Gene Symbol | Pygo1 |
Entrez Gene ID | 72135 |
Full Name | pygopus 1 |
Synonyms | 2600014C22Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Pygo1 cDNA ORF clone
Gene Symbol | Pygo1 |
Entrez Gene ID | 72135 |
Full Name | pygopus 1 |
Synonyms | 2600014C22Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_028116.3 | NP_082392.1 | pygopus homolog 1 |
NM_028116.2 | NP_082392.1 | pygopus homolog 1 |
Danio rerio (zebrafish) | pygo1 | NP_001107109.1 |
Xenopus tropicalis (tropical clawed frog) | pygo1 | XP_002942500.2 |
PYGO1 | XP_001090005.2 | |
Canis lupus familiaris (dog) | PYGO1 | XP_005638747.1 |
Rattus norvegicus (Norway rat) | Pygo1 | NP_001178046.1 |
Homo sapiens (human) | PYGO1 | NP_056432.1 |
Bos taurus (cattle) | PYGO1 | XP_002690938.1 |
Pan troglodytes (chimpanzee) | PYGO1 | XP_523199.1 |
Mus musculus (house mouse) | Pygo1 | NP_082392.1 |
Gallus gallus (chicken) | PYGO1 | NP_001019862.1 |
A cytoplasmic role of Wnt/?-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.
Cant? C, Pagella P, Shajiei TD, Zimmerli D, Valenta T, Hausmann G, Basler K, Mitsiadis TA
Science signaling10(465)(2017 Feb)
Pax6-dependent, but ?-catenin-independent, function of Bcl9 proteins in mouse lens development.
Cant? C, Zimmerli D, Hausmann G, Valenta T, Moor A, Aguet M, Basler K
Genes & development28(17)1879-84(2014 Sep)
Pygo2 regulates ?-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia.
Sun P, Watanabe K, Fallahi M, Lee B, Afetian ME, Rheaume C, Wu D, Horsley V, Dai X
Proceedings of the National Academy of Sciences of the United States of America111(28)10215-20(2014 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Transcriptional cofactors Bcl9, Bcl9l and Pygo1/2 act independently of beta-catenin to ensure proper enamel formation.
Title: A cytoplasmic role of Wnt/?-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.
even in the absence of the potentially redundant Pygo1, Pygo2 does not require the H3K4me2/3 binding activity to sustain its function during mouse development
Title: The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription.
These results suggest that the Pygopus1 plant homeodomain (PHD) dimerization is functionally important for Lgs/Bcl9 recognition as well as for the regulation of the Wnt/beta-catenin signaling pathway.
Title: Crystal structure analysis of the PHD domain of the transcription co-activator Pygopus.
In mammals, the Pygo1/Pygo2 genes are not absolutely required for canonical Wnt signaling in most developing systems, but rather function as quantitative transducers, or modulators, of Wnt signal intensity
Title: Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development.
The following Pygo1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pygo1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu20157 | |
Clone ID Related Accession (Same CDS sequence) | NM_028116.3 , NM_028116.2 | |
Accession Version | NM_028116.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-31 | |
Organism | Mus musculus(house mouse) | |
Product | pygopus homolog 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC158997.2. On Jan 25, 2019 this sequence version replaced NM_028116.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK011208.1, BC116631.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTCAGCGG AACAGGACAA GGAGCCCATC GCGCTGAAGA GAGTTAGAGG TGGTGACAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_082392.1 |
CDS | 268..1521 |
Translation |
Target ORF information:
Target ORF information:
|
NM_028116.3 |
1 | ATGTCAGCGG AACAGGACAA GGAGCCCATC GCGCTGAAGA GAGTTAGAGG TGGTGACAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu20157 | |
Clone ID Related Accession (Same CDS sequence) | NM_028116.3 , NM_028116.2 | |
Accession Version | NM_028116.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-08-10 | |
Organism | Mus musculus(house mouse) | |
Product | pygopus homolog 1 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK011208.1. On Oct 4, 2009 this sequence version replaced NM_028116.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK011208.1, BC116630.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTCAGCGG AACAGGACAA GGAGCCCATC GCGCTGAAGA GAGTTAGAGG TGGTGACAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_082392.1 |
CDS | 263..1516 |
Translation |
Target ORF information:
Target ORF information:
|
NM_028116.2 |
1 | ATGTCAGCGG AACAGGACAA GGAGCCCATC GCGCTGAAGA GAGTTAGAGG TGGTGACAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
A cytoplasmic role of Wnt/?-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation. |
Pax6-dependent, but ?-catenin-independent, function of Bcl9 proteins in mouse lens development. |
Pygo2 regulates ?-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia. |