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Jam3 cDNA ORF clone, Mus musculus(house mouse)

Summary

Gene Symbol Jam3
Entrez Gene ID 83964
Full Name junction adhesion molecule 3
Synonyms 1110002N23Rik,JAM-3,JAM-C,Jcam3
General protein information
Preferred Names

junction adhesion molecule 3

Names

junctional adhesion molecule C
junction cell adhesion molecule 3
junction cell adhesion molecule C
junctional adhesion molecule 3
Gene Type protein-coding
Organism Mus musculus(house mouse)
Genome

9

9|9 A4

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_030244741.1 XP_030100601.1 junctional adhesion molecule C isoform X1
NM_023277.4 NP_075766.1 junctional adhesion molecule C precursor

Pathways from BioSystems


Homologies


Canis lupus familiaris (dog) JAM3 XP_005619600.1
Xenopus tropicalis (tropical clawed frog) jam3 XP_004916068.1
Homo sapiens (human) JAM3 NP_116190.3
Bos taurus (cattle) JAM3 NP_001098834.1
Mus musculus (house mouse) Jam3 NP_075766.1
Danio rerio (zebrafish) jam3a XP_001338123.1
Pan troglodytes (chimpanzee) JAM3 XP_529458.3
Rattus norvegicus (Norway rat) Jam3 NP_001004269.1
Gallus gallus (chicken) JAM3 XP_004948061.1
Danio rerio (zebrafish) jam3b NP_001076332.2

Gene Ontology


Bibliography

Related articles in PubMed

JAM-C maintains VEGR2 expression to promote retinal pigment epithelium cell survival under oxidative stress.
Jia X, Zhao C, Chen Q, Du Y, Huang L, Ye Z, Ren X, Wang S, Lee C, Tang Z, Li X, Ju R
Thrombosis and haemostasis117(4)750-757(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

JAM-B/JAM-C mediated interaction between endothelial cells and stellate cells stabilizes vessel walls and may control the sinusoidal diameter.
Title: Murine junctional adhesion molecules JAM-B and JAM-C mediate endothelial and stellate cell interactions during hepatic fibrosis.

Study provides evidence that JAM-C downregulation may contribute to acute pancreatitis-associated lung injury via reverse transendothelial migration of neutrophils.
Title: Reverse-migrated neutrophils regulated by JAM-C are involved in acute pancreatitis-associated lung injury.

Endothelial-specific deletion of JAM-C promoted endothelial cell sprouting, and consequently vessel normalisation and revascularisation of the hypoxic retina without altering pathologic neovascularisation.
Title: Endothelial-specific deficiency of Junctional Adhesion Molecule-C promotes vessel normalisation in proliferative retinopathy.

JAM-C blockade can finely-tune the innate cell migration and accelerate the consequent immune response to L. major without changing the type of the T helper cell response.
Title: Blocking junctional adhesion molecule C enhances dendritic cell migration and boosts the immune responses against Leishmania major.

Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells.
Title: Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells.

The following Jam3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Jam3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OMu01144 NM_023277.4
Latest version!		 Mus musculus junction adhesion molecule 3 (Jam3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OMu90325 XM_030244741.1
Latest version!		 Mus musculus junction adhesion molecule 3 (Jam3), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $139.30
$199.00

