Gene Symbol | Ppa2 |
Entrez Gene ID | 74776 |
Full Name | pyrophosphatase (inorganic) 2 |
Synonyms | 1110013G13Rik,Sid6306 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Ppa2 cDNA ORF clone
gRNAs
Gene Symbol | Ppa2 |
Entrez Gene ID | 74776 |
Full Name | pyrophosphatase (inorganic) 2 |
Synonyms | 1110013G13Rik,Sid6306 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006502216.3 | XP_006502279.1 | inorganic pyrophosphatase 2, mitochondrial isoform X1 |
XM_006502216.4 | XP_006502279.1 | inorganic pyrophosphatase 2, mitochondrial isoform X1 |
XM_030252858.1 | XP_030108718.1 | inorganic pyrophosphatase 2, mitochondrial isoform X4 |
NM_001293641.1 | NP_001280570.1 | inorganic pyrophosphatase 2, mitochondrial isoform 2 precursor |
XM_006502217.3 | XP_006502280.1 | inorganic pyrophosphatase 2, mitochondrial isoform X2 |
XM_030252857.1 | XP_030108717.1 | inorganic pyrophosphatase 2, mitochondrial isoform X2 |
XM_006502217.4 | XP_006502280.1 | inorganic pyrophosphatase 2, mitochondrial isoform X3 |
NM_146141.2 | NP_666253.1 | inorganic pyrophosphatase 2, mitochondrial isoform 1 precursor |
Homo sapiens (human) | PPA2 | NP_789845.1 |
Rattus norvegicus (Norway rat) | Ppa2 | NP_001129343.1 |
Pan troglodytes (chimpanzee) | PPA2 | XP_517378.2 |
Canis lupus familiaris (dog) | PPA2 | XP_535679.3 |
Xenopus tropicalis (tropical clawed frog) | ppa1 | NP_001017130.1 |
PPA2 | XP_001082969.2 | |
Mus musculus (house mouse) | Ppa2 | NP_666253.1 |
Danio rerio (zebrafish) | ppa1a | NP_957027.1 |
Bos taurus (cattle) | PPA2 | NP_001069864.1 |
Gallus gallus (chicken) | PPA2 | XP_420502.3 |
Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model.
Qi Z, Yang W, Liu Y, Cui T, Gao H, Duan C, Lu L, Zhao C, Zhao H, Yang H
Neurochemistry international59(5)572-81(2011 Oct)
Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis.
Xing Y, Igarashi H, Wang X, Sakaguchi N
The Journal of experimental medicine202(5)707-19(2005 Sep)
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M
Cell115(5)629-40(2003 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
downregulation of protein phosphatase 2 activity in PINK1-silenced cells promotes the protective effect of autophagy through phosphorylation of Bcl-2
Title: Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model.
The following Ppa2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppa2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu32373 | |
Clone ID Related Accession (Same CDS sequence) | XM_006502217.3 , XM_006502217.4 | |
Accession Version | XM_006502217.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | inorganic pyrophosphatase 2, mitochondrial isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006502217.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACTCTTC TGGAAATGCC ACCCACTTTC AGATGGGATT ACCCAGACAA ATTAGAGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006502280.1 |
CDS | 28..669 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGACTCTTC TGGAAATGCC ACCCACTTTC AGATGGGATT ACCCAGACAA ATTAGAGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu23434 | |
Clone ID Related Accession (Same CDS sequence) | NM_146141.2 | |
Accession Version | NM_146141.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-21 | |
Organism | Mus musculus(house mouse) | |
Product | inorganic pyrophosphatase 2, mitochondrial isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AA444705.1, AK143475.1 and AK090384.1. On Jun 11, 2014 this sequence version replaced NM_146141.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC011417.1, SRR1660811.332823.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCGCGCGC TGCTGCCGCT GCTGAGCGTC GGCCGAGGGT GGCGCGTGGG GGCCGCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_666253.1 |
CDS | 31..1023 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCGCGCGC TGCTGCCGCT GCTGAGCGTC GGCCGAGGGT GGCGCGTGGG GGCCGCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu32372 | |
Clone ID Related Accession (Same CDS sequence) | XM_006502216.3 , XM_006502216.4 | |
Accession Version | XM_006502216.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 819bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | inorganic pyrophosphatase 2, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006502216.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGCGCGC TGCTGCCGCT GCTGAGCGTC GGCCGAGGGT GGCGCGTGGG GGCCGCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006502279.1 |
CDS | 82..900 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCGCGCGC TGCTGCCGCT GCTGAGCGTC GGCCGAGGGT GGCGCGTGGG GGCCGCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu32373 | |
Clone ID Related Accession (Same CDS sequence) | XM_006502217.3 , XM_006502217.4 | |
Accession Version | XM_006502217.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | inorganic pyrophosphatase 2, mitochondrial isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006502217.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACTCTTC TGGAAATGCC ACCCACTTTC AGATGGGATT ACCCAGACAA ATTAGAGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006502280.1 |
CDS | 80..721 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGACTCTTC TGGAAATGCC ACCCACTTTC AGATGGGATT ACCCAGACAA ATTAGAGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu88306 | |
Clone ID Related Accession (Same CDS sequence) | XM_030252857.1 | |
Accession Version | XM_030252857.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | inorganic pyrophosphatase 2, mitochondrial isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGCGCGC TGCTGCCGCT GCTGAGCGTC GGCCGAGGGT GGCGCGTGGG GGCCGCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030108717.1 |
CDS | 82..897 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCGCGCGC TGCTGCCGCT GCTGAGCGTC GGCCGAGGGT GGCGCGTGGG GGCCGCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu88307 | |
Clone ID Related Accession (Same CDS sequence) | XM_030252858.1 | |
Accession Version | XM_030252858.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 639bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | inorganic pyrophosphatase 2, mitochondrial isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACTCTTC TGGAAATGCC ACCCACTTTC AGATGGGATT ACCCAGACAA ATTAGAGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030108718.1 |
CDS | 75..713 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGACTCTTC TGGAAATGCC ACCCACTTTC AGATGGGATT ACCCAGACAA ATTAGAGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu23435 | |
Clone ID Related Accession (Same CDS sequence) | NM_001293641.1 | |
Accession Version | NM_001293641.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-21 | |
Organism | Mus musculus(house mouse) | |
Product | inorganic pyrophosphatase 2, mitochondrial isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AA444705.1, AK090384.1 and AC125040.4. On Jun 11, 2014 this sequence version replaced XM_006502214.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK090384.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCGCGCGC TGCTGCCGCT GCTGAGCGTC GGCCGAGGGT GGCGCGTGGG GGCCGCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001280570.1 |
CDS | 31..1020 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCGCGCGC TGCTGCCGCT GCTGAGCGTC GGCCGAGGGT GGCGCGTGGG GGCCGCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu32372 | |
Clone ID Related Accession (Same CDS sequence) | XM_006502216.3 , XM_006502216.4 | |
Accession Version | XM_006502216.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 819bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | inorganic pyrophosphatase 2, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006502216.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGCGCGC TGCTGCCGCT GCTGAGCGTC GGCCGAGGGT GGCGCGTGGG GGCCGCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006502279.1 |
CDS | 71..889 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCGCGCGC TGCTGCCGCT GCTGAGCGTC GGCCGAGGGT GGCGCGTGGG GGCCGCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model. |
Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis. |
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. |