Gene Symbol | Dram1 |
Entrez Gene ID | 71712 |
Full Name | DNA-damage regulated autophagy modulator 1 |
Synonyms | 1200002N14Rik,Dram |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Dram1 cDNA ORF clone
gRNAs
Gene Symbol | Dram1 |
Entrez Gene ID | 71712 |
Full Name | DNA-damage regulated autophagy modulator 1 |
Synonyms | 1200002N14Rik,Dram |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_011243576.1 | XP_011241878.1 | DNA damage-regulated autophagy modulator protein 1 isoform X1 |
NM_027878.2 | NP_082154.2 | DNA damage-regulated autophagy modulator protein 1 |
XM_017314100.1 | XP_017169589.1 | DNA damage-regulated autophagy modulator protein 1 isoform X1 |
XM_011243576.2 | XP_011241878.1 | DNA damage-regulated autophagy modulator protein 1 isoform X1 |
DRAM1 | XP_001093215.1 | |
Mus musculus (house mouse) | Dram1 | NP_082154.2 |
Danio rerio (zebrafish) | dram1 | NP_001006049.1 |
Homo sapiens (human) | DRAM1 | NP_060840.2 |
Rattus norvegicus (Norway rat) | Dram1 | NP_001166898.1 |
Bos taurus (cattle) | DRAM1 | NP_001026937.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000808 | XP_311347.4 |
Pan troglodytes (chimpanzee) | DRAM1 | XP_001155589.1 |
Canis lupus familiaris (dog) | DRAM1 | XP_855009.1 |
Gallus gallus (chicken) | DRAM1 | XP_001234899.2 |
Drosophila melanogaster (fruit fly) | CG4025 | NP_569979.1 |
Xenopus tropicalis (tropical clawed frog) | dram1 | NP_001015869.1 |
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)
DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy.
Yu M, Jiang Y, Feng Q, Ouyang Y, Gan J
International journal of molecular sciences15(10)19253-64(2014 Oct)
Sin3a is essential for the genome integrity and viability of pluripotent cells.
McDonel P, Demmers J, Tan DW, Watt F, Hendrich BD
Developmental biology363(1)62-73(2012 Mar)
DRAM-1 encodes multiple isoforms that regulate autophagy.
Mah LY, O'Prey J, Baudot AD, Hoekstra A, Ryan KM
Autophagy8(1)18-28(2012 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
DRAM1 knockdown aggravates OGD/R-induced cell injury.
Title: DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy.
DRAM-1 encodes not just one mRNA, but a series of p53-inducible splice variants which are expressed at varying levels in multiple human and mouse cell lines.
Title: DRAM-1 encodes multiple isoforms that regulate autophagy.
The following Dram1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dram1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu44843 | |
Clone ID Related Accession (Same CDS sequence) | XM_011243576.1 , XM_017314100.1 , XM_011243576.2 | |
Accession Version | XM_011243576.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | DNA damage-regulated autophagy modulator protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATAAACT TCTCTGCATT TCTTGGCGCA GCTACGATGT ACACAAGATA CAAGATAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011241878.1 |
CDS | 254..796 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGATAAACT TCTCTGCATT TCTTGGCGCA GCTACGATGT ACACAAGATA CAAGATAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu44843 | |
Clone ID Related Accession (Same CDS sequence) | XM_011243576.1 , XM_017314100.1 , XM_011243576.2 | |
Accession Version | XM_017314100.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | DNA damage-regulated autophagy modulator protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATAAACT TCTCTGCATT TCTTGGCGCA GCTACGATGT ACACAAGATA CAAGATAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017169589.1 |
CDS | 137..679 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGATAAACT TCTCTGCATT TCTTGGCGCA GCTACGATGT ACACAAGATA CAAGATAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu04711 | |
Clone ID Related Accession (Same CDS sequence) | NM_027878.2 | |
Accession Version | NM_027878.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Mus musculus(house mouse) | |
Product | DNA damage-regulated autophagy modulator protein 1 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK004552.1. On Apr 6, 2007 this sequence version replaced NM_027878.1. ##Evidence-Data-START## Transcript exon combination :: AK004552.1, BY704777.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGCTGTGCT TCCTCAGGGG AATGGCTTTC GTCCCCTTCC TCCTGGTGAC TTGGTCGTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_082154.2 |
CDS | 154..870 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCTGTGCT TCCTCAGGGG AATGGCTTTC GTCCCCTTCC TCCTGGTGAC TTGGTCGTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu44843 | |
Clone ID Related Accession (Same CDS sequence) | XM_011243576.1 , XM_017314100.1 , XM_011243576.2 | |
Accession Version | XM_011243576.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | DNA damage-regulated autophagy modulator protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011243576.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATAAACT TCTCTGCATT TCTTGGCGCA GCTACGATGT ACACAAGATA CAAGATAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011241878.1 |
CDS | 230..772 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGATAAACT TCTCTGCATT TCTTGGCGCA GCTACGATGT ACACAAGATA CAAGATAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
High-throughput discovery of novel developmental phenotypes. |
DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy. |
Sin3a is essential for the genome integrity and viability of pluripotent cells. |
DRAM-1 encodes multiple isoforms that regulate autophagy. |