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NEU4 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol NEU4
Entrez Gene ID 129807
Full Name neuraminidase 4
General protein information
Preferred Names

neuraminidase 4

Names

sialidase-4
N-acetyl-alpha-neuraminidase 4
neuraminidase 4 (sialidase)
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

2

2q37.3
Summary The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2009].
Disorder MIM:

608527


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_001167602.2 NP_001161074.1 sialidase-4 isoform 3
NM_001167601.2 NP_001161073.1 sialidase-4 isoform 3
NM_080741.3 NP_542779.2 sialidase-4 isoform 1
NM_080741.4 NP_542779.2 sialidase-4 isoform 1
NM_001167602.3 NP_001161074.1 sialidase-4 isoform 3
NM_001167599.3 NP_001161071.1 sialidase-4 isoform 2
NM_001167599.2 NP_001161071.1 sialidase-4 isoform 2
NM_001167600.2 NP_001161072.1 sialidase-4 isoform 3
NM_001167601.3 NP_001161073.1 sialidase-4 isoform 3
NM_001167600.3 NP_001161072.1 sialidase-4 isoform 3

Pathways from BioSystems


Homologies


Bos taurus (cattle) NEU4 XP_002686672.1
Rattus norvegicus (Norway rat) Neu4 NP_001101704.1
Xenopus tropicalis (tropical clawed frog) LOC100486976 XP_002943103.2
NEU4 XP_001095081.2
Mus musculus (house mouse) Neu4 NP_776133.1
Danio rerio (zebrafish) neu4 NP_001018384.1
Homo sapiens (human) NEU4 NP_001161071.1
Gallus gallus (chicken) NEU4 XP_004937059.1

Gene Ontology


Bibliography

Related articles in PubMed

Integrin-mediated cell migration is blocked by inhibitors of human neuraminidase.
Jia F, Howlader MA, Cairo CW
Biochimica et biophysica acta1861(9 Pt A)1170-1179(2016 09)

Sialidase NEU4 is involved in glioblastoma stem cell survival.
Silvestri I, Testa F, Zappasodi R, Cairo CW, Zhang Y, Lupo B, Galli R, Di Nicola M, Venerando B, Tringali C
Cell death & disease5e1381(2014 Aug)

A proline-rich loop mediates specific functions of human sialidase NEU4 in SK-N-BE neuronal differentiation.
Bigi A, Tringali C, Forcella M, Mozzi A, Venerando B, Monti E, Fusi P
Glycobiology23(12)1499-509(2013 Dec)

NEU4L sialidase overexpression promotes ?-catenin signaling in neuroblastoma cells, enhancing stem-like malignant cell growth.
Tringali C, Cirillo F, Lamorte G, Papini N, Anastasia L, Lupo B, Silvestri I, Tettamanti G, Venerando B
International journal of cancer131(8)1768-78(2012 Oct)

Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons.
Takahashi K, Mitoma J, Hosono M, Shiozaki K, Sato C, Yamaguchi K, Kitajima K, Higashi H, Nitta K, Shima H, Miyagi T
The Journal of biological chemistry287(18)14816-26(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The most potent compound tested targeted the human Neu4 isoenzyme, and was able to substantially reduce the rate of cell migration. We found that the lateral mobility of integrins was reduced by treatment of cells with Neu3, suggesting that Neu3 enzyme activity resulted in changes to integrin-co-receptor or integrin-cytoskeleton interactions
Title: Integrin-mediated cell migration is blocked by inhibitors of human neuraminidase.

The silencing or chemical inhibition of NEU4 changes the entire glycosylation pattern of proteins and lipids, making it more similar to that of differentiated GBM cells and drastically reduces GSCs survival.
Title: Sialidase NEU4 is involved in glioblastoma stem cell survival.

The results demonstrate that the proline-rich region can also enhance cell proliferation and retinoic acid (RA)-induced neuronal differentiation and it is also involved in NEU4 interaction with Akt.
Title: A proline-rich loop mediates specific functions of human sialidase NEU4 in SK-N-BE neuronal differentiation.

Overexpression of NEU4 is associated with neuroblastoma.
Title: NEU4L sialidase overexpression promotes ?-catenin signaling in neuroblastoma cells, enhancing stem-like malignant cell growth.

NEU4 is involved in regulation of neuronal function by polySia degradation in mammals.
Title: Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons.

The following NEU4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NEU4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu23274 NM_001167601.3
Latest version!		 Homo sapiens neuraminidase 4 (NEU4), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $159.50-$223.30
$319.00
OHu23274 NM_001167602.3
Latest version!		 Homo sapiens neuraminidase 4 (NEU4), transcript variant 5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $159.50-$223.30
$319.00
OHu23274 NM_001167600.3
Latest version!		 Homo sapiens neuraminidase 4 (NEU4), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $159.50-$223.30
$319.00
OHu23544 NM_080741.4
Latest version!		 Homo sapiens neuraminidase 4 (NEU4), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $159.50-$223.30
$319.00
OHu24025 NM_001167599.3
Latest version!		 Homo sapiens neuraminidase 4 (NEU4), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $159.50-$223.30
$319.00
View Old Accession Versions >>
OHu23544 NM_080741.3 Homo sapiens neuraminidase 4 (NEU4), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $159.50-$223.30
$319.00
OHu23274 NM_001167602.2 Homo sapiens neuraminidase 4 (NEU4), transcript variant 5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $159.50-$223.30
$319.00
OHu24025 NM_001167599.2 Homo sapiens neuraminidase 4 (NEU4), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $159.50-$223.30
$319.00
OHu23274 NM_001167601.2 Homo sapiens neuraminidase 4 (NEU4), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $159.50-$223.30
$319.00
OHu23274 NM_001167600.2 Homo sapiens neuraminidase 4 (NEU4), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $159.50-$223.30
$319.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu23274
Clone ID Related Accession (Same CDS sequence) NM_001167602.2 , NM_001167601.2 , NM_001167602.3 , NM_001167600.2 , NM_001167601.3 , NM_001167600.3
Accession Version NM_001167602.2 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1455bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2018-06-29
Organism Homo sapiens(human)
Product sialidase-4 isoform 3
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC131097.6, AK091038.1 and BC063465.1. On Apr 12, 2014 this sequence version replaced NM_001167602.1. Transcript Variant: This variant (5) contains an additional exon at the 5' end compared to variant 1, resulting in translation initiation from an in-frame downstream AUG, and an isoform (3, also known as NEU4 short) with a shorter N-terminus compared to isoform 1. Variants 3-5 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK091038.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA1970526 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
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241
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361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGGGGTCC CTCGTACCCC TTCACGGACA GTGCTCTTCG AGCGGGAGAG GACGGGCCTG 
ACCTACCGCG TGCCCTCGCT GCTCCCCGTG CCCCCCGGGC CCACCCTGCT GGCCTTTGTG 
GAGCAGCGGC TCAGCCCTGA CGACTCCCAC GCCCACCGCC TGGTGCTGAG GAGGGGCACG 
CTGGCCGGGG GCTCCGTGCG GTGGGGTGCC CTGCACGTGC TGGGGACAGC AGCCCTGGCG 
GAGCACCGGT CCATGAACCC CTGCCCTGTG CACGATGCTG GCACGGGCAC CGTCTTCCTC 
TTCTTCATCG CGGTGCTGGG CCACACGCCT GAGGCCGTGC AGATCGCCAC GGGAAGGAAC 
GCCGCGCGCC TCTGCTGTGT GGCCAGCCGT GACGCCGGCC TCTCGTGGGG CAGCGCCCGG 
GACCTCACCG AGGAGGCCAT CGGTGGTGCC GTGCAGGACT GGGCCACATT CGCTGTGGGT 
CCCGGCCACG GTGTGCAGCT GCCCTCAGGC CGCCTGCTGG TACCCGCCTA CACCTACCGC 
GTGGACCGCC GAGAGTGTTT TGGCAAGATC TGCCGGACCA GCCCTCACTC CTTCGCCTTC 
TACAGCGATG ACCACGGCCG CACCTGGCGC TGTGGAGGCC TCGTGCCCAA CCTGCGCTCA 
GGCGAGTGCC AGCTGGCAGC GGTGGACGGT GGGCAGGCCG GCAGCTTCCT CTACTGCAAT 
GCCCGGAGCC CACTGGGCAG CCGTGTGCAG GCGCTCAGCA CTGACGAGGG CACCTCCTTC 
CTGCCCGCAG AGCGCGTGGC TTCCCTGCCC GAGACTGCCT GGGGCTGCCA GGGCAGCATC 
GTGGGCTTCC CAGCCCCCGC CCCCAACAGG CCACGGGATG ACAGTTGGTC AGTGGGCCCC 
GGGAGTCCCC TCCAGCCTCC ACTCCTCGGT CCTGGAGTCC ACGAACCCCC AGAGGAGGCT 
GCTGTAGACC CCCGTGGAGG CCAGGTGCCT GGTGGGCCCT TCAGCCGTCT GCAGCCTCGG 
GGGGATGGCC CCAGGCAGCC TGGCCCCAGG CCTGGGGTCA GTGGGGATGT GGGGTCCTGG 
ACCCTGGCAC TCCCCATGCC CTTTGCTGCC CCGCCCCAGA GCCCCACGTG GCTGCTGTAC 
TCCCACCCAG TGGGGCGCAG GGCTCGGCTA CACATGGGTA TCCGCCTGAG CCAGTCCCCG 
CTGGACCCGC GCAGCTGGAC AGAGCCCTGG GTGATCTACG AGGGCCCCAG CGGCTACTCC 
GACCTGGCGT CCATCGGGCC GGCCCCTGAG GGGGGCCTGG TTTTTGCCTG CCTGTACGAG 
AGCGGGGCCA GGACCTCCTA TGATGAGATT TCCTTTTGTA CATTCTCCCT GCGTGAGGTC 
CTGGAGAACG TGCCCGCCAG CCCCAAACCG CCCAACCTTG GGGACAAGCC TCGGGGGTGC 
TGCTGGCCCT CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001161074.1
CDS715..2169
Translation

Target ORF information:

