Gene Symbol | Nectin4 |
Entrez Gene ID | 71740 |
Full Name | nectin cell adhesion molecule 4 |
Synonyms | 1200017F15Rik,Prr4,Pvrl4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Nectin4 cDNA ORF clone
gRNAs
Gene Symbol | Nectin4 |
Entrez Gene ID | 71740 |
Full Name | nectin cell adhesion molecule 4 |
Synonyms | 1200017F15Rik,Prr4,Pvrl4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_027893.3 | NP_082169.2 | nectin-4 isoform a precursor |
NM_001122680.1 | NP_001116152.1 | nectin-4 isoform b precursor |
Canis lupus familiaris (dog) | PVRL4 | XP_005641000.1 |
Mus musculus (house mouse) | Pvrl4 | NP_082169.2 |
PVRL4 | XP_001117709.1 | |
Rattus norvegicus (Norway rat) | Pvrl4 | NP_001102546.1 |
Bos taurus (cattle) | PVRL4 | NP_001019665.1 |
Danio rerio (zebrafish) | LOC560512 | XP_005172277.1 |
Homo sapiens (human) | PVRL4 | NP_112178.2 |
Pan troglodytes (chimpanzee) | PVRL4 | XP_003308602.1 |
Danio rerio (zebrafish) | pvrl4 | XP_001334985.4 |
p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate.
Richardson R, Mitchell K, Hammond NL, Mollo MR, Kouwenhoven EN, Wyatt ND, Donaldson IJ, Zeef L, Burgis T, Blance R, van Heeringen SJ, Stunnenberg HG, Zhou H, Missero C, Romano RA, Sinha S, Dixon MJ, Dixon J
PLoS genetics13(6)e1006828(2017 Jun)
Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway.
Maruoka M, Kedashiro S, Ueda Y, Mizutani K, Takai Y
The Journal of biological chemistry292(17)6895-6909(2017 04)
A Novel Nectin-mediated Cell Adhesion Apparatus That Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development.
Kitayama M, Mizutani K, Maruoka M, Mandai K, Sakakibara S, Ueda Y, Komori T, Shimono Y, Takai Y
The Journal of biological chemistry291(11)5817-31(2016 Mar)
Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.
Gu Z, Imai F, Kim IJ, Fujita H, Katayama Ki, Mori K, Yoshihara Y, Yoshida Y
PloS one10(3)e0121550(2015)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
nectin-4 serves as a stimulatory co-receptor for the prolactin receptor by regulating the feedback inhibition of SOCS1 in the JAK2-STAT5a signaling pathway
Title: Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway.
Novel type of cell adhesion apparatus is mediated by Nectin-1 and Nectin-4. It's implicated in prolactin receptor signaling for mammary gland development.
Title: A Novel Nectin-mediated Cell Adhesion Apparatus That Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development.
Pvrl1 is a bona fide target gene of the transcription factor p63, whereas Pvrl4 regulation is linked to epidermal differentiation and is under Irf6
Title: p63-dependent and independent mechanisms of nectin-1 and nectin-4 regulation in the epidermis.
Mouse PVRL4 functions less efficiently as a receptor for measles virus than the human homologue.
Title: Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus.
Ectodermal dysplasia-syndactyly syndrome is the second known "nectinopathy" caused by mutations in a nectin adhesion molecule.
Title: Mutations in PVRL4, encoding cell adhesion molecule nectin-4, cause ectodermal dysplasia-syndactyly syndrome.
The following Nectin4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nectin4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu23587 | |
Clone ID Related Accession (Same CDS sequence) | NM_001122680.1 | |
Accession Version | NM_001122680.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1452bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-05 | |
Organism | Mus musculus(house mouse) | |
Product | nectin-4 isoform b precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY154786.1, AK004821.1, AK028479.1 and BX638135.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C-termini compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK004821.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCCCCTGT CCCTGGGAGC CGAGATGTGG GGCCCTGAAG CCTGGCTGCG GCTGTTGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001116152.1 |
CDS | 496..1947 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCCCCTGT CCCTGGGAGC CGAGATGTGG GGCCCTGAAG CCTGGCTGCG GCTGTTGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu23590 | |
Clone ID Related Accession (Same CDS sequence) | NM_027893.3 | |
Accession Version | NM_027893.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1527bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Mus musculus(house mouse) | |
Product | nectin-4 isoform a precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY154786.1, AK004821.1, AK028479.1 and BX638135.1. On Mar 15, 2008 this sequence version replaced NM_027893.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK028479.1, BC024948.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCCCCTGT CCCTGGGAGC CGAGATGTGG GGCCCTGAAG CCTGGCTGCG GCTGTTGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_082169.2 |
CDS | 496..2022 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCCCCTGT CCCTGGGAGC CGAGATGTGG GGCCCTGAAG CCTGGCTGCG GCTGTTGTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate. |
Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway. |
A Novel Nectin-mediated Cell Adhesion Apparatus That Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development. |
Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. |