Gene Symbol | Dhcr24 |
Entrez Gene ID | 74754 |
Full Name | 24-dehydrocholesterol reductase |
Synonyms | 2310076D10Rik,5830417J06Rik,mKIAA0018 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Dhcr24 cDNA ORF clone
Gene Symbol | Dhcr24 |
Entrez Gene ID | 74754 |
Full Name | 24-dehydrocholesterol reductase |
Synonyms | 2310076D10Rik,5830417J06Rik,mKIAA0018 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_053272.2 | NP_444502.2 | delta(24)-sterol reductase precursor |
Canis lupus familiaris (dog) | DHCR24 | XP_546693.4 |
Mus musculus (house mouse) | Dhcr24 | NP_444502.2 |
Gallus gallus (chicken) | DHCR24 | NP_001026459.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_16834 | XP_003712445.1 |
Homo sapiens (human) | DHCR24 | NP_055577.1 |
Xenopus tropicalis (tropical clawed frog) | dhcr24 | NP_001016800.1 |
DHCR24 | XP_001108186.2 | |
Rattus norvegicus (Norway rat) | Dhcr24 | NP_001073617.1 |
Arabidopsis thaliana (thale cress) | DWF1 | NP_850616.1 |
Pan troglodytes (chimpanzee) | DHCR24 | XP_001153930.1 |
Bos taurus (cattle) | DHCR24 | NP_001096746.1 |
Danio rerio (zebrafish) | dhcr24 | NP_001008645.1 |
Caenorhabditis elegans (roundworm) | F52H2.6 | NP_508463.1 |
Oryza sativa (rice) | Os10g0397400 | NP_001064534.1 |
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K
PLoS genetics12(9)e1006355(2016 Sep)
Seladin-1/DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke.
Hern?ndez-Jim?nez M, Mart?nez-L?pez D, Gaband?-Rodr?guez E, Mart?n-Segura A, Lizasoain I, Ledesma MD, Dotti CG, Moro MA
Stroke47(1)206-13(2016 Jan)
A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.
?i?ecio?lu M, Budak H, Geffers L, ?ankaya M, ?iftci M, Thaller C, Eichele G, K?frevio?lu ??, ?zdemir H
Journal of lipid research56(8)1551-9(2015 Aug)
Altered expression of 3-betahydroxysterol delta-24-reductase/selective Alzheimer's disease indicator-1 gene in Huntington's disease models.
Samara A, Galbiati M, Luciani P, Deledda C, Messi E, Peri A, Maggi R
Journal of endocrinological investigation37(8)729-37(2014 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
When DHCR24 is genetically deleted there is a decreased association of EAAT2 with lipid rafts after ischemia.
Title: Seladin-1/DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke.
Data (including data from transgenic mice) suggest that expression of Dhcr24 is down-regulated in brain tissues of mice exhibiting symptoms modeling advanced Huntington's disease.
Title: Altered expression of 3-betahydroxysterol delta-24-reductase/selective Alzheimer's disease indicator-1 gene in Huntington's disease models.
RE1-silencing transcription factor acts because it is bound in close proximity to SREBP, thus amplifying its ability to upregulate 24-dehydrocholesterol reductase
Title: Desmosterol in brain is elevated because DHCR24 needs REST for Robust Expression but REST is poorly expressed.
concluded that TH up-regulates Seladin-1 gene expression at the transcriptional level and LXR-alpha maintains the gene expression
Title: Crosstalk between thyroid hormone receptor and liver X receptor in the regulation of selective Alzheimer's disease indicator-1 gene expression.
This is the first demonstration that DHCR24 plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species.
Title: 3?-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species.
The following Dhcr24 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dhcr24 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu09486 | |
Clone ID Related Accession (Same CDS sequence) | NM_053272.2 | |
Accession Version | NM_053272.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1551bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-06-03 | |
Organism | Mus musculus(house mouse) | |
Product | delta(24)-sterol reductase precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX511043.7 and AL929585.11. On Sep 7, 2006 this sequence version replaced NM_053272.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK129036.1, BC019797.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGCCCG CCGTGTCGCT GGCCGTGTGC GCGCTGCTCT TTCTGCTCTG GGTGCGAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_444502.2 |
CDS | 130..1680 |
Translation |
Target ORF information:
Target ORF information:
|
NM_053272.2 |
1 | ATGGAGCCCG CCGTGTCGCT GGCCGTGTGC GCGCTGCTCT TTCTGCTCTG GGTGCGAGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. |
Seladin-1/DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke. |
A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo. |
Altered expression of 3-betahydroxysterol delta-24-reductase/selective Alzheimer's disease indicator-1 gene in Huntington's disease models. |