RefSeq Version NM_001167602.2
Organism Homo sapiens(human)
Definition Homo sapiens neuraminidase 4 (NEU4), transcript variant 5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001167602.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGGGGTCC CTCGTACCCC TTCACGGACA GTGCTCTTCG AGCGGGAGAG GACGGGCCTG 
ACCTACCGCG TGCCCTCGCT GCTCCCCGTG CCCCCCGGGC CCACCCTGCT GGCCTTTGTG 
GAGCAGCGGC TCAGCCCTGA CGACTCCCAC GCCCACCGCC TGGTGCTGAG GAGGGGCACG 
CTGGCCGGGG GCTCCGTGCG GTGGGGTGCC CTGCACGTGC TGGGGACAGC AGCCCTGGCG 
GAGCACCGGT CCATGAACCC CTGCCCTGTG CACGATGCTG GCACGGGCAC CGTCTTCCTC 
TTCTTCATCG CGGTGCTGGG CCACACGCCT GAGGCCGTGC AGATCGCCAC GGGAAGGAAC 
GCCGCGCGCC TCTGCTGTGT GGCCAGCCGT GACGCCGGCC TCTCGTGGGG CAGCGCCCGG 
GACCTCACCG AGGAGGCCAT CGGTGGTGCC GTGCAGGACT GGGCCACATT CGCTGTGGGT 
CCCGGCCACG GTGTGCAGCT GCCCTCAGGC CGCCTGCTGG TACCCGCCTA CACCTACCGC 
GTGGACCGCC GAGAGTGTTT TGGCAAGATC TGCCGGACCA GCCCTCACTC CTTCGCCTTC 
TACAGCGATG ACCACGGCCG CACCTGGCGC TGTGGAGGCC TCGTGCCCAA CCTGCGCTCA 
GGCGAGTGCC AGCTGGCAGC GGTGGACGGT GGGCAGGCCG GCAGCTTCCT CTACTGCAAT 
GCCCGGAGCC CACTGGGCAG CCGTGTGCAG GCGCTCAGCA CTGACGAGGG CACCTCCTTC 
CTGCCCGCAG AGCGCGTGGC TTCCCTGCCC GAGACTGCCT GGGGCTGCCA GGGCAGCATC 
GTGGGCTTCC CAGCCCCCGC CCCCAACAGG CCACGGGATG ACAGTTGGTC AGTGGGCCCC 
GGGAGTCCCC TCCAGCCTCC ACTCCTCGGT CCTGGAGTCC ACGAACCCCC AGAGGAGGCT 
GCTGTAGACC CCCGTGGAGG CCAGGTGCCT GGTGGGCCCT TCAGCCGTCT GCAGCCTCGG 
GGGGATGGCC CCAGGCAGCC TGGCCCCAGG CCTGGGGTCA GTGGGGATGT GGGGTCCTGG 
ACCCTGGCAC TCCCCATGCC CTTTGCTGCC CCGCCCCAGA GCCCCACGTG GCTGCTGTAC 
TCCCACCCAG TGGGGCGCAG GGCTCGGCTA CACATGGGTA TCCGCCTGAG CCAGTCCCCG 
CTGGACCCGC GCAGCTGGAC AGAGCCCTGG GTGATCTACG AGGGCCCCAG CGGCTACTCC 
GACCTGGCGT CCATCGGGCC GGCCCCTGAG GGGGGCCTGG TTTTTGCCTG CCTGTACGAG 
AGCGGGGCCA GGACCTCCTA TGATGAGATT TCCTTTTGTA CATTCTCCCT GCGTGAGGTC 
CTGGAGAACG TGCCCGCCAG CCCCAAACCG CCCAACCTTG GGGACAAGCC TCGGGGGTGC 
TGCTGGCCCT CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23274
Clone ID Related Accession (Same CDS sequence) NM_001167602.2 , NM_001167601.2 , NM_001167602.3 , NM_001167600.2 , NM_001167601.3 , NM_001167600.3
Accession Version NM_001167601.2 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1455bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2018-06-29
Organism Homo sapiens(human)
Product sialidase-4 isoform 3
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC412650.1, AY203952.1, AC131097.6 and BC063465.1. On Apr 12, 2014 this sequence version replaced NM_001167601.1. Transcript Variant: This variant (4) contains an alternate exon at the 5' end and uses an alternate acceptor splice site at the next exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (3, also known as NEU4 short) with a shorter N-terminus compared to isoform 1. Variants 3-5 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY203952.1, DC300516.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGGGGTCC CTCGTACCCC TTCACGGACA GTGCTCTTCG AGCGGGAGAG GACGGGCCTG 
ACCTACCGCG TGCCCTCGCT GCTCCCCGTG CCCCCCGGGC CCACCCTGCT GGCCTTTGTG 
GAGCAGCGGC TCAGCCCTGA CGACTCCCAC GCCCACCGCC TGGTGCTGAG GAGGGGCACG 
CTGGCCGGGG GCTCCGTGCG GTGGGGTGCC CTGCACGTGC TGGGGACAGC AGCCCTGGCG 
GAGCACCGGT CCATGAACCC CTGCCCTGTG CACGATGCTG GCACGGGCAC CGTCTTCCTC 
TTCTTCATCG CGGTGCTGGG CCACACGCCT GAGGCCGTGC AGATCGCCAC GGGAAGGAAC 
GCCGCGCGCC TCTGCTGTGT GGCCAGCCGT GACGCCGGCC TCTCGTGGGG CAGCGCCCGG 
GACCTCACCG AGGAGGCCAT CGGTGGTGCC GTGCAGGACT GGGCCACATT CGCTGTGGGT 
CCCGGCCACG GTGTGCAGCT GCCCTCAGGC CGCCTGCTGG TACCCGCCTA CACCTACCGC 
GTGGACCGCC GAGAGTGTTT TGGCAAGATC TGCCGGACCA GCCCTCACTC CTTCGCCTTC 
TACAGCGATG ACCACGGCCG CACCTGGCGC TGTGGAGGCC TCGTGCCCAA CCTGCGCTCA 
GGCGAGTGCC AGCTGGCAGC GGTGGACGGT GGGCAGGCCG GCAGCTTCCT CTACTGCAAT 
GCCCGGAGCC CACTGGGCAG CCGTGTGCAG GCGCTCAGCA CTGACGAGGG CACCTCCTTC 
CTGCCCGCAG AGCGCGTGGC TTCCCTGCCC GAGACTGCCT GGGGCTGCCA GGGCAGCATC 
GTGGGCTTCC CAGCCCCCGC CCCCAACAGG CCACGGGATG ACAGTTGGTC AGTGGGCCCC 
GGGAGTCCCC TCCAGCCTCC ACTCCTCGGT CCTGGAGTCC ACGAACCCCC AGAGGAGGCT 
GCTGTAGACC CCCGTGGAGG CCAGGTGCCT GGTGGGCCCT TCAGCCGTCT GCAGCCTCGG 
GGGGATGGCC CCAGGCAGCC TGGCCCCAGG CCTGGGGTCA GTGGGGATGT GGGGTCCTGG 
ACCCTGGCAC TCCCCATGCC CTTTGCTGCC CCGCCCCAGA GCCCCACGTG GCTGCTGTAC 
TCCCACCCAG TGGGGCGCAG GGCTCGGCTA CACATGGGTA TCCGCCTGAG CCAGTCCCCG 
CTGGACCCGC GCAGCTGGAC AGAGCCCTGG GTGATCTACG AGGGCCCCAG CGGCTACTCC 
GACCTGGCGT CCATCGGGCC GGCCCCTGAG GGGGGCCTGG TTTTTGCCTG CCTGTACGAG 
AGCGGGGCCA GGACCTCCTA TGATGAGATT TCCTTTTGTA CATTCTCCCT GCGTGAGGTC 
CTGGAGAACG TGCCCGCCAG CCCCAAACCG CCCAACCTTG GGGACAAGCC TCGGGGGTGC 
TGCTGGCCCT CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001161073.1
CDS217..1671
Translation

Target ORF information:

RefSeq Version NM_001167601.2
Organism Homo sapiens(human)
Definition Homo sapiens neuraminidase 4 (NEU4), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001167601.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGGGGTCC CTCGTACCCC TTCACGGACA GTGCTCTTCG AGCGGGAGAG GACGGGCCTG 
ACCTACCGCG TGCCCTCGCT GCTCCCCGTG CCCCCCGGGC CCACCCTGCT GGCCTTTGTG 
GAGCAGCGGC TCAGCCCTGA CGACTCCCAC GCCCACCGCC TGGTGCTGAG GAGGGGCACG 
CTGGCCGGGG GCTCCGTGCG GTGGGGTGCC CTGCACGTGC TGGGGACAGC AGCCCTGGCG 
GAGCACCGGT CCATGAACCC CTGCCCTGTG CACGATGCTG GCACGGGCAC CGTCTTCCTC 
TTCTTCATCG CGGTGCTGGG CCACACGCCT GAGGCCGTGC AGATCGCCAC GGGAAGGAAC 
GCCGCGCGCC TCTGCTGTGT GGCCAGCCGT GACGCCGGCC TCTCGTGGGG CAGCGCCCGG 
GACCTCACCG AGGAGGCCAT CGGTGGTGCC GTGCAGGACT GGGCCACATT CGCTGTGGGT 
CCCGGCCACG GTGTGCAGCT GCCCTCAGGC CGCCTGCTGG TACCCGCCTA CACCTACCGC 
GTGGACCGCC GAGAGTGTTT TGGCAAGATC TGCCGGACCA GCCCTCACTC CTTCGCCTTC 
TACAGCGATG ACCACGGCCG CACCTGGCGC TGTGGAGGCC TCGTGCCCAA CCTGCGCTCA 
GGCGAGTGCC AGCTGGCAGC GGTGGACGGT GGGCAGGCCG GCAGCTTCCT CTACTGCAAT 
GCCCGGAGCC CACTGGGCAG CCGTGTGCAG GCGCTCAGCA CTGACGAGGG CACCTCCTTC 
CTGCCCGCAG AGCGCGTGGC TTCCCTGCCC GAGACTGCCT GGGGCTGCCA GGGCAGCATC 
GTGGGCTTCC CAGCCCCCGC CCCCAACAGG CCACGGGATG ACAGTTGGTC AGTGGGCCCC 
GGGAGTCCCC TCCAGCCTCC ACTCCTCGGT CCTGGAGTCC ACGAACCCCC AGAGGAGGCT 
GCTGTAGACC CCCGTGGAGG CCAGGTGCCT GGTGGGCCCT TCAGCCGTCT GCAGCCTCGG 
GGGGATGGCC CCAGGCAGCC TGGCCCCAGG CCTGGGGTCA GTGGGGATGT GGGGTCCTGG 
ACCCTGGCAC TCCCCATGCC CTTTGCTGCC CCGCCCCAGA GCCCCACGTG GCTGCTGTAC 
TCCCACCCAG TGGGGCGCAG GGCTCGGCTA CACATGGGTA TCCGCCTGAG CCAGTCCCCG 
CTGGACCCGC GCAGCTGGAC AGAGCCCTGG GTGATCTACG AGGGCCCCAG CGGCTACTCC 
GACCTGGCGT CCATCGGGCC GGCCCCTGAG GGGGGCCTGG TTTTTGCCTG CCTGTACGAG 
AGCGGGGCCA GGACCTCCTA TGATGAGATT TCCTTTTGTA CATTCTCCCT GCGTGAGGTC 
CTGGAGAACG TGCCCGCCAG CCCCAAACCG CCCAACCTTG GGGACAAGCC TCGGGGGTGC 
TGCTGGCCCT CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23274
Clone ID Related Accession (Same CDS sequence) NM_001167602.2 , NM_001167601.2 , NM_001167602.3 , NM_001167600.2 , NM_001167601.3 , NM_001167600.3
Accession Version NM_001167602.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1455bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-02
Organism Homo sapiens(human)
Product sialidase-4 isoform 3
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC131097.6, AK091038.1 and BC063465.1. On Jun 2, 2019 this sequence version replaced NM_001167602.2. Transcript Variant: This variant (5) contains an additional exon at the 5' end compared to variant 1, resulting in translation initiation from an in-frame downstream AUG, and an isoform (3, also known as NEU4 short) with a shorter N-terminus compared to isoform 1. Variants 3-5 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK091038.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA1970526 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGGGGTCC CTCGTACCCC TTCACGGACA GTGCTCTTCG AGCGGGAGAG GACGGGCCTG 
ACCTACCGCG TGCCCTCGCT GCTCCCCGTG CCCCCCGGGC CCACCCTGCT GGCCTTTGTG 
GAGCAGCGGC TCAGCCCTGA CGACTCCCAC GCCCACCGCC TGGTGCTGAG GAGGGGCACG 
CTGGCCGGGG GCTCCGTGCG GTGGGGTGCC CTGCACGTGC TGGGGACAGC AGCCCTGGCG 
GAGCACCGGT CCATGAACCC CTGCCCTGTG CACGATGCTG GCACGGGCAC CGTCTTCCTC 
TTCTTCATCG CGGTGCTGGG CCACACGCCT GAGGCCGTGC AGATCGCCAC GGGAAGGAAC 
GCCGCGCGCC TCTGCTGTGT GGCCAGCCGT GACGCCGGCC TCTCGTGGGG CAGCGCCCGG 
GACCTCACCG AGGAGGCCAT CGGTGGTGCC GTGCAGGACT GGGCCACATT CGCTGTGGGT 
CCCGGCCACG GTGTGCAGCT GCCCTCAGGC CGCCTGCTGG TACCCGCCTA CACCTACCGC 
GTGGACCGCC GAGAGTGTTT TGGCAAGATC TGCCGGACCA GCCCTCACTC CTTCGCCTTC 
TACAGCGATG ACCACGGCCG CACCTGGCGC TGTGGAGGCC TCGTGCCCAA CCTGCGCTCA 
GGCGAGTGCC AGCTGGCAGC GGTGGACGGT GGGCAGGCCG GCAGCTTCCT CTACTGCAAT 
GCCCGGAGCC CACTGGGCAG CCGTGTGCAG GCGCTCAGCA CTGACGAGGG CACCTCCTTC 
CTGCCCGCAG AGCGCGTGGC TTCCCTGCCC GAGACTGCCT GGGGCTGCCA GGGCAGCATC 
GTGGGCTTCC CAGCCCCCGC CCCCAACAGG CCACGGGATG ACAGTTGGTC AGTGGGCCCC 
GGGAGTCCCC TCCAGCCTCC ACTCCTCGGT CCTGGAGTCC ACGAACCCCC AGAGGAGGCT 
GCTGTAGACC CCCGTGGAGG CCAGGTGCCT GGTGGGCCCT TCAGCCGTCT GCAGCCTCGG 
GGGGATGGCC CCAGGCAGCC TGGCCCCAGG CCTGGGGTCA GTGGGGATGT GGGGTCCTGG 
ACCCTGGCAC TCCCCATGCC CTTTGCTGCC CCGCCCCAGA GCCCCACGTG GCTGCTGTAC 
TCCCACCCAG TGGGGCGCAG GGCTCGGCTA CACATGGGTA TCCGCCTGAG CCAGTCCCCG 
CTGGACCCGC GCAGCTGGAC AGAGCCCTGG GTGATCTACG AGGGCCCCAG CGGCTACTCC 
GACCTGGCGT CCATCGGGCC GGCCCCTGAG GGGGGCCTGG TTTTTGCCTG CCTGTACGAG 
AGCGGGGCCA GGACCTCCTA TGATGAGATT TCCTTTTGTA CATTCTCCCT GCGTGAGGTC 
CTGGAGAACG TGCCCGCCAG CCCCAAACCG CCCAACCTTG GGGACAAGCC TCGGGGGTGC 
TGCTGGCCCT CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001161074.1
CDS251..1705
Translation

Target ORF information:

RefSeq Version NM_001167602.3
Organism Homo sapiens(human)
Definition Homo sapiens neuraminidase 4 (NEU4), transcript variant 5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001167602.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGGGGTCC CTCGTACCCC TTCACGGACA GTGCTCTTCG AGCGGGAGAG GACGGGCCTG 
ACCTACCGCG TGCCCTCGCT GCTCCCCGTG CCCCCCGGGC CCACCCTGCT GGCCTTTGTG 
GAGCAGCGGC TCAGCCCTGA CGACTCCCAC GCCCACCGCC TGGTGCTGAG GAGGGGCACG 
CTGGCCGGGG GCTCCGTGCG GTGGGGTGCC CTGCACGTGC TGGGGACAGC AGCCCTGGCG 
GAGCACCGGT CCATGAACCC CTGCCCTGTG CACGATGCTG GCACGGGCAC CGTCTTCCTC 
TTCTTCATCG CGGTGCTGGG CCACACGCCT GAGGCCGTGC AGATCGCCAC GGGAAGGAAC 
GCCGCGCGCC TCTGCTGTGT GGCCAGCCGT GACGCCGGCC TCTCGTGGGG CAGCGCCCGG 
GACCTCACCG AGGAGGCCAT CGGTGGTGCC GTGCAGGACT GGGCCACATT CGCTGTGGGT 
CCCGGCCACG GTGTGCAGCT GCCCTCAGGC CGCCTGCTGG TACCCGCCTA CACCTACCGC 
GTGGACCGCC GAGAGTGTTT TGGCAAGATC TGCCGGACCA GCCCTCACTC CTTCGCCTTC 
TACAGCGATG ACCACGGCCG CACCTGGCGC TGTGGAGGCC TCGTGCCCAA CCTGCGCTCA 
GGCGAGTGCC AGCTGGCAGC GGTGGACGGT GGGCAGGCCG GCAGCTTCCT CTACTGCAAT 
GCCCGGAGCC CACTGGGCAG CCGTGTGCAG GCGCTCAGCA CTGACGAGGG CACCTCCTTC 
CTGCCCGCAG AGCGCGTGGC TTCCCTGCCC GAGACTGCCT GGGGCTGCCA GGGCAGCATC 
GTGGGCTTCC CAGCCCCCGC CCCCAACAGG CCACGGGATG ACAGTTGGTC AGTGGGCCCC 
GGGAGTCCCC TCCAGCCTCC ACTCCTCGGT CCTGGAGTCC ACGAACCCCC AGAGGAGGCT 
GCTGTAGACC CCCGTGGAGG CCAGGTGCCT GGTGGGCCCT TCAGCCGTCT GCAGCCTCGG 
GGGGATGGCC CCAGGCAGCC TGGCCCCAGG CCTGGGGTCA GTGGGGATGT GGGGTCCTGG 
ACCCTGGCAC TCCCCATGCC CTTTGCTGCC CCGCCCCAGA GCCCCACGTG GCTGCTGTAC 
TCCCACCCAG TGGGGCGCAG GGCTCGGCTA CACATGGGTA TCCGCCTGAG CCAGTCCCCG 
CTGGACCCGC GCAGCTGGAC AGAGCCCTGG GTGATCTACG AGGGCCCCAG CGGCTACTCC 
GACCTGGCGT CCATCGGGCC GGCCCCTGAG GGGGGCCTGG TTTTTGCCTG CCTGTACGAG 
AGCGGGGCCA GGACCTCCTA TGATGAGATT TCCTTTTGTA CATTCTCCCT GCGTGAGGTC 
CTGGAGAACG TGCCCGCCAG CCCCAAACCG CCCAACCTTG GGGACAAGCC TCGGGGGTGC 
TGCTGGCCCT CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23274
Clone ID Related Accession (Same CDS sequence) NM_001167602.2 , NM_001167601.2 , NM_001167602.3 , NM_001167600.2 , NM_001167601.3 , NM_001167600.3
Accession Version NM_001167600.2 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1455bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2018-06-29
Organism Homo sapiens(human)
Product sialidase-4 isoform 3
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC412650.1, AK289421.1, AC131097.6 and BC063465.1. On Apr 12, 2014 this sequence version replaced NM_001167600.1. Transcript Variant: This variant (3) contains an alternate exon at the 5' end compared to variant 1, resulting in translation initiation from an in-frame downstream AUG, and an isoform (3, also known as NEU4 short) with a shorter N-terminus compared to isoform 1. Variants 3-5 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK289421.1, AK300969.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGGGGTCC CTCGTACCCC TTCACGGACA GTGCTCTTCG AGCGGGAGAG GACGGGCCTG 
ACCTACCGCG TGCCCTCGCT GCTCCCCGTG CCCCCCGGGC CCACCCTGCT GGCCTTTGTG 
GAGCAGCGGC TCAGCCCTGA CGACTCCCAC GCCCACCGCC TGGTGCTGAG GAGGGGCACG 
CTGGCCGGGG GCTCCGTGCG GTGGGGTGCC CTGCACGTGC TGGGGACAGC AGCCCTGGCG 
GAGCACCGGT CCATGAACCC CTGCCCTGTG CACGATGCTG GCACGGGCAC CGTCTTCCTC 
TTCTTCATCG CGGTGCTGGG CCACACGCCT GAGGCCGTGC AGATCGCCAC GGGAAGGAAC 
GCCGCGCGCC TCTGCTGTGT GGCCAGCCGT GACGCCGGCC TCTCGTGGGG CAGCGCCCGG 
GACCTCACCG AGGAGGCCAT CGGTGGTGCC GTGCAGGACT GGGCCACATT CGCTGTGGGT 
CCCGGCCACG GTGTGCAGCT GCCCTCAGGC CGCCTGCTGG TACCCGCCTA CACCTACCGC 
GTGGACCGCC GAGAGTGTTT TGGCAAGATC TGCCGGACCA GCCCTCACTC CTTCGCCTTC 
TACAGCGATG ACCACGGCCG CACCTGGCGC TGTGGAGGCC TCGTGCCCAA CCTGCGCTCA 
GGCGAGTGCC AGCTGGCAGC GGTGGACGGT GGGCAGGCCG GCAGCTTCCT CTACTGCAAT 
GCCCGGAGCC CACTGGGCAG CCGTGTGCAG GCGCTCAGCA CTGACGAGGG CACCTCCTTC 
CTGCCCGCAG AGCGCGTGGC TTCCCTGCCC GAGACTGCCT GGGGCTGCCA GGGCAGCATC 
GTGGGCTTCC CAGCCCCCGC CCCCAACAGG CCACGGGATG ACAGTTGGTC AGTGGGCCCC 
GGGAGTCCCC TCCAGCCTCC ACTCCTCGGT CCTGGAGTCC ACGAACCCCC AGAGGAGGCT 
GCTGTAGACC CCCGTGGAGG CCAGGTGCCT GGTGGGCCCT TCAGCCGTCT GCAGCCTCGG 
GGGGATGGCC CCAGGCAGCC TGGCCCCAGG CCTGGGGTCA GTGGGGATGT GGGGTCCTGG 
ACCCTGGCAC TCCCCATGCC CTTTGCTGCC CCGCCCCAGA GCCCCACGTG GCTGCTGTAC 
TCCCACCCAG TGGGGCGCAG GGCTCGGCTA CACATGGGTA TCCGCCTGAG CCAGTCCCCG 
CTGGACCCGC GCAGCTGGAC AGAGCCCTGG GTGATCTACG AGGGCCCCAG CGGCTACTCC 
GACCTGGCGT CCATCGGGCC GGCCCCTGAG GGGGGCCTGG TTTTTGCCTG CCTGTACGAG 
AGCGGGGCCA GGACCTCCTA TGATGAGATT TCCTTTTGTA CATTCTCCCT GCGTGAGGTC 
CTGGAGAACG TGCCCGCCAG CCCCAAACCG CCCAACCTTG GGGACAAGCC TCGGGGGTGC 
TGCTGGCCCT CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001161072.1
CDS214..1668
Translation