ORF Online Only Promotion

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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OMu01144
Clone ID Related Accession (Same CDS sequence) NM_023277.4
Accession Version NM_023277.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 933bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-27
Organism Mus musculus(house mouse)
Product junctional adhesion molecule C precursor
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AW106511.1, AK013156.1 and AI850297.1. On Mar 22, 2011 this sequence version replaced NM_023277.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC024357.1, AK003326.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN00849385 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGCGCTGA GCCGGCGGCT GCGACTTCGA CTGTACGCGC GGCTGCCTGA CTTCTTCCTG 
CTGCTGCTCT TCAGGGGCTG CATGATAGAG GCAGTGAATC TCAAATCCAG CAACCGAAAC 
CCAGTGGTAC ATGAATTTGA AAGTGTGGAA TTGTCTTGCA TCATTACGGA CTCACAGACA 
AGTGACCCTA GGATTGAATG GAAGAAAATC CAAGATGGCC AAACCACATA TGTGTATTTT 
GACAACAAGA TTCAAGGAGA CCTGGCAGGT CGCACAGATG TGTTTGGAAA AACTTCCCTG 
AGGATCTGGA ATGTGACACG ATCGGATTCA GCCATCTATC GCTGTGAGGT CGTTGCTCTA 
AATGACCGAA AAGAAGTTGA TGAGATTACC ATTGAGTTAA TTGTGCAAGT GAAGCCAGTG 
ACCCCTGTCT GCAGAATTCC AGCCGCTGTA CCTGTAGGCA AGACGGCAAC ACTGCAGTGC 
CAAGAGAGCG AGGGCTATCC CCGGCCTCAC TACAGCTGGT ACCGCAATGA TGTGCCACTG 
CCTACAGATT CCAGAGCCAA TCCCAGGTTC CAGAATTCCT CTTTCCATGT GAACTCGGAG 
ACAGGCACTC TGGTTTTCAA TGCTGTCCAC AAGGACGACT CTGGGCAGTA CTACTGCATT 
GCTTCCAATG ACGCAGGTGC AGCCAGGTGT GAGGGGCAGG ACATGGAAGT CTATGATTTG 
AACATTGCTG GGATTATTGG GGGAGTCCTT GTTGTCCTTA TTGTTCTTGC TGTGATTACG 
ATGGGCATCT GCTGTGCGTA CAGACGAGGC TGCTTCATCA GCAGTAAACA AGATGGAGAA 
AGCTATAAGA GCCCAGGGAA GCATGACGGT GTTAACTACA TCCGGACGAG TGAGGAGGGT 
GACTTCAGAC ACAAATCGTC CTTTGTTATC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_075766.1
CDS56..988
Translation

Target ORF information:

RefSeq Version NM_023277.4
Organism Mus musculus(house mouse)
Definition Mus musculus junction adhesion molecule 3 (Jam3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_023277.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGCGCTGA GCCGGCGGCT GCGACTTCGA CTGTACGCGC GGCTGCCTGA CTTCTTCCTG 
CTGCTGCTCT TCAGGGGCTG CATGATAGAG GCAGTGAATC TCAAATCCAG CAACCGAAAC 
CCAGTGGTAC ATGAATTTGA AAGTGTGGAA TTGTCTTGCA TCATTACGGA CTCACAGACA 
AGTGACCCTA GGATTGAATG GAAGAAAATC CAAGATGGCC AAACCACATA TGTGTATTTT 
GACAACAAGA TTCAAGGAGA CCTGGCAGGT CGCACAGATG TGTTTGGAAA AACTTCCCTG 
AGGATCTGGA ATGTGACACG ATCGGATTCA GCCATCTATC GCTGTGAGGT CGTTGCTCTA 
AATGACCGAA AAGAAGTTGA TGAGATTACC ATTGAGTTAA TTGTGCAAGT GAAGCCAGTG 
ACCCCTGTCT GCAGAATTCC AGCCGCTGTA CCTGTAGGCA AGACGGCAAC ACTGCAGTGC 
CAAGAGAGCG AGGGCTATCC CCGGCCTCAC TACAGCTGGT ACCGCAATGA TGTGCCACTG 
CCTACAGATT CCAGAGCCAA TCCCAGGTTC CAGAATTCCT CTTTCCATGT GAACTCGGAG 
ACAGGCACTC TGGTTTTCAA TGCTGTCCAC AAGGACGACT CTGGGCAGTA CTACTGCATT 
GCTTCCAATG ACGCAGGTGC AGCCAGGTGT GAGGGGCAGG ACATGGAAGT CTATGATTTG 
AACATTGCTG GGATTATTGG GGGAGTCCTT GTTGTCCTTA TTGTTCTTGC TGTGATTACG 
ATGGGCATCT GCTGTGCGTA CAGACGAGGC TGCTTCATCA GCAGTAAACA AGATGGAGAA 
AGCTATAAGA GCCCAGGGAA GCATGACGGT GTTAACTACA TCCGGACGAG TGAGGAGGGT 
GACTTCAGAC ACAAATCGTC CTTTGTTATC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu90325
Clone ID Related Accession (Same CDS sequence) XM_030244741.1
Accession Version XM_030244741.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 852bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-07
Organism Mus musculus(house mouse)
Product junctional adhesion molecule C isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

