Gene Symbol | Lonp1 |
Entrez Gene ID | 74142 |
Full Name | lon peptidase 1, mitochondrial |
Synonyms | 1200017E13Rik,LON,Prss15 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Lonp1 cDNA ORF clone
Gene Symbol | Lonp1 |
Entrez Gene ID | 74142 |
Full Name | lon peptidase 1, mitochondrial |
Synonyms | 1200017E13Rik,LON,Prss15 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_028782.2 | NP_083058.2 | lon protease homolog, mitochondrial precursor |
Pan troglodytes (chimpanzee) | LONP1 | XP_001143873.1 |
Canis lupus familiaris (dog) | LONP1 | XP_854391.2 |
Mus musculus (house mouse) | Lonp1 | NP_083058.2 |
Rattus norvegicus (Norway rat) | Lonp1 | NP_596895.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010451 | XP_311497.4 |
Caenorhabditis elegans (roundworm) | C34B2.6 | NP_492796.1 |
Homo sapiens (human) | LONP1 | NP_004784.2 |
Bos taurus (cattle) | LONP1 | NP_001015569.2 |
Danio rerio (zebrafish) | lonp1 | XP_691712.4 |
Saccharomyces cerevisiae (baker's yeast) | PIM1 | NP_009531.1 |
Kluyveromyces lactis | KLLA0E10407g | XP_454420.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_11141 | XP_003714792.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100492505 | XP_002938599.1 |
LONP1 | XP_001088663.2 | |
Gallus gallus (chicken) | LONP1 | XP_001232112.2 |
Oryza sativa (rice) | Os07g0689300 | NP_001175344.1 |
Schizosaccharomyces pombe (fission yeast) | lon1 | NP_593035.1 |
Drosophila melanogaster (fruit fly) | Lon | NP_649133.1 |
Neurospora crassa | NCU05261 | XP_961826.1 |
Arabidopsis thaliana (thale cress) | LON1 | NP_568490.3 |
Dysfunction of mitochondrial Lon protease and identification of oxidized protein in mouse brain following exposure to MPTP: Implications for Parkinson disease.
Bulteau AL, Mena NP, Auch?re F, Lee I, Prigent A, Lobsiger CS, Camadro JM, Hirsch EC
Free radical biology & medicine108236-246(2017 Jul)
Mitochondrial LON protease-dependent degradation of cytochrome c oxidase subunits under hypoxia and myocardial ischemia.
Sepuri NBV, Angireddy R, Srinivasan S, Guha M, Spear J, Lu B, Anandatheerthavarada HK, Suzuki CK, Avadhani NG
Biochimica et biophysica acta1858(7)519-528(2017 07)
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K
PLoS genetics12(9)e1006355(2016 Sep)
ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis.
Luo B, Wang M, Hou N, Hu X, Jia G, Qin X, Zuo X, Liu Y, Luo K, Song W, Wang K, Pang M
Neoplasia (New York, N.Y.)18(4)242-52(2016 04)
HtrA2/Omi influences the stability of LON protease 1 and prohibitin, proteins involved in mitochondrial homeostasis.
Goo HG, Rhim H, Kang S
Experimental cell research328(2)456-65(2014 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Lon preferentially degrades the phosphorylated subunits of CcO and plays a role in the regulation of CcO activity in hypoxia and ischemia/reperfusion injury.
Title: Mitochondrial LON protease-dependent degradation of cytochrome c oxidase subunits under hypoxia and myocardial ischemia.
Lon protease (Lonp1), which is a key inductive of mitochondrial unfolded protein response (UPR(mt)) and is required to maintain the mitochondrial quality, was greatly induced in H. pylori infected gastric epithelial cells.
Title: ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis.
LONP1 knockdown inhibits cellular proliferation and tumor and metastasis formation, whereas its overexpression increases tumorigenesis.
Title: ATP-dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity.
The correlative effect of Lon and ClpP upregulation on loss of mitochondrial Fe-S proteins during the progression of the disease may suggest that Fe-S proteins are potential targets of Lon and ClpP proteases in FRDA.
Title: Frataxin deficiency causes upregulation of mitochondrial Lon and ClpP proteases and severe loss of mitochondrial Fe-S proteins.
Modulation of Lon protease activity during aging and oxidative stress.
Title: Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress.
The following Lonp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lonp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu18824 | |
Clone ID Related Accession (Same CDS sequence) | NM_028782.2 | |
Accession Version | NM_028782.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2850bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-02 | |
Organism | Mus musculus(house mouse) | |
Product | lon protease homolog, mitochondrial precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY247676.1, AK160071.1 and CK428749.1. On Oct 13, 2006 this sequence version replaced NM_028782.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK004820.1, AK131910.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGCGA GCACAGGCTA CGTGCGGCTC TGGGCCGCTG CGCGGTGCTG GGTTCTGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_083058.2 |
CDS | 31..2880 |
Translation |
Target ORF information:
Target ORF information:
|
NM_028782.2 |
1 | ATGGCGGCGA GCACAGGCTA CGTGCGGCTC TGGGCCGCTG CGCGGTGCTG GGTTCTGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Dysfunction of mitochondrial Lon protease and identification of oxidized protein in mouse brain following exposure to MPTP: Implications for Parkinson disease. |
Mitochondrial LON protease-dependent degradation of cytochrome c oxidase subunits under hypoxia and myocardial ischemia. |
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. |
ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis. |
HtrA2/Omi influences the stability of LON protease 1 and prohibitin, proteins involved in mitochondrial homeostasis. |