Target ORF information:

RefSeq Version NM_001167600.2
Organism Homo sapiens(human)
Definition Homo sapiens neuraminidase 4 (NEU4), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001167600.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGGGGTCC CTCGTACCCC TTCACGGACA GTGCTCTTCG AGCGGGAGAG GACGGGCCTG 
ACCTACCGCG TGCCCTCGCT GCTCCCCGTG CCCCCCGGGC CCACCCTGCT GGCCTTTGTG 
GAGCAGCGGC TCAGCCCTGA CGACTCCCAC GCCCACCGCC TGGTGCTGAG GAGGGGCACG 
CTGGCCGGGG GCTCCGTGCG GTGGGGTGCC CTGCACGTGC TGGGGACAGC AGCCCTGGCG 
GAGCACCGGT CCATGAACCC CTGCCCTGTG CACGATGCTG GCACGGGCAC CGTCTTCCTC 
TTCTTCATCG CGGTGCTGGG CCACACGCCT GAGGCCGTGC AGATCGCCAC GGGAAGGAAC 
GCCGCGCGCC TCTGCTGTGT GGCCAGCCGT GACGCCGGCC TCTCGTGGGG CAGCGCCCGG 
GACCTCACCG AGGAGGCCAT CGGTGGTGCC GTGCAGGACT GGGCCACATT CGCTGTGGGT 
CCCGGCCACG GTGTGCAGCT GCCCTCAGGC CGCCTGCTGG TACCCGCCTA CACCTACCGC 
GTGGACCGCC GAGAGTGTTT TGGCAAGATC TGCCGGACCA GCCCTCACTC CTTCGCCTTC 
TACAGCGATG ACCACGGCCG CACCTGGCGC TGTGGAGGCC TCGTGCCCAA CCTGCGCTCA 
GGCGAGTGCC AGCTGGCAGC GGTGGACGGT GGGCAGGCCG GCAGCTTCCT CTACTGCAAT 
GCCCGGAGCC CACTGGGCAG CCGTGTGCAG GCGCTCAGCA CTGACGAGGG CACCTCCTTC 
CTGCCCGCAG AGCGCGTGGC TTCCCTGCCC GAGACTGCCT GGGGCTGCCA GGGCAGCATC 
GTGGGCTTCC CAGCCCCCGC CCCCAACAGG CCACGGGATG ACAGTTGGTC AGTGGGCCCC 
GGGAGTCCCC TCCAGCCTCC ACTCCTCGGT CCTGGAGTCC ACGAACCCCC AGAGGAGGCT 
GCTGTAGACC CCCGTGGAGG CCAGGTGCCT GGTGGGCCCT TCAGCCGTCT GCAGCCTCGG 
GGGGATGGCC CCAGGCAGCC TGGCCCCAGG CCTGGGGTCA GTGGGGATGT GGGGTCCTGG 
ACCCTGGCAC TCCCCATGCC CTTTGCTGCC CCGCCCCAGA GCCCCACGTG GCTGCTGTAC 
TCCCACCCAG TGGGGCGCAG GGCTCGGCTA CACATGGGTA TCCGCCTGAG CCAGTCCCCG 
CTGGACCCGC GCAGCTGGAC AGAGCCCTGG GTGATCTACG AGGGCCCCAG CGGCTACTCC 
GACCTGGCGT CCATCGGGCC GGCCCCTGAG GGGGGCCTGG TTTTTGCCTG CCTGTACGAG 
AGCGGGGCCA GGACCTCCTA TGATGAGATT TCCTTTTGTA CATTCTCCCT GCGTGAGGTC 
CTGGAGAACG TGCCCGCCAG CCCCAAACCG CCCAACCTTG GGGACAAGCC TCGGGGGTGC 
TGCTGGCCCT CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23274
Clone ID Related Accession (Same CDS sequence) NM_001167602.2 , NM_001167601.2 , NM_001167602.3 , NM_001167600.2 , NM_001167601.3 , NM_001167600.3
Accession Version NM_001167601.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1455bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-02
Organism Homo sapiens(human)
Product sialidase-4 isoform 3
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC412650.1, AY203952.1, AC131097.6 and BC063465.1. On Jun 2, 2019 this sequence version replaced NM_001167601.2. Transcript Variant: This variant (4) contains an alternate exon at the 5' end and uses an alternate acceptor splice site at the next exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (3, also known as NEU4 short) with a shorter N-terminus compared to isoform 1. Variants 3-5 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY203952.1, DC300516.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGGGGTCC CTCGTACCCC TTCACGGACA GTGCTCTTCG AGCGGGAGAG GACGGGCCTG 
ACCTACCGCG TGCCCTCGCT GCTCCCCGTG CCCCCCGGGC CCACCCTGCT GGCCTTTGTG 
GAGCAGCGGC TCAGCCCTGA CGACTCCCAC GCCCACCGCC TGGTGCTGAG GAGGGGCACG 
CTGGCCGGGG GCTCCGTGCG GTGGGGTGCC CTGCACGTGC TGGGGACAGC AGCCCTGGCG 
GAGCACCGGT CCATGAACCC CTGCCCTGTG CACGATGCTG GCACGGGCAC CGTCTTCCTC 
TTCTTCATCG CGGTGCTGGG CCACACGCCT GAGGCCGTGC AGATCGCCAC GGGAAGGAAC 
GCCGCGCGCC TCTGCTGTGT GGCCAGCCGT GACGCCGGCC TCTCGTGGGG CAGCGCCCGG 
GACCTCACCG AGGAGGCCAT CGGTGGTGCC GTGCAGGACT GGGCCACATT CGCTGTGGGT 
CCCGGCCACG GTGTGCAGCT GCCCTCAGGC CGCCTGCTGG TACCCGCCTA CACCTACCGC 
GTGGACCGCC GAGAGTGTTT TGGCAAGATC TGCCGGACCA GCCCTCACTC CTTCGCCTTC 
TACAGCGATG ACCACGGCCG CACCTGGCGC TGTGGAGGCC TCGTGCCCAA CCTGCGCTCA 
GGCGAGTGCC AGCTGGCAGC GGTGGACGGT GGGCAGGCCG GCAGCTTCCT CTACTGCAAT 
GCCCGGAGCC CACTGGGCAG CCGTGTGCAG GCGCTCAGCA CTGACGAGGG CACCTCCTTC 
CTGCCCGCAG AGCGCGTGGC TTCCCTGCCC GAGACTGCCT GGGGCTGCCA GGGCAGCATC 
GTGGGCTTCC CAGCCCCCGC CCCCAACAGG CCACGGGATG ACAGTTGGTC AGTGGGCCCC 
GGGAGTCCCC TCCAGCCTCC ACTCCTCGGT CCTGGAGTCC ACGAACCCCC AGAGGAGGCT 
GCTGTAGACC CCCGTGGAGG CCAGGTGCCT GGTGGGCCCT TCAGCCGTCT GCAGCCTCGG 
GGGGATGGCC CCAGGCAGCC TGGCCCCAGG CCTGGGGTCA GTGGGGATGT GGGGTCCTGG 
ACCCTGGCAC TCCCCATGCC CTTTGCTGCC CCGCCCCAGA GCCCCACGTG GCTGCTGTAC 
TCCCACCCAG TGGGGCGCAG GGCTCGGCTA CACATGGGTA TCCGCCTGAG CCAGTCCCCG 
CTGGACCCGC GCAGCTGGAC AGAGCCCTGG GTGATCTACG AGGGCCCCAG CGGCTACTCC 
GACCTGGCGT CCATCGGGCC GGCCCCTGAG GGGGGCCTGG TTTTTGCCTG CCTGTACGAG 
AGCGGGGCCA GGACCTCCTA TGATGAGATT TCCTTTTGTA CATTCTCCCT GCGTGAGGTC 
CTGGAGAACG TGCCCGCCAG CCCCAAACCG CCCAACCTTG GGGACAAGCC TCGGGGGTGC 
TGCTGGCCCT CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001161073.1
CDS89..1543
Translation

Target ORF information:

