Gene Symbol | Stx18 |
Entrez Gene ID | 71116 |
Full Name | syntaxin 18 |
Synonyms | 1810035L21Rik,4933425D03Rik,AU041562 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Stx18 cDNA ORF clone
gRNAs
Gene Symbol | Stx18 |
Entrez Gene ID | 71116 |
Full Name | syntaxin 18 |
Synonyms | 1810035L21Rik,4933425D03Rik,AU041562 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001359398.1 | NP_001346327.1 | syntaxin-18 isoform 4 |
NM_026959.3 | NP_081235.2 | syntaxin-18 isoform 1 |
XM_006504112.3 | XP_006504175.1 | syntaxin-18 isoform X2 |
XM_006504111.3 | XP_006504174.1 | syntaxin-18 isoform X1 |
NM_001289535.1 | NP_001276464.1 | syntaxin-18 isoform 2 |
XM_030254807.1 | XP_030110667.1 | syntaxin-18 isoform X1 |
NM_001289536.1 | NP_001276465.1 | syntaxin-18 isoform 3 |
XM_006504112.4 | XP_006504175.1 | syntaxin-18 isoform X2 |
STX18 | XP_001094903.1 | |
Arabidopsis thaliana (thale cress) | SYP81 | NP_564597.1 |
Canis lupus familiaris (dog) | STX18 | XP_851021.1 |
Bos taurus (cattle) | STX18 | NP_001093189.1 |
Mus musculus (house mouse) | Stx18 | NP_081235.2 |
Danio rerio (zebrafish) | stx18 | NP_001019596.1 |
Xenopus tropicalis (tropical clawed frog) | stx18 | NP_001016709.1 |
Rattus norvegicus (Norway rat) | Stx18 | NP_001012151.1 |
Drosophila melanogaster (fruit fly) | Syx18 | NP_524485.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP011160 | XP_309489.4 |
Homo sapiens (human) | STX18 | NP_058626.1 |
Pan troglodytes (chimpanzee) | STX18 | XP_001154387.1 |
Gallus gallus (chicken) | STX18 | NP_001239087.1 |
Oryza sativa (rice) | Os04g0530400 | NP_001053389.1 |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Sec22b is a negative regulator of phagocytosis in macrophages.
Hatsuzawa K, Hashimoto H, Hashimoto H, Arai S, Tamura T, Higa-Nishiyama A, Wada I
Molecular biology of the cell20(20)4435-43(2009 Oct)
Bovine papillomavirus type 1 infection is mediated by SNARE syntaxin 18.
Laniosz V, Nguyen KC, Meneses PI
Journal of virology81(14)7435-48(2007 Jul)
Involvement of syntaxin 18, an endoplasmic reticulum (ER)-localized SNARE protein, in ER-mediated phagocytosis.
Hatsuzawa K, Tamura T, Hashimoto H, Hashimoto H, Yokoya S, Miura M, Nagaya H, Wada I
Molecular biology of the cell17(9)3964-77(2006 Sep)
Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development.
Hurle B, Lane K, Kenney J, Tarantino LM, Bucan M, Brownstein BH, Ornitz DM
Genomics77(3)189-99(2001 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Domain analyses of Sec22b revealed that the R-SNARE motif, a selective domain for forming a SNARE complex with syntaxin18 and/or D12, was responsible for the inhibition of phagocytosis.
Title: Sec22b is a negative regulator of phagocytosis in macrophages.
Syntaxin 18 is involved in endoplasmic reticulum (ER)-mediated phagocytosis, presumably by regulating the specific and direct fusion of the ER and plasma or phagosomal membranes.
Title: Involvement of syntaxin 18, an endoplasmic reticulum (ER)-localized SNARE protein, in ER-mediated phagocytosis.