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181
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841
ATGATAGAGG CAGTGAATCT CAAATCCAGC AACCGAAACC CAGTGGTACA TGAATTTGAA 
AGTGTGGAAT TGTCTTGCAT CATTACGGAC TCACAGACAA GTGACCCTAG GATTGAATGG 
AAGAAAATCC AAGATGGCCA AACCACATAT GTGTATTTTG ACAACAAGAT TCAAGGAGAC 
CTGGCAGGTC GCACAGATGT GTTTGGAAAA ACTTCCCTGA GGATCTGGAA TGTGACACGA 
TCGGATTCAG CCATCTATCG CTGTGAGGTC GTTGCTCTAA ATGACCGAAA AGAAGTTGAT 
GAGATTACCA TTGAGTTAAT TGTGCAAGTG AAGCCAGTGA CCCCTGTCTG CAGAATTCCA 
GCCGCTGTAC CTGTAGGCAA GACGGCAACA CTGCAGTGCC AAGAGAGCGA GGGCTATCCC 
CGGCCTCACT ACAGCTGGTA CCGCAATGAT GTGCCACTGC CTACAGATTC CAGAGCCAAT 
CCCAGGTTCC AGAATTCCTC TTTCCATGTG AACTCGGAGA CAGGCACTCT GGTTTTCAAT 
GCTGTCCACA AGGACGACTC TGGGCAGTAC TACTGCATTG CTTCCAATGA CGCAGGTGCA 
GCCAGGTGTG AGGGGCAGGA CATGGAAGTC TATGATTTGA ACATTGCTGG GATTATTGGG 
GGAGTCCTTG TTGTCCTTAT TGTTCTTGCT GTGATTACGA TGGGCATCTG CTGTGCGTAC 
AGACGAGGCT GCTTCATCAG CAGTAAACAA GATGGAGAAA GCTATAAGAG CCCAGGGAAG 
CATGACGGTG TTAACTACAT CCGGACGAGT GAGGAGGGTG ACTTCAGACA CAAATCGTCC 
TTTGTTATCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_030100601.1
CDS3755..4606
Translation

Target ORF information:

RefSeq Version XM_030244741.1
Organism Mus musculus(house mouse)
Definition Mus musculus junction adhesion molecule 3 (Jam3), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_030244741.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGATAGAGG CAGTGAATCT CAAATCCAGC AACCGAAACC CAGTGGTACA TGAATTTGAA 
AGTGTGGAAT TGTCTTGCAT CATTACGGAC TCACAGACAA GTGACCCTAG GATTGAATGG 
AAGAAAATCC AAGATGGCCA AACCACATAT GTGTATTTTG ACAACAAGAT TCAAGGAGAC 
CTGGCAGGTC GCACAGATGT GTTTGGAAAA ACTTCCCTGA GGATCTGGAA TGTGACACGA 
TCGGATTCAG CCATCTATCG CTGTGAGGTC GTTGCTCTAA ATGACCGAAA AGAAGTTGAT 
GAGATTACCA TTGAGTTAAT TGTGCAAGTG AAGCCAGTGA CCCCTGTCTG CAGAATTCCA 
GCCGCTGTAC CTGTAGGCAA GACGGCAACA CTGCAGTGCC AAGAGAGCGA GGGCTATCCC 
CGGCCTCACT ACAGCTGGTA CCGCAATGAT GTGCCACTGC CTACAGATTC CAGAGCCAAT 
CCCAGGTTCC AGAATTCCTC TTTCCATGTG AACTCGGAGA CAGGCACTCT GGTTTTCAAT 
GCTGTCCACA AGGACGACTC TGGGCAGTAC TACTGCATTG CTTCCAATGA CGCAGGTGCA 
GCCAGGTGTG AGGGGCAGGA CATGGAAGTC TATGATTTGA ACATTGCTGG GATTATTGGG 
GGAGTCCTTG TTGTCCTTAT TGTTCTTGCT GTGATTACGA TGGGCATCTG CTGTGCGTAC 
AGACGAGGCT GCTTCATCAG CAGTAAACAA GATGGAGAAA GCTATAAGAG CCCAGGGAAG 
CATGACGGTG TTAACTACAT CCGGACGAGT GAGGAGGGTG ACTTCAGACA CAAATCGTCC 
TTTGTTATCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

JAM-C maintains VEGR2 expression to promote retinal pigment epithelium cell survival under oxidative stress.
Thrombosis and haemostasis117(4)750-757(2017 Apr)
Jia X,Zhao C,Chen Q,Du Y,Huang L,Ye Z,Ren X,Wang S,Lee C,Tang Z,Li X,Ju R