RefSeq Version NM_001167601.3
Organism Homo sapiens(human)
Definition Homo sapiens neuraminidase 4 (NEU4), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001167601.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGGGGTCC CTCGTACCCC TTCACGGACA GTGCTCTTCG AGCGGGAGAG GACGGGCCTG 
ACCTACCGCG TGCCCTCGCT GCTCCCCGTG CCCCCCGGGC CCACCCTGCT GGCCTTTGTG 
GAGCAGCGGC TCAGCCCTGA CGACTCCCAC GCCCACCGCC TGGTGCTGAG GAGGGGCACG 
CTGGCCGGGG GCTCCGTGCG GTGGGGTGCC CTGCACGTGC TGGGGACAGC AGCCCTGGCG 
GAGCACCGGT CCATGAACCC CTGCCCTGTG CACGATGCTG GCACGGGCAC CGTCTTCCTC 
TTCTTCATCG CGGTGCTGGG CCACACGCCT GAGGCCGTGC AGATCGCCAC GGGAAGGAAC 
GCCGCGCGCC TCTGCTGTGT GGCCAGCCGT GACGCCGGCC TCTCGTGGGG CAGCGCCCGG 
GACCTCACCG AGGAGGCCAT CGGTGGTGCC GTGCAGGACT GGGCCACATT CGCTGTGGGT 
CCCGGCCACG GTGTGCAGCT GCCCTCAGGC CGCCTGCTGG TACCCGCCTA CACCTACCGC 
GTGGACCGCC GAGAGTGTTT TGGCAAGATC TGCCGGACCA GCCCTCACTC CTTCGCCTTC 
TACAGCGATG ACCACGGCCG CACCTGGCGC TGTGGAGGCC TCGTGCCCAA CCTGCGCTCA 
GGCGAGTGCC AGCTGGCAGC GGTGGACGGT GGGCAGGCCG GCAGCTTCCT CTACTGCAAT 
GCCCGGAGCC CACTGGGCAG CCGTGTGCAG GCGCTCAGCA CTGACGAGGG CACCTCCTTC 
CTGCCCGCAG AGCGCGTGGC TTCCCTGCCC GAGACTGCCT GGGGCTGCCA GGGCAGCATC 
GTGGGCTTCC CAGCCCCCGC CCCCAACAGG CCACGGGATG ACAGTTGGTC AGTGGGCCCC 
GGGAGTCCCC TCCAGCCTCC ACTCCTCGGT CCTGGAGTCC ACGAACCCCC AGAGGAGGCT 
GCTGTAGACC CCCGTGGAGG CCAGGTGCCT GGTGGGCCCT TCAGCCGTCT GCAGCCTCGG 
GGGGATGGCC CCAGGCAGCC TGGCCCCAGG CCTGGGGTCA GTGGGGATGT GGGGTCCTGG 
ACCCTGGCAC TCCCCATGCC CTTTGCTGCC CCGCCCCAGA GCCCCACGTG GCTGCTGTAC 
TCCCACCCAG TGGGGCGCAG GGCTCGGCTA CACATGGGTA TCCGCCTGAG CCAGTCCCCG 
CTGGACCCGC GCAGCTGGAC AGAGCCCTGG GTGATCTACG AGGGCCCCAG CGGCTACTCC 
GACCTGGCGT CCATCGGGCC GGCCCCTGAG GGGGGCCTGG TTTTTGCCTG CCTGTACGAG 
AGCGGGGCCA GGACCTCCTA TGATGAGATT TCCTTTTGTA CATTCTCCCT GCGTGAGGTC 
CTGGAGAACG TGCCCGCCAG CCCCAAACCG CCCAACCTTG GGGACAAGCC TCGGGGGTGC 
TGCTGGCCCT CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23274
Clone ID Related Accession (Same CDS sequence) NM_001167602.2 , NM_001167601.2 , NM_001167602.3 , NM_001167600.2 , NM_001167601.3 , NM_001167600.3
Accession Version NM_001167600.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1455bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-02
Organism Homo sapiens(human)
Product sialidase-4 isoform 3
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK289421.1, AC131097.6 and BC063465.1. On Jun 2, 2019 this sequence version replaced NM_001167600.2. Transcript Variant: This variant (3) contains an alternate exon at the 5' end compared to variant 1, resulting in translation initiation from an in-frame downstream AUG, and an isoform (3, also known as NEU4 short) with a shorter N-terminus compared to isoform 1. Variants 3-5 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK289421.1, AK300969.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGGGGTCC CTCGTACCCC TTCACGGACA GTGCTCTTCG AGCGGGAGAG GACGGGCCTG 
ACCTACCGCG TGCCCTCGCT GCTCCCCGTG CCCCCCGGGC CCACCCTGCT GGCCTTTGTG 
GAGCAGCGGC TCAGCCCTGA CGACTCCCAC GCCCACCGCC TGGTGCTGAG GAGGGGCACG 
CTGGCCGGGG GCTCCGTGCG GTGGGGTGCC CTGCACGTGC TGGGGACAGC AGCCCTGGCG 
GAGCACCGGT CCATGAACCC CTGCCCTGTG CACGATGCTG GCACGGGCAC CGTCTTCCTC 
TTCTTCATCG CGGTGCTGGG CCACACGCCT GAGGCCGTGC AGATCGCCAC GGGAAGGAAC 
GCCGCGCGCC TCTGCTGTGT GGCCAGCCGT GACGCCGGCC TCTCGTGGGG CAGCGCCCGG 
GACCTCACCG AGGAGGCCAT CGGTGGTGCC GTGCAGGACT GGGCCACATT CGCTGTGGGT 
CCCGGCCACG GTGTGCAGCT GCCCTCAGGC CGCCTGCTGG TACCCGCCTA CACCTACCGC 
GTGGACCGCC GAGAGTGTTT TGGCAAGATC TGCCGGACCA GCCCTCACTC CTTCGCCTTC 
TACAGCGATG ACCACGGCCG CACCTGGCGC TGTGGAGGCC TCGTGCCCAA CCTGCGCTCA 
GGCGAGTGCC AGCTGGCAGC GGTGGACGGT GGGCAGGCCG GCAGCTTCCT CTACTGCAAT 
GCCCGGAGCC CACTGGGCAG CCGTGTGCAG GCGCTCAGCA CTGACGAGGG CACCTCCTTC 
CTGCCCGCAG AGCGCGTGGC TTCCCTGCCC GAGACTGCCT GGGGCTGCCA GGGCAGCATC 
GTGGGCTTCC CAGCCCCCGC CCCCAACAGG CCACGGGATG ACAGTTGGTC AGTGGGCCCC 
GGGAGTCCCC TCCAGCCTCC ACTCCTCGGT CCTGGAGTCC ACGAACCCCC AGAGGAGGCT 
GCTGTAGACC CCCGTGGAGG CCAGGTGCCT GGTGGGCCCT TCAGCCGTCT GCAGCCTCGG 
GGGGATGGCC CCAGGCAGCC TGGCCCCAGG CCTGGGGTCA GTGGGGATGT GGGGTCCTGG 
ACCCTGGCAC TCCCCATGCC CTTTGCTGCC CCGCCCCAGA GCCCCACGTG GCTGCTGTAC 
TCCCACCCAG TGGGGCGCAG GGCTCGGCTA CACATGGGTA TCCGCCTGAG CCAGTCCCCG 
CTGGACCCGC GCAGCTGGAC AGAGCCCTGG GTGATCTACG AGGGCCCCAG CGGCTACTCC 
GACCTGGCGT CCATCGGGCC GGCCCCTGAG GGGGGCCTGG TTTTTGCCTG CCTGTACGAG 
AGCGGGGCCA GGACCTCCTA TGATGAGATT TCCTTTTGTA CATTCTCCCT GCGTGAGGTC 
CTGGAGAACG TGCCCGCCAG CCCCAAACCG CCCAACCTTG GGGACAAGCC TCGGGGGTGC 
TGCTGGCCCT CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001161072.1
CDS86..1540
Translation

Target ORF information:

RefSeq Version NM_001167600.3
Organism Homo sapiens(human)
Definition Homo sapiens neuraminidase 4 (NEU4), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001167600.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGGGGTCC CTCGTACCCC TTCACGGACA GTGCTCTTCG AGCGGGAGAG GACGGGCCTG 
ACCTACCGCG TGCCCTCGCT GCTCCCCGTG CCCCCCGGGC CCACCCTGCT GGCCTTTGTG 
GAGCAGCGGC TCAGCCCTGA CGACTCCCAC GCCCACCGCC TGGTGCTGAG GAGGGGCACG 
CTGGCCGGGG GCTCCGTGCG GTGGGGTGCC CTGCACGTGC TGGGGACAGC AGCCCTGGCG 
GAGCACCGGT CCATGAACCC CTGCCCTGTG CACGATGCTG GCACGGGCAC CGTCTTCCTC 
TTCTTCATCG CGGTGCTGGG CCACACGCCT GAGGCCGTGC AGATCGCCAC GGGAAGGAAC 
GCCGCGCGCC TCTGCTGTGT GGCCAGCCGT GACGCCGGCC TCTCGTGGGG CAGCGCCCGG 
GACCTCACCG AGGAGGCCAT CGGTGGTGCC GTGCAGGACT GGGCCACATT CGCTGTGGGT 
CCCGGCCACG GTGTGCAGCT GCCCTCAGGC CGCCTGCTGG TACCCGCCTA CACCTACCGC 
GTGGACCGCC GAGAGTGTTT TGGCAAGATC TGCCGGACCA GCCCTCACTC CTTCGCCTTC 
TACAGCGATG ACCACGGCCG CACCTGGCGC TGTGGAGGCC TCGTGCCCAA CCTGCGCTCA 
GGCGAGTGCC AGCTGGCAGC GGTGGACGGT GGGCAGGCCG GCAGCTTCCT CTACTGCAAT 
GCCCGGAGCC CACTGGGCAG CCGTGTGCAG GCGCTCAGCA CTGACGAGGG CACCTCCTTC 
CTGCCCGCAG AGCGCGTGGC TTCCCTGCCC GAGACTGCCT GGGGCTGCCA GGGCAGCATC 
GTGGGCTTCC CAGCCCCCGC CCCCAACAGG CCACGGGATG ACAGTTGGTC AGTGGGCCCC 
GGGAGTCCCC TCCAGCCTCC ACTCCTCGGT CCTGGAGTCC ACGAACCCCC AGAGGAGGCT 
GCTGTAGACC CCCGTGGAGG CCAGGTGCCT GGTGGGCCCT TCAGCCGTCT GCAGCCTCGG 
GGGGATGGCC CCAGGCAGCC TGGCCCCAGG CCTGGGGTCA GTGGGGATGT GGGGTCCTGG 
ACCCTGGCAC TCCCCATGCC CTTTGCTGCC CCGCCCCAGA GCCCCACGTG GCTGCTGTAC 
TCCCACCCAG TGGGGCGCAG GGCTCGGCTA CACATGGGTA TCCGCCTGAG CCAGTCCCCG 
CTGGACCCGC GCAGCTGGAC AGAGCCCTGG GTGATCTACG AGGGCCCCAG CGGCTACTCC 
GACCTGGCGT CCATCGGGCC GGCCCCTGAG GGGGGCCTGG TTTTTGCCTG CCTGTACGAG 
AGCGGGGCCA GGACCTCCTA TGATGAGATT TCCTTTTGTA CATTCTCCCT GCGTGAGGTC 
CTGGAGAACG TGCCCGCCAG CCCCAAACCG CCCAACCTTG GGGACAAGCC TCGGGGGTGC 
TGCTGGCCCT CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23544
Clone ID Related Accession (Same CDS sequence) NM_080741.3 , NM_080741.4
Accession Version NM_080741.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1491bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2018-06-29
Organism Homo sapiens(human)
Product sialidase-4 isoform 1
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC131097.6, BC117214.1 and BC063465.1. On Apr 12, 2014 this sequence version replaced NM_080741.2. Transcript Variant: This variant (1) encodes isoform 1 (also known as NEU4 long). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012899.1, AK290076.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154665, SAMN03465404 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGATGAGCT CTGCAGCCTT CCCAAGGTGG CTGAGCATGG GGGTCCCTCG TACCCCTTCA 
CGGACAGTGC TCTTCGAGCG GGAGAGGACG GGCCTGACCT ACCGCGTGCC CTCGCTGCTC 
CCCGTGCCCC CCGGGCCCAC CCTGCTGGCC TTTGTGGAGC AGCGGCTCAG CCCTGACGAC 
TCCCACGCCC ACCGCCTGGT GCTGAGGAGG GGCACGCTGG CCGGGGGCTC CGTGCGGTGG 
GGTGCCCTGC ACGTGCTGGG GACAGCAGCC CTGGCGGAGC ACCGGTCCAT GAACCCCTGC 
CCTGTGCACG ATGCTGGCAC GGGCACCGTC TTCCTCTTCT TCATCGCGGT GCTGGGCCAC 
ACGCCTGAGG CCGTGCAGAT CGCCACGGGA AGGAACGCCG CGCGCCTCTG CTGTGTGGCC 
AGCCGTGACG CCGGCCTCTC GTGGGGCAGC GCCCGGGACC TCACCGAGGA GGCCATCGGT 
GGTGCCGTGC AGGACTGGGC CACATTCGCT GTGGGTCCCG GCCACGGTGT GCAGCTGCCC 
TCAGGCCGCC TGCTGGTACC CGCCTACACC TACCGCGTGG ACCGCCGAGA GTGTTTTGGC 
AAGATCTGCC GGACCAGCCC TCACTCCTTC GCCTTCTACA GCGATGACCA CGGCCGCACC 
TGGCGCTGTG GAGGCCTCGT GCCCAACCTG CGCTCAGGCG AGTGCCAGCT GGCAGCGGTG 
GACGGTGGGC AGGCCGGCAG CTTCCTCTAC TGCAATGCCC GGAGCCCACT GGGCAGCCGT 
GTGCAGGCGC TCAGCACTGA CGAGGGCACC TCCTTCCTGC CCGCAGAGCG CGTGGCTTCC 
CTGCCCGAGA CTGCCTGGGG CTGCCAGGGC AGCATCGTGG GCTTCCCAGC CCCCGCCCCC 
AACAGGCCAC GGGATGACAG TTGGTCAGTG GGCCCCGGGA GTCCCCTCCA GCCTCCACTC 
CTCGGTCCTG GAGTCCACGA ACCCCCAGAG GAGGCTGCTG TAGACCCCCG TGGAGGCCAG 
GTGCCTGGTG GGCCCTTCAG CCGTCTGCAG CCTCGGGGGG ATGGCCCCAG GCAGCCTGGC 
CCCAGGCCTG GGGTCAGTGG GGATGTGGGG TCCTGGACCC TGGCACTCCC CATGCCCTTT 
GCTGCCCCGC CCCAGAGCCC CACGTGGCTG CTGTACTCCC ACCCAGTGGG GCGCAGGGCT 
CGGCTACACA TGGGTATCCG CCTGAGCCAG TCCCCGCTGG ACCCGCGCAG CTGGACAGAG 
CCCTGGGTGA TCTACGAGGG CCCCAGCGGC TACTCCGACC TGGCGTCCAT CGGGCCGGCC 
CCTGAGGGGG GCCTGGTTTT TGCCTGCCTG TACGAGAGCG GGGCCAGGAC CTCCTATGAT 
GAGATTTCCT TTTGTACATT CTCCCTGCGT GAGGTCCTGG AGAACGTGCC CGCCAGCCCC 
AAACCGCCCA ACCTTGGGGA CAAGCCTCGG GGGTGCTGCT GGCCCTCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_542779.2
CDS498..1988
Translation

