Ucn3 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Ucn3 |
| Entrez Gene ID | 83428 |
| Full Name | urocortin 3 |
| Synonyms | ucn III |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome | |
| Summary | This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. The pancreatic islets isolated from mice lacking the encoded protein secrete less insulin in response to high glucose concentrations. Transgenic mice overexpressing the encoded protein exhibit a metabolically favorable phenotype resisting obesity and hyperglycemia on a high-fat diet. [provided by RefSeq, Sep 2016]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_031250.5 | NP_112540.2 | urocortin-3 preproprotein |
| Bos taurus (cattle) | UCN3 | NP_001069995.1 |
| Danio rerio (zebrafish) | ucn3l | NP_001076423.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100488336 | XP_002931892.1 |
| Homo sapiens (human) | UCN3 | NP_444277.2 |
| Rattus norvegicus (Norway rat) | Ucn3 | NP_001073677.1 |
| Pan troglodytes (chimpanzee) | UCN3 | XP_507632.2 |
| UCN3 | XP_001104616.1 | |
| Canis lupus familiaris (dog) | UCN3 | XP_003638933.1 |
| Mus musculus (house mouse) | Ucn3 | NP_112540.2 |
| Gallus gallus (chicken) | UCN3 | XP_001231711.1 |
Related articles in PubMed
Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets.
Sinagoga KL, Stone WJ, Schiesser JV, Schweitzer JI, Sampson L, Zheng Y, Wells JM
Development (Cambridge, England)144(13)2402-2414(2017 07)
Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans.
Lu HC, Tan Q, Rousseaux MW, Wang W, Kim JY, Richman R, Wan YW, Yeh SY, Patel JM, Liu X, Lin T, Lee Y, Fryer JD, Han J, Chahrour M, Finnell RH, Lei Y, Zurita-Jimenez ME, Ahimaz P, Anyane-Yeboa K, Van Maldergem L, Lehalle D, Jean-Marcais N, Mosca-Boidron AL, Thevenon J, Cousin MA, Bro DE, Lanpher BC, Klee EW, Alexander N, Bainbridge MN, Orr HT, Sillitoe RV, Ljungberg MC, Liu Z, Schaaf CP, Zoghbi HY
Nature genetics49(4)527-536(2017 Apr)
Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics.
Shemesh Y, Forkosh O, Mahn M, Anpilov S, Sztainberg Y, Manashirov S, Shlapobersky T, Elliott E, Tabouy L, Ezra G, Adler ES, Ben-Efraim YJ, Gil S, Kuperman Y, Haramati S, Dine J, Eder M, Deussing JM, Schneidman E, Yizhar O, Chen A
Nature neuroscience19(11)1489-1496(2016 Nov)
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)
Identification of proliferative and mature ?-cells in the islets of Langerhans.
Bader E, Migliorini A, Gegg M, Moruzzi N, Gerdes J, Roscioni SS, Bakhti M, Brandl E, Irmler M, Beckers J, Aichler M, Feuchtinger A, Leitzinger C, Zischka H, Wang-Sattler R, Jastroch M, Tsch?p M, Machicao F, Staiger H, H?ring HU, Chmelova H, Chouinard JA, Oskolkov N, Korsgren O, Speier S, Lickert H
Nature535(7612)430-4(2016 07)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
findings collectively suggest that the MeA Ucn3-CRF-R2 system modulates the ability of mice to cope with social challenges
Title: Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics.
The paracrine actions of Ucn3 activate a negative feedback loop that promotes somatostatin release to ensure the timely reduction of insulin secretion upon normalization of plasma glucose.
Title: Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion.
Ucn3 KO mice displayed significantly increased ethanol intake and preference compared with WT. There were no long-term effects of chronic pain on alcohol drinking behavior, regardless of genotype.
Title: Increased alcohol consumption in urocortin 3 knockout mice is unaffected by chronic inflammatory pain.
This study aims to investigate the cellular localization of CRF and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation.
Title: Expression of corticotropin-releasing factor and urocortins in the normal and Schistosoma mansoni-infected mouse ileum.
UCN3 expression enhances glucose disposal and signalling in muscle by an autocrine/paracrine mechanism that is separate from its pro-hypertrophic effects.
Title: Urocortin 3 activates AMPK and AKT pathways and enhances glucose disposal in rat skeletal muscle.
The following Ucn3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ucn3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu22690 | |
| Clone ID Related Accession (Same CDS sequence) | NM_031250.5 | |
| Accession Version | NM_031250.5 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-20 | |
| Organism | Mus musculus(house mouse) | |
| Product | urocortin-3 preproprotein | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK148451.1 and AC139323.4. On Mar 11, 2009 this sequence version replaced NM_031250.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK148451.1, BY741576.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGCTGATGC CCACCTACTT CCTGCTGCCA CTTCTGCTGC TCCTAGGAGG TCCAAGGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_112540.2 |
| CDS | 516..1010 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_031250.5 |
ORF Insert Sequence:
1 | ATGCTGATGC CCACCTACTT CCTGCTGCCA CTTCTGCTGC TCCTAGGAGG TCCAAGGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets. |
|
Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans. |
|
Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics. |
|
High-throughput discovery of novel developmental phenotypes. |
|
Identification of proliferative and mature ?-cells in the islets of Langerhans. |