H3c8 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	H3c8
Entrez Gene ID	97908
Full Name	histone cluster 1, H3g
Synonyms	H3.1-221,M32460
General protein information	Preferred Names histone cluster 1, H3g Names histone H3.1 histone 1, H3g
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 A3.1
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015].

mRNA and Protein(s)

mRNA Protein Name

NM_145073.2 NP_659539.1 histone H3.1
Pathways from BioSystems

mRNA	Protein	Name
NM_145073.2	NP_659539.1	histone H3.1

Homologies

	LOC100425854	XP_002803686.1
Bos taurus (cattle)	LOC540148	XP_002697552.2
Caenorhabditis elegans (roundworm)	his-25	NP_496895.1
Arabidopsis thaliana (thale cress)	AT4G40030	NP_001078516.1
Oryza sativa (rice)	Os06g0130900	NP_001056693.1
Mus musculus (house mouse)	Hist1h3g	NP_659539.1
Caenorhabditis elegans (roundworm)	his-17	NP_505297.1
Caenorhabditis elegans (roundworm)	his-42	NP_496899.1
Caenorhabditis elegans (roundworm)	his-63	NP_502153.1
Homo sapiens (human)	HIST1H3J	NP_003526.1
Canis lupus familiaris (dog)	LOC488277	XP_005640184.1
Danio rerio (zebrafish)	LOC100004914	XP_005172223.1
Caenorhabditis elegans (roundworm)	his-6	NP_505199.1
Caenorhabditis elegans (roundworm)	his-49	NP_505276.1
Caenorhabditis elegans (roundworm)	his-2	NP_507033.1
Caenorhabditis elegans (roundworm)	his-13	NP_496890.1
Caenorhabditis elegans (roundworm)	his-45	NP_502134.1
Xenopus tropicalis (tropical clawed frog)	LOC101732029	XP_004915774.1
Pan troglodytes (chimpanzee)	LOC471875	XP_527253.2
Rattus norvegicus (Norway rat)	LOC680498	XP_001057443.3
Drosophila melanogaster (fruit fly)	His3:CG33830	NP_001027328.1
Caenorhabditis elegans (roundworm)	his-55	NP_502138.1
Caenorhabditis elegans (roundworm)	his-9	NP_496894.1
Caenorhabditis elegans (roundworm)	his-32	NP_501407.1
Caenorhabditis elegans (roundworm)	his-27	NP_505292.1
Caenorhabditis elegans (roundworm)	his-59	NP_501204.1
Arabidopsis thaliana (thale cress)	AT5G10980	NP_196659.1
Arabidopsis thaliana (thale cress)	AT4G40040	NP_849529.1

Gene Ontology
Bibliography

Related articles in PubMed

cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development.
Bird AD, Flecknoe SJ, Tan KH, Olsson PF, Antony N, Mantamadiotis T, Mollard R, Hooper SB, Cole TJ
PloS one6(3)e17843(2011 Mar)

Organismal differences in post-translational modifications in histones H3 and H4.
Garcia BA, Hake SB, Diaz RL, Kauer M, Morris SA, Recht J, Shabanowitz J, Mishra N, Strahl BD, Allis CD, Hunt DF
The Journal of biological chemistry282(10)7641-55(2007 Mar)

Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification.
Morris SA, Rao B, Garcia BA, Hake SB, Diaz RL, Shabanowitz J, Hunt DF, Allis CD, Lieb JD, Strahl BD
The Journal of biological chemistry282(10)7632-40(2007 Mar)

Stimulation of the Ras-MAPK pathway leads to independent phosphorylation of histone H3 on serine 10 and 28.
Dunn KL, Davie JR
Oncogene24(21)3492-502(2005 May)

MAP kinase-mediated phosphorylation of distinct pools of histone H3 at S10 or S28 via mitogen- and stress-activated kinase 1/2.
Dyson MH, Thomson S, Inagaki M, Goto H, Arthur SJ, Nightingale K, Iborra FJ, Mahadevan LC
Journal of cell science118(Pt 10)2247-59(2005 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following H3c8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H3c8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14644	NM_145073.2 Latest version!	Mus musculus H3 clustered histone 8 (H3c8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H3c8 ( NM_145073.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_659539.1 Mus musculus H3 clustered histone 8 (H3c8), mRNA.