Target ORF information:

RefSeq Version NM_080741.3
Organism Homo sapiens(human)
Definition Homo sapiens neuraminidase 4 (NEU4), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_080741.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGATGAGCT CTGCAGCCTT CCCAAGGTGG CTGAGCATGG GGGTCCCTCG TACCCCTTCA 
CGGACAGTGC TCTTCGAGCG GGAGAGGACG GGCCTGACCT ACCGCGTGCC CTCGCTGCTC 
CCCGTGCCCC CCGGGCCCAC CCTGCTGGCC TTTGTGGAGC AGCGGCTCAG CCCTGACGAC 
TCCCACGCCC ACCGCCTGGT GCTGAGGAGG GGCACGCTGG CCGGGGGCTC CGTGCGGTGG 
GGTGCCCTGC ACGTGCTGGG GACAGCAGCC CTGGCGGAGC ACCGGTCCAT GAACCCCTGC 
CCTGTGCACG ATGCTGGCAC GGGCACCGTC TTCCTCTTCT TCATCGCGGT GCTGGGCCAC 
ACGCCTGAGG CCGTGCAGAT CGCCACGGGA AGGAACGCCG CGCGCCTCTG CTGTGTGGCC 
AGCCGTGACG CCGGCCTCTC GTGGGGCAGC GCCCGGGACC TCACCGAGGA GGCCATCGGT 
GGTGCCGTGC AGGACTGGGC CACATTCGCT GTGGGTCCCG GCCACGGTGT GCAGCTGCCC 
TCAGGCCGCC TGCTGGTACC CGCCTACACC TACCGCGTGG ACCGCCGAGA GTGTTTTGGC 
AAGATCTGCC GGACCAGCCC TCACTCCTTC GCCTTCTACA GCGATGACCA CGGCCGCACC 
TGGCGCTGTG GAGGCCTCGT GCCCAACCTG CGCTCAGGCG AGTGCCAGCT GGCAGCGGTG 
GACGGTGGGC AGGCCGGCAG CTTCCTCTAC TGCAATGCCC GGAGCCCACT GGGCAGCCGT 
GTGCAGGCGC TCAGCACTGA CGAGGGCACC TCCTTCCTGC CCGCAGAGCG CGTGGCTTCC 
CTGCCCGAGA CTGCCTGGGG CTGCCAGGGC AGCATCGTGG GCTTCCCAGC CCCCGCCCCC 
AACAGGCCAC GGGATGACAG TTGGTCAGTG GGCCCCGGGA GTCCCCTCCA GCCTCCACTC 
CTCGGTCCTG GAGTCCACGA ACCCCCAGAG GAGGCTGCTG TAGACCCCCG TGGAGGCCAG 
GTGCCTGGTG GGCCCTTCAG CCGTCTGCAG CCTCGGGGGG ATGGCCCCAG GCAGCCTGGC 
CCCAGGCCTG GGGTCAGTGG GGATGTGGGG TCCTGGACCC TGGCACTCCC CATGCCCTTT 
GCTGCCCCGC CCCAGAGCCC CACGTGGCTG CTGTACTCCC ACCCAGTGGG GCGCAGGGCT 
CGGCTACACA TGGGTATCCG CCTGAGCCAG TCCCCGCTGG ACCCGCGCAG CTGGACAGAG 
CCCTGGGTGA TCTACGAGGG CCCCAGCGGC TACTCCGACC TGGCGTCCAT CGGGCCGGCC 
CCTGAGGGGG GCCTGGTTTT TGCCTGCCTG TACGAGAGCG GGGCCAGGAC CTCCTATGAT 
GAGATTTCCT TTTGTACATT CTCCCTGCGT GAGGTCCTGG AGAACGTGCC CGCCAGCCCC 
AAACCGCCCA ACCTTGGGGA CAAGCCTCGG GGGTGCTGCT GGCCCTCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23544
Clone ID Related Accession (Same CDS sequence) NM_080741.3 , NM_080741.4
Accession Version NM_080741.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1491bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-02
Organism Homo sapiens(human)
Product sialidase-4 isoform 1
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC117214.1, AC131097.6 and BC063465.1. On Jun 2, 2019 this sequence version replaced NM_080741.3. Transcript Variant: This variant (1) encodes isoform 1 (also known as NEU4 long). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC067780.1, SRR3476690.328614.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154665, SAMN03465404 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGATGAGCT CTGCAGCCTT CCCAAGGTGG CTGAGCATGG GGGTCCCTCG TACCCCTTCA 
CGGACAGTGC TCTTCGAGCG GGAGAGGACG GGCCTGACCT ACCGCGTGCC CTCGCTGCTC 
CCCGTGCCCC CCGGGCCCAC CCTGCTGGCC TTTGTGGAGC AGCGGCTCAG CCCTGACGAC 
TCCCACGCCC ACCGCCTGGT GCTGAGGAGG GGCACGCTGG CCGGGGGCTC CGTGCGGTGG 
GGTGCCCTGC ACGTGCTGGG GACAGCAGCC CTGGCGGAGC ACCGGTCCAT GAACCCCTGC 
CCTGTGCACG ATGCTGGCAC GGGCACCGTC TTCCTCTTCT TCATCGCGGT GCTGGGCCAC 
ACGCCTGAGG CCGTGCAGAT CGCCACGGGA AGGAACGCCG CGCGCCTCTG CTGTGTGGCC 
AGCCGTGACG CCGGCCTCTC GTGGGGCAGC GCCCGGGACC TCACCGAGGA GGCCATCGGT 
GGTGCCGTGC AGGACTGGGC CACATTCGCT GTGGGTCCCG GCCACGGTGT GCAGCTGCCC 
TCAGGCCGCC TGCTGGTACC CGCCTACACC TACCGCGTGG ACCGCCGAGA GTGTTTTGGC 
AAGATCTGCC GGACCAGCCC TCACTCCTTC GCCTTCTACA GCGATGACCA CGGCCGCACC 
TGGCGCTGTG GAGGCCTCGT GCCCAACCTG CGCTCAGGCG AGTGCCAGCT GGCAGCGGTG 
GACGGTGGGC AGGCCGGCAG CTTCCTCTAC TGCAATGCCC GGAGCCCACT GGGCAGCCGT 
GTGCAGGCGC TCAGCACTGA CGAGGGCACC TCCTTCCTGC CCGCAGAGCG CGTGGCTTCC 
CTGCCCGAGA CTGCCTGGGG CTGCCAGGGC AGCATCGTGG GCTTCCCAGC CCCCGCCCCC 
AACAGGCCAC GGGATGACAG TTGGTCAGTG GGCCCCGGGA GTCCCCTCCA GCCTCCACTC 
CTCGGTCCTG GAGTCCACGA ACCCCCAGAG GAGGCTGCTG TAGACCCCCG TGGAGGCCAG 
GTGCCTGGTG GGCCCTTCAG CCGTCTGCAG CCTCGGGGGG ATGGCCCCAG GCAGCCTGGC 
CCCAGGCCTG GGGTCAGTGG GGATGTGGGG TCCTGGACCC TGGCACTCCC CATGCCCTTT 
GCTGCCCCGC CCCAGAGCCC CACGTGGCTG CTGTACTCCC ACCCAGTGGG GCGCAGGGCT 
CGGCTACACA TGGGTATCCG CCTGAGCCAG TCCCCGCTGG ACCCGCGCAG CTGGACAGAG 
CCCTGGGTGA TCTACGAGGG CCCCAGCGGC TACTCCGACC TGGCGTCCAT CGGGCCGGCC 
CCTGAGGGGG GCCTGGTTTT TGCCTGCCTG TACGAGAGCG GGGCCAGGAC CTCCTATGAT 
GAGATTTCCT TTTGTACATT CTCCCTGCGT GAGGTCCTGG AGAACGTGCC CGCCAGCCCC 
AAACCGCCCA ACCTTGGGGA CAAGCCTCGG GGGTGCTGCT GGCCCTCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_542779.2
CDS34..1524
Translation

