480.1, AK028498.1, BC055330.1 and CJ287261.1. On Mar 14, 2014 this sequence version replaced XM_006541544.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK028498.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTGTTCTC TTTGTCATTG TCCTGGAGCA ACCATTGGCT GTGATGTGAA AACCTGCCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001277475.1 |
CDS | 224..1078 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTGTTCTC TTTGTCATTG TCCTGGAGCA ACCATTGGCT GTGATGTGAA AACCTGCCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes. |
Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. |
High-throughput discovery of novel developmental phenotypes. |