Gene Symbol | Trim8 |
Entrez Gene ID | 93679 |
Full Name | tripartite motif-containing 8 |
Synonyms | AA408830,BB006755,GERP,Rnf27 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Trim8 cDNA ORF clone
gRNAs
Gene Symbol | Trim8 |
Entrez Gene ID | 93679 |
Full Name | tripartite motif-containing 8 |
Synonyms | AA408830,BB006755,GERP,Rnf27 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006527488.4 | XP_006527551.1 | probable E3 ubiquitin-protein ligase TRIM8 isoform X1 |
NM_053100.2 | NP_444330.2 | probable E3 ubiquitin-protein ligase TRIM8 |
XM_006527488.3 | XP_006527551.1 | probable E3 ubiquitin-protein ligase TRIM8 isoform X1 |
Danio rerio (zebrafish) | trim8a | NP_001265783.1 |
Mus musculus (house mouse) | Trim8 | NP_444330.2 |
Rattus norvegicus (Norway rat) | Trim8 | NP_001121555.1 |
TRIM8 | XP_001113109.1 | |
Bos taurus (cattle) | TRIM8 | NP_001178405.1 |
Gallus gallus (chicken) | TRIM8 | NP_001026404.1 |
Xenopus tropicalis (tropical clawed frog) | trim8 | NP_001027512.1 |
Pan troglodytes (chimpanzee) | TRIM8 | XP_003951785.1 |
Canis lupus familiaris (dog) | TRIM8 | XP_543993.3 |
Danio rerio (zebrafish) | trim8 | NP_001038379.1 |
Homo sapiens (human) | TRIM8 | NP_112174.2 |
TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF-TBK1 Interaction.
Ye W, Hu MM, Lei CQ, Zhou Q, Lin H, Sun MS, Shu HB
Journal of immunology (Baltimore, Md. : 1950)199(5)1856-1864(2017 Sep)
The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis.
Yan FJ, Zhang XJ, Wang WX, Ji YX, Wang PX, Yang Y, Gong J, Shen LJ, Zhu XY, Huang Z, Li H
Hepatology (Baltimore, Md.)65(5)1492-1511(2017 05)
Tripartite Motif 8 (TRIM8) Positively Regulates Pro-inflammatory Responses in Pseudomonas aeruginosa-Induced Keratitis Through Promoting K63-Linked Polyubiquitination of TAK1 Protein.
Guo L, Dong W, Fu X, Lin J, Dong Z, Tan X, Zhang T
Inflammation40(2)454-463(2017 Apr)
Tripartite Motif 8 Contributes to Pathological Cardiac Hypertrophy Through Enhancing Transforming Growth Factor ?-Activated Kinase 1-Dependent Signaling Pathways.
Chen L, Huang J, Ji YX, Mei F, Wang PX, Deng KQ, Jiang X, Ma G, Li H
Hypertension (Dallas, Tex. : 1979)69(2)249-258(2017 02)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
these studies reveal an additional regulatory function of TRIM8 in innate immune responses: TRIM8 catalyzes polyubiquitination of TRIF, resulting in disruption of TRIF-TBK1 interaction
Title: TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF-TBK1 Interaction.
potent regulator that exacerbates steatohepatitis and metabolic disorders dependent on its binding and ubiquitinating capacity on transforming growth factor-beta-activated kinase 1
Title: The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis.
TRIM8 has pro-inflammatory effect on Pseudomonas aeruginosa -induced keratitis
Title: Tripartite Motif 8 (TRIM8) Positively Regulates Pro-inflammatory Responses in Pseudomonas aeruginosa-Induced Keratitis Through Promoting K63-Linked Polyubiquitination of TAK1 Protein.
TRIM8 plays a deleterious role in pressure overload-induced cardiac hypertrophy by accelerating the activation of TAK1-dependent signaling pathways.
Title: Tripartite Motif 8 Contributes to Pathological Cardiac Hypertrophy Through Enhancing Transforming Growth Factor ?-Activated Kinase 1-Dependent Signaling Pathways.
Gerp transcribes interferon-gamma in epithelial and lymphoid cells and is expressed almost ubiquitously in tissues.
Title: Genomic organization and cytokine-mediated inducibility of the human TRIM-8/Gerp gene.
The following Trim8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Trim8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu13394 | |
Clone ID Related Accession (Same CDS sequence) | NM_053100.2 | |
Accession Version | NM_053100.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1656bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-15 | |
Organism | Mus musculus(house mouse) | |
Product | probable E3 ubiquitin-protein ligase TRIM8 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM944255.1 and BC082298.1. On Jul 31, 2007 this sequence version replaced NM_053100.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC082298.1, AK155303.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCGGAGA ATTGGAAGAA CTGCTTTGAG GAGGAGCTCA TCTGCCCCAT CTGCCTGCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_444330.2 |
CDS | 797..2452 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGGCGGAGA ATTGGAAGAA CTGCTTTGAG GAGGAGCTCA TCTGCCCCAT CTGCCTGCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu55829 | |
Clone ID Related Accession (Same CDS sequence) | XM_006527488.4 , XM_006527488.3 | |
Accession Version | XM_006527488.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | probable E3 ubiquitin-protein ligase TRIM8 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000085.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006527488.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTCATGA AGCAGCAGGA GCGGCTGGAG GAGAGAGAGC AGGACATTGA GGACCAGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006527551.1 |
CDS | 511..1593 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGCTCATGA AGCAGCAGGA GCGGCTGGAG GAGAGAGAGC AGGACATTGA GGACCAGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu55829 | |
Clone ID Related Accession (Same CDS sequence) | XM_006527488.4 , XM_006527488.3 | |
Accession Version | XM_006527488.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1083bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | probable E3 ubiquitin-protein ligase TRIM8 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000085.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006527488.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTCATGA AGCAGCAGGA GCGGCTGGAG GAGAGAGAGC AGGACATTGA GGACCAGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006527551.1 |
CDS | 509..1591 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCTCATGA AGCAGCAGGA GCGGCTGGAG GAGAGAGAGC AGGACATTGA GGACCAGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF-TBK1 Interaction. |
The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis. |
Tripartite Motif 8 (TRIM8) Positively Regulates Pro-inflammatory Responses in Pseudomonas aeruginosa-Induced Keratitis Through Promoting K63-Linked Polyubiquitination of TAK1 Protein. |
Tripartite Motif 8 Contributes to Pathological Cardiac Hypertrophy Through Enhancing Transforming Growth Factor ?-Activated Kinase 1-Dependent Signaling Pathways. |