Target ORF information:

RefSeq Version NM_080741.4
Organism Homo sapiens(human)
Definition Homo sapiens neuraminidase 4 (NEU4), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_080741.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGATGAGCT CTGCAGCCTT CCCAAGGTGG CTGAGCATGG GGGTCCCTCG TACCCCTTCA 
CGGACAGTGC TCTTCGAGCG GGAGAGGACG GGCCTGACCT ACCGCGTGCC CTCGCTGCTC 
CCCGTGCCCC CCGGGCCCAC CCTGCTGGCC TTTGTGGAGC AGCGGCTCAG CCCTGACGAC 
TCCCACGCCC ACCGCCTGGT GCTGAGGAGG GGCACGCTGG CCGGGGGCTC CGTGCGGTGG 
GGTGCCCTGC ACGTGCTGGG GACAGCAGCC CTGGCGGAGC ACCGGTCCAT GAACCCCTGC 
CCTGTGCACG ATGCTGGCAC GGGCACCGTC TTCCTCTTCT TCATCGCGGT GCTGGGCCAC 
ACGCCTGAGG CCGTGCAGAT CGCCACGGGA AGGAACGCCG CGCGCCTCTG CTGTGTGGCC 
AGCCGTGACG CCGGCCTCTC GTGGGGCAGC GCCCGGGACC TCACCGAGGA GGCCATCGGT 
GGTGCCGTGC AGGACTGGGC CACATTCGCT GTGGGTCCCG GCCACGGTGT GCAGCTGCCC 
TCAGGCCGCC TGCTGGTACC CGCCTACACC TACCGCGTGG ACCGCCGAGA GTGTTTTGGC 
AAGATCTGCC GGACCAGCCC TCACTCCTTC GCCTTCTACA GCGATGACCA CGGCCGCACC 
TGGCGCTGTG GAGGCCTCGT GCCCAACCTG CGCTCAGGCG AGTGCCAGCT GGCAGCGGTG 
GACGGTGGGC AGGCCGGCAG CTTCCTCTAC TGCAATGCCC GGAGCCCACT GGGCAGCCGT 
GTGCAGGCGC TCAGCACTGA CGAGGGCACC TCCTTCCTGC CCGCAGAGCG CGTGGCTTCC 
CTGCCCGAGA CTGCCTGGGG CTGCCAGGGC AGCATCGTGG GCTTCCCAGC CCCCGCCCCC 
AACAGGCCAC GGGATGACAG TTGGTCAGTG GGCCCCGGGA GTCCCCTCCA GCCTCCACTC 
CTCGGTCCTG GAGTCCACGA ACCCCCAGAG GAGGCTGCTG TAGACCCCCG TGGAGGCCAG 
GTGCCTGGTG GGCCCTTCAG CCGTCTGCAG CCTCGGGGGG ATGGCCCCAG GCAGCCTGGC 
CCCAGGCCTG GGGTCAGTGG GGATGTGGGG TCCTGGACCC TGGCACTCCC CATGCCCTTT 
GCTGCCCCGC CCCAGAGCCC CACGTGGCTG CTGTACTCCC ACCCAGTGGG GCGCAGGGCT 
CGGCTACACA TGGGTATCCG CCTGAGCCAG TCCCCGCTGG ACCCGCGCAG CTGGACAGAG 
CCCTGGGTGA TCTACGAGGG CCCCAGCGGC TACTCCGACC TGGCGTCCAT CGGGCCGGCC 
CCTGAGGGGG GCCTGGTTTT TGCCTGCCTG TACGAGAGCG GGGCCAGGAC CTCCTATGAT 
GAGATTTCCT TTTGTACATT CTCCCTGCGT GAGGTCCTGG AGAACGTGCC CGCCAGCCCC 
AAACCGCCCA ACCTTGGGGA CAAGCCTCGG GGGTGCTGCT GGCCCTCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu24025
Clone ID Related Accession (Same CDS sequence) NM_001167599.3 , NM_001167599.2
Accession Version NM_001167599.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1494bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-02
Organism Homo sapiens(human)
Product sialidase-4 isoform 2
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB173219.1, AK091038.1, AC131097.6 and BC063465.1. On Jun 2, 2019 this sequence version replaced NM_001167599.2. Transcript Variant: This variant (2) uses an alternate acceptor splice site at one of the coding exons compared to variant 1, resulting in an isoform (2) that is 1 aa longer than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063465.1, BI754607.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGATGAGCT CTGCAGCCTT CCCAAGGTGG CTGCAGAGCA TGGGGGTCCC TCGTACCCCT 
TCACGGACAG TGCTCTTCGA GCGGGAGAGG ACGGGCCTGA CCTACCGCGT GCCCTCGCTG 
CTCCCCGTGC CCCCCGGGCC CACCCTGCTG GCCTTTGTGG AGCAGCGGCT CAGCCCTGAC 
GACTCCCACG CCCACCGCCT GGTGCTGAGG AGGGGCACGC TGGCCGGGGG CTCCGTGCGG 
TGGGGTGCCC TGCACGTGCT GGGGACAGCA GCCCTGGCGG AGCACCGGTC CATGAACCCC 
TGCCCTGTGC ACGATGCTGG CACGGGCACC GTCTTCCTCT TCTTCATCGC GGTGCTGGGC 
CACACGCCTG AGGCCGTGCA GATCGCCACG GGAAGGAACG CCGCGCGCCT CTGCTGTGTG 
GCCAGCCGTG ACGCCGGCCT CTCGTGGGGC AGCGCCCGGG ACCTCACCGA GGAGGCCATC 
GGTGGTGCCG TGCAGGACTG GGCCACATTC GCTGTGGGTC CCGGCCACGG TGTGCAGCTG 
CCCTCAGGCC GCCTGCTGGT ACCCGCCTAC ACCTACCGCG TGGACCGCCG AGAGTGTTTT 
GGCAAGATCT GCCGGACCAG CCCTCACTCC TTCGCCTTCT ACAGCGATGA CCACGGCCGC 
ACCTGGCGCT GTGGAGGCCT CGTGCCCAAC CTGCGCTCAG GCGAGTGCCA GCTGGCAGCG 
GTGGACGGTG GGCAGGCCGG CAGCTTCCTC TACTGCAATG CCCGGAGCCC ACTGGGCAGC 
CGTGTGCAGG CGCTCAGCAC TGACGAGGGC ACCTCCTTCC TGCCCGCAGA GCGCGTGGCT 
TCCCTGCCCG AGACTGCCTG GGGCTGCCAG GGCAGCATCG TGGGCTTCCC AGCCCCCGCC 
CCCAACAGGC CACGGGATGA CAGTTGGTCA GTGGGCCCCG GGAGTCCCCT CCAGCCTCCA 
CTCCTCGGTC CTGGAGTCCA CGAACCCCCA GAGGAGGCTG CTGTAGACCC CCGTGGAGGC 
CAGGTGCCTG GTGGGCCCTT CAGCCGTCTG CAGCCTCGGG GGGATGGCCC CAGGCAGCCT 
GGCCCCAGGC CTGGGGTCAG TGGGGATGTG GGGTCCTGGA CCCTGGCACT CCCCATGCCC 
TTTGCTGCCC CGCCCCAGAG CCCCACGTGG CTGCTGTACT CCCACCCAGT GGGGCGCAGG 
GCTCGGCTAC ACATGGGTAT CCGCCTGAGC CAGTCCCCGC TGGACCCGCG CAGCTGGACA 
GAGCCCTGGG TGATCTACGA GGGCCCCAGC GGCTACTCCG ACCTGGCGTC CATCGGGCCG 
GCCCCTGAGG GGGGCCTGGT TTTTGCCTGC CTGTACGAGA GCGGGGCCAG GACCTCCTAT 
GATGAGATTT CCTTTTGTAC ATTCTCCCTG CGTGAGGTCC TGGAGAACGT GCCCGCCAGC 
CCCAAACCGC CCAACCTTGG GGACAAGCCT CGGGGGTGCT GCTGGCCCTC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001161071.1
CDS34..1527
Translation

Target ORF information:

RefSeq Version NM_001167599.3
Organism Homo sapiens(human)
Definition Homo sapiens neuraminidase 4 (NEU4), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001167599.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGATGAGCT CTGCAGCCTT CCCAAGGTGG CTGCAGAGCA TGGGGGTCCC TCGTACCCCT 
TCACGGACAG TGCTCTTCGA GCGGGAGAGG ACGGGCCTGA CCTACCGCGT GCCCTCGCTG 
CTCCCCGTGC CCCCCGGGCC CACCCTGCTG GCCTTTGTGG AGCAGCGGCT CAGCCCTGAC 
GACTCCCACG CCCACCGCCT GGTGCTGAGG AGGGGCACGC TGGCCGGGGG CTCCGTGCGG 
TGGGGTGCCC TGCACGTGCT GGGGACAGCA GCCCTGGCGG AGCACCGGTC CATGAACCCC 
TGCCCTGTGC ACGATGCTGG CACGGGCACC GTCTTCCTCT TCTTCATCGC GGTGCTGGGC 
CACACGCCTG AGGCCGTGCA GATCGCCACG GGAAGGAACG CCGCGCGCCT CTGCTGTGTG 
GCCAGCCGTG ACGCCGGCCT CTCGTGGGGC AGCGCCCGGG ACCTCACCGA GGAGGCCATC 
GGTGGTGCCG TGCAGGACTG GGCCACATTC GCTGTGGGTC CCGGCCACGG TGTGCAGCTG 
CCCTCAGGCC GCCTGCTGGT ACCCGCCTAC ACCTACCGCG TGGACCGCCG AGAGTGTTTT 
GGCAAGATCT GCCGGACCAG CCCTCACTCC TTCGCCTTCT ACAGCGATGA CCACGGCCGC 
ACCTGGCGCT GTGGAGGCCT CGTGCCCAAC CTGCGCTCAG GCGAGTGCCA GCTGGCAGCG 
GTGGACGGTG GGCAGGCCGG CAGCTTCCTC TACTGCAATG CCCGGAGCCC ACTGGGCAGC 
CGTGTGCAGG CGCTCAGCAC TGACGAGGGC ACCTCCTTCC TGCCCGCAGA GCGCGTGGCT 
TCCCTGCCCG AGACTGCCTG GGGCTGCCAG GGCAGCATCG TGGGCTTCCC AGCCCCCGCC 
CCCAACAGGC CACGGGATGA CAGTTGGTCA GTGGGCCCCG GGAGTCCCCT CCAGCCTCCA 
CTCCTCGGTC CTGGAGTCCA CGAACCCCCA GAGGAGGCTG CTGTAGACCC CCGTGGAGGC 
CAGGTGCCTG GTGGGCCCTT CAGCCGTCTG CAGCCTCGGG GGGATGGCCC CAGGCAGCCT 
GGCCCCAGGC CTGGGGTCAG TGGGGATGTG GGGTCCTGGA CCCTGGCACT CCCCATGCCC 
TTTGCTGCCC CGCCCCAGAG CCCCACGTGG CTGCTGTACT CCCACCCAGT GGGGCGCAGG 
GCTCGGCTAC ACATGGGTAT CCGCCTGAGC CAGTCCCCGC TGGACCCGCG CAGCTGGACA 
GAGCCCTGGG TGATCTACGA GGGCCCCAGC GGCTACTCCG ACCTGGCGTC CATCGGGCCG 
GCCCCTGAGG GGGGCCTGGT TTTTGCCTGC CTGTACGAGA GCGGGGCCAG GACCTCCTAT 
GATGAGATTT CCTTTTGTAC ATTCTCCCTG CGTGAGGTCC TGGAGAACGT GCCCGCCAGC 
CCCAAACCGC CCAACCTTGG GGACAAGCCT CGGGGGTGCT GCTGGCCCTC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu24025
Clone ID Related Accession (Same CDS sequence) NM_001167599.3 , NM_001167599.2
Accession Version NM_001167599.2 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1494bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2018-06-29
Organism Homo sapiens(human)
Product sialidase-4 isoform 2
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC131097.6, DB173219.1, AK091038.1 and BC063465.1. On Apr 12, 2014 this sequence version replaced NM_001167599.1. Transcript Variant: This variant (2) uses an alternate acceptor splice site at one of the coding exons compared to variant 1, resulting in an isoform (2) that is 1 aa longer than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063465.1, BI754607.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGATGAGCT CTGCAGCCTT CCCAAGGTGG CTGCAGAGCA TGGGGGTCCC TCGTACCCCT 
TCACGGACAG TGCTCTTCGA GCGGGAGAGG ACGGGCCTGA CCTACCGCGT GCCCTCGCTG 
CTCCCCGTGC CCCCCGGGCC CACCCTGCTG GCCTTTGTGG AGCAGCGGCT CAGCCCTGAC 
GACTCCCACG CCCACCGCCT GGTGCTGAGG AGGGGCACGC TGGCCGGGGG CTCCGTGCGG 
TGGGGTGCCC TGCACGTGCT GGGGACAGCA GCCCTGGCGG AGCACCGGTC CATGAACCCC 
TGCCCTGTGC ACGATGCTGG CACGGGCACC GTCTTCCTCT TCTTCATCGC GGTGCTGGGC 
CACACGCCTG AGGCCGTGCA GATCGCCACG GGAAGGAACG CCGCGCGCCT CTGCTGTGTG 
GCCAGCCGTG ACGCCGGCCT CTCGTGGGGC AGCGCCCGGG ACCTCACCGA GGAGGCCATC 
GGTGGTGCCG TGCAGGACTG GGCCACATTC GCTGTGGGTC CCGGCCACGG TGTGCAGCTG 
CCCTCAGGCC GCCTGCTGGT ACCCGCCTAC ACCTACCGCG TGGACCGCCG AGAGTGTTTT 
GGCAAGATCT GCCGGACCAG CCCTCACTCC TTCGCCTTCT ACAGCGATGA CCACGGCCGC 
ACCTGGCGCT GTGGAGGCCT CGTGCCCAAC CTGCGCTCAG GCGAGTGCCA GCTGGCAGCG 
GTGGACGGTG GGCAGGCCGG CAGCTTCCTC TACTGCAATG CCCGGAGCCC ACTGGGCAGC 
CGTGTGCAGG CGCTCAGCAC TGACGAGGGC ACCTCCTTCC TGCCCGCAGA GCGCGTGGCT 
TCCCTGCCCG AGACTGCCTG GGGCTGCCAG GGCAGCATCG TGGGCTTCCC AGCCCCCGCC 
CCCAACAGGC CACGGGATGA CAGTTGGTCA GTGGGCCCCG GGAGTCCCCT CCAGCCTCCA 
CTCCTCGGTC CTGGAGTCCA CGAACCCCCA GAGGAGGCTG CTGTAGACCC CCGTGGAGGC 
CAGGTGCCTG GTGGGCCCTT CAGCCGTCTG CAGCCTCGGG GGGATGGCCC CAGGCAGCCT 
GGCCCCAGGC CTGGGGTCAG TGGGGATGTG GGGTCCTGGA CCCTGGCACT CCCCATGCCC 
TTTGCTGCCC CGCCCCAGAG CCCCACGTGG CTGCTGTACT CCCACCCAGT GGGGCGCAGG 
GCTCGGCTAC ACATGGGTAT CCGCCTGAGC CAGTCCCCGC TGGACCCGCG CAGCTGGACA 
GAGCCCTGGG TGATCTACGA GGGCCCCAGC GGCTACTCCG ACCTGGCGTC CATCGGGCCG 
GCCCCTGAGG GGGGCCTGGT TTTTGCCTGC CTGTACGAGA GCGGGGCCAG GACCTCCTAT 
GATGAGATTT CCTTTTGTAC ATTCTCCCTG CGTGAGGTCC TGGAGAACGT GCCCGCCAGC 
CCCAAACCGC CCAACCTTGG GGACAAGCCT CGGGGGTGCT GCTGGCCCTC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001161071.1
CDS498..1991
Translation

Target ORF information:

RefSeq Version NM_001167599.2
Organism Homo sapiens(human)
Definition Homo sapiens neuraminidase 4 (NEU4), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001167599.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGATGAGCT CTGCAGCCTT CCCAAGGTGG CTGCAGAGCA TGGGGGTCCC TCGTACCCCT 
TCACGGACAG TGCTCTTCGA GCGGGAGAGG ACGGGCCTGA CCTACCGCGT GCCCTCGCTG 
CTCCCCGTGC CCCCCGGGCC CACCCTGCTG GCCTTTGTGG AGCAGCGGCT CAGCCCTGAC 
GACTCCCACG CCCACCGCCT GGTGCTGAGG AGGGGCACGC TGGCCGGGGG CTCCGTGCGG 
TGGGGTGCCC TGCACGTGCT GGGGACAGCA GCCCTGGCGG AGCACCGGTC CATGAACCCC 
TGCCCTGTGC ACGATGCTGG CACGGGCACC GTCTTCCTCT TCTTCATCGC GGTGCTGGGC 
CACACGCCTG AGGCCGTGCA GATCGCCACG GGAAGGAACG CCGCGCGCCT CTGCTGTGTG 
GCCAGCCGTG ACGCCGGCCT CTCGTGGGGC AGCGCCCGGG ACCTCACCGA GGAGGCCATC 
GGTGGTGCCG TGCAGGACTG GGCCACATTC GCTGTGGGTC CCGGCCACGG TGTGCAGCTG 
CCCTCAGGCC GCCTGCTGGT ACCCGCCTAC ACCTACCGCG TGGACCGCCG AGAGTGTTTT 
GGCAAGATCT GCCGGACCAG CCCTCACTCC TTCGCCTTCT ACAGCGATGA CCACGGCCGC 
ACCTGGCGCT GTGGAGGCCT CGTGCCCAAC CTGCGCTCAG GCGAGTGCCA GCTGGCAGCG 
GTGGACGGTG GGCAGGCCGG CAGCTTCCTC TACTGCAATG CCCGGAGCCC ACTGGGCAGC 
CGTGTGCAGG CGCTCAGCAC TGACGAGGGC ACCTCCTTCC TGCCCGCAGA GCGCGTGGCT 
TCCCTGCCCG AGACTGCCTG GGGCTGCCAG GGCAGCATCG TGGGCTTCCC AGCCCCCGCC 
CCCAACAGGC CACGGGATGA CAGTTGGTCA GTGGGCCCCG GGAGTCCCCT CCAGCCTCCA 
CTCCTCGGTC CTGGAGTCCA CGAACCCCCA GAGGAGGCTG CTGTAGACCC CCGTGGAGGC 
CAGGTGCCTG GTGGGCCCTT CAGCCGTCTG CAGCCTCGGG GGGATGGCCC CAGGCAGCCT 
GGCCCCAGGC CTGGGGTCAG TGGGGATGTG GGGTCCTGGA CCCTGGCACT CCCCATGCCC 
TTTGCTGCCC CGCCCCAGAG CCCCACGTGG CTGCTGTACT CCCACCCAGT GGGGCGCAGG 
GCTCGGCTAC ACATGGGTAT CCGCCTGAGC CAGTCCCCGC TGGACCCGCG CAGCTGGACA 
GAGCCCTGGG TGATCTACGA GGGCCCCAGC GGCTACTCCG ACCTGGCGTC CATCGGGCCG 
GCCCCTGAGG GGGGCCTGGT TTTTGCCTGC CTGTACGAGA GCGGGGCCAG GACCTCCTAT 
GATGAGATTT CCTTTTGTAC ATTCTCCCTG CGTGAGGTCC TGGAGAACGT GCCCGCCAGC 
CCCAAACCGC CCAACCTTGG GGACAAGCCT CGGGGGTGCT GCTGGCCCTC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Integrin-mediated cell migration is blocked by inhibitors of human neuraminidase.
Biochimica et biophysica acta1861(9 Pt A)1170-1179(2016 09)
Jia F,Howlader MA,Cairo CW


book

Sialidase NEU4 is involved in glioblastoma stem cell survival.
Cell death & disease5e1381(2014 Aug)
Silvestri I,Testa F,Zappasodi R,Cairo CW,Zhang Y,Lupo B,Galli R,Di Nicola M,Venerando B,Tringali C


book

A proline-rich loop mediates specific functions of human sialidase NEU4 in SK-N-BE neuronal differentiation.
Glycobiology23(12)1499-509(2013 Dec)
Bigi A,Tringali C,Forcella M,Mozzi A,Venerando B,Monti E,Fusi P


book

NEU4L sialidase overexpression promotes ?-catenin signaling in neuroblastoma cells, enhancing stem-like malignant cell growth.
International journal of cancer131(8)1768-78(2012 Oct)
Tringali C,Cirillo F,Lamorte G,Papini N,Anastasia L,Lupo B,Silvestri I,Tettamanti G,Venerando B


book

Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons.
The Journal of biological chemistry287(18)14816-26(2012 Apr)
Takahashi K,Mitoma J,Hosono M,Shiozaki K,Sato C,Yamaguchi K,Kitajima K,Higashi H,Nitta K,Shima H,Miyagi T