The following Stx18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Stx18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu17056 | |
Clone ID Related Accession (Same CDS sequence) | NM_001289535.1 | |
Accession Version | NM_001289535.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 927bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-23 | |
Organism | Mus musculus(house mouse) | |
Product | syntaxin-18 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY037320.1, AK007700.1, AK169273.1 and AC115931.7. On Jan 23, 2014 this sequence version replaced XM_006504110.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK007700.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGTGG ACATCACACT GCTCTTCCGG GCTAGCGTCA AGACAGTGAA GACGCGGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001276464.1 |
CDS | 103..1029 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGGTGG ACATCACACT GCTCTTCCGG GCTAGCGTCA AGACAGTGAA GACGCGGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu35194 | |
Clone ID Related Accession (Same CDS sequence) | NM_001359398.1 , XM_006504111.3 | |
Accession Version | NM_001359398.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 843bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-09-29 | |
Organism | Mus musculus(house mouse) | |
Product | syntaxin-18 isoform 4 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC121811.2 and AC115931.7. On Jan 4, 2018 this sequence version replaced XM_006504111.3. Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.207204.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCAGCCG GGACGAGCTG TTCCGCAGAA GCCCTCGGCC CAAGGGAGAC TTCTCCAGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001346327.1 |
CDS | 197..1039 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCAGCCG GGACGAGCTG TTCCGCAGAA GCCCTCGGCC CAAGGGAGAC TTCTCCAGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu57950 | |
Clone ID Related Accession (Same CDS sequence) | NM_001289536.1 | |
Accession Version | NM_001289536.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 927bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-23 | |
Organism | Mus musculus(house mouse) | |
Product | syntaxin-18 isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC121811.2 and AC115931.7. Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC021362.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGTGG ACATCACACT GCTCTTCCGG GCTAGCGTCA AGACAGTGAA GACGCGGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001276465.1 |
CDS | 103..1029 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGGTGG ACATCACACT GCTCTTCCGG GCTAGCGTCA AGACAGTGAA GACGCGGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu58316 | |
Clone ID Related Accession (Same CDS sequence) | NM_026959.3 | |
Accession Version | NM_026959.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-23 | |
Organism | Mus musculus(house mouse) | |
Product | syntaxin-18 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY037320.1, AK169273.1 and AC115931.7. On Jan 23, 2014 this sequence version replaced NM_026959.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.14409.1, AK169273.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGTGG ACATCACACT GCTCTTCCGG GCTAGCGTCA AGACAGTGAA GACGCGGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_081235.2 |
CDS | 103..1107 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGGTGG ACATCACACT GCTCTTCCGG GCTAGCGTCA AGACAGTGAA GACGCGGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu35194 | |
Clone ID Related Accession (Same CDS sequence) | NM_001359398.1 , XM_006504111.3 | |
Accession Version | XM_006504111.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 843bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(House mouse) | |
Product | syntaxin-18 isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006504111.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGCCG GGACGAGCTG TTCCGCAGAA GCCCTCGGCC CAAGGGAGAC TTCTCCAGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006504174.1 |
CDS | 795..1637 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCAGCCG GGACGAGCTG TTCCGCAGAA GCCCTCGGCC CAAGGGAGAC TTCTCCAGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu35195 | |
Clone ID Related Accession (Same CDS sequence) | XM_006504112.3 , XM_006504112.4 | |
Accession Version | XM_006504112.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 762bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | syntaxin-18 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006504112.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCTGACT ATGGGAGGAT GACAGACACA GAGCGAGACC AGATAGACCA GGATGCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006504175.1 |
CDS | 170..931 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCTGACT ATGGGAGGAT GACAGACACA GAGCGAGACC AGATAGACCA GGATGCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu35195 | |
Clone ID Related Accession (Same CDS sequence) | XM_006504112.3 , XM_006504112.4 | |
Accession Version | XM_006504112.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 762bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | syntaxin-18 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006504112.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCTGACT ATGGGAGGAT GACAGACACA GAGCGAGACC AGATAGACCA GGATGCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006504175.1 |
CDS | 169..930 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCTGACT ATGGGAGGAT GACAGACACA GAGCGAGACC AGATAGACCA GGATGCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu89015 | |
Clone ID Related Accession (Same CDS sequence) | XM_030254807.1 | |
Accession Version | XM_030254807.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 765bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | syntaxin-18 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGCCG GGACGAGCTG TTCCGCAGAA GCCCTCGGCC CAAGGGAGAC TTCTCCAGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030110667.1 |
CDS | 2698..3462 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCAGCCG GGACGAGCTG TTCCGCAGAA GCCCTCGGCC CAAGGGAGAC TTCTCCAGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Sec22b is a negative regulator of phagocytosis in macrophages. |
Bovine papillomavirus type 1 infection is mediated by SNARE syntaxin 18. |
Involvement of syntaxin 18, an endoplasmic reticulum (ER)-localized SNARE protein, in ER-mediated phagocytosis. |
Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development. |