Gene Symbol | Abcb5 |
Entrez Gene ID | 77706 |
Full Name | ATP-binding cassette, sub-family B (MDR/TAP), member 5 |
Synonyms | 9230106F14Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Abcb5 cDNA ORF clone
Gene Symbol | Abcb5 |
Entrez Gene ID | 77706 |
Full Name | ATP-binding cassette, sub-family B (MDR/TAP), member 5 |
Synonyms | 9230106F14Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_017315245.1 | XP_017170734.1 | ATP-binding cassette sub-family B member 5 isoform X2 |
XM_017315245.2 | XP_017170734.1 | ATP-binding cassette sub-family B member 5 isoform X2 |
XM_006516370.3 | XP_006516433.1 | ATP-binding cassette sub-family B member 5 isoform X1 |
NM_029961.2 | NP_084237.1 | ATP-binding cassette sub-family B member 5 |
Pan troglodytes (chimpanzee) | ABCB5 | XP_001152831.2 |
LOC712883 | XP_001102010.2 | |
Bos taurus (cattle) | LOC536724 | XP_002686751.1 |
Mus musculus (house mouse) | Abcb5 | NP_084237.1 |
Rattus norvegicus (Norway rat) | Abcb5 | XP_006240775.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_15334 | XP_003714927.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_14400 | XP_003713269.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100492825 | XP_002933334.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100485969 | XP_002932444.2 |
Arabidopsis thaliana (thale cress) | PGP13 | NP_174115.1 |
Xenopus tropicalis (tropical clawed frog) | abcb5 | NP_989254.1 |
Canis lupus familiaris (dog) | ABCB5 | XP_005628664.1 |
Arabidopsis thaliana (thale cress) | PGP14 | NP_174122.1 |
Homo sapiens (human) | ABCB5 | NP_001157413.1 |
Upregulation of cellular glutathione levels in human ABCB5- and murine Abcb5-transfected cells.
Kondo S, Hongama K, Hanaya K, Yoshida R, Kawanobe T, Katayama K, Noguchi K, Sugimoto Y
BMC pharmacology & toxicology1637(2015 Dec)
The role of Abcb5 alleles in susceptibility to haloperidol-induced toxicity in mice and humans.
Zheng M, Zhang H, Dill DL, Clark JD, Tu S, Yablonovitch AL, Tan MH, Zhang R, Rujescu D, Wu M, Tessarollo L, Vieira W, Gottesman MM, Deng S, Eberlin LS, Zare RN, Billard JM, Gillet JP, Li JB, Peltz G
PLoS medicine12(2)e1001782(2015 Feb)
ABCB5 is a limbal stem cell gene required for corneal development and repair.
Ksander BR, Kolovou PE, Wilson BJ, Saab KR, Guo Q, Ma J, McGuire SP, Gregory MS, Vincent WJ, Perez VL, Cruz-Guilloty F, Kao WW, Call MK, Tucker BA, Zhan Q, Murphy GF, Lathrop KL, Alt C, Mortensen LJ, Lin CP, Zieske JD, Frank MH, Frank NY
Nature511(7509)353-7(2014 Jul)
The helicase HAGE expressed by malignant melanoma-initiating cells is required for tumor cell proliferation in vivo.
Linley AJ, Mathieu MG, Miles AK, Rees RC, McArdle SE, Regad T
The Journal of biological chemistry287(17)13633-43(2012 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Results suggest that ATP binding cassette subfamily B member 5 ABCB5/Abcb5 upregulates cellular glutathione levels to protect cells from various poisons.
Title: Upregulation of cellular glutathione levels in human ABCB5- and murine Abcb5-transfected cells.
ABCB5 alleles alter susceptibility to haloperidol-induced toxicity (HIT) in mouse and humans.
Title: The role of Abcb5 alleles in susceptibility to haloperidol-induced toxicity in mice and humans.
ATP-binding cassette, sub-family B, member 5 (ABCB5) marks limbal stem cells (LSCs) and is required for LSC maintenance, corneal development and repair
Title: ABCB5 is a limbal stem cell gene required for corneal development and repair.
the helicase HAGE is required for ABCB5+ MMIC-dependent tumor growth through promoting RAS protein expression
Title: The helicase HAGE expressed by malignant melanoma-initiating cells is required for tumor cell proliferation in vivo.
Expression of Abcb5.ts (testis-specific) (AY766239), a transporter consisting of 1255 amino acids and comprising two transmembrane and nucleotide binding domains, is restricted to testis tissue. In contrast, Abcb5.e (AY766238) is ubiquitously expressed.
Title: ABCB5 gene amplification in human leukemia cells.
The following Abcb5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Abcb5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu78342 | |
Clone ID Related Accession (Same CDS sequence) | XM_017315245.1 , XM_017315245.2 | |
Accession Version | XM_017315245.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2832bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | ATP-binding cassette sub-family B member 5 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAAATT CTGAAAGAAC CAACGGGTTG CAAGAAACTA ATCAGAGATA TGGACCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017170734.1 |
CDS | 211..3042 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017315245.1 |
1 | ATGGCAAATT CTGAAAGAAC CAACGGGTTG CAAGAAACTA ATCAGAGATA TGGACCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu78342 | |
Clone ID Related Accession (Same CDS sequence) | XM_017315245.1 , XM_017315245.2 | |
Accession Version | XM_017315245.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2832bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | ATP-binding cassette sub-family B member 5 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017315245.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAAATT CTGAAAGAAC CAACGGGTTG CAAGAAACTA ATCAGAGATA TGGACCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017170734.1 |
CDS | 98..2929 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017315245.2 |
1 | ATGGCAAATT CTGAAAGAAC CAACGGGTTG CAAGAAACTA ATCAGAGATA TGGACCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu07746 | |
Clone ID Related Accession (Same CDS sequence) | NM_029961.2 | |
Accession Version | NM_029961.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3768bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | ATP-binding cassette sub-family B member 5 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK020318.1, AC126277.3, AK139832.1 and AC131717.3. On Aug 11, 2009 this sequence version replaced NM_029961.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AY766239.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCAAATT CTGAAAGAAC CAACGGGTTG CAAGAAACTA ATCAGAGATA TGGACCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_084237.1 |
CDS | 85..3852 |
Translation |
Target ORF information:
Target ORF information:
|
NM_029961.2 |
1 | ATGGCAAATT CTGAAAGAAC CAACGGGTTG CAAGAAACTA ATCAGAGATA TGGACCTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu48194 | |
Clone ID Related Accession (Same CDS sequence) | XM_006516370.3 | |
Accession Version | XM_006516370.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3732bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | ATP-binding cassette sub-family B member 5 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006516370.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGTTTCTG GGACCAGACC TCTGCAAGAA CAAGTGCCTA AAGTGGGAAA TCAAGCTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006516433.1 |
CDS | 42..3773 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006516370.3 |
1 | ATGGTTTCTG GGACCAGACC TCTGCAAGAA CAAGTGCCTA AAGTGGGAAA TCAAGCTGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Upregulation of cellular glutathione levels in human ABCB5- and murine Abcb5-transfected cells. |
The role of Abcb5 alleles in susceptibility to haloperidol-induced toxicity in mice and humans. |
ABCB5 is a limbal stem cell gene required for corneal development and repair. |
The helicase HAGE expressed by malignant melanoma-initiating cells is required for tumor cell proliferation in vivo. |