Gene Symbol | Cul2 |
Entrez Gene ID | 71745 |
Full Name | cullin 2 |
Synonyms | 1300003D18Rik,4932411N15Rik,AI327301,mKIAA4106 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Cul2 cDNA ORF clone
gRNAs
Gene Symbol | Cul2 |
Entrez Gene ID | 71745 |
Full Name | cullin 2 |
Synonyms | 1300003D18Rik,4932411N15Rik,AI327301,mKIAA4106 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006526275.3 | XP_006526338.1 | cullin-2 isoform X1 |
XM_006526274.3 | XP_006526337.1 | cullin-2 isoform X1 |
XM_006526275.4 | XP_006526338.1 | cullin-2 isoform X1 |
NM_001360829.1 | NP_001347758.1 | cullin-2 |
NM_029402.3 | NP_083678.2 | cullin-2 |
XM_030250610.1 | XP_030106470.1 | cullin-2 isoform X1 |
Bos taurus (cattle) | CUL2 | NP_001070377.1 |
Homo sapiens (human) | CUL2 | NP_001185707.1 |
Canis lupus familiaris (dog) | CUL2 | XP_005616994.1 |
Rattus norvegicus (Norway rat) | Cul2 | NP_001101887.1 |
Gallus gallus (chicken) | CUL2 | NP_001026141.1 |
CUL2 | XP_001087735.2 | |
Danio rerio (zebrafish) | cul2 | XP_002666627.1 |
Drosophila melanogaster (fruit fly) | Cul-2 | NP_724352.1 |
Pan troglodytes (chimpanzee) | CUL2 | XP_003312567.1 |
Mus musculus (house mouse) | Cul2 | NP_083678.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP003605 | XP_313365.4 |
Caenorhabditis elegans (roundworm) | cul-2 | NP_499825.3 |
Xenopus tropicalis (tropical clawed frog) | cul2 | XP_002935209.2 |
Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses.
Curtis VF, Ehrentraut SF, Campbell EL, Glover LE, Bayless A, Kelly CJ, Kominsky DJ, Colgan SP
FASEB journal : official publication of the Federation of American Societies for Experimental Biology29(1)208-15(2015 Jan)
Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors.
Sim? S, Cooper JA
Developmental cell27(4)399-411(2013 Nov)
The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7.
Tron AE, Arai T, Duda DM, Kuwabara H, Olszewski JL, Fujiwara Y, Bahamon BN, Signoretti S, Schulman BA, DeCaprio JA
Molecular cell46(1)67-78(2012 Apr)
Huntingtin interacting proteins are genetic modifiers of neurodegeneration.
Kaltenbach LS, Romero E, Becklin RR, Chettier R, Bell R, Phansalkar A, Strand A, Torcassi C, Savage J, Hurlburt A, Cha GH, Ukani L, Chepanoske CL, Zhen Y, Sahasrabudhe S, Olson J, Kurschner C, Ellerby LM, Peltier JM, Botas J, Hughes RE
PLoS genetics3(5)e82(2007 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following Cul2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cul2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu21398 | |
Clone ID Related Accession (Same CDS sequence) | XM_006526275.3 , XM_006526274.3 , XM_006526275.4 , NM_001360829.1 , NM_029402.3 , XM_030250610.1 | |
Accession Version | NM_001360829.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2238bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-23 | |
Organism | Mus musculus(house mouse) | |
Product | cullin-2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC124336.10. On Feb 15, 2018 this sequence version replaced XM_006526274.3. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.163636.1, SRR1660817.28676.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTCTTTAA AACCAAGAGT AGTGGATTTT GATGAGACAT GGAACAAACT CCTAACTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001347758.1 |
CDS | 226..2463 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCTTTAA AACCAAGAGT AGTGGATTTT GATGAGACAT GGAACAAACT CCTAACTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu21398 | |
Clone ID Related Accession (Same CDS sequence) | XM_006526275.3 , XM_006526274.3 , XM_006526275.4 , NM_001360829.1 , NM_029402.3 , XM_030250610.1 | |
Accession Version | NM_029402.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2238bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-26 | |
Organism | Mus musculus(house mouse) | |
Product | cullin-2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK004875.2, AK144693.1, AK162910.1 and AC124336.10. On Mar 15, 2008 this sequence version replaced NM_029402.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660811.216382.1, AK220287.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTCTTTAA AACCAAGAGT AGTGGATTTT GATGAGACAT GGAACAAACT CCTAACTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_083678.2 |
CDS | 196..2433 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCTTTAA AACCAAGAGT AGTGGATTTT GATGAGACAT GGAACAAACT CCTAACTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu21398 | |
Clone ID Related Accession (Same CDS sequence) | XM_006526275.3 , XM_006526274.3 , XM_006526275.4 , NM_001360829.1 , NM_029402.3 , XM_030250610.1 | |
Accession Version | XM_006526275.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2238bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | cullin-2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000084.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006526275.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCTTTAA AACCAAGAGT AGTGGATTTT GATGAGACAT GGAACAAACT CCTAACTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006526338.1 |
CDS | 249..2486 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCTTTAA AACCAAGAGT AGTGGATTTT GATGAGACAT GGAACAAACT CCTAACTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu21398 | |
Clone ID Related Accession (Same CDS sequence) | XM_006526275.3 , XM_006526274.3 , XM_006526275.4 , NM_001360829.1 , NM_029402.3 , XM_030250610.1 | |
Accession Version | XM_006526274.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2238bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | cullin-2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000084.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006526274.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCTTTAA AACCAAGAGT AGTGGATTTT GATGAGACAT GGAACAAACT CCTAACTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006526337.1 |
CDS | 226..2463 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCTTTAA AACCAAGAGT AGTGGATTTT GATGAGACAT GGAACAAACT CCTAACTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu21398 | |
Clone ID Related Accession (Same CDS sequence) | XM_006526275.3 , XM_006526274.3 , XM_006526275.4 , NM_001360829.1 , NM_029402.3 , XM_030250610.1 | |
Accession Version | XM_006526275.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2238bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | cullin-2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000084.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006526275.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCTTTAA AACCAAGAGT AGTGGATTTT GATGAGACAT GGAACAAACT CCTAACTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006526338.1 |
CDS | 472..2709 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCTTTAA AACCAAGAGT AGTGGATTTT GATGAGACAT GGAACAAACT CCTAACTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu21398 | |
Clone ID Related Accession (Same CDS sequence) | XM_006526275.3 , XM_006526274.3 , XM_006526275.4 , NM_001360829.1 , NM_029402.3 , XM_030250610.1 | |
Accession Version | XM_030250610.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2238bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | cullin-2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000084.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCTTTAA AACCAAGAGT AGTGGATTTT GATGAGACAT GGAACAAACT CCTAACTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030106470.1 |
CDS | 474..2711 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCTTTAA AACCAAGAGT AGTGGATTTT GATGAGACAT GGAACAAACT CCTAACTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses. |
Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors. |
The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7. |
Huntingtin interacting proteins are genetic modifiers of neurodegeneration. |