Gene Symbol | Htra3 |
Entrez Gene ID | 78558 |
Full Name | HtrA serine peptidase 3 |
Synonyms | 2210021K23Rik,9530081K03Rik,Prsp,Tasp |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Htra3 cDNA ORF clone
gRNAs
Gene Symbol | Htra3 |
Entrez Gene ID | 78558 |
Full Name | HtrA serine peptidase 3 |
Synonyms | 2210021K23Rik,9530081K03Rik,Prsp,Tasp |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_030254908.1 | XP_030110768.1 | serine protease HTRA3 isoform X3 |
XM_011240796.2 | XP_011239098.1 | serine protease HTRA3 isoform X2 |
NM_001042615.2 | NP_001036080.1 | serine protease HTRA3 isoform b precursor |
NM_030127.3 | NP_084403.2 | serine protease HTRA3 isoform a precursor |
XM_006504186.1 | XP_006504249.1 | serine protease HTRA3 isoform X1 |
XM_011240796.3 | XP_011239098.1 | serine protease HTRA3 isoform X2 |
Canis lupus familiaris (dog) | HTRA3 | XP_005618790.1 |
Mus musculus (house mouse) | Htra3 | NP_084403.2 |
Gallus gallus (chicken) | HTRA3 | XP_420813.3 |
Homo sapiens (human) | HTRA3 | NP_444272.1 |
Pan troglodytes (chimpanzee) | HTRA3 | XP_517597.3 |
HTRA3 | XP_002804039.1 | |
Bos taurus (cattle) | HTRA3 | XP_002688528.2 |
Rattus norvegicus (Norway rat) | Htra3 | NP_001257956.1 |
Danio rerio (zebrafish) | LOC573378 | XP_692974.6 |
Xenopus tropicalis (tropical clawed frog) | htra3 | XP_002938688.1 |
Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood.
Li Y, Salamonsen LA, Hyett J, Costa FDS, Nie G
Scientific reports7(1)4627(2017 Jul)
Abnormal development of placenta in HtrA1-deficient mice.
Hasan MZ, Ikawati M, Tocharus J, Kawaichi M, Oka C
Developmental biology397(1)89-102(2015 Jan)
Transcriptomic analysis of mouse limb tendon cells during development.
Havis E, Bonnin MA, Olivera-Martinez I, Nazaret N, Ruggiu M, Weibel J, Durand C, Guerquin MJ, Bonod-Bidaud C, Ruggiero F, Schweitzer R, Duprez D
Development (Cambridge, England)141(19)3683-96(2014 Oct)
High-temperature requirement factor A3 (Htra3): a novel serine protease and its potential role in ovarian function and ovarian cancers.
Bowden MA, Drummond AE, Fuller PJ, Salamonsen LA, Findlay JK, Nie G
Molecular and cellular endocrinology327(1-2)13-8(2010 Oct)
HtrA3, a serine protease possessing an IGF-binding domain, is selectively expressed at the maternal-fetal interface during placentation in the mouse.
Nie G, Li Y, He H, Findlay JK, Salamonsen LA
Placenta27(4-5)491-501(2006 Apr-May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Both mRNA and protein of HtrA3 were localized specifically in the maternal decidua. Only the maternal decidual cells, but not blood vessels or uterine NK cells that are present in large numbers, were positive for HtrA3.
Title: HtrA3, a serine protease possessing an IGF-binding domain, is selectively expressed at the maternal-fetal interface during placentation in the mouse.
Plays an important role in the formation/function of the placenta.
Title: A novel serine protease of the mammalian HtrA family is up-regulated in mouse uterus coinciding with placentation.
The following Htra3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Htra3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu00939 | |
Clone ID Related Accession (Same CDS sequence) | NM_001042615.2 | |
Accession Version | NM_001042615.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1092bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-23 | |
Organism | Mus musculus(house mouse) | |
Product | serine protease HTRA3 isoform b precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK035194.1, AY156509.1, AK008764.1 and AI481644.1. On Nov 5, 2013 this sequence version replaced NM_001042615.1. Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform a. ##Evidence-Data-START## Transcript exon combination :: AY280664.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCAGGCGC GCGCGCTGCT CCCCGCCACG CTGGCCATTC TGGCCACGCT GGCTGTGTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001036080.1 |
CDS | 435..1526 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCAGGCGC GCGCGCTGCT CCCCGCCACG CTGGCCATTC TGGCCACGCT GGCTGTGTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu07954 | |
Clone ID Related Accession (Same CDS sequence) | NM_030127.3 | |
Accession Version | NM_030127.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1380bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-23 | |
Organism | Mus musculus(house mouse) | |
Product | serine protease HTRA3 isoform a precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK035194.1, AK020653.1, AK008764.1 and AY156509.1. On Nov 5, 2013 this sequence version replaced NM_030127.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). ##Evidence-Data-START## Transcript exon combination :: AY156509.1, AK035194.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCAGGCGC GCGCGCTGCT CCCCGCCACG CTGGCCATTC TGGCCACGCT GGCTGTGTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_084403.2 |
CDS | 435..1814 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCAGGCGC GCGCGCTGCT CCCCGCCACG CTGGCCATTC TGGCCACGCT GGCTGTGTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu35258 | |
Clone ID Related Accession (Same CDS sequence) | XM_006504186.1 | |
Accession Version | XM_006504186.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1404bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | serine protease HTRA3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAGGCGC GCGCGCTGCT CCCCGCCACG CTGGCCATTC TGGCCACGCT GGCTGTGTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006504249.1 |
CDS | 468..1871 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCAGGCGC GCGCGCTGCT CCCCGCCACG CTGGCCATTC TGGCCACGCT GGCTGTGTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu71718 | |
Clone ID Related Accession (Same CDS sequence) | XM_011240796.2 , XM_011240796.3 | |
Accession Version | XM_011240796.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | serine protease HTRA3 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011240796.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCAGAAG CCGGTTTGAT CGTCACCAAC GCCCACGTGG TCTCCAGCTC CAGCACTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011239098.1 |
CDS | 516..1364 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCAGAAG CCGGTTTGAT CGTCACCAAC GCCCACGTGG TCTCCAGCTC CAGCACTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu71718 | |
Clone ID Related Accession (Same CDS sequence) | XM_011240796.2 , XM_011240796.3 | |
Accession Version | XM_011240796.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | serine protease HTRA3 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011240796.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCAGAAG CCGGTTTGAT CGTCACCAAC GCCCACGTGG TCTCCAGCTC CAGCACTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011239098.1 |
CDS | 517..1365 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCAGAAG CCGGTTTGAT CGTCACCAAC GCCCACGTGG TCTCCAGCTC CAGCACTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu89042 | |
Clone ID Related Accession (Same CDS sequence) | XM_030254908.1 | |
Accession Version | XM_030254908.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 825bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | serine protease HTRA3 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCAGAAG CCGGTTTGAT CGTCACCAAC GCCCACGTGG TCTCCAGCTC CAGCACTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030110768.1 |
CDS | 517..1341 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTCAGAAG CCGGTTTGAT CGTCACCAAC GCCCACGTGG TCTCCAGCTC CAGCACTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Maternal HtrA3 optimizes placental development to influence offspring birth weight and subsequent white fat gain in adulthood. |
Abnormal development of placenta in HtrA1-deficient mice. |
Transcriptomic analysis of mouse limb tendon cells during development. |
High-temperature requirement factor A3 (Htra3): a novel serine protease and its potential role in ovarian function and ovarian cancers. |
HtrA3, a serine protease possessing an IGF-binding domain, is selectively expressed at the maternal-fetal interface during placentation in the mouse. |