Gene Symbol | GJA1 |
Entrez Gene ID | 100008935 |
Full Name | gap junction protein alpha 1 |
Synonyms | Cx43 |
Gene Type | protein-coding |
Organism | Oryctolagus cuniculus(rabbit) |
ORF » Species Summary » Oryctolagus cuniculus » GJA1 cDNA ORF clone
Gene Symbol | GJA1 |
Entrez Gene ID | 100008935 |
Full Name | gap junction protein alpha 1 |
Synonyms | Cx43 |
Gene Type | protein-coding |
Organism | Oryctolagus cuniculus(rabbit) |
mRNA | Protein | Name |
---|---|---|
NM_001198948.1 | NP_001185877.1 | gap junction alpha-1 protein |
XM_008263297.2 | XP_008261519.1 | gap junction alpha-1 protein isoform X1 |
The stress kinase JNK regulates gap junction Cx43 gene expression and promotes atrial fibrillation in the aged heart.
Yan J, Thomson JK, Zhao W, Wu X, Gao X, DeMarco D, Kong W, Tong M, Sun J, Bakhos M, Fast VG, Liang Q, Prabhu SD, Ai X
Journal of molecular and cellular cardiology114105-115(2017 Nov)
Impaired osteogenic differentiation associated with connexin43/microRNA-206 in steroid-induced avascular necrosis of the femoral head.
Liu G, Luo G, Bo Z, Liang X, Huang J, Li D
Experimental and molecular pathology101(1)89-99(2016 08)
Remodeling of rabbit abdominal aorta and Cx43 gap junctions after stent placement: effect of balloon injury plus cholesterol-enriched diet.
Hung TC, Lu SK, Su CH, Wu YJ, Hsieh CL, Lee WH, Tsai CH, Yeh HI
International angiology : a journal of the International Union of Angiology31(1)62-9(2012 Feb)
[Effect of antiarrhythmic peptide on ventricular arrhythmia induced by lysophosphatidic acid].
Zhou Q, Wang TJ, Zhang CT, Ruan L, Li LD, Xu RD, Quan XQ, Ni MK
Zhonghua xin xue guan bing za zhi39(4)301-4(2011 Apr)
[Mitochondrial connexin43 and postconditioning protection in rabbits underwent myocardial ischemia/reperfusion injury].
He Y, Zeng ZY, Zhong GQ, Li JY, Li WK, Li W
Zhonghua xin xue guan bing za zhi38(4)357-62(2010 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These findings indicated that Cx43/miR-206 is involved in the pathogenesis of early stage steroid-induced avascular necrosis of the femoral head.
Title: Impaired osteogenic differentiation associated with connexin43/microRNA-206 in steroid-induced avascular necrosis of the femoral head.
Vascular remodeling post stent implantation varied according to the presence of balloon injury, cholesterol-enriched diet, or both.
Title: Remodeling of rabbit abdominal aorta and Cx43 gap junctions after stent placement: effect of balloon injury plus cholesterol-enriched diet.
Gap junction enhancer AAP10 could attenuate the pro-arrhythmic effect of lysophosphatidic acid, probably by downregulating myocardial nonphosphorylated Cx43 expression.
Title: [Effect of antiarrhythmic peptide on ventricular arrhythmia induced by lysophosphatidic acid].
Ischemic postconditioning protected the heart from I/R injury by attenuating I/R induced decrease of mitochondria Cx43 expression.
Title: [Mitochondrial connexin43 and postconditioning protection in rabbits underwent myocardial ischemia/reperfusion injury].
In addition to Cx43 dephosphorylation, downregulation of Cx43 plays an essential role in reduced cell coupling in the failing rabbit heart
Title: Connexin43 knockdown or overexpression modulates cell coupling in control and failing rabbit left ventricular myocytes.
The following GJA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GJA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OOb00234 | |
Clone ID Related Accession (Same CDS sequence) | NM_001198948.1 , XM_008263297.2 | |
Accession Version | NM_001198948.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1149bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-26 | |
Organism | Oryctolagus cuniculus(rabbit) | |
Product | gap junction alpha-1 protein | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AAGW02029113.1. On Nov 17, 2010 this sequence version replaced XM_002714790.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on orthologous alignments. |
1 | ATGGGTGACT GGAGTGCCTT AGGCAAGCTC CTGGACAAAG TCCAAGCCTA CTCCACTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001185877.1 |
CDS | 1..1149 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001198948.1 |
1 | ATGGGTGACT GGAGTGCCTT AGGCAAGCTC CTGGACAAAG TCCAAGCCTA CTCCACTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OOb00234 | |
Clone ID Related Accession (Same CDS sequence) | NM_001198948.1 , XM_008263297.2 | |
Accession Version | XM_008263297.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1149bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-22 | |
Organism | Oryctolagus cuniculus(rabbit) | |
Product | gap junction alpha-1 protein isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_013680.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 23, 2016 this sequence version replaced XM_008263297.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Oryctolagus cuniculus Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGTGACT GGAGTGCCTT AGGCAAGCTC CTGGACAAAG TCCAAGCCTA CTCCACTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_008261519.1 |
CDS | 224..1372 |
Translation |
Target ORF information:
Target ORF information:
|
XM_008263297.2 |
1 | ATGGGTGACT GGAGTGCCTT AGGCAAGCTC CTGGACAAAG TCCAAGCCTA CTCCACTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The stress kinase JNK regulates gap junction Cx43 gene expression and promotes atrial fibrillation in the aged heart. |
Impaired osteogenic differentiation associated with connexin43/microRNA-206 in steroid-induced avascular necrosis of the femoral head. |
Remodeling of rabbit abdominal aorta and Cx43 gap junctions after stent placement: effect of balloon injury plus cholesterol-enriched diet. |
[Effect of antiarrhythmic peptide on ventricular arrhythmia induced by lysophosphatidic acid]. |
[Mitochondrial connexin43 and postconditioning protection in rabbits underwent myocardial ischemia/reperfusion injury]. |