Price & Availability↑

CloneID	OMu14644
Clone ID Related Accession (Same CDS sequence)	NM_145073.2
Accession Version	NM_145073.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Mus musculus(house mouse)
Product	histone H3.1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL592149.8. On Sep 21, 2005 this sequence version replaced NM_145073.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC125355.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCGTA CTAAGCAGAC CGCTCGCAAG TCTACCGGCG GCAAGGCCCC GCGCAAGCAG 
CTGGCCACCA AGGCCGCCCG CAAGAGCGCC CCGGCCACCG GCGGCGTGAA GAAGCCTCAC 
CGCTACCGTC CCGGCACTGT GGCGCTGCGC GAGATCCGGC GCTACCAGAA GTCGACCGAG 
CTGCTGATCC GCAAGCTGCC GTTCCAGCGC CTGGTGCGCG AGATCGCGCA GGACTTCAAG 
ACCGACCTGC GCTTCCAGAG CTCGGCCGTC ATGGCTCTGC AGGAGGCCTG TGAGGCCTAC 
CTCGTGGGTC TGTTTGAGGA CACCAACCTG TGCGCCATCC ACGCCAAGCG TGTCACCATC 
ATGCCCAAGG ACATCCAGCT GGCCCGTCGC ATCCGCGGGG AGAGGGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_659539.1
CDS	29..439
Translation	MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Target ORF information:

RefSeq Version	NM_145073.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus H3 clustered histone 8 (H3c8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145073.2

ORF Insert Sequence:

ATGGCTCGTA CTAAGCAGAC CGCTCGCAAG TCTACCGGCG GCAAGGCCCC GCGCAAGCAG 
CTGGCCACCA AGGCCGCCCG CAAGAGCGCC CCGGCCACCG GCGGCGTGAA GAAGCCTCAC 
CGCTACCGTC CCGGCACTGT GGCGCTGCGC GAGATCCGGC GCTACCAGAA GTCGACCGAG 
CTGCTGATCC GCAAGCTGCC GTTCCAGCGC CTGGTGCGCG AGATCGCGCA GGACTTCAAG 
ACCGACCTGC GCTTCCAGAG CTCGGCCGTC ATGGCTCTGC AGGAGGCCTG TGAGGCCTAC 
CTCGTGGGTC TGTTTGAGGA CACCAACCTG TGCGCCATCC ACGCCAAGCG TGTCACCATC 
ATGCCCAAGG ACATCCAGCT GGCCCGTCGC ATCCGCGGGG AGAGGGCTTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development.
PloS one6(3)e17843(2011 Mar)
Bird AD,Flecknoe SJ,Tan KH,Olsson PF,Antony N,Mantamadiotis T,Mollard R,Hooper SB,Cole TJ

Organismal differences in post-translational modifications in histones H3 and H4.
The Journal of biological chemistry282(10)7641-55(2007 Mar)
Garcia BA,Hake SB,Diaz RL,Kauer M,Morris SA,Recht J,Shabanowitz J,Mishra N,Strahl BD,Allis CD,Hunt DF

Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification.
The Journal of biological chemistry282(10)7632-40(2007 Mar)
Morris SA,Rao B,Garcia BA,Hake SB,Diaz RL,Shabanowitz J,Hunt DF,Allis CD,Lieb JD,Strahl BD

Stimulation of the Ras-MAPK pathway leads to independent phosphorylation of histone H3 on serine 10 and 28.
Oncogene24(21)3492-502(2005 May)
Dunn KL,Davie JR

MAP kinase-mediated phosphorylation of distinct pools of histone H3 at S10 or S28 via mitogen- and stress-activated kinase 1/2.
Journal of cell science118(Pt 10)2247-59(2005 May)
Dyson MH,Thomson S,Inagaki M,Goto H,Arthur SJ,Nightingale K,Iborra FJ,Mahadevan LC

REQUEST A QUOTE

EMAIL

[email protected]

PHONE

1-877-436-7274

ONLINE FORM

Online Quote Submission

ONLINE FORM

Online Quote Submission

H3c8 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

REQUEST A QUOTE

EMAIL

PHONE

ONLINE FORM

ONLINE FORM

SUPPORT

COMPANY

SUPPORT